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Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals

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https://www.readbyqxmd.com/read/29334244/evolving-concepts-and-use-of-immunohistochemical-biomarkers-in-flat-non-neoplastic-urothelial-lesions-who-2016-classification-update-with-diagnostic-algorithm
#1
Francesca Sanguedolce, Matteo Brunelli, Alessandro D'Amuri, Beppe Calò, Vito Mancini, Giuseppe Carrieri, Luigi Cormio
CONTEXT: The classification of flat non-neoplastic urothelial lesions has been evolved through the years in the attempt to better define a spectrum of morphologic entities with somewhat overlapping features. Differentiating these lesions is important because of differences in patient management and clinical outcome. Materials and methods and objective: A systematic review of the literature has been carried out in order to (1) assess the most striking clinical features of each lesion, and (2) identify those morphological traits and immunophenotypical markers which may aid in the differential diagnosis...
January 15, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29325454/down-expression-of-p2rx2-kcnq5-erbb3-and-socs3-through-dna-hypermethylation-in-elderly-women-with-presbycusis
#2
Amal Bouzid, Ibtihel Smeti, Leila Dhouib, Magali Roche, Imen Achour, Aida Khalfallah, Abdullah Ahmed Gibriel, Ilhem Charfeddine, Hammadi Ayadi, Joel Lachuer, Abdelmonem Ghorbel, Christine Petit, Saber Masmoudi
CONTEXT: Presbycusis, an age-related hearing impairment (ARHI), represents the most common sensory disability in adults. Today, the molecular mechanisms underlying presbycusis remain unclear. This is in particular due to the fact that ARHI is a multifactorial complex disorder resulting from several genomic factors interacting with lifelong cumulative effects of: disease, diet, and environment. OBJECTIVE: Identification of novel biomarkers for presbycusis. MATERIALS AND METHODS: We selectively ascertained eighteen elderly unrelated women lacking environmental and metabolic risk factors...
January 11, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29308929/new-scoring-system-combining-the-fib-4-index-and-cytokeratin-18-fragments-for-predicting-steatohepatitis-and-liver-fibrosis-in-patients-with-nonalcoholic-fatty-liver-disease
#3
Toshifumi Tada, Takashi Kumada, Hidenori Toyoda, Toshiji Saibara, Masafumi Ono, Masayoshi Kage
PURPOSE: To establishe a new scoring system as a noninvasive tool for predicting steatohepatitis and liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 170 patients histologically diagnosed with nonalcoholic steatohepatitis (NASH) (n = 130) or nonalcoholic fatty liver (NAFL) (n = 40) were enrolled. We analyzed receiver operating characteristic (ROC) curves and performed multivariate analysis to predict steatohepatitis and liver fibrosis...
January 8, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29307233/role-of-neutrophil-to-lymphocyte-ratio-nlr-platelet-to-lymphocyte-ratio-plr-and-mean-platelet-volume-mpv-in-assessing-disease-control-in-asian-patients-with-axial-spondyloarthritis
#4
Jun Jie Benjamin Seng, Yu Heng Kwan, Lian Leng Low, Julian Thumboo, Weng Seng Warren Fong
INTRODUCTION: C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) which are used for assessment of axial spondyloarthritis (AxSpA) related disease activity have poor specificity and sensitivity. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) have not been investigated as disease activity markers among Asian AxSpA patients. METHODOLOGY: A retrospective, cross-sectional study was conducted in Singapore General Hospital from January 2013 to December 2015 to investigate the role of NLR, PLR and MPV as disease activity markers in AxSpA patients...
January 8, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29297708/determinants-of-elevated-carbohydrate-antigen-125-in-patients-with-severe-symptomatic-aortic-valve-stenosis-referred-for-transcatheter-aortic-valve-implantation
#5
Tobias Rheude, Costanza Pellegrini, Wibke Reinhard, Teresa Trenkwalder, Wolfgang Koenig, N Patrick Mayr, Michael Joner, Julio Núñez, Stefan Holdenrieder, Heribert Schunkert, Adnan Kastrati, Christian Hengstenberg, Oliver Husser
PURPOSE: Elevated carbohydrate antigen 125 (CA125) predicts adverse outcome after transcatheter aortic valve implantation (TAVI). While known underlying pathophysiological mechanisms of elevated CA125 include serosal effusions and inflammatory stimuli, clinical determinants associated with elevated CA125 in patients referred for TAVI remain unknown. Therefore, we investigated clinical, laboratory and echocardiographic determinants of elevated CA125 in patients with severe aortic valve stenosis referred for TAVI...
