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Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals

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https://www.readbyqxmd.com/read/28303731/the-value-of-microparticles-in-detecting-acute-rejection-episodes-after-liver-transplantation
#1
Mehmet Haluk Morgul, Katrin Splith, Christoph Leonhardt, Nathanael Raschzok, Anja Reutzel-Selke, Rosa Bianca Schmuck, Andreas Andreou, Georgi Atanasov, Christian Benzing, Felix Krenzien, Hans-Michael Hau, Philipp Felgendreff, Sergej Klunk, Johann Pratschke, Igor Maximillian Sauer, Moritz Schmelzle
CONTEXT: Non-invasive markers for diagnosis of acute rejection (AR) following liver transplantation have not been developed, yet. OBJECTIVE: We analysed the correlation of plasma microparticle levels (MP) with AR. MATERIALS AND METHODS: MP (CD4, CD8, CD25, CD31, MHC) of 11 AR patients and 11 controls were analysed within the first week after transplantation. RESULTS: CD4, CD8 and CD31 positive MP were higher in the AR, whereas overall MP count, CD25 and MHCI positive MP proportions did not differ between both groups...
March 17, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28298141/using-multiple-biomarkers-and-determinants-to-obtain-a-better-measurement-of-oxidative-stress-a-latent-variable-structural-equation-model-approach
#2
Ronald C Eldridge, W Dana Flanders, Roberd M Bostick, Veronika Fedirko, Myron Gross, Bharat Thyagarajan, Michael Goodman
PURPOSE: Since oxidative stress involves a variety of cellular changes, no single biomarker can serve as a complete measure of this complex biological process. The analytic technique of structural equation modeling (SEM) provides a possible solution to this problem by modeling a latent (unobserved) variable constructed from the covariance of multiple biomarkers. METHODS: Using three pooled datasets, we modeled a latent oxidative stress variable from five biomarkers related to oxidative stress: F2-isoprostanes (FIP), fluorescent oxidation products, mitochondrial DNA copy number, γ-tocopherol (Gtoc), and C-reactive protein (CRP, an inflammation marker closely linked to oxidative stress)...
March 16, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28286966/comment-on-shahadevan-et%C3%A2-al-the-relationship-of-single-strand-breaks-in-dna-to-breast-cancer-risk-and-to-tissue-concentrations-of-estrogens
#3
Boege Fritz
No abstract text is available yet for this article.
March 13, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28276926/the-relationship-of-single-strand-breaks-in-dna-to-breast-cancer-risk-and-to-tissue-concentrations-of-oestrogens
#4
Mathavi Sahadevan, Oukseub Lee, Miguel Muzzio, Belinda Phan, Lisa Jacobs, Nagi Khouri, Jun Wang, Hong Hu, Vered Stearns, Robert T Chatterton
CONTEXT: Clinical study of breast cancer patients in Chicago, IL, USA. OBJECTIVE: Ascertain the utility of measurements of single-strand breaks (SSB) in DNA for assessment of breast cancer risk. METHODS: Fine-needle aspirates of the breast, SSB by nick translation, percent breast density (PBD), Gail model risk, cumulative methylation index (CMI), enzymes of DNA repair and tissue antioxidants. RESULTS: DNA repair enzymes and 4-hydroxyestradiol were negatively associated with SSB; CMI and PBD were positively associated...
February 28, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28103113/micronuclei-as-a-marker-for-medical-screening-of-subjects-continuously-occupationally-exposed-to-low-doses-of-ionizing-radiation
#5
S M J Mortazavi, S A R Mortazavi, Maryam Paknahad
No abstract text is available yet for this article.
February 1, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28135849/mir-200b-3p-in-plasma-is-a-potential-diagnostic-biomarker-in-oral-squamous-cell-carcinoma
#6
Guan Sun, Ying Cao, Peibei Wang, Hongmao Song, Tongwu Bie, Min Li, De Huai
CONTEXT: Circulating miRNAs are emerging as novel biomarkers for tumor. OBJECTIVE: Evaluate the diagnostic potential of plasma miR-200b-3p in oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: miR-200b-3p was detected by qRT-PCR in paired pre-operative and post-operative plasmas from 80 OSCC patients and 80 healthy controls. RESULTS: Plasma miR-200b-3p was significantly upregulated in OSCC, and it was higher in WHO II/III grade than WHO I grade...
