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Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals

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https://www.readbyqxmd.com/read/30632403/high-sensitivity-troponin-t-in-asymptomatic-severe-aortic-stenosis
#1
Elena Ferrer-Sistach, Josep Lupón, Germán Cediel, Albert Teis, Francisco Gual, Sílvia Serrano, Nuria Vallejo, Gladys Juncà, Jorge López-Ayerbe, Antoni Bayés-Genís
Background-In asymptomatic severe aortic stenosis (ASAS), treatment decisions are made on an individual basis, and case management presents a clinical conundrum Methods-We prospectively phenotyped consecutive patients with ASAS using echocardiography, exercise echocardiography, cardiac MRI, and biomarkers (NT-proBNP, high-sensitivity troponin T (hs-TnT), and ST2) (n = 58). The primary endpoint was a composite of cardiovascular death, new-onset symptoms, cardiac hospitalization, guideline-driven indication for valve replacement, and cardiovascular death at 12 months...
January 11, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30624084/circulating-nitric-oxide-metabolites-and-the-risk-of-cardiometabolic-outcomes-a-prospective-population-based-study
#2
Parvin Mirmiran, Zahra Bahadoran, Zhaleh Tahmasebinejad, Fereidoun Azizi, Asghar Ghasemi
AIM: This study was conducted to investigate whether serum NO metabolites (NOx) could predict the occurrence of type 2 diabetes (T2DM), hypertension (HTN), and metabolic syndrome (MetS) Methods: We measured serum NOx concentrations in the Tehran Lipid and Glucose Study participants (aged ≥19 years) and followed them for a median of 7.7 years for the incidence of outcomes. To determine the appropriate cut-off points of serum NOx for predicting clinical events, a random sampling method (50: 50 ratio) was used for the population and for analysis, receiver operator characteristic (ROC) curve was used...
January 9, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30526121/how-many-copies-of-gstm1-and-gstt1-are-associated-with-head-and-neck-cancer-risk
#3
Isabela Firigato, Fernanda de Toledo Gonçalves, Juliana De Antonio, Otávio Alberto Curioni, Mariana Rocha Silva, Gilka Jorge Fígaro Gattás
PURPOSE: GSTM1 and GSTT1 present a polymorphism that can drive complete gene deletions. The current methodology can powerfully determine GSTM1 and GSTT1 copy number variations (CNVs), which may clarify the real contribution of each gene copies to the cellular detoxification process and tumour risk. However, only analysing the presence/absence of these genes yielded controversial results for several disorders, including cancer. Because head and neck cancer (HNC) is becoming a serious global health problem, this study determined the CNVs of GSTM1 and GSTT1 in an HNC case-control population and investigated the possible association between gene copy numbers and tumour risk...
December 11, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30521401/urine-catecholamines-in-children-with-severe-enterovirus-a71-infection-comparison-with-paediatric-septic-shock
#4
Sheng-Ling Jan, Ming-Chih Lin, Sheng-Ching Chan, Hsiu-Fen Lee, Po-Yen Chen, Fang-Liang Huang
PURPOSE: Hypercatecholaminemia-related heart failure has been proposed as the main cause of enterovirus A71-related (EV-A71) early mortality. The purpose of this study was to measure urine catecholamine concentrations in severe EV-A71-infected children. METHODS: A total of 35 children, aged 2.5 ± 2.1 years, were divided into three groups. Group 1: 15 septic shock patients, group 2: 17 EV-A71-stage-2 patients, and group 3: 3 EV-A71-stage-4 patients. The laboratory results, cardiac biomarkers and urine catecholamine concentrations were statistically analyzed...
December 6, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30516070/new-markers-of-cell-migration-and-inflammation-in-children-with-chronic-kidney-disease
#5
Kinga Musiał, Danuta Zwolińska
CONTEXT: Chronic kidney disease (CKD) is characterized by immunocompetent cell migration and inflammation. Monocyte chemoattractant protein (MCP)-1 and macrophage colony-stimulating factor (MCSF) stimulate monocyte migration and transition into macrophages, with subsequent release of neopterin. OBJECTIVE: The aim of the study was to analyze these parameters in children with various stages of CKD. MATERIAL AND METHODS: The study group consisted of 41 CKD children, 19 patients on hemodialysis (HD), 22 children on automated peritoneal dialysis (APD), and 23 controls...
