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Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals

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https://www.readbyqxmd.com/read/27918196/riboflavin-as-an-independent-and-accurate-biomarker-for-adherence-in-a-randomized-double-blind-and-placebo-controlled-clinical-trial
#1
V-M Sadagopa Ramanujam, Fatima Nayeem, Karl E Anderson, Yong-Fang Kuo, Nai-Wei Chen, Hyunsu Ju, Lee-Jane W Lu
BACKGROUND: Medication adherence is critical for success of clinical trials. OBJECTIVE: To assess oral riboflavin is an adherence marker. METHODS: Riboflavin was incorporated into active treatment and placebo pills for a clinical trial lasting for 2 years. RESULTS: The accuracy (area under the receiver operating curve) of urinary riboflavin was 0.91 as a binary classifier of adherence, and was similar or better than for two active study ingredients daidzein (0...
December 5, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27903076/the-potential-of-optimizing-prehospital-triage-of-patients-with-suspected-acute-myocardial-infarction-using-high-sensitivity-cardiac-troponin-t-and-copeptin
#2
Carsten Stengaard, Jacob T Sørensen, Søren A Ladefoged, Jens F Lassen, Martin B Rasmussnen, Claus Kjær Pedersen, Antoine Ayer, Hans Erik Bøtker, Christian J Terkelsen, Kristian Thygesen
PURPOSE: In patients with a suspected acute myocardial infarction (AMI), to evaluate the potential for early triage based on measurement of high-sensitivity cardiac troponin T (hs-cTnT) and copeptin in blood samples collected in the prehospital phase. MATERIALS AND METHODS: In this retrospective study, we measured hs-cTnT and copeptin in blood samples collected in the ambulance form 962 patients with suspected AMI. The diagnostic accuracy was estimated by receiver-operating characteristics curve area under the curve (AUC) for both biomarkers and a combined model...
December 1, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27797276/bacterial-pili-with-emphasis-on-mycobacterium-tuberculosis-curli-pili-potential-biomarkers-for-point-of-care-tests-and-therapeutics
#3
Natasha Naidoo, Manormoney Pillay
CONTEXT: Novel biomarkers are essential for developing rapid diagnostics and therapeutic interventions Objective: This review aimed to highlight biomarker characterisation and assessment of unique bacterial pili. METHODS: A PubMed search for bacterial pili, diagnostics, vaccine and therapeutics was performed, with emphasis on the well characterised pili. RESULTS: In total, 46 papers were identified and reviewed. CONCLUSION: Extensive analyses of pili enabled by advanced nanotechnology and whole genome sequencing provide evidence that they are strong biomarker candidates...
December 1, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27899037/a-comparison-of-hmgb1-concentrations-between-cerebrospinal-fluid-and-blood-in-patients-with-neurological-disease
#4
Lauren Elizabeth Walker, Michael Griffiths, Fiona McGill, Penelope Lewthwaite, Graeme John Sills, Andrea Jorgensen, Daniel James Antoine, Tom Solomon, Anthony Guy Marson, Munir Pirmohamed
AIMS: To determine whether a correlation exists between paired cerebrospinal fluid (CSF) and serum levels of a novel inflammatory biomarker, HMGB1, in different neurological conditions. METHODS: HMGB1 was measured in the serum and CSF of 46 neurological patients (18 idiopathic intracranial hypertension (IIH), 18 neurological infection/inflammation (NII) and 10 Rasmussen's encephalitis (RE)). RESULTS: Mean serum (± SD) HMGB1 levels were 1...
November 30, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27899026/circulating-levels-of-apoptotic-markers-and-oxidative-stress-parameters-in-women-with-polycystic-ovary-syndrome-a-case-controlled-descriptive-study
#5
Hacer Uyanikoglu, Tevfik Sabuncu, Huseyin Dursun, Hatice Sezen, Nurten Aksoy
CONTEXT: Apoptotic dysregulation plays a role in the pathogenesis of polycystic ovary syndrome (PCOS). OBJECTIVE: To evaluate circulatory apoptotic markers and oxidative stress in patients with PCOS. MATERIALS AND METHODS: Forty-four women with PCOS, and 44 healthy women as controls were enrolled in the study. Oxidative stress parameters and caspases levels were measured in serum. RESULTS: The caspase 9 level was significantly lower and related with oxidant status in patients with PCOS, while the circulating levels of caspases 3 and 7 were statistically similar in both groups...
