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Regenerative Biomaterials

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https://www.readbyqxmd.com/read/29977596/the-directional-migration-and-differentiation-of-mesenchymal-stem-cells-toward-vascular-endothelial-cells-stimulated-by-biphasic-calcium-phosphate-ceramic
#1
Ying Chen, Jing Wang, Xiangdong Zhu, Xuening Chen, Xiao Yang, Kai Zhang, Yujiang Fan, Xingdong Zhang
Osteoinductivity of porous calcium phosphate (CaP) ceramics has been widely investigated and confirmed, and it might be attributed to the rapid formation of the vascular networks after in vivo implantation of the ceramics. In this study, to explore the vascularization mechanism within the CaP ceramics, the migration and differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) under the stimulation of porous biphasic calcium phosphate (BCP) ceramic with excellent osteoinductivity were systematically investigated...
June 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29977595/smart-scaffolds-in-tissue-regeneration
#2
Samad Ahadian, Ali Khademhosseini
Recent advances in biofabrication technologies and chemical synthesis approaches have enabled the fabrication of smart scaffolds that aim to mimic the dynamic nature of the native extracellular matrix. These scaffolds have paved the way for tissue regeneration in a dynamic and controllable manner.
June 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29942650/endovascular-stent-induced-alterations-in-host-artery-mechanical-environments-and-their-roles-in-stent-restenosis-and-late-thrombosis
#3
REVIEW
Jinxuan Wang, Xuepu Jin, Yuhua Huang, Xiaolin Ran, Desha Luo, Dongchuan Yang, Dongyu Jia, Kang Zhang, Jianhua Tong, Xiaoyan Deng, Guixue Wang
Cardiovascular stent restenosis remains a major challenge in interventional treatment of cardiovascular occlusive disease. Although the changes in arterial mechanical environment due to stent implantation are the main causes of the initiation of restenosis and thrombosis, the mechanisms that cause this initiation are still not fully understood. In this article, we reviewed the studies on the issue of stent-induced alterations in arterial mechanical environment and discussed their roles in stent restenosis and late thrombosis from three aspects: (i) the interaction of the stent with host blood vessel, involve the response of vascular wall, the mechanism of mechanical signal transmission, the process of re-endothelialization and late thrombosis; (ii) the changes of hemodynamics in the lumen of the vascular segment and (iii) the changes of mechanical microenvironment within the vascular segment wall due to stent implantation...
June 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29942649/poly-ethylene-glycol-hydrogel-elasticity-influences-human-mesenchymal-stem-cell-behavior
#4
Anna K Whitehead, Haley H Barnett, Mary E Caldorera-Moore, Jamie J Newman
Coordinated investigations into the interactions between biologically mimicking (biomimetic) material constructs and stem cells advance the potential for the regeneration and possible direct replacement of diseased cells and tissues. Any clinically relevant therapies will require the development and optimization of methods that mass produce fully functional cells and tissues. Despite advances in the design and synthesis of biomaterial scaffolds, one of the biggest obstacles facing tissue engineering is understanding how specific extracellular cues produced by biomaterial scaffolds influence the proliferation and differentiation of various cell sources...
June 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29942648/synthesis-of-photo-reactive-poly-vinyl-alcohol-and-construction-of-scaffold-free-cartilage-like-pellets-in-vitro
#5
Bao Li, Yongli Gao, Likun Guo, Yujiang Fan, Naoki Kawazoe, Hongsong Fan, Xingdong Zhang, Guoping Chen
Photo-reactive poly(vinyl alcohol) (PRPVA) was synthesized by introduction of phenyl azido groups into poly(vinyl alcohol) (PVA) and applied for surface modification. PRPVA was grafted onto cell culture plate surface homogeneously or in a micropattern. Human mesenchymal stem cells (hMSCs) cultured on cell culture plate surface and PVA-modified surface showed different behaviors. Cells adhered and spread well on cell culture plate surface, while they did not adhere on PVA-grafted surface at all. When hMSCs were cultured on PVA-micropatterned surface, they formed a cell micropattern...
