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Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals

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https://www.readbyqxmd.com/read/30411980/inflammatory-signature-in-lung-tissues-in-patients-with-combined-pulmonary-fibrosis-and-emphysema
#1
William D Cornwell, Cynthia Kim, Alejandra C Lastra, Chandra Dass, Sudhir Bolla, He Wang, Huaqing Zhao, Frederick V Ramsey, Nathaniel Marchetti, Thomas J Rogers, Gerard J Criner
BACKGROUND: The etiology and inflammatory profile of combined pulmonary fibrosis and emphysema (CPFE) remain uncertain currently. OBJECTIVE: We aimed to examine the levels of inflammatory proteins in lung tissue in a cohort of patients with emphysema, interstitial pulmonary fibrosis (IPF), and CPFE. MATERIALS AND METHODS: Explanted lungs were obtained from subjects with emphysema, IPF, CPFE, (or normal subjects), and tissue extracts were prepared...
November 9, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30387691/specific-induction-of-the-unique-gpr15-expression-in-heterogeneous-blood-lymphocytes-by-tobacco-smoking
#2
Authors Mario Bauer, Jörg Hackermüller, Jana Schor, Virginie Dubourg, Stephan Schreiber, Beate Fink, Arkadiusz Pierzchalski, Gunda Herberth
PURPOSE: In the peripheral blood, it has been shown that smoking is, to date, the only specific condition leading to an increase in GPR15+ T cells. We therefore aimed to characterize GPR15-expressing blood T cells in more detail. MATERIALS AND METHODS: The whole transcriptome by RNAseq as a proxy for protein expression was analyzed in GPR15+ and GPR15- T cells. A deep immuno-phenotyping was conducted for identification of T cell subtypes. RESULTS: The expression of GPR15 seemed to be unique, not concomitantly accompanied with expression of another protein...
November 2, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30387681/micrornas-expression-profiles-as-diagnostic-biomarkers-of-gastric-cancer-a-systematic-literature-review
#3
Jovana Stojanovic, Alessia Tognetto, Danilo Francesco Tiziano, Emanuele Leoncini, Brunella Posteraro, Roberta Pastorino, Stefania Boccia
OBJECTIVE: The early identification of gastric cancer (GC) represents a major clinical challenge. We conducted systematic review of studies evaluating the miRNA expression profiling as diagnostic tool in GC. METHODS: We performed a search of PubMed, ISI Web of Science, and SCOPUS databases for studies on diagnostic miRNAs and GC, published in English up to October, 2017. Eligibility criteria included case-control studies evaluating blood or tissue-based miRNA expression profiles, and incorporating at least two detection phases (screening and validation)...
November 2, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30375257/cigarette-smoking-affects-micrornas-and-inflammatory-biomarkers-in-healthy-individuals-and-an-association-to-single-nucleotide-polymorphisms-is-indicated
#4
Bengt-Åke Andersson, Shariel Sayardoust, Sture Löfgren, Lars Erik Rutqvist, Nongnit Laytragoon-Lewin
BACKGROUND: Cigarette smoke induces inflammation and remodels immune response. Genetic and epigenetic alterations might be involved in the pathogenesis of smoking related diseases. In this study, we investigated the effect of smoking on systemic inflammation biomarkers and epigenetic changes at microRNA (miRNA) expression level. We also examined if the levels of inflammatory biomarkers were associated with selected single nucleotide polymorphisms (SNPs). METHOD: From 39 smokers and 101 non-smokers, levels of total white blood cells (WBCs) and its subpopulations, plasma cytokines/chemokines/proteins and miRNAs were analysed...
October 30, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30369264/global-dna-methylation-profiling-in-peripheral-blood-cells-of-south-african-women-with-gestational-diabetes-mellitus
#5
Stephanie Dias, Sumaiya Adam, Nastasja Van Wyk, Paul Rheeder, Johan Louw, Carmen Pheiffer
BACKGROUND/OBJECTIVE: Recently, several studies have reported that DNA methylation changes in tissue are reflected in blood, sparking interest in the potential use of global DNA methylation as a biomarker for Gestational diabetes mellitus (GDM). This study investigated whether global DNA methylation is associated with GDM in South African women. METHODS: Global DNA methylation was quantified in peripheral blood cells of women with (n = 63) or without (n = 138) GDM using the MDQ1 Imprint® DNA Quantification Kit...
