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Regenerative Biomaterials

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https://www.readbyqxmd.com/read/27482467/high-shear-stress-induces-atherosclerotic-vulnerable-plaque-formation-through-angiogenesis
#1
REVIEW
Yi Wang, Juhui Qiu, Shisui Luo, Xiang Xie, Yiming Zheng, Kang Zhang, Zhiyi Ye, Wanqian Liu, Hans Gregersen, Guixue Wang
Rupture of atherosclerotic plaques causing thrombosis is the main cause of acute coronary syndrome and ischemic strokes. Inhibition of thrombosis is one of the important tasks developing biomedical materials such as intravascular stents and vascular grafts. Shear stress (SS) influences the formation and development of atherosclerosis. The current review focuses on the vulnerable plaques observed in the high shear stress (HSS) regions, which localizes at the proximal region of the plaque intruding into the lumen...
December 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27482466/electrospun-silk-fibroin-poly-l-lactide-%C3%AE%C2%B5-caplacton-graft-with-platelet-rich-growth-factor-for-inducing-smooth-muscle-cell-growth-and-infiltration
#2
Anlin Yin, Gary L Bowlin, Rifang Luo, Xingdong Zhang, Yunbing Wang, Xiumei Mo
The construction of a smooth muscle layer for blood vessel through electrospinning method plays a key role in vascular tissue engineering. However, smooth muscle cells (SMCs) penetration into the electrospun graft to form a smooth muscle layer is limited due to the dense packing of fibers and lack of inducing factors. In this paper, silk fibroin/poly (L-lactide-ε-caplacton) (SF/PLLA-CL) vascular graft loaded with platelet-rich growth factor (PRGF) was fabricated by electrospinning. The in vitro results showed that SMCs cultured in the graft grew fast, and the incorporation of PRGF could induce deeper SMCs infiltrating compared to the SF/PLLA-CL graft alone...
December 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27482465/preparation-and-characterization-of-a-degradable-magnesium-phosphate-bone-cement
#3
Ying Yu, Chao Xu, Honglian Dai
A kind of degradable magnesium phosphate bone cement (MPBC) was fabricated by using the mixed powders of magnesium oxide (MgO), potassium dihydrogen phosphate (KH2PO4) and calcium dihydrogen phosphate (Ca(H2PO4)2.H2O). As MgKPO4, the main product of MgO and KH2PO4 was alkaline, the Ca(H2PO4)2.H2O was added to neutralize the alkali of the system. And the effects of Ca(H2PO4)2.H2O on the performance of MPBC were discussed. The results showed that the adding of Ca(H2PO4)2.H2O extended the setting time, which was about 6 min to 18 min...
December 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27482464/reduction-of-polyethylenimine-coated-iron-oxide-nanoparticles-induced-autophagy-and-cytotoxicity-by-lactosylation
#4
Jiuju Du, Wencheng Zhu, Li Yang, Changqiang Wu, Bingbing Lin, Jun Wu, Rongrong Jin, Taipeng Shen, Hua Ai
Superparamagnetic iron oxide (SPIO) nanoparticles are excellent magnetic resonance contrast agents and surface engineering can expand their applications. When covered with amphiphilic alkyl-polyethyleneimine (PEI), the modified SPIO nanoparticles can be used as MRI visible gene/drug delivery carriers and cell tracking probes. However, the positively charged amines of PEI can also cause cytotoxicity and restricts their further applications. In this study, we used lactose to modify amphiphilic low molecular weight polyethylenimine (C12-PEI2K) at different lactosylation degree...
December 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27482463/hydrogen-peroxide-detection-with-high-specificity-in-living-cells-and-inflamed-tissues
#5
Lei Rong, Chi Zhang, Qi Lei, Ming-Ming Hu, Jun Feng, Hong-Bing Shu, Yi Liu, Xian-Zheng Zhang
Hydrogen peroxide (H2O2) detection in biological systems is of significant importance, which act as critical second messenger in fundamental biological processes. Here, we report on a chemoselective fluorescent naphthylimide peroxide probe (NPP) for the H2O2 detection in vitro and in vivo. NPP is a phenylboronic acid-caged chromophore that selectively responds to H2O2 through a self-immolate mechanism. NPP exhibited high sensitivity and selectivity to H2O2 with distinctive fluorescence change due to the excellent two-photon excitation property, which permits the facile detection of inflammation produced H2O2 and offers chance to monitor the inflammatory stages in diseased cells...