June 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29942647/a-study-of-the-initial-adhesive-force-of-cells-on-silk-fibroin-based-materials-using-micropipette-aspiration
#6
Xiaojie Lian, Shichao Liu, Liming Liu, Rui Xu, Miaomiao Du, Song Wang, Hesun Zhu, Qiang Lu, Quanyou Zhang, Yali Wu, Di Huang, Yan Wei
With the development of biomaterials, more attention is paid to the adhesion characteristics between cells and materials. It is necessary to study the adhesive force with a suitable method. Silk fibroin (SF) is widely investigated in biomedical application due to its novel biocompatibility and mechanical properties. In this article, the micropipette aspiration method and measurement pattern of uniform cells in round shape (UCR) was used to study the initial adhesive force of three types of cells on pure silk fibroin films (SFFs)...
June 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29942646/lactosylated-n-alkyl-polyethylenimine-coated-iron-oxide-nanoparticles-induced-autophagy-in-mouse-dendritic-cells
#7
Taipeng Shen, Wencheng Zhu, Li Yang, Li Liu, Rongrong Jin, Jimei Duan, James M Anderson, Hua Ai
Dendritic cell (DC)-based vaccines have shown promising therapeutic results in cancer and some immune disorders. It is critical to track in vivo migration behaviours of DCs and monitor the whole process dynamically and non-invasively. Superparamagnetic iron oxide (SPIO) nanoparticles are chosen for DC labelling under magnetic resonance imaging (MRI) because of their proven biosafety as contrast agents. However, when used for cell labelling, sensitive biological indicators such as cell autophagy may be helpful to better understand the process and improve the probe design...
June 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29644093/effect-of-microporosity-on-scaffolds-for-bone-tissue-engineering
#8
REVIEW
Ke Zhang, Yubo Fan, Nicholas Dunne, Xiaoming Li
Microporosity has a critical role in improving the osteogenesis of scaffolds for bone tissue engineering. Although the exact mechanism, by which it promotes new bone formation, is not well recognized yet, the related hypothesis can be found in many previous studies. This review presents those possible mechanisms about how the microporosity enhances the osteogenic-related functions of cells in vitro and the osteogenic activity of scaffolds in vivo . In summary, the increased specific surface areas by microporosity can offer more protein adsorption sites and accelerate the release of degradation products, which facilitate the interactions between scaffolds and cells...
March 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29644092/the-grafts-modified-by-heparinization-and-catalytic-nitric-oxide-generation-used-for-vascular-implantation-in-rats
#9
Jingchen Gao, Li Jiang, Qinge Liang, Jie Shi, Ding Hou, Di Tang, Siyuan Chen, Deling Kong, Shufang Wang
Small-diameter (<6 mm) vascular grafts are increasingly needed in peripheral vascular surgery but have few successes because of acute thrombosis, incomplete endothelialization and intimal hyperplasia after implantation. This study used electrospun poly(ε-caprolactone) as the matrix material. Heparin and selenium-containing catalyst-organoselenium modified polyethyleneimine were introduced through layer-by-layer assembly in order to build a vascular graft with in situ nitric oxide (NO) generation. The aim of this study was to explore the application of the graft with improved histocompatibility and biological function for vascular implantation in rats...
March 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29644091/comparison-of-the-osteogenic-capability-of-rat-bone-mesenchymal-stem-cells-on-collagen-collagen-hydroxyapatite-hydroxyapatite-and-biphasic-calcium-phosphate
#10
Xiaoyu Sun, Wen Su, Xiaomin Ma, Huaiying Zhang, Zhe Sun, Xudong Li
Collagen (COL), collagen/hydroxyapatite (COL/HA), HA and biphasic calcium phosphate were prepared as representative bone grafting materials with composition analogous to bone, and their structural characteristics were analyzed. The rat bone mesenchymal stem cells (BMSCs) were further seeded onto four groups of materials, and BMSCs grown in basic medium and standard osteogenic medium were set as controls of a reference model to show the basic and osteogenic behavior of cells without the intervention of materials...