October 27, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30280616/metabolic-syndrome-is-associated-to-high-sensitivity-cardiac-troponin-t-elevation
#6
Assi Milwidsky, Eyal Fisher, Rafael Y Brzezinski, Michal Ehrenwald, Gabi Shefer, Naftali Stern, Itzhak Shapira, David Zeltser, Zach Rosenbaum, Dahlia Greidinger, Shlomo Berliner, Shani Shenhar-Tsarfaty, Ori Rogowski
INTRODUCTION: Metabolic syndrome (MetS) and high-sensitivity cardiac troponin T (hs-TnT) are associated with higher risk for cardiovascular diseases (CVD). Our aim was to assess the relation between hs-TnT elevation and MetS in a general population sample. MATERIALS AND METHODS: Individuals participating in an annual health survey program between 2010 and 2016 were included in the study. Blood samples including hs-TnT levels were collected. The study population was divided into three groups based on hs-TnT levels - undetectable (<5 ng/L), intermediate (5-14 ng/L) and elevated (>14 ng/L)...
October 25, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30231650/multiple-biomarker-approach-in-the-fiddler-crab-to-assess-anthropogenic-pollution-in-tropical-coastal-environments
#7
Beatriz Yáñez-Rivera, Alejandra García-Gasca, Diana Corona-Vadillo, Gabriela Aguilar-Zárate, Irma Martínez-Rodríguez, Rubí Hernández-Cornejo, Facundo J Márquez-Rocha, Leticia García-Rico, Miguel Betancourt-Lozano
CONTEXT: Fiddler crabs are important to the ecology of estuarine systems around the world, however, few studies have incorporated them as bioindicators. Urias estuary represents one of the most urbanized lagoons in the Gulf of California region and received discharges from different sources: shrimp farm, thermoelectric plant, fish processing plants, and untreated domestic and sewage wastes. OBJECTIVE: Assess the effects on anthropogenic contamination on female fiddler crabs reproduction, survival and genetic stability...
October 25, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30126316/monic-acid-a-a-biomarker-in-clinical-intra-nasal-mupirocin-medication-for-mrsa-decolonisation
#8
Theo O Dare, Andrew W Nicholls, Peter G Mantle
CONTEXT: Mupirocin (BactrobanR ) is widely prescribed for intra-nasal decolonisation of MRSA for in-patients awaiting surgery or self-medicated for out-patients although adherence for the latter is not monitored. Non-adherence is a widespread pharmaceutical problem but could encourage selection of antibiotic resistance. Mupirocin is only a topical antibiotic because it decomposes in stomach acidity to monic acid A, but this has not previously been exploited as a biomarker for clinical intra-nasal medication...
October 25, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30280938/hair-follicle-mirnas-a-novel-biomarker-for-primary-blast-induced-mild-traumatic-brain-injury
#9
Jing Zhang, Rosalinda Knight, Yushan Wang, Thomas W Sawyer, Christopher J Martyniuk, Valerie S Langlois
CONTEXT: Due to the wide use of improvised explosive devices during modern warfare, primary blast-derived mild traumatic brain injury (mTBI) has become a major medical condition in the military. With minimal visually identifiable symptoms, an effective molecular biomarker system is desirable. OBJECTIVE: We assessed the potential of mammalian hair follicle miRNAs as an mTBI biomarker. MATERIALS AND METHODS: Due to their well-established roles in mTBI molecular pathology, the expression level of miR-183, miR-26a, miR-181c, miR-29a, miR-34a, and miR-27b was determined using qRT-PCR in whisker hair follicles from rats subject to head-only exposure to a single pulse shock wave...
October 3, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30265160/chromosome-3-is-a-valid-marker-for-prognostic-testing-of-biopsy-material-from-uveal-melanoma-later-treated-by-brachytherapy
#10
Claudia Helga Dorothee Le Guin, Klaus Alfred Metz, Nils Lehmann, Stefan Horst Kreis, Norbert Bornfeld, Dietmar Rudolf Lohmann, Michael Zeschnigk
PURPOSE: Monosomy 3 (M3) in uveal melanoma (UM) obtained after enucleation is significantly associated with metastatic death. With improved biopsy techniques, samples from patients treated with eye-preserving methods have become available. As the choice of treatment depends on tumour size, patients treated with eye-preserving brachytherapy tend to have smaller tumours. It has to be determined if M3 is a valid marker for prognosis of these patients. METHODS: Follow-up and clinical data were collected from a total of 451 UM patients: 291 patients were treated by brachytherapy...
