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Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals

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https://www.readbyqxmd.com/read/30015