March 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29644090/human-bone-graft-cytocompatibility-with-mesenchymal-stromal-cells-is-comparable-after-thermal-sterilization-and-washing-followed-by-%C3%AE-irradiation-an-in-vitro-study
#11
Dmitry Labutin, Konstantin Vorobyov, Svetlana Bozhkova, Ekaterina Polyakova, Tatyana Vodopyanova
Human bone allografts present a better alternative to autografts in terms of minimization of the harvesting procedure complications. Prior to the use in clinical applications, they require sterilization which aims to reduce bioburden. This often comes at the expense of their biological properties as carriers of cells. In this study, we evaluated the cytocompatibility of human bone allografts processed and sterilized by three different methods with mesenchymal stromal cells. Bone morphology, biological and biochemical properties of the extracted bone-conditioned medium and viability of cells were assessed...
March 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29644089/heterotopic-bone-formation-in-the-musculus-latissimus-dorsi-of-sheep-using-%C3%AE-tricalcium-phosphate-scaffolds-evaluation-of-different-seeding-techniques
#12
Simon Spalthoff, Rüdiger Zimmerer, Jan Dittmann, Horst Kokemüller, Marco Tiede, Laura Flohr, Philippe Korn, Nils-Claudius Gellrich, Philipp Jehn
Osseous reconstruction of large bone defects remains a challenge in oral and maxillofacial surgery. In addition to autogenous bone grafts, which despite potential donor-site mobility still represent the gold standard in reconstructive surgery, many studies have investigated less invasive alternatives such as in vitro cultivation techniques. This study compared different types of seeding techniques on pure β-tricalcium phosphate scaffolds in terms of bone formation and ceramic resorption in vivo . Cylindrical scaffolds loaded with autologous cancellous bone, venous blood, bone marrow aspirate concentrate or extracorporeal in vitro cultivated bone marrow stromal cells were cultured in sheep on a perforator vessel of the musculus latissimus dorsi over a 6-month period...
March 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29644088/anti-biofilm-and-remineralization-effects-of-chitosan-hydrogel-containing-amelogenin-derived-peptide-on-initial-caries-lesions
#13
Qian Ren, Zhongcheng Li, Longjiang Ding, Xiuqing Wang, Yumei Niu, Xi Qin, Xuedong Zhou, Linglin Zhang
In this study, we have designed a more clinically powerful anti-caries treatment by applying the amelogenin-derived peptide QP5 to the antibacterial carrier material chitosan in a hydrogel (CS-QP5 hydrogel), and characterized its effects on the inhibition of a cariogenic biofilm and the promotion of the remineralization of the initial caries lesions. The results indicated that the CS-QP5 hydrogel sustainably inhibited the growth of the Streptococcus mutans biofilm, lactic acid production and the metabolic activity over a prolonged period of time...
March 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29644087/clinical-observation-of-biomimetic-mineralized-collagen-artificial-bone-putty-for-bone-reconstruction-of-calcaneus-fracture
#14
Yong-Xiong Pan, Guang-Gang Yang, Zhong-Wan Li, Zhong-Min Shi, Zhan-Dong Sun
This study investigated clinical outcomes of biomimetic mineralized collagen artificial bone putty for bone reconstruction in the treatment of calcaneus fracture. Sixty cases of calcaneal fractures surgically treated with open reduction and internal fixation in our hospital from June 2014-2015 were chosen and randomly divided into two groups, including 30 cases treated with biomimetic mineralized collagen artificial bone putty as treatment group, and 30 cases treated with autogenous ilia as control group. The average follow-up time was 17...
March 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29423267/the-material-and-biological-characteristics-of-osteoinductive-calcium-phosphate-ceramics
#15
REVIEW
Zhurong Tang, Xiangfeng Li, Yanfei Tan, Hongsong Fan, Xingdong Zhang
The discovery of osteoinductivity of calcium phosphate (Ca-P) ceramics has set an enduring paradigm of conferring biological regenerative activity to materials with carefully designed structural characteristics. The unique phase composition and porous structural features of osteoinductive Ca-P ceramics allow it to interact with signaling molecules and extracellular matrices in the host system, creating a local environment conducive to new bone formation. Mounting evidence now indicate that the osteoinductive activity of Ca-P ceramics is linked to their physicochemical and three-dimensional structural properties...