September 28, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30252501/urinary-d-serine-level-as-a-predictive-biomarker-for-deterioration-of-renal-function-in-patients-with-atherosclerotic-risk-factors
#11
Hidehiro Iwakawa, Shin Makabe, Tomokazu Ito, Tohru Yoshimura, Hiroyuki Watanabe
BACKGROUND: D-serine, the enantiomer of L-serine, was identified in mammals 20 years ago. Although a close relationship between D-serine and renal dysfunction has been shown, the clinical implications of urinary D- and L-serine in humans are poorly understood. The aim of this study was to evaluate the relationship between urinary D- and L-serine with well-known renal biomarkers, and clarify the prognostic value of D- and L-serine for renal events. METHODS: This cross-sectional, prospective study included 65 patients with atherosclerotic risk factors, who were followed up for a median of 16 months...
September 25, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30252499/circulating-liver-specific-micrornas-as-non-invasive-diagnostic-biomarkers-of-hepatic-diseases-in-human
#12
Ghulam Musaddaq, Naveed Shahzad, Muhammad Adnan Ashraf, Muhammad Imran Arshad
CONTEXT: Hepatitis is an endemic disease worldwide leading to chronic and debilitating cancers. The viral agents and hepatotoxic substances lead to damage of hepatocytes and release of damage associated molecules in circulation. The lack of timely and rapid diagnosis of hepatitis results in chronic disease. OBJECTIVE: The present review aimed to describe regulation, release and functions of microRNAs (miR) during human liver pathology and insights into their promising use as non-invasive biomarkers of hepatitis...
September 25, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30126300/longitudinal-analysis-of-tear-cathepsin-s-activity-levels-in-male-non-obese-diabetic-mice-suggests-its-potential-as-an-early-stage-biomarker-of-sj%C3%A3-gren-s-syndrome
#13
Srikanth R Janga, Mihir Shah, Yaping Ju, Zhen Meng, Maria C Edman, Sarah F Hamm-Alvarez
CONTEXT: Cathepsin S (CTSS) activity is elevated in Sjögren's Syndrome (SS) patient tears. OBJECTIVE: To evaluate longitudinal expression of tear and tissue CTSS activity relative to other disease indicators in Non-Obese Diabetic (NOD) mice. METHODS: CTSS activity was measured in tears and lacrimal glands (LG) from male 1-6 month (M) NOD and 1 and 6 M BALB/c mice. Lymphocytic infiltration was quantified by histopathology, while disease-related proteins (Rab3D, CTSS, collagen 1) were quantified using q-PCR and immunofluorescence...
September 12, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29733687/prognostic-and-diagnostic-significance-of-mid-regional-pro-atrial-natriuretic-peptide-in-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-and-acute-heart-failure-data-from-the-ace-2-study
#14
Mohammad Osman Pervez, Jacob A Winther, Jon Brynildsen, Heidi Strand, Geir Christensen, Arne Didrik Høiseth, Peder L Myhre, Ragnhild Røysland, Magnus Nakrem Lyngbakken, Torbjørn Omland, Helge Røsjø
PURPOSE: To compare the diagnostic and prognostic value of mid-regional pro-ANP (MR-proANP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with acute dyspnea. METHODS: MR-proANP and NT-proBNP were measured with commercial immunoassays at hospital admission (n = 313), on day 2 (n = 234), and before discharge (n = 91) and compared for diagnosing acute heart failure (HF; n = 143) and to predict mortality among patients with acute HF and acute exacerbation of chronic obstructive pulmonary disease (AECOPD; n = 84) separately...
September 12, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30074408/exhaled-breath-profiling-by-electronic-nose-enabled-discrimination-of-allergic-rhinitis-and-extrinsic-asthma
#15
Silvano Dragonieri, Vitaliano N Quaranta, Pierluigi Carratu, Teresa Ranieri, Onofrio Resta
AIM: To assess whether an e-nose could discriminate between subjects affected by allergic rhinitis with and without concomitant extrinsic asthma, as well as from healthy controls, in terms of exhaled VOC-profile. METHODS: Fourteen patients with Extrinsic Asthma and Allergic Rhinitis (AAR), 14 patients with Allergic Rhinitis without asthma (AR) and 14 healthy controls (HC) participated in a cross-sectional study. Exhaled breath was collected by a standardized method and sampled by an e-nose (Cyranose 320)...