December 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27482462/accelerating-degradation-rate-of-pure-iron-by-zinc-ion-implantation
#6
Tao Huang, Yufeng Zheng, Yong Han
Pure iron has been considered as a promising candidate for biodegradable implant applications. However, a faster degradation rate of pure iron is needed to meet the clinical requirement. In this work, metal vapor vacuum arc technology was adopted to implant zinc ions into the surface of pure iron. Results showed that the implantation depth of zinc ions was about 60 nm. The degradation rate of pure iron was found to be accelerated after zinc ion implantation. The cytotoxicity tests revealed that the implanted zinc ions brought a slight increase on cytotoxicity of the tested cells...
December 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27699063/determining-the-critical-size-of-a-rabbit-rib-segmental-bone-defect-model
#7
Fengzhen Liu, Kun Chen, Lei Hou, Keyi Li, Dawei Wang, Bin Zhang, Xiumei Wang
In order to establish and standardize the rabbit rib segmental bone defect model, it is of vital importance to determine rabbit rib critical size defect (CSD). According to the general time needed for spontaneous long-bone regeneration, three-month observation period was set to determine the CSD. The rabbit rib segmental bone defects with different sizes from 1 to 5 cm with or without periosteum were performed in the eighth rib of 4-month-old male New Zealand rabbits and underwent X-ray examinations at the 4th, 8th and 12th weeks postoperatively...
October 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27699062/comparison-of-safety-and-efficiency-of-microendoscopic-discectomy-with-automatic-nerve-retractor-and-with-nerve-hook
#8
He-Ping Yin, Yu-Peng Wang, Zhi-Ye Qiu, Zhi-Cai Du, Yi-Min Wu, Shu-Wen Li
This study compares the safety and efficiency of two techniques in microendoscopic discectomy (MED) for lumbar disc herniation. The two techniques are MED with automatic nerve retractor and MED with nerve hook which had been widely used for many years. The former involves a newly developed MED device which contains three parts to protect nerve roots during operation. Four hundred and twenty-eight patients underwent MED treatments between October 2010 and September 2015 were recruited and randomized to either intraoperative utilization of automatic nerve retractor (n = 315, group A) or application of nerve hook during surgery (n = 113, group B)...
October 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27699061/drug-nanoencapsulated-plga-microspheres-prepared-by-emulsion-electrospray-with-controlled-release-behavior
#9
Shenglian Yao, Huiying Liu, Shukui Yu, Yuanyuan Li, Xiumei Wang, Luning Wang
The development of modern therapeutics has raised the requirement for controlled drug delivery system which is able to efficiently encapsulate bioactive agents and achieve their release at a desired rate satisfying the need of the practical system. In this study, two kind of aqueous model drugs with different molecule weight, Congo red and albumin from bovine serum (BSA) were nano-encapsulated in poly (dl-lactic-co-glycolic acid) (PLGA) microspheres by emulsion electrospray. In the preparation process, the aqueous phase of drugs was added into the PLGA chloroform solution to form the emulsion solution...
October 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27699060/efficient-gsh-delivery-using-pamam-gsh-into-mpp-induced-pc12-cellular-model-for-parkinson-s-disease
#10
Hong-Ji Sun, Yan Wang, Tong Hao, Chang-Yong Wang, Qi-Yu Wang, Xiao-Xia Jiang
Glutathione (GSH) depletion has been an important contributor to the dysfunction of dopamine neurons. Polyamidoamine-GSH (PAMAM-GSH) was synthesized and the delivery effect of GSH into PC12 cells was tested. MTT assessment for cytotoxicity and reactive oxygen species (ROS) as well as nitrite oxide (NO) and intracelluar superoxide dismutase (SOD) detection for antioxidative ability were performed. Furthermore, the antiapoptotic ability was analysed by assessing caspase-3, JNK1/2 and Erk1/2 expression. Our data indicated that PAMAM-GSH is an effective agent to replenish GSH into PC12 cells...