January 30, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28132515/prognostic-prediction-in-acute-heart-failure-patients-with-extreme-bnp-values
#7
Patrícia Lourenço, Ana Ribeiro, Mariana Pintalhão, Filipe M Cunha, Joana Pereira, Pedro Marques, João Pedro Vilaça, Marta Amorim, Sérgio Silva, Paulo Bettencourt
BACKGROUND: Some patients have good prognosis despite elevated B-type natriuretic peptide (BNP), while others have ominous outcome with low BNP. We aimed to characterize these groups of patients. METHODS: We analysed patients prospectively included in an acute HF registry. Vital status within 1-year post discharge was ascertained. A receiver-operating characteristic curve was used to define discharge BNP cut-offs for 1-year death prediction. Among survivors, we compared patients with low and not-low BNP (cut-off 400pg/mL); and among non-survivors those with high vs not-high BNP (cut-off 2000pg/mL)...
January 30, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28055285/sleep-disordered-breathing-is-associated-with-higher-carboxymethyllysine-level-in-elderly-women-but-not-elderly-men-in-the-cardiovascular-health-study
#8
Peter D Ahiawodzi, Richard A Kerber, Kira C Taylor, Frank D Groves, Elizabeth O'Brien, Joachim H Ix, Jorge R Kizer, Luc Djoussé, Russell P Tracy, Anne B Newman, David S Siscovick, John Robbins, Kenneth Mukamal
CONTEXT: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. OBJECTIVE: The objective of this study is to investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress - and CML. MATERIALS AND METHODS: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. RESULTS: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1...
January 25, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28055283/crp-velocity-and-short-term-mortality-in-st-segment-elevation-myocardial-infarction
#9
Assi Milwidsky, Tomer Ziv-Baran, Sevan Letourneau-Shesaf, Gad Keren, Philippe Taieb, Shlomo Berliner, Yacov Shacham
CONTEXT: There is a known association between C-reactive protein (CRP) levels and adverse outcomes in patients presenting with ST-elevation myocardial infarction (STEMI). The optimal time frame to measure CRP for risk stratification is not known. OBJECTIVE: The aim of the current study was to evaluate the relation between the change in CRP velocity (CRPv) and 30-d mortality among STEMI patients. MATERIAL AND METHODS: We included consecutive patients with a diagnosis of STEMI who presented to Tel-Aviv Medical Center between 2008 and 2014 and had their CRP measured with a wide range assay (wr-CRP) at least twice during the 24 h after admission...
January 25, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28055279/salivary-protein-changes-in-response-to-acute-stress-in-medical-residents-performing-advanced-clinical-simulations-a-pilot-proteomics-study
#10
Rachel K Marvin, Muncharie B Saepoo, Simiao Ye, Donald B White, Rong Liu, Kenneth Hensley, Paul Rega, Viviane Kazan, David R Giovannucci, Dragan Isailovic
CONTEXT: Quantitative changes of salivary proteins due to acute stress were detected. OBJECTIVE: To explore protein markers of stress in saliva of eight medical residents who performed emergency medicine simulations. MATERIALS AND METHODS: Saliva was collected before the simulations, after the simulations, and following morning upon waking. Proteins were separated by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE), identified by mass spectrometry (MS), and relatively quantified by densitometry...