December 5, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30514120/the-temporal-pattern-of-immune-and-inflammatory-proteins-prior-to-a-recurrent-coronary-event-in-post-acute-coronary-syndrome-patients
#6
Maxime M Vroegindewey, Rohit M Oemrawsingh, Isabella Kardys, Folkert W Asselbergs, Pim van der Harst, Anton J Oude Ophuis, G Etienne Cramer, Arthur Maas, S Hong Kie The, Alexander J Wardeh, Henk Mouthaan, Eric Boersma, K Martijn Akkerhuis
PURPOSE: We assessed the temporal pattern of 29 immune and inflammatory proteins in post-acute coronary syndrome (ACS) patients, prior to the development of recurrent ACS. METHODS: High-frequency blood sampling was performed in 844 patients admitted for ACS during one-year follow-up. We conducted a case-control study on the 45 patients who experienced reACS (cases) and two matched event-free patients (controls) per case. Olink Proteomics' immunoassay was used to obtain serum levels of the 29 proteins, expressed in an arbitrary unit on the log2-scale (Normalized Protein eXpression, NPX)...
December 4, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30512980/effect-of-pesticide-exposure-on-the-cholinesterase-activity-of-the-occupationally-exposed-tea-garden-workers-of-northern-part-of-west-bengal-india
#7
Susmita Dutta, Min Bahadur
CONTEXT: Pesticide poisoning and related deaths is a global concern, but there is little information about its effect on the occupationally exposed tea garden workers of North Bengal. OBJECTIVE: This study investigates the level of AChE and BuChE in the blood of the tea garden workers, at risk of exposure to a mixture of pesticides. MATERIALS AND METHODS: The study sample consisted of pesticide exposed workers, non exposed (control), smokers and alcoholics...
December 4, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30512977/sst2-as-a-novel-biomarker-for-the-prediction-of-in-hospital-mortality-after-coronary-artery-bypass-grafting
#8
Meagan E Stabler, Michael E Rezaee, Devin M Parker, Todd A MacKenzie, Andrew R Bohm, Anthony W DiScipio, David J Malenka, Jeremiah R Brown
OBJECTIVES: Soluble suppression of tumorgenicity 2 (sST2) biomarker is an emerging predictor of adverse clinical outcomes, but its prognostic value for in-hospital mortality after coronary artery bypass grafting (CABG) is not well understood. This study measured the association between operative sST2 levels and in-hospital mortality after CABG. METHODS: A prospective cohort of 1,560 CABG patients were analysed from the Northern New England Cardiovascular Disease Study Group Biomarker Study...
December 4, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30512969/pulicaria-crispa-mitigates-gastric-ulcer-induced-by-ethanol-in-rats-role-of-treatment-and-auto-healing
#9
Abdelgawad A Fahmi, Mariam Abdur-Rahman, Asmaa F Aboul-Naser, Manal A Hamed, Howida I Abd-Alla, Mohamed I Nasr
CONTEXT: Stomach ulcers are the common gastrointestinal disorders worldwide. OBJECTIVE: This study aimed to investigate the therapeutic impact of Pulicaria crispa aerial part ethanol extract against gastric ulcer in rats. MATERIALS AND METHODS: Ulcer was induced by one oral dose of ethanol (0.5 ml/100g body weight) on 24 hours empty stomach, then the plant extract (500 mg/kg b.wt.) was orally administered daily for one week. Ranitidine (100mg/kg b...
December 4, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30475075/detection-and-analysis-of-endogenous-polar-volatile-organic-compounds-pvocs-in-urine-for-human-exposome-research
#10
Cassandra R O'Lenick, Joachim D Pleil, Matthew A Stiegel, Jon R Sobus, M Ariel Geer Wallace
BACKGROUND: The human exposome, defined as "…everything that is not the genome", comprises all chemicals in the body interacting with life processes. The exposome drives genes x environment (GxE) interactions that can cause long-term latency and chronic diseases. The exposome constantly changes in response to external exposures and internal metabolism. Different types of compounds are found in different biological media. OBJECTIVE: Measure polar volatile organic compounds (PVOCs) excreted in urine to document endogenous metabolites and exogenous compounds from environmental exposures...
