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Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals

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https://www.readbyqxmd.com/read/29130773/alteration-of-salivary-glycopatterns-in-oral-lichen-planus
#1
Liang Fang, Qing Liu, Pengfei He, Xinwen Wang, Ying Wang, Minghui Wei, Lihua Chen
BACKGROUND: Oral lichen planus (OLP) is one of the most common oral mucosal lesions affecting 0.5% to 2% of the adult population. It is difficult to distinguish between OLP and other oral mucosal diseases. Structural changes in the glycans of saliva proteins might be reliable indicators of OLP. However, little is known about the alteration of salivary glycopatterns during OLP. OBJECTIVE: We aimed to investigate the alterations of salivary protein glycosylation related to OLP...
November 13, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29130350/podocyturia-as-an-early-diagnostic-marker-of-preeclampsia-a-literature-review
#2
Karolina Panek-Laszczyńska, Andrzej Konieczny, Ewa Milewska, Krystyna Dąbrowska, Remigiusz Bąchor, Wojciech Witkiewicz, Zbigniew Szewczuk
CONTEXT: Preeclampsia (PE) is a pregnancy-related disease, and it is a leading cause of maternal and neonatal morbidity and mortality. It is characterized by the new onset of hypertension after 20 weeks of gestation together with signs of organ damage, most commonly the kidneys. The treatment of PE is symptomatic and final intervention requires delivery, regardless of the gestational age of the foetus. Furthermore, PE is a risk factor for developing cardiovascular disease and chronic kidney disease - even many years after the delivery...
November 13, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29105498/can-adipokines-serum-levels-be-used-as-biomarkers-of-hand-osteoarthritis
#3
A Fioravanti, S Cheleschi, A De Palma, O Addimanda, L Mancarella, E Pignotti, L Pulsatelli, M Galeazzi, R Meliconi
PURPOSE: To evaluate serum levels of visfatin, resistin and adiponectin in patients with erosive (E) and non-erosive (NE) osteoarthritis (OA) of the hand (HOA) compared to normal controls (NC). METHODS: 94 outpatients with E HOA and NE HOA and 21 NC were enrolled. The radiological assessment of both hands was performed according to the Kellgren-Lawrence and Kallman score. Patients were divided into two subsets (lone HOA or generalized OA) based on clinically OA involvement of knee and hip...
November 5, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29105495/elevated-serum-lactate-in-emergency-department-patients-predicts-hospital-admission-unrelated-to-diagnosis-but-no-more
#4
Christian Hohenstein, Maria Bernhardt
PURPOSE: The value of lactate as a screening biomarker in the emergency department is debated. We analyzed all unselected patients in the emergency department with serum lactate measured with regard to different outcome parameters. MATERIAL AND METHODS: In a retrospective single center study we analyzed all digitalized patient data of a two week period of all patients ≥18 where a serum lactate was measured. The lactate levels as well as demographic and other laboratory data were correlated in a logistic regression analysis, univariable as well as multivariable, with the outcome parameters...
November 5, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29098879/regulation-of-circulating-chromogranin-b-levels-in-heart-failure
#5
Felix M Heidrich, Carolin Melz, Mimi S Buechau, Christian Pfluecke, Silvio Quick, Uwe Speiser, David M Poitz, Antje Augstein, Tobias Ruf, Nadine K Wäßnig, Akram Youssef, Ruth H Strasser, Stephan Wiedemann
BACKGROUND: Chromogranin B (CGB) regulates B-type natriuretic peptide (BNP) production. Circulating CGB levels are elevated in heart failure (HF) animal models and HF patients, but also increase in healthy individuals in response to physical activity. Therefore, CGB seems to integrate information from myocardial stress and systemic neuro-endocrine activation. Substantial gaps remain in our understanding of CGB regulation in HF. METHODS AND RESULTS: We conducted a retrospective registry study including 372 patients...
November 3, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29068262/correction-to-zhang-et-al-quantification-of-manganese-and-mercury-in-toenail-in-vivo-using-portable-x-ray-fluorescence-xrf
#6
(no author information available yet)
No abstract text is available yet for this article.