January 25, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28055277/matrix-metalloproteinase-multiplex-screening-identifies-increased-mmp-2-urine-concentrations-in-women-predicted-to-develop-preeclampsia
#11
Margarita L Martinez-Fierro, Aurelio Perez-Favila, Idalia Garza-Veloz, Marcela A Espinoza-Juarez, Lorena Avila-Carrasco, Ivan Delgado-Enciso, Yolanda Ortiz-Castro, Edith Cardenas-Vargas, Miguel A Cid-Baez, Rosa M Ramirez-Santoyo, Victor H Cervantes-Kardasch, Iram P Rodriguez-Sanchez, Jose I Badillo-Almaraz, Rodrigo Castañeda-Miranda, Luis O Solis-Sanchez, Jose M Ortiz-Rodriguez
BACKGROUND: Preeclampsia, a pregnancy disorder characterized by hypertension and proteinuria, represents the leading cause of fetal and maternal morbidity and mortality in developing countries. The identification of novel and accurate biomarkers that are predictive of preeclampsia is necessary to improve the prognosis of patients with preeclampsia. OBJECTIVE: The objective of this study is to evaluate the usefulness of nine urinary metalloproteinases to predict the risk of preeclampsia development...
January 25, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28117601/blood-markers-of-inflammation-and-endothelial-dysfunction-in-cardioembolic-stroke-systematic-review-and-meta-analysis
#12
Benedetta Piccardi, Dolors Giralt, Alejandro Bustamante, Victor Llombart, Teresa García-Berrocoso, Domenico Inzitari, Joan Montaner
CONTEXT: various processes including inflammation and endothelial dysfunction have been implicated in the pathogenesis of cardioembolic (CE) strokes. OBJECTIVE: to review the evidence and investigate the association between immune-inflammatory biomarkers and CE strokes versus other stroke subtypes. METHODS: we systematically reviewed the literature (sources: MEDLINE, web-based register http://stroke-biomarkers.com , reference lists) with quality assessment and meta-analysis of selected articles...
January 24, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28114823/comparison-of-urinary-aflatoxin-m1-and-aflatoxin-albumin-adducts-as-biomarkers-for-assessing-aflatoxin-exposure-in-tanzanian-children
#13
Gaoyun Chen, Yun Yun Gong, Martin E Kimanya, Candida P Shirima, Michael N Routledge
PURPOSE: To determine levels of urinary AFM1 in children and correlate the concentrations with previously reported aflatoxin albumin adduct (AF-alb) levels in these children. MATERIALS AND METHODS: Matched urine and blood samples were collected from 84 Tanzanian children aged 6-14 months old. From 31 children in one village (Kigwa), samples were collected at three time points six months apart. Samples were collected from 31 and 22 children from two different regions at the second time point only...
January 24, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28074664/recent-advances-in-molecular-biomarkers-for-diabetes-mellitus-a-systematic-review
#14
Ty Lees, Najah Nassif, Ann Simpson, Fatima Shad-Kaneez, Rosetta Martiniello-Wilks, Yiguang Lin, Allan Jones, Xianqin Qu, Sara Lal
CONTEXT: Diabetes is a growing global metabolic epidemic. Current research is focussing on exploring how the biological processes and clinical outcomes of diabetes are related and developing novel biomarkers to measure these relationships, as this can subsequently improve diagnostic, therapeutic and management capacity. OBJECTIVE: The objective of this study is to identify the most recent advances in molecular biomarkers of diabetes and directions that warrant further research...
January 24, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28067540/soluble-st2-is-associated-with-disease-severity-in-arrhythmogenic-right-ventricular-cardiomyopathy
#15
Kaspar Broch, Ida S Leren, Jørg Saberniak, Thor Ueland, Thor Edvardsen, Lars Gullestad, Kristina H Haugaa
PURPOSE: Diagnostic and prognostic evaluation remains challenging in arrhythmogenic right ventricular cardiomyopathy (ARVC). We measured plasma concentration of soluble ST2 (sST2) and assessed its association with right ventricular (RV) function and ventricular arrhythmias in patients with ARVC. METHODS: We included patients with ARVC and genotype positive relatives. Soluble ST2 was determined by ELISA. We assessed myocardial function by echocardiography including strain by speckle tracking technique...