January 3, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29297706/review-of-biomarkers-to-assess-the-effects-of-switching-from-cigarettes-to-modified-risk-tobacco-products
#6
Michael J Peck, Edward B Sanders, Gerhard Scherer, Frank Lüdicke, Rolf Weitkunat
CONTEXT: One approach to reducing the harm caused by cigarette smoking, at both individual and population level, is to develop, assess and commercialise modified risk alternatives that adult smokers can switch to. Studies to demonstrate the exposure and risk reduction potential of such products generally involve the measuring of biomarkers, of both exposure and effect, sampled in various biological matrices. OBJECTIVE: In this review, we detail the pros and cons for using several biomarkers as indicators of effects of changing from conventional cigarettes to modified risk products...
January 3, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29297244/how-is-the-relationship-between-twist-1-and-bcr-abl1-gene-expressions-in-chronic-myeloid-leukemia-patients
#7
Nazanin Heidari, Tina Vosoughi, Javad Mohammadi Asl, Amal Saki Malehi, Najmaldin Saki
BACKGROUND: The activation and increased expression of BCR-ABL1 lead to malignant chronic myelogenous leukemia (CML) cells, as well as the resistance to antitumor agents and apoptosis inducers. Moreover, TWIST-1 protein is a prognostic factor of leukemogenesis, and its level is raised in CML patients with cytogenetic resistance to imatinib. So, there is a likely relationship between BCR-ABL1 and TWIST-1 genes. OBJECTIVE: The aim of the study was to assess the relationship between TWIST-1 and BCR-ABL1 expressions...
January 3, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29297241/exosomal-small-rna-sequencing-uncovers-the-microrna-dose-markers-for-power-frequency-electromagnetic-field-exposure
#8
Hualiang Li, Lin Lin, Li Li, Liang Zhou, Ying Zhang, Shuai Hao, Zhenhua Ding
PURPOSE: The potential health risks caused by power frequency electromagnetic field (PFEMF) have led to increasing public health concerns. However, the diagnosis and prognosis remain challenging in determination of exact dose of PFEMF exposure. MATERIALS AND METHODS: Mice were exposed to different magnetic doses of PFEMF for the following isolation of serum exosomes, microRNAs (miRNAs) extraction and small RNA sequencing. After small RNA sequencing, bioinformatic analysis and qRT-PCR validation, serum exosomal miRNA biomarkers were determined...
January 3, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29297231/micrornas-as-possible-biomarkers-for-screening-of-aortic-aneurysms-a-systematic-review-and-validation-study
#9
Areti Moushi, Kyriaki Michailidou, Marinos Soteriou, Marios Cariolou, Evy Bashiardes
CONTEXT: There is an urgent need to identify non-invasive biomarkers for the early detection of aortic aneurysms, preceding a fatal event. The potential role for miRNAs as diagnostic markers for aortic aneurysms was investigated through the present systematic review. OBJECTIVE: To perform a comprehensive review on published studies examining the association of miRNAs with aortic aneurysms and further validate these results with plasma samples collected from TAA patients...
January 3, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29264950/diagnostic-accuracy-of-maldi-tof-mass-spectrometry-for-non-small-cell-lung-cancer-a-meta-analysis
#10
Zhaolian Lu, Yingjian Chen, Xinyan Jing, Chengjin Hu
OBJECTIVE: To assess the overall accuracy of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in identifying non-small cell lung cancer (NSCLC). METHODS: A comprehensive search of PubMed, EMBASE and CNKI databases as well as the reference lists from relevant articles was performed prior to July 2017. Two authors independently screened articles based on inclusion and exclusion criteria and assessed the quality of each study using the Quality Assessment of Diagnostic Accuracy Studies 2 (QADAS-2) tool...