October 25, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29047308/characterization-of-organophosphate-pesticides-in-urine-and-home-environment-dust-in-an-agricultural-community
#7
Catherine M Tamaro, Marissa N Smith, Tomomi Workman, William C Griffith, Beti Thompson, Elaine M Faustman
CONTEXT: Organophosphorus insecticides (OPs) have been used to control agricultural pests found in Washington state. Farmworkers (FW) have higher exposure to OP pesticides than non-farmworkers (NFW), and FW children may in turn have higher exposure than NFW children. OBJECTIVE: To examine the association between the concentration in house dust of five OPs used commonly in pome fruit orchards and the concentration in urine of dialkylphosphate metabolites (DAP), in a cohort of Hispanic FW and NFW and their children...
October 19, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29034721/biological-monitoring-of-exposure-to-low-concentrations-of-benzene-in-workers-at-a-metallurgical-coke-production-plant-new-insights-into-s-phenylmercapturic-acid-and-urinary-benzene
#8
Piero Lovreglio, Giuseppe De Palma, Anna Barbieri, Roberta Andreoli, Ignazio Drago, Luciano Greco, Elisabetta Gallo, Laura Diomede, Pietro Scaramuzzo, Maria Cristina Ricossa, Jacopo Fostinelli, Pietro Apostoli, Leonardo Soleo
CONTEXT: Urinary S-phenylmercapturic acid (SPMA) and benzene (U-Ben) are usually measured at the end of the work shift (ES), although their kinetic of elimination is not clearly known. OBJECTIVE: To investigate SPMA and U-Ben elimination 16 h after the ES, in 93 coke production workers exposed to low benzene concentrations. MATERIALS AND METHODS: Airborne benzene (A-Ben) was measured by passive samplings, while SPMA, U-Ben, methyl-tert-butyl ether (U-MTBE), cotinine (U-Cot) and creatinine were determined on urine samples collected at ES and before the beginning of the next work shift (next BS)...
October 16, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29034718/the-prognostic-value-of-the-furosemide-stress-test-in-predicting-delayed-graft-function-following-deceased-donor-kidney-transplantation
#9
Blaithin A McMahon, Jay L Koyner, Tessa Novick, Steve Menez, Robert A Moran, Bonnie E Lonze, Niraj Desai, Sami Alasfar, Marvin Borja, William T Merritt, Promise Ariyo, Lakhmir S Chawla, Edward Kraus
OBJECTIVES AND METHODS: The Furosemide Stress Test (FST) is a novel dynamic assessment of tubular function that has been shown in preliminary studies to predict patients who will progress to advanced stage acute kidney injury, including those who receive renal replacement therapy (RRT). The aim of this study is to investigate if the urinary response to a single intraoperative dose of intravenous furosemide predicts delayed graft function (DGF) in patients undergoing deceased donor kidney transplant...
October 16, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29017403/protective-effect-of-zizyphus-lotus-jujube-fruits-against-cypermethrin-induced-oxidative-stress-and-neurotoxicity-in-mice
#10
Khazri Abdelhafidh, Lazher Mhadhbi, Ali Mezni, Sellami Badreddine, Hamouda Beyrem, Ezzeddine Mahmoudi
CONTEXT: Cypermethrin (CYP) is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control. The toxicity of CYP is well studied in many organisms Objective: The aim of present study was to investigate the protective effect of Zizyphus lotus (Zizyp) fruit against neurotoxicity and oxidative stress induced by CYP in mice. MATERIALS AND METHODS: Mice were divided into four groups of six each: groups I and II were used as control and CYP control (20mg/kg body weight)...
October 11, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28901783/quantification-of-manganese-and-mercury-in-toenail-in-vivo-using-portable-x-ray-fluorescence-xrf
#11
Xinxin Zhang, Aaron J Specht, Marc G Weisskopf, Jennifer Weuve, Linda H Nie
BACKGROUND AND OBJECTIVE: Toenail is an advantageous biomarker to assess exposure to metals such as manganese and mercury. Toenail Mn and Hg are in general analyzed by chemical methods such as inductively coupled plasma mass spectrometry and atomic absorption spectrophotometry. In this project, a practical and convenient technology-portable X-ray florescence (XRF)-is studied for the noninvasive in vivo quantification of manganese and mercury in toenail. MATERIAL AND METHODS: The portable XRF method has advantages in that it does not require toenail clipping and it can be done in 3 min, which will greatly benefit human studies involving the assessment of manganese and mercury exposures...