October 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27699059/ectopic-osteogenesis-and-angiogenesis-regulated-by-porous-architecture-of-hydroxyapatite-scaffolds-with-similar-interconnecting-structure-in-vivo
#11
Jinyu Li, Wei Zhi, Taotao Xu, Feng Shi, Ke Duan, Jianxin Wang, Yandong Mu, Jie Weng
The macro-pore sizes of porous scaffold play a key role for regulating ectopic osteogenesis and angiogenesis but many researches ignored the influence of interconnection between macro-pores with different sizes. In order to accurately reveal the relationship between ectopic osteogenesis and macro-pore sizes in dorsal muscle and abdominal cavities of dogs, hydroxyapatite (HA) scaffolds with three different macro-pore sizes of 500-650, 750-900 and 1100-1250 µm were prepared via sugar spheres-leaching process, which also had similar interconnecting structure determined by keeping the d/s ratio of interconnecting window diameter to macro-pore size constant...
October 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27699058/stability-research-on-polydopamine-and-immobilized-albumin-on-316l-stainless-steel
#12
Hao Zhang, Lingxia Xie, Jinchuan Deng, Weihua Zhuang, Rifang Luo, Jin Wang, Nan Huang, Yunbing Wang
In this study, the polydopamine (PDA) film was coated on polished 316Lss and then thermally treated at 150 °C (labeled as PDA-Th150), and the stability of coatings was also investigated. Straining test indicated that PDA-Th150 coating performed better in affording sufficient adherence to 316 L SS substrate. Moreover, both PDA and PDA-Th150 coating suffered slight swelling during immersion in deionized water (pH = 6.5). X-ray photoelectron spectroscopy results showed that during immersion, latent nucleophilic reaction via amines inside PDA coating occurred...
October 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27699057/controlling-the-strontium-doping-in-calcium-phosphate-microcapsules-through-yeast-regulated-biomimetic-mineralization
#13
Miaojun Huang, Tianjie Li, Ting Pan, Naru Zhao, Yongchang Yao, Zhichen Zhai, Jiaan Zhou, Chang Du, Yingjun Wang
Yeast cells have controllable biosorption on metallic ions during metabolism. However, few studies were dedicated to using yeast-regulated biomimetic mineralization process to control the strontium-doped positions in calcium phosphate microcapsules. In this study, the yeast cells were allowed to pre-adsorb strontium ions metabolically and then served as sacrificing template for the precipitation and calcination of mineral shell. The pre-adsorption enabled the microorganism to enrich of strontium ions into the inner part of the microcapsules, which ensured a slow-release profile of the trace element from the microcapsule...
October 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27252889/scientific-collaboration-a-social-network-analysis-based-on-literature-of-animal-derived-regenerative-implantable-medical-devices
#14
REVIEW
Shu-Yang Yu, Hong-Man Wang
The collaboration network of English publications on animal-derived regenerative implantable medical devices based on tissue engineering technology and its evolving processes and current states were mapped in this paper. A total of 10 159 English papers published before 1 January 2015 were obtained in eight databases. Social network analysis was conducted on these papers by utilizing UCINET software and Statistical Analysis Software for Informatics researched and developed by Peking University. The collaboration network has evolved from scattered formation to single-core dominated, and then to a core-edge one; collaboration has become more frequent and wider; network density and centrality have decreased; USA, UK and China are the top three countries with Wake Forest University, Harvard University and Tufts University being the top three contributing institutions cooperated mostly during the period between 2010 and 2014; plenty of edge institutes exist...
September 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27252888/calcium-phosphate-nanoparticles-based-systems-for-sirna-delivery
#15
REVIEW
Xiaochun Xu, Zehao Li, Xueqin Zhao, Lawrence Keen, Xiangdong Kong
Despite the enormous therapeutic potential of siRNA as a treatment strategy, the delivery is still a problem due to unfavorable biodistribution profiles and poor intracellular bioavailability. Calcium phosphate (CaP) co-precipitate has been used for nearly 40 years for in vitro transfection due to its non-toxic nature and simplicity of preparation. The surface charge of CaP will be tuned into positive by surface modification, which is important for siRNA loading and crossing cell membrane without enzymatic degradation...
