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ER Stress Promotes Inflammation through Re-wIREd Macrophages in Obesity.
Molecular Cell 2017 June 16
A new mechanism linking ER dysfunction to metabolic inflammation is discovered in a recent study by Shan et al. (2017), which demonstrated ER stress-induced rewiring of adipose tissue macrophage polarization by IRE1α activation, leading to impaired systemic glucose homeostasis.
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