November 26, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30457356/citrullinated-vimentin-and-biglycan-protein-fingerprints-as-candidate-serological-biomarkers-for-disease-activity-in-systemic-sclerosis-a-pilot-study
#11
Anne Sofie Siebuhr, Pernille Juhl, Anne-C Bay-Jensen, Morten A Karsdal, Nathalie Franchimont, Juan C Chavez
PURPOSE: Extracellular matrix (ECM) deposition and remodelling in skin and lungs of systemic sclerosis (SSc) subjects lead to release of metabolites/biomarkers into circulation. We investigated if biomarkers of ECM degradation (biglycan and elastin) and macrophage activation (citrullinated vimentin) could identify diffuse SSc (dSSc) subjects from controls and the biomarkers discriminative power. METHODS: DSSc subjects (n = 40) fulfilling the 2013 EULAR/ACR classification criteria were divided in early (<2years of symptoms) and late (≥10years of symptoms)...
November 20, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30514118/lymphocytes-dna-damages-and-exposure-to-chlorpyrifos-deltamethrin-penconazole-copper-oxicloride
#12
Giovanni Maria Ferri, Domenica Cavone, Marcantonio Dambrosio, Graziana Intranuovo, Nunzia Schiavulli, Francesco Birtolo, Valeria Vilardi, Maria Celeste Delfino, Linda Macinagrossa, Vincenzo Corrado, Luigi Vimercati
PURPOSE: The evaluation of the association between different exposure to pesticides and different types of comet images among a group of 26 recruited subject. MATERIAL AND METHODS: We have recruited 26 subjects (farmers and not farmers). They were submitted to a blood drawing of 10 mL and a questionnaire was administered to investigate personal habits and work history. By means of the comet assay it was assessed the oxidative DNA damage of peripheral lymphocytes by pesticides in the exposed and non-exposed workers...
November 16, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30444137/the-clinical-efficacy-of-angiotensin-ii-type1-receptor-blockers-on-inflammatory-markers-in-patients-with-hypertension-a-multicenter-randomized-controlled-trial-muscat-3-study
#13
Ryoko Umebayashi, Haruhito A Uchida, Yuka Okuyama, Yuki Kakio, Yoshihisa Hanayama, Kenichi Shikata, Jun Wada
PURPOSE: The purpose of present study was to evaluate the clinical efficacy of irbesartan on the anti-inflammatory and anti-oxidative stress effect in patients with hypertension compared to other ARBs. Further, we assessed the effect of the ARBs on kidney function and urinary albumin excretion. METHODS: Eighty-five outpatients with hypertension who took an ARB except irbesartan more than 3 months were assigned into 2 groups, one continued the same ARB and the other switched the ARB to irbesartan for 6 months...
November 16, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30442069/combining-information-from-multiple-bone-turnover-markers-as-diagnostic-indices-for-osteoporosis-using-support-vector-machines
#14
Tianxiao Zhang, Ping Liu, Yunzhi Zhang, Weiwei Wang, Yiwen Lu, Ming Xi, Sirui Duan, Fanglin Guan
CONTEXT: Osteoporosis (OP) is a progressive systemic bone disease. Dual-energy X-ray absorptiometry (DXA) is routinely employed and is considered the gold standard method for the diagnosis of OP. OBJECTIVE: We aimed to investigate the potential use of combined information from multiple bone turnover markers (BTMs) as a clinical diagnostic tool for OP. MATERIALS AND METHODS: A total of 9053 Chinese postmenopausal women (2464 primary OP patients and 6589 healthy controls) were recruited...
November 15, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30280938/hair-follicle-mirnas-a-novel-biomarker-for-primary-blast-induced-mild-traumatic-brain-injury
#15
Jing Zhang, Rosalinda Knight, Yushan Wang, Thomas W Sawyer, Christopher J Martyniuk, Valérie S Langlois
CONTEXT: Due to the wide use of improvised explosive devices during modern warfare, primary blast-derived mild traumatic brain injury (mTBI) has become a major medical condition in the military. With minimal visually identifiable symptoms, an effective molecular biomarker system is desirable. OBJECTIVE: We assessed the potential of mammalian hair follicle miRNAs as an mTBI biomarker. MATERIALS AND METHODS: Due to their well-established roles in mTBI molecular pathology, the expression level of miR-183, miR-26a, miR-181c, miR-29a, miR-34a and miR-27b was determined using qRT-PCR in whisker hair follicles from rats subject to head-only exposure to a single-pulse shock wave...