December 21, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29264937/rationale-and-design-of-the-impact-eu-trial-improve-management-of-heart-failure-with-procalcitonin-biomarkers-in-cardiology-bic-18
#11
Martin Möckel, Anna Slagman, Jörn Ole Vollert, Stefan Ebmeyer, Jan C Wiemer, Julia Searle, Evangelos Giannitsis, John A Kellum, Alan Maisel
Objectives To evaluate the effectiveness of Procalcitonin (PCT)-guided antibiotic treatment compared to current treatment practice to reduce 90-day all-cause mortality in emergency patients with shortness of breath (SOB) and suspected acute heart failure (AHF). Background Concomitant AHF and lower respiratory tract (or other bacterial) infection in emergency patients with dyspnea are common and can be difficult to diagnose. Early and adequate initiation of antibiotic therapy (ABX) significantly improves patient outcome, but superfluous prescription of ABX maybe harmful...
December 21, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29250973/association-of-low-dose-exposure-to-persistent-organic-pollutants-with-e-cadherin-promoter-methylation-in-healthy-koreans
#12
Ji Yun Lee, Kyung Min Lee, Duk Hee Lee, Dong Sun Kim
BACKGROUND: Persistent organic pollutants (POPs), despite their considerably low levels in humans, are an increasing concern for the general populations given their various adverse health problems, including metabolic and carcinogenic effects. DNA methylation deregulation is thought to be a key mechanism in the development of human chronic diseases including cancer. METHODS: In an attempt to identify biomarkers monitoring low-dose exposure and hazard, we explored whether organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) may influence the methylation of tumor suppressor gene E-cadherin (CDH1) using peripheral blood cells from 364 healthy Korean subjects...
December 18, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29179598/serum-paracetamol-protein-adducts-in-ambulatory-subjects-relationship-to-recent-reported-paracetamol-use
#13
Kennon Heard, Victoria E Anderson, Eric J Lavonas, Richard C Dart, Jody L Green
Context- Serum paracetamol-protein adducts (PPA) are a novel potential biomarker of paracetamol exposure. The relationship between serum PPA concentrations and reported paracetamol use in ambulatory adults has not been previously described. Materials and Methods- This was a cross-sectional study of ambulatory adults. A detailed medication history was obtained from all subjects and subjects were stratified by reported paracetamol use in the 2 weeks prior to enrollment. Serum PPA were measured in all subjects and correlated with reported dose, time of last ingestion and demographics...
November 28, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29179593/de-novo-identification-of-specific-exposure-biomarkers-of-the-alternative-plasticizer-di-2-ethylhexyl-terephthalate-dehtp-after-low-oral-dosage-to-male-volunteers-by-hplc-q-orbitrap-ms
#14
Frederik Lessmann, Daniel Bury, Tobias Weiss, Heiko Hayen, Thomas Brüning, Holger M Koch
CONTEXT: Human exposure biomonitoring relies on the availability of specific, sensitive biomarkers. For emerging chemicals, the identification (prediction, synthesis, verification) of such biomarkers is time and cost intensive. OBJECTIVE: This study aimed to further elucidate the urinary metabolic profile of the plasticizer di(2-ethylhexyl) terephthalate (DEHTP) in search of probably additional biomarkers of exposure. MATERIALS AND METHODS: Urine samples of an oral low dose volunteer study were analysed by HPLC-Q-Orbitrap-MS combined with a commercial data mining software...
November 28, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29166788/histopathological-indices-and-inflammatory-response-in-the-digestive-gland-of-the-mussel-mytilus-galloprovincialis-as-biomarker-of-immunotoxicity-to-silver-nanoparticles
#15
Younes Bouallegui, Ridha Ben Younes, Houda Bellamine, Ridha Oueslati
BACKGROUND: Histopathological assessments approaches in bivalves have become an important tool in environmental toxicology. This study seeks to develop a quantitative histopathological index (Ih) and inflammation score as biomarkers in the aim to assess the health status of nanoparticles exposed mussels. METHODS: Digestive gland Hematoxylin and eosin (H&E) stained sections from Mytilus galloprovincialis were assessed after in vivo exposure (for 3, 6 and 12h) to silver nanoparticles (Ag-NPs < 50nm and Ag-NPs < 100nm) prior and after manipulating the potential uptake pathways (clathrin- and caveolae-mediated endocytosis) using amantadine and nystatin as blockers...
