Bilateral Acute Anterior Uveitis and Conjunctivitis following Intravenous Zoledronic Acid.

The ocular side-effects of bisphosphonates have the potential to escalate with their widespread use. We report a patient of osteoporosis who was treated with zoledronic acid infusion. He developed ocular pain, redness, watering, photophobia and swelling of both the eyes. He was diagnosed with acute anterior uveitis and conjunctivitis and treated with topical 1% prednisolone acetate and 1% atropine sulphate. The signs of inflammation abated by one week and the steroids were tapered over the next six weeks. There were no further recurrences. Patients must be educated about the ocular side-effects of bisphosphonate therapy, monitored closely after intravenous infusion and advised to seek ophthalmic consultation promptly if any ocular symptoms or signs develop.