January 24, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28103129/the-role-of-urinary-kim-1-ngal-ca19-9-and-%C3%AE-2-microglobulin-in-the-assessment-of-ureteropelvic-junction-obstruction-in-adults
#16
Eduardo P Miranda, Ricardo Jordão Duarte, José de Bessa, Roberto Iglesias Lopes, Victor Srougi, Hiury Silva Andrade, Rodolfo Ast Bandeira, Marco Antônio Arap, Anuar Ibrahim Mitre, Nayara Izabel Viana, Sabrina Thalita Dos Reis, Kátia Ramos Moreira Leite, Miguel Srougi
PURPOSE: To evaluate the diagnostic properties of urinary biomarkers in adults with ureteropelvic junction obstruction: KIM-1, NGAL, CA19-9, and β2-microglobulin. We also assessed urinary biomarker concentrations following pyeloplasty. MATERIAL AND METHODS: We prospectively studied adults from December 2013 to February 2015. We included 47 patients with a mean age of 38.6 ± 12.7 years. Each patient provided four samples of voided urine for biomarker measurement, one at preoperative consultation and the others at 1, 3 and 6 months of postoperative follow-up...
January 19, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28043162/micronucleus-frequency-and-content-in-healthy-relatives-of-cancer-patients
#17
Friedo Zölzer, Marcela Křížová, Zuzana Freitinger Skalická, Andrea Rössnerová, Radim Šrám
OBJECTIVE: To compare chromosomal damage in lymphocytes of individuals who did or did not report first-degree relatives with cancer. MATERIALS AND METHODS: Cases and controls (68 each) were matched for sex, age and radon exposure. Chromosomal damage was quantified as frequency of micronucleus-containing cells and proportion of centromere-free micronuclei. RESULTS: Individuals not reporting cancer in their families showed lower values of both the frequency of micronucleus-containing cells (n...
January 19, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28010124/validation-of-a-protein-panel-for-the-noninvasive-detection-of-recurrent-non-muscle-invasive-bladder-cancer
#18
Selma Gogalic, Ursula Sauer, Sara Doppler, Andreas Heinzel, Paul Perco, Arno Lukas, Guy Simpson, Hardev Pandha, Andras Horvath, Claudia Preininger
CONTEXT: About 50-70% of patients with non-muscle invasive bladder cancer (NMIBC) experience relapse of disease. OBJECTIVE: To establish a panel of protein biomarkers incorporated in a multiplexed microarray (BCa chip) and a classifier for diagnosing recurrent NMIBC. MATERIALS AND METHODS: Urine samples from 45 patients were tested. Diagnostic performance was evaluated by receiver operating characteristic (ROC) analysis. RESULTS: A multi biomarker panel (ECadh, IL8, MMP9, EN2, VEGF, past recurrences, BCG therapies and stage at diagnosis) was identified yielding an area under the curve of 0...
January 19, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27805415/determination-of-natural-moisturizing-factors-in-the-skin-raman-microspectroscopy-versus-hplc
#19
S A Koppes, P Kemperman, I Van Tilburg, F Calkoen-Kwa, K A Engebretsen, G J Puppels, P J Caspers, S Kezic
BACKGROUND: Natural moisturizing factor (NMF) is used as genotypic and phenotypic biomarker in diagnostics. This study is a side-to-side comparison of two different methods to determine NMF in atopic dermatitis patients: Raman microspectroscopy and stratum corneum tape stripping followed by HPLC. RESULTS: Measured NMF values were significantly correlated (R(2) = .61; p < .0001), both methods demonstrated a concentration-depth dependence of NMF and reduced NMF levels in the carriers of filaggrin null mutations...
January 19, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28043168/plasma-levels-of-pentraxin-3-in-patients-with-spondyloarthritis
#20
Renato Nisihara, Thelma L Skare, João Otávio Zeni, Henrique Rasera, Karita Lidani, Iara Messias-Reason
CONTEXT: Determining the disease's inflammatory activity in spondyloarthritis (SpA) is difficult although very important as it is this that drives treatment. OBJECTIVE: To investigate if plasma pentraxin-3 (PTX3) could act as an inflammatory marker in SpA. METHODS: Eighty one SpA patients (11 with psoriatic arthritis (PsoA) and 70 with ankylosing spondylitis (AS)) and 90 gender and age paired controls were studied for plasma PTX3 levels by ELISA...
January 17, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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