September 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27252887/biomedical-titanium-alloys-with-young-s-moduli-close-to-that-of-cortical-bone
#16
REVIEW
Mitsuo Niinomi, Yi Liu, Masaki Nakai, Huihong Liu, Hua Li
Biomedical titanium alloys with Young's moduli close to that of cortical bone, i.e., low Young's modulus titanium alloys, are receiving extensive attentions because of their potential in preventing stress shielding, which usually leads to bone resorption and poor bone remodeling, when implants made of their alloys are used. They are generally β-type titanium alloys composed of non-toxic and allergy-free elements such as Ti-29Nb-13Ta-4.6Zr referred to as TNTZ, which is highly expected to be used as a biomaterial for implants replacing failed hard tissue...
September 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27252886/sirolimus-loaded-cap-coating-on-co-cr-alloy-for-drug-eluting-stent
#17
Jingxin Yang, In-Seop Lee, Fuzhai Cui
To achieve polymer-free and controllable drug-eluting system, there have been many efforts to modify the surface composition and topography of metal stent. Recently, calcium phosphate is commonly applied to metallic implants as a coating material for fast fixation and firm-implant bone attachment on the account of its demonstrated bioactive and osteoconductive properties. In the present study, the release of sirolimus could be controllable because of immobilization of sirolimus during the process of biomimetic CaP coating forming...
September 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27252885/degradation-characteristics-cell-viability-and-host-tissue-responses-of-pdlla-based-scaffold-with-prgd-and-%C3%AE-tcp-nanoparticles-incorporation
#18
Jiling Yi, Feng Xiong, Binbin Li, Heping Chen, Yixia Yin, Honglian Dai, Shipu Li
This study is aimed to evaluate the degradation characteristics, cell viability and host tissue responses of PDLLA/PRGD/β-TCP (PRT) composite nerve scaffold, which was fabricated by poly(d, l-lactic acid) (PDLLA), RGD peptide(Gly-Arg-Gly-Asp-Tyr, GRGDY, abbreviated as RGD) modified poly-{(lactic acid)-co-[(glycolic acid)-alt-(l-lysine)]}(PRGD) and β-tricalcium phosphate (β-TCP). The scaffolds' in vitro degradation behaviors were investigated in detail by analysing changes in weight loss, pH and morphology...
September 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27252884/investigation-of-enhanced-hemocompatibility-and-tissue-compatibility-associated-with-multi-functional-coating-based-on-hyaluronic-acid-and-type-iv-collagen
#19
Jingan Li, Kun Zhang, Wenyong Ma, Feng Wu, Ping Yang, Zikun He, Nan Huang
The biocompatibility of cardiovascular devices has always been considered crucial for their clinical efficacy. Therefore, a biofunctional coating composed of Type IV collagen (CoIV) and hyaluronan (HA) was previously fabricated onto the titanium (Ti) substrate for the application of promoting vascular smooth muscle cell contractile phenotype and improving surface endothelialization. However, the anti-inflammation property, blood compatibility and in vivo tissue compatibility of the HA/CoIV coating, as paramount consideration of cardiovascular materials surface coating, have not been investigated...
September 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27047683/critical-questions-in-development-of-targeted-nanoparticle-therapeutics
#20
REVIEW
Richard Korsmeyer
One of the fourteen Grand Challenges for Engineering articulated by the US National Academy of Engineering is 'Engineer Better Medicines'. Although there are many ways that better medicines could be engineered, one of the most promising ideas is to improve our ability to deliver the therapeutic molecule more precisely to the desired target. Most conventional drug delivery methods (oral absorption, intravenous infusion etc.) result in systemic exposure to the therapeutic molecule, which places severe constraints on the types of molecules that can be used...
June 2016: Regenerative Biomaterials
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