February 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29423266/promoting-proliferation-and-differentiation-of-bmscs-by-green-tea-polyphenols-functionalized-porous-calcium-phosphate
#16
Kang Zhou, Xiuli Ren, Mengen Zhao, Xifan Mei, Peng Zhang, Zhenhua Chen, Xiangdong Zhu
In this article, we proposed a facile protocol to functionalize porous calcium phosphate ceramics (PCPC) using dietary tea polyphenols (TP). TP molecules was attracted and anchored by Ca2+ ions from the surface of CPC. These TP molecules modulated the nucleation and crystallization of calcium phosphate nanorods assemblies on the surface of PCPC. Our results prove that these calcium phosphate nanorods assemblies accompanies functional groups of TP make PCPC/TP effectively promote proliferation and differentiation of bone mesenchymal stem cells (BMSCs)...
February 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29423265/a-high-throughput-study-on-endothelial-cell-adhesion-and-growth-mediated-by-adsorbed-serum-protein-via-signaling-pathway-pcr-array
#17
Xiaoying Lü, Yayun Qu, Ying Hong, Yan Huang, Yiwen Zhang, Dayun Yang, Fudan Zhang, Tingfei Xi, Deyuan Zhang
The purpose of this paper is to utilize the signaling pathway polymerase chain reaction (PCR) arrays to investigate the activation of two important biological signaling pathways in endothelial cell adhesion and growth mediated by adsorbed serum protein on the surface of bare and titanium nitride (TiN)-coated nickel titanium (NiTi) alloys. First, the endothelial cells were cultured on the bare and TiN-coated NiTi alloys and chitosan films as control for 4 h and 24 h, respectively. Then, the total RNA of the cells was collected and the PCR arrays were performed...
February 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29423264/a-biomimetic-and-ph-sensitive-polymeric-micelle-as-carrier-for-paclitaxel-delivery
#18
Boxuan Ma, Weihua Zhuang, Gongyan Liu, Yunbing Wang
As nano-scale drug delivery systems, smart micelles that are sensitive to specific biological environment and allowed for target site-triggered drug release by reversible stabilization of micelle structure are attractive. In this work, a biocompatible and pH-sensitive copolymer is synthesized through bridging poly (2-methacryloyloxyethyl phosphorylcholine) (PMPC) block and poly (D, L -lactide) (PLA) block by a benzoyl imine linkage ( Blink ). Biomimetic micelles with excellent biocompatibility based on such PLA- Blink -PMPC copolymer are prepared as carriers for paclitaxel (PTX) delivery...
February 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29423263/evaluation-of-repeated-exposure-systemic-toxicity-test-of-pvc-with-new-plasticizer-on-rats-via-dual-parenteral-routes
#19
Li Hou, Chunguang Fan, Chenghu Liu, Qiujin Qu, Chunren Wang, Yanping Shi
Systemic toxicity caused by repeated exposure to both polar and nonpolar leachables of di(2-ethylhexyl)-1,2-cyclohexane plasticized polyvinyl chloride (PVC) was evaluated with dual routes of parenteral administration method on rats in the study. Experimental group and control group were designed by researchers. Tail intravenous injection with 0.9% sodium chloride injection extracts and intraperitoneal injection with corn oil extracts were conducted to the experimental rats while tail intravenous injection with 0...
February 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29423262/a-fully-absorbable-biomimetic-polymeric-micelle-loaded-with-cisplatin-as-drug-carrier-for-cancer-therapy
#20
Weihua Zhuang, Boxuan Ma, Gongyan Liu, Xiaobing Chen, Yunbing Wang
cis-dichlorodiammineplatinum(II) (CDDP)-loaded polymeric micelles for cancer therapy have been developed to reduce the serious side effects of cisplatin CDDP. Herein, polymeric micelles incorporated with cisplatin are prepared based on the complexation between CDDP and hydrophilic poly (L -glutamic acid)-b-poly (2-methacryloyloxyethyl phosphorylcholine) (PLG-b-PMPC) diblock copolymers. These CDDP-loaded micelles possess an average size of 91 nm with narrow distribution, providing remarkable stability in media containing proteins...
February 2018: Regenerative Biomaterials
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