Application of PMMA bone cement composited with bone-mineralized collagen in percutaneous kyphoplasty.

We investigated the feasibility of applying polymethylmethacrylate bone cement composited with biomimetic bone-mineralizsed collagen to percutaneous kyphoplasty (PKP). We performed PKP in 95 patients diagnosed with osteoporotic vertebral compression fracture. All patients had fractures of a single vertebral body, and they were divided randomly into control (group A, 47 patients) and experimental (group B, 48 patients) groups. Patients in group A were treated with acrylic cement, and those in group B were treated with acrylic cement composited with the bone graft material. All patients were evaluated by a visual analogue scale (VAS), Oswestry disability index (ODI), Cobb angle and anterior vertebral body height preoperatively, and 3 days and 3 months postoperatively. All patients successfully completed surgery and were followed up thereafter. The VAS score, ODI index, Cobb angle and anterior vertebral body height compression rate in both groups had significant changes (P < 0.05) preoperatively, and at 3 days and 3 months postoperatively. There was no significant difference between the two groups at different times (P > 0.05). The analgesic effects of bone cement composited with bone-mineralized collagen are similar to those of bone cement only. Mineralized collagen has excellent promotion prospects by inducing new bone formation and reducing the incidence of adverse reactions caused by bone cement.