October 10, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28972805/role-of-il-1ra-and-granzyme-b-as-biomarkers-in-active-crohn-s-disease-patients
#12
Tae Jun Kim, Ja Seol Koo, Sung Jin Kim, Sung Noh Hong, You Sun Kim, Suk-Kyun Yang, Young-Ho Kim
BACKGROUND AND AIM: Altered gene expression in intestinal mucosa is thought to contribute to inflammatory process in Crohn's disease (CD). The present study investigated changes in the expression of genes associated with gut inflammation in CD patients by RNA microarray to identify disease biomarkers. METHODS: Microarray analysis was carried out in formalin-fixed, paraffin-embedded intestinal tissue specimens from six CD patients who underwent surgery without prior treatment and from two healthy control subjects...
October 3, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28862880/club-cell-protein-cc16-in-plasma-bronchial-brushes-bal-and-urine-following-an-inhaled-allergen-challenge-in-allergic-asthmatics
#13
Henning Stenberg, Erik Wadelius, Subhabrata Moitra, Ida Åberg, Jaro Ankerst, Zuzana Diamant, Leif Bjermer, Ellen Tufvesson
BACKGROUND: Club cell protein (CC16) is a pneumoprotein secreted by epithelial club cells. CC16 possesses anti-inflammatory properties and is a potential biomarker for airway epithelial damage. We studied the effect of inhaled allergen on pulmonary and systemic CC16 levels. METHODS: Thirty-four subjects with allergic asthma underwent an inhaled allergen challenge. Bronchoscopy with bronchoalveolar lavage (BAL) and brushings was performed before and 24 h after the challenge...
September 18, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28862876/quantification-of-cotinine-in-dried-blood-spots-as-a-biomarker-of-exposure-to-tobacco-smoke
#14
Daniel Ladror, Bruce Pitt, William Funk
OBJECTIVE: We present an ultra-sensitive, minimally-invasive method for quantifying cotinine in dried blood spot (DBS) samples as a biomarker of exposure to tobacco smoke that can be collected using a simple heel or finger prick to obtain blood samples. METHODS: Cotinine levels were measured in matched plasma and reconstituted DBS samples from smokers and nonsmokers to evaluate assay parameters. In addition, we applied this new method to finger-prick DBS samples that were collected from infants, children and young adults ages 1-21 to estimate exposure to tobacco smoke...
September 18, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28678539/histone-3-modifications-and-blood-pressure-in-the-beijing-truck-driver-air-pollution-study
#15
Jacob K Kresovich, Zhou Zhang, Fang Fang, Yinan Zheng, Marco Sanchez-Guerra, Brian T Joyce, Jia Zhong, Yana Chervona, Sheng Wang, Dou Chang, John P McCracken, Anaite Díaz, Matteo Bonzini, Michele Carugno, Petros Koutrakis, Choong-Min Kang, Shurui Bian, Tao Gao, Hyang-Min Byun, Joel Schwartz, Andrea A Baccarelli, Lifang Hou
CONTEXT: Histone modifications regulate gene expression; dysregulation has been linked with cardiovascular diseases. Associations between histone modification levels and blood pressure in humans are unclear. OBJECTIVE: We examine the relationship between global histone concentrations and various markers of blood pressure. MATERIALS AND METHODS: Using the Beijing Truck Driver Air Pollution Study, we investigated global peripheral white blood cell histone modifications (H3K9ac, H3K9me3, H3K27me3, and H3K36me3) associations with pre- and post-work measurements of systolic (SBP) and diastolic (DBP) blood pressure, mean arterial pressure (MAP), and pulse pressure (PP) using multivariable mixed-effect models...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28583029/p-gp-expression-levels-in-the-erythrocytes-of-brown-trout-a-new-tool-for-aquatic-sentinel-biomarker-development
#16
Emeline Valton, Ivan Wawrzyniak, Christian Amblard, Bruno Combourieu, Marie-Laure Bayle, François Desmolles, Fabrice Kwiatkowski, Frédérique Penault-Llorca, Mahchid Bamdad