November 23, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29144175/pregnancy-associated-plasma-protein-a-as-a-prognostic-biomarker-of-all-cause-mortality-and-cardiovascular-events-in-patients-presenting-with-chest-pain-a-systematic-review
#16
Christos A Papanastasiou, Damianos G Kokkinidis, Evangelos K Oikonomou, Vasileios G Mantziaris, T Raymond Foley, Theodoros D Karamitsos, Stephen W Waldo, Ehrin J Armstrong
AIM: Novel biomarkers have been proposed for identification of patients at greater risk of future adverse events among those presenting with chest pain. In this review, we aim to elucidate the ability of pregnancy associated plasma protein-A (PAPP-A) to predict mortality and other cardiovascular events in this patient population. METHODS: A literature search of the electronic databases Medline, Scopus, Cochrane Library and ClinicalTrials.gov was performed in order to identify studies investigating the utility of PAPP-A to predict mortality and adverse cardiovascular events in patients with chest pain...
November 16, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29130773/alteration-of-salivary-glycopatterns-in-oral-lichen-planus
#17
Liang Fang, Qing Liu, Pengfei He, Xinwen Wang, Ying Wang, Minghui Wei, Lihua Chen
BACKGROUND: Oral lichen planus (OLP) is one of the most common oral mucosal lesions affecting 0.5% to 2% of the adult population. It is difficult to distinguish between OLP and other oral mucosal diseases. Structural changes in the glycans of saliva proteins might be reliable indicators of OLP. However, little is known about the alteration of salivary glycopatterns during OLP. OBJECTIVE: We aimed to investigate the alterations of salivary protein glycosylation related to OLP...
November 13, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29130350/podocyturia-as-an-early-diagnostic-marker-of-preeclampsia-a-literature-review
#18
Karolina Panek-Laszczyńska, Andrzej Konieczny, Ewa Milewska, Krystyna Dąbrowska, Remigiusz Bąchor, Wojciech Witkiewicz, Zbigniew Szewczuk
CONTEXT: Preeclampsia (PE) is a pregnancy-related disease, and it is a leading cause of maternal and neonatal morbidity and mortality. It is characterized by the new onset of hypertension after 20 weeks of gestation together with signs of organ damage, most commonly the kidneys. The treatment of PE is symptomatic and final intervention requires delivery, regardless of the gestational age of the foetus. Furthermore, PE is a risk factor for developing cardiovascular disease and chronic kidney disease - even many years after the delivery...
November 13, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29105498/can-adipokines-serum-levels-be-used-as-biomarkers-of-hand-osteoarthritis
#19
A Fioravanti, S Cheleschi, A De Palma, O Addimanda, L Mancarella, E Pignotti, L Pulsatelli, M Galeazzi, R Meliconi
PURPOSE: To evaluate serum levels of visfatin, resistin and adiponectin in patients with erosive (E) and non-erosive (NE) osteoarthritis (OA) of the hand (HOA) compared to normal controls (NC). METHODS: 94 outpatients with E HOA and NE HOA and 21 NC were enrolled. The radiological assessment of both hands was performed according to the Kellgren-Lawrence and Kallman score. Patients were divided into two subsets (lone HOA or generalized OA) based on clinically OA involvement of knee and hip...
November 5, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29105495/elevated-serum-lactate-in-emergency-department-patients-predicts-hospital-admission-unrelated-to-diagnosis-but-no-more
#20
Christian Hohenstein, Maria Bernhardt
PURPOSE: The value of lactate as a screening biomarker in the emergency department is debated. We analyzed all unselected patients in the emergency department with serum lactate measured with regard to different outcome parameters. MATERIAL AND METHODS: In a retrospective single center study we analyzed all digitalized patient data of a two week period of all patients ≥18 where a serum lactate was measured. The lactate levels as well as demographic and other laboratory data were correlated in a logistic regression analysis, univariable as well as multivariable, with the outcome parameters...
November 5, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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