September 6, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29578363/high-prevalence-of-serum-folate-receptor-autoantibodies-in-children-with-autism-spectrum-disorders
#16
Jiaxiu Zhou, Aiping Liu, Fusheng He, Ya Jin, Shaoming Zhou, Ruihuan Xu, Hailiang Guo, Wenhao Zhou, Qiufen Wei, Mingbang Wang
BACKGROUND: Supplementation of folic acid by pregnant mothers is thought to lower the risk of autism spectrum disorders (ASDs) in the offspring. Folic acid is taken up by cells via receptors with high affinity for folate and reduced folic acid derivatives. However, this is blocked by the presence of folate receptor autoantibodies (FRAA). Cerebral FRAA have been detected with high frequency in children with ASDs, suggesting the existence of a link between folic acid uptake and disease aetiology...
September 6, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30041555/multi-biomarker-analysis-in-patients-after-transcatheter-aortic-valve-implantation-tavi
#17
Moritz Mirna, Bernhard Wernly, Vera Paar, Christian Jung, Peter Jirak, Hans-Reiner Figulla, Daniel Kretzschmar, Marcus Franz, Uta C Hoppe, Michael Lichtenauer, Alexander Lauten
BACKGROUND: In this study we sought to examine whether transcatheter aortic valve implantation (TAVI) is followed by a change in the plasma levels of novel cardiovascular biomarkers. METHODS: We collected blood samples of 79 patients with severe aortic valve stenosis undergoing TAVI before and at 7 days, 1 month, 3 months and 6 months post TAVI and analyzed the plasma concentrations of GDF-15, H-FABP, fetuin-A, galectin 3, sST2 and suPAR by means of ELISA. RESULTS: There was a significant increase in the concentration of fetuin-A (median: 52...
August 31, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30015512/influence-of-il-6-il-10-ifn-%C3%AE-and-tnf-%C3%AE-genetic-variants-on-susceptibility-to-diabetic-kidney-disease-in-type-2-diabetes-mellitus-patients
#18
Shadia A Fathy, Mohamed R Mohamed, Mohamed A M Ali, Ashraf E El-Helaly, Abdulnabi T Alattar
BACKGROUND: Data from previous studies on the role of inflammatory cytokines as biomarkers for diabetic kidney disease (DKD) are contradictory. The association of a particular inflammatory cytokine single nucleotide polymorphism (SNP) with susceptibility to DKD has not been consistently replicated. We aimed to investigate the utility of inflammatory cytokines as biomarkers for DKD in type 2 diabetes mellitus (T2DM) patients. Association of inflammatory cytokine gene SNPs with the development of DKD was also explored...
August 31, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30051724/procalcitonin-and-cellulitis-correlation-of-procalcitonin-blood-levels-with-measurements-of-severity-and-outcome-in-patients-with-limb-cellulitis
#19
R J Brindle, A Ijaz, P Davies
BACKGROUND: Procalcitonin levels may be raised in bacterial infections and have been used to guide antibiotic therapy. There is little data on procalcitonin and limb cellulitis. OBJECTIVES: Within a clinical trial of antibiotic therapy, we examined the correlation between clinical observations, blood tests and local measurements of skin damage, with serum procalcitonin levels. METHODS: The data is from a subset of the patients recruited into a clinical trial of antibiotic therapy for cellulitis (clindamycin for cellulitis, NCT01876628) whose procalcitonin levels were correlated with clinical and laboratory measurements...
August 23, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30041557/the-rs9939609-polymorphism-in-the-fat-mass-and-obesity-associated-fto-gene-is-associated-with-obesity-in-tunisian-population
#20
Meriam Ben Halima, Amani Kallel, Abir Baara, Safa Ben Wafi, Haifa Sanhagi, Hedia Slimane, Riadh Jemaa, Moncef Feki
CONTEXT: Variations in the fat mass and obesity-associated gene (FTO) has been associated with obesity in many populations, but the results are conflicting. OBJECTIVE: The aim of this study was to evaluate the effect of the rs9939609 polymorphism in the FTO gene on obesity risk and plasma leptin, adiponectin, insulin and lipid concentrations in Tunisians. MATERIALS AND METHODS: Four hundred and ninety-four subjects with obesity and 334 non-obese participated in this study...
August 23, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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