CONTEXT: P-glycoprotein (P-gp) is a ubiquitous membrane detoxification pump involved in cellular defence against xenobiotics. Blood is a hub for the trade and transport of physiological molecules and xenobiotics. Our recent studies have highlighted the expression of a 140-kDa P-gp in brown trout erythrocytes in primary cell culture and its dose-dependent response to Benzo[a]pyrene pollutant. OBJECTIVE: The purpose of this study was focused on using P-gp expression in brown trout erythrocytes as a biomarker for detecting the degree of river pollution...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28581828/biomarkers-used-in-studying-air-pollution-exposure-during-pregnancy-and-perinatal-outcomes-a-review
#17
Gauri Desai, Li Chu, Yanjun Guo, Ajay A Myneni, Lina Mu
PURPOSE: This review focuses on studies among pregnant women that used biomarkers to assess air pollution exposure, or to understand the mechanisms by which it affects perinatal outcomes. METHODS: We searched PubMed and Google scholar databases to find articles. RESULTS AND CONCLUSIONS: We found 29 articles, mostly consisting of cohort studies. Interpolation models were most frequently used to assess exposure. The most consistent positive association was between polycyclic aromatic hydrocarbon (PAH) exposure during entire pregnancy and cord blood PAH DNA adducts...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28434254/association-of-gstt1-null-xpd-751%C3%A2-cc-and-xpc-939%C3%A2-cc-genotypes-with-increased-levels-of-genomic-damage-among-hospital-pathologists
#18
Alfredo Santovito, Marta Delsoglio, Eleonora Manitta, Giulia Picco, Giulia Meschiati, Michela Chiarizio, Claudio Gendusa, Piero Cervella
CONTEXT: Hospital workers are at risk for genotoxic damage following occupationally exposure to xenobiotics. Pathologists are exposed to chemicals during their use in health care environments, particularly throughout inhalation of airborne agents, absorption through skin or contact with the patient's body fluids. OBJECTIVE: We evaluated the level of genomic damage in a sample of 61 hospital pathologists (occupationally exposed to antineoplastic drugs and sterilizing agents) and 60 control subjects...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28393561/hsp72-is-an-early-biomarker-to-detect-cisplatin-and-acetaminophen-nephrotoxicity
#19
Rosalba Pérez-Villalva, Jonatan Barrera-Chimal, Juan Carlos Aguilar-Carrasco, Ixchel Lima-Posada, Cristino Cruz, Victoria Ramírez, Yvett González-Bobadilla, Norma Uribe, Laura Trumper, Norma A Bobadilla
OBJECTIVE: To evaluate whether the urinary HSP72 levels (uHSP72) are a useful biomarker for early diagnosis of acute kidney injury (AKI) induced by two widely used drugs: cisplatin and acetaminophen. MATERIALS AND METHODS: To analyze the time-course of nephrotoxic injury and uHSP72 levels, male Wistar rats were administered a single high dose of cisplatin (7 mg/kg) or acetaminophen (750 mg/kg) and were assessed at 6, 12, 24, 48, 72, 96 and 120 h. RESULTS: AKI induced by cisplatin was characterized by tubular injury that started at 6 h and was enhanced after 48 h...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28368680/transcriptional-variations-in-biomarkers-of-mytilus-galloprovincialis-sampled-from-central-adriatic-coastal-waters-marche-region-italy
#20
Paolo Cocci, Martina Capriotti, Gilberto Mosconi, Francesco Alessandro Palermo
OBJECTIVE: this work evaluates the expression of several biomarker genes (i.e. CAT, HSPs, MT10, p53, GSTpi, ER1/2) in Mytilus galloprovincialis native specimens to identify pollution related transcriptional changes. METHODS: gene expression levels were analysed in the gills of mussels from five sites along a coastal area of the central Adriatic Sea, using qPCR. RESULTS: we observed higher expression levels of biomarker genes in mussels from the local harbour or river mouths than in mussels from the reference site and offshore platform...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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