November 30, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27885846/big-endothelin-1-level-is-a-useful-marker-for-predicting-the-presence-of-isolated-coronary-artery-ectasia
#6
Yao Wang, Yan Zhang, Cheng-Gang Zhu, Yuan-Lin Guo, Qiao-Juan Huang, Na-Qiong Wu, Ying Gao, Ping Qing, Geng Liu, Qian Dong, Jian-Jun Li
CONTEXT: Endothelin-1(ET-1) has been implicated in coronary artery disease (CAD) and may be associated with coronary artery ectasia (CAE). OBJECTIVE: To clarify the relationship between big ET-1 and isolated CAE. METHODS: We measured big ET-1 with ELISA in 216 patients (CAE, n = 72; CAD, n = 72; normal, n = 72) and evaluated the link with isolated CAE. RESULTS: The level of plasma big ET-1 was significantly higher in patients with isolated CAE (p < 0...
November 25, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27885841/the-utility-of-saliva-for-the-assessment-of-anti-pneumococcal-antibodies-investigation-of-saliva-as-a-marker-of-antibody-status-in-serum
#7
Jennifer L J Heaney, Anna C Phillips, Douglas Carroll, Mark T Drayson
CONTEXT: Salivary antibodies may act as non-invasive marker of systemic immunity enabling assessment of vaccination and protection against bacterial infections. OBJECTIVE: To assess if levels of anti-pneumococcal antibodies in saliva reflect concentrations in serum and determine whether saliva can accurately identify protective concentrations in serum. METHODS: IgG, IgA and IgM antibody levels in paired saliva and serum samples were measured against 12 pneumococcal polysaccharide antigens in 72 healthy adults...
November 25, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27882774/usefulness-of-copeptin-as-a-potential-biomarker-in-tbe
#8
Piotr Czupryna, Anna Moniuszko-Malinowska, Adam Garkowski, Justyna Dunaj, Renata Swierzbinska, Sławomir Pancewicz, Joanna Gościk, Maciej Kondrusik, Sambor Grygorczuk, Joanna Zajkowska
OBJECTIVE: The aim of the study was the evaluation of copeptin usefulness for differentiation of hyponatremia in the course of tick-borne encephalitis (TBE) and for being a prognostic marker of the severity of TBE. MATERIALS AND METHODS: 114 patients with TBE were included in the study. The control group consisted of 62 patients diagnosed with viral meningitis. RESULTS: Copeptin concentration did not differ in patients with hyponatremia and normonatremia...
November 24, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27881022/elevated-serum-ykl-40-levels-in-patients-with-kawasaki-disease
#9
K Y Kim, Y Ahn, D Y Kim, Ho-Seong Kim, D S Kim
CONTEXT: YKL-40 is an inflammatory biomarker for endothelial dysfunction that may have a role in Kawasaki disease (KD). OBJECTIVES: We investigated the association of serum YKL-40 levels with KD and established laboratory parameters for YKL-40 levels and other inflammatory markers. METHODS: YKL-40 levels and other inflammatory markers of 23 KD patients, 9 disease control patients, and 11 age-matched healthy controls. RESULTS: YKL-40 concentration in the serum of KD patients significantly increased during the acute disease phase compared with those of disease controls and healthy controls...
November 24, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27879166/sex-differences-in-release-of-cardiac-troponin-t-after-endurance-exercise
#10
Zhaowei Kong, Jinlei Nie, Hua Lin, Keith George, Gang Zhao, Haifeng Zhang, Tomas K Tong, Qingde Shi
CONTEXT: Post-exercise cardiac troponin release has been extensively described in athletic groups but little attention has been given to any role of sex in mediating this phenomnenon. OBJECTIVE: We compared the release of cardiac troponin T (cTnT) after endurance running in training-experience, biological-age and maturity-matched young male and female runners. MATERIALS AND METHODS: Nineteen male (training history: 2.3±1.0 yr; mean age: 16...
