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Mutation in the beta3 subunit of Guanine nucleotide-binding protein (GNB3) gene is not associated with Type II diabetes mellitus risk: a case-control study of a North Indian population.
Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals 2017 December
CONTEXT: Genetics play a major role in development and pathophysiology of Type 2 diabetes mellitus (T2DM).
OBJECTIVE: To asses the association of Guanine nucleotide-binding protein (GNB3) (C825T) gene's polymorphism with T2DM.
MATERIALS AND METHODS: A case-control study including 400 North Indians was performed using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) approach to analyze genetic polymorphism.
RESULTS: No significant difference was observed in genotype and allele frequencies of GNB3 gene on comparing cases with controls.
DISCUSSION: Our study is in agreement with studies on Polish, Japanese, Hispanic-American and Danish populations who observed no significant association between GNB3 (C825T) polymorphism and T2DM.
CONCLUSION: GNB3 (C825T) polymorphism is not associated with T2DM.
OBJECTIVE: To asses the association of Guanine nucleotide-binding protein (GNB3) (C825T) gene's polymorphism with T2DM.
MATERIALS AND METHODS: A case-control study including 400 North Indians was performed using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) approach to analyze genetic polymorphism.
RESULTS: No significant difference was observed in genotype and allele frequencies of GNB3 gene on comparing cases with controls.
DISCUSSION: Our study is in agreement with studies on Polish, Japanese, Hispanic-American and Danish populations who observed no significant association between GNB3 (C825T) polymorphism and T2DM.
CONCLUSION: GNB3 (C825T) polymorphism is not associated with T2DM.
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