November 13, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30411980/inflammatory-signature-in-lung-tissues-in-patients-with-combined-pulmonary-fibrosis-and-emphysema
#16
William D Cornwell, Cynthia Kim, Alejandra C Lastra, Chandra Dass, Sudhir Bolla, He Wang, Huaqing Zhao, Frederick V Ramsey, Nathaniel Marchetti, Thomas J Rogers, Gerard J Criner
BACKGROUND: The aetiology and inflammatory profile of combined pulmonary fibrosis and emphysema (CPFE) remain uncertain currently. OBJECTIVE: We aimed to examine the levels of inflammatory proteins in lung tissue in a cohort of patients with emphysema, interstitial pulmonary fibrosis (IPF), and CPFE. MATERIALS AND METHODS: Explanted lungs were obtained from subjects with emphysema, IPF, CPFE, (or normal subjects), and tissue extracts were prepared...
November 9, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30387691/specific-induction-of-the-unique-gpr15-expression-in-heterogeneous-blood-lymphocytes-by-tobacco-smoking
#17
Authors Mario Bauer, Jörg Hackermüller, Jana Schor, Virginie Dubourg, Stephan Schreiber, Beate Fink, Arkadiusz Pierzchalski, Gunda Herberth
PURPOSE: In the peripheral blood, it has been shown that smoking is, to date, the only specific condition leading to an increase in GPR15+ T cells. We therefore aimed to characterize GPR15-expressing blood T cells in more detail. MATERIALS AND METHODS: The whole transcriptome by RNAseq as a proxy for protein expression was analyzed in GPR15+ and GPR15- T cells. A deep immuno-phenotyping was conducted for identification of T cell subtypes. RESULTS: The expression of GPR15 seemed to be unique, not concomitantly accompanied with expression of another protein...
November 2, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30387681/micrornas-expression-profiles-as-diagnostic-biomarkers-of-gastric-cancer-a-systematic-literature-review
#18
Jovana Stojanovic, Alessia Tognetto, Danilo Francesco Tiziano, Emanuele Leoncini, Brunella Posteraro, Roberta Pastorino, Stefania Boccia
OBJECTIVE: The early identification of gastric cancer (GC) represents a major clinical challenge. We conducted a systematic review of studies evaluating the miRNA expression profiling as a diagnostic tool in GC. METHODS: We performed a search of PubMed, ISI Web of Science and SCOPUS databases for studies on diagnostic miRNAs and GC, published in English up to October 2017. Eligibility criteria included case-control studies evaluating blood or tissue-based miRNA expression profiles, and incorporating at least two detection phases (screening and validation)...
November 2, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30375257/cigarette-smoking-affects-micrornas-and-inflammatory-biomarkers-in-healthy-individuals-and-an-association-to-single-nucleotide-polymorphisms-is-indicated
#19
Bengt-Åke Andersson, Shariel Sayardoust, Sture Löfgren, Lars Erik Rutqvist, Nongnit Laytragoon-Lewin
BACKGROUND: Cigarette smoke induces inflammation and remodels immune response. Genetic and epigenetic alterations might be involved in the pathogenesis of smoking related diseases. In this study, we investigated the effect of smoking on systemic inflammation biomarkers and epigenetic changes at microRNA (miRNA) expression level. We also examined if the levels of inflammatory biomarkers were associated with selected single nucleotide polymorphisms (SNPs). METHOD: From 39 smokers and 101 non-smokers, levels of total white blood cells (WBCs) and its subpopulations, plasma cytokines/chemokines/proteins and miRNAs were analysed...
October 30, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30369264/global-dna-methylation-profiling-in-peripheral-blood-cells-of-south-african-women-with-gestational-diabetes-mellitus
#20
Stephanie Dias, Sumaiya Adam, Nastasja Van Wyk, Paul Rheeder, Johan Louw, Carmen Pheiffer
BACKGROUND/OBJECTIVE: Recently, several studies have reported that DNA methylation changes in tissue are reflected in blood, sparking interest in the potential use of global DNA methylation as a biomarker for Gestational diabetes mellitus (GDM). This study investigated whether global DNA methylation is associated with GDM in South African women. METHODS: Global DNA methylation was quantified in peripheral blood cells of women with (n = 63) or without (n = 138) GDM using the MDQ1 Imprint® DNA Quantification Kit...
October 27, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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