November 23, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27879165/eahfe-tropica2-study-prognostic-value-of-troponin-in-patients-with-acute-heart-failure-treated-in-spanish-hospital-emergency-departments
#11
Javier Jacob, Alex Roset, Òscar Miró, Aitor Alquézar, Pablo Herrero, Francisco Javier Martín-Sanchez, Martin Möckel, Christian Müller, Pere Llorens
OBJECTIVE: Evaluate the use of different cardiac troponin (cTn) immunoassays and the prognostic value of increased cTn values in patients diagnosed with acute heart failure (AHF) in the emergency department (ED). METHOD: The EAHFE-TROPICA2 is a retrospective study including patients with AHF admitted in 34 Spanish EDs with cTn values determined in the ED. We studied the prevalence of elevated troponin (value above the established reference limit) for the different types of troponin...
November 23, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27879161/neopterin-and-oxidative-stress-markers-in-the-diagnosis-of-extrapulmonary-tuberculosis
#12
Nisha Goyal, Bineeta Kashyap, N P Singh, Iqbal R Kaur
BACKGROUND: Extrapulmonary tuberculosis (EPTB) often presents with non-specific signs and symptoms. Further the paucibacillary nature of extrapulmonary specimens and irregular distribution of bacilli lower the sensitivity of conventional diagnostic methods making EPTB, a diagnostic dilemma. Objective To study neopterin, protein carbonyl and malondialdehyde in extrapulmonary tuberculosis. METHODS: 69 clinically confirmed cases with an equal number of age and sex matched healthy controls were enrolled...
November 23, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27879158/potential-of-lysophosphatidylinositol-as-a-prognostic-indicator-of-cardiac-arrest-using-a-rat-model
#13
Junhwan Kim, Tai Yin, Koichiro Shinozaki, Joshua W Lampe, Lance B Becker
AIMS: The potential of a lysophosphatidylinositol species, LPI(18:0), as an biomarker of ischaemia was tested using a rat model of cardiac arrest (CA). METHODS: Male Sprague-Dawley rats were subjected to asphyxia-induced CA or CA followed by cardiopulmonary bypass (CPB) resuscitation. Brain, heart, kidney, and liver tissues were harvested from rats after 0, 5, 10, 20, 30, and 60 min CA and 30 min CA followed by 60 min CPB resuscitation. Blood samples were collected from inferior vena cava and hepatic veins following 30 min CA...
November 23, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27775443/biomarker-discovery-for-drug-induced-phospholipidosis-phenylacetylglycine-to-hippuric-acid-ratio-in-urine-and-plasma-as-potential-markers
#14
Hidenori Kamiguchi, Mika Murabayashi, Ikuo Mori, Akira Horinouchi, Kazutaka Higaki
CONTEXT: Drug-induced phospholipidosis is one of the significant concerns in drug development, especially in safety assessment and noninvasive diagnostic tool is highly desirable. OBJECTIVE: The objective of this study is to explored novel biomarkers for phospholipidosis using a metabolomic approach. METHOD: NMR spectrometry and LC/MS/MS analyses were applied to urine and plasma of rats administrated cationic amphiphilic drugs. RESULTS: The phenylacetylglycine to hippuric acid ratio in plasma was increased in time and dose-dependent manners; and it was well correlated with histopathological observation...
November 21, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27805426/the-metabolomics-and-lipidomics-window-into-thyroid-cancer-research
#15
R Farrokhi Yekta, M Rezaie Tavirani, A Arefi Oskouie, M R Mohajeri-Tehrani, A R Soroush
CONTEXT: Thyroid carcinoma is the most common endocrine system malignancy with a fast rising incidence in the last decade for unknown reasons. Fine needle aspiration (FNA) biopsy, the gold standard in thyroid cancer (TC) screening has still its own challenges and in some cases needs a proceeding surgery. OBJECTIVE: This review highlights the role of the two most recent "omics" approaches, "metabolomics" and "lipidomics", in the field of TC research. METHODS: All the previous studies have been extracted from the literature and major concepts were detailed in the field of TC metabolomics and lipidomics...
November 15, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27775439/panel-of-serex-defined-antigens-for-breast-cancer-autoantibodies-profile-detection
#16
Olga Kostianets, Maksym Shyyan, Stepan Vasil'ovich Antoniuk, Valeriy Filonenko, Ramziya Kiyamova
CONTENT: Identification of panel of SEREX-defined antigens for breast cancer autoantibodies profile detection. OBJECTIVE: To create panel of antigens that can differentiate breast cancer patients and healthy individuals. METHODS: SEREX (serological analysis of cDNA expression libraries) method, ELISA (enzyme-linked immunosorbent assay), qPCR (quantitative polymerase chain reaction). RESULTS: In large-scale screening of 16 SEREX-antigens by sera of breast cancer patients and healthy donors, a combination of six antigens (RAD50, PARD3, SPP1, SAP30BP, NY-BR-62 and NY-CO-58) was identified, which can differentiate breast cancer patients and healthy donors with 70% sensitivity and 91% specificity...
November 9, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27805415/determination-of-natural-moisturizing-factors-in-the-skin-raman-microspectroscopy-versus-hplc
#17
S A Koppes, P Kemperman, I van Tilburg, F Calkoen-Kwa, K A Engebretsen, G J Puppels, P J Caspers, S Kezic
BACKGROUND: Natural moisturizing factors (NMF) is used as genotypic and phenotypic biomarker in diagnostics. This study is a side-to-side comparison of two different methods to determine NMF in atopic dermatitis patients: Raman microspectroscopy and stratum corneum tape stripping followed by HPLC. RESULTS: Measured NMF values were significantly correlated (R2 = 0.61; P < 0.0001), both methods demonstrated a concentration-depth dependence of NMF and reduced NMF levels in the carriers of filaggrin null mutations...
November 2, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27800690/order-of-aging-of-major-human-organs-and-systems-and-evaluation-of-health-status-based-on-aging
#18
Chengfang Wang, Chunqing Liu, Hanboya Gao, Hui Liu
To determine the functional age of an individual, a quantitative system for the assessment of aging status was developed in the present study. 1579 subjects were selected randomly from patients undergoing physical examination. the index of organic mild impairment (IOMI) and IOMI corrected for age (COMI) were calculated. By receiver operating characteristic curve analysis of the IOMIs of younger and elderly subjects, a cut-off value for COMI of 30% was obtained. About 95% of <30-year-old subjects were healthy...
November 1, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27790922/serum-uromodulin-predicts-graft-failure-in-renal-transplant-recipients
#19
Dominik Steubl, Matthias Block, Victor Herbst, Wolfgang Schlumberger, Andreas Nockher, Susanne Angermann, Christoph Schmaderer, Uwe Heemann, Lutz Renders, Jürgen Scherberich
: Objective&Methods: Test the ability of serum uromodulin concentrations 1-3 months after renal transplantation to predict all-cause mortality and graft loss (GL) in 91 patients. RESULTS: uromodulin predicted GL equivalently to the other markers studied: the risk for GL was reduced by 0.21 per one standard deviation increase (SD) (cystatin C: HR 4.57, creatinine: HR 4.53, BUN: HR 2.50, eGFR: HR 0.10). In ROC analysis, uromodulin predicted GL with an area-under-the curve of 0...
October 28, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27788598/propeptide-big-endothelin-n-terminal-pro-brain-natriuretic-peptide-and-mortality-the-ludwigshafen-risk-and-cardiovascular-health-luric-study
#20
Ingrid Gergei, Bernhard K Krämer, Scharnagl Hubert, Tatjana Stojakovic, März Winfried, Ulrich Mondorf
CONTEXT: The endothelin system (Big-ET-1) is a key regulator in cardiovascular (CV) disease and congestive heart failure (CHF). OBJECTIVES: We have examined the incremental value of Big-ET-1in predicting total and CV mortality next to the well-established CV risk marker N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP). METHODS: Big-ET-1 and NT-proBNP were determined in 2829 participants referred for coronary angiography (follow-up 9.9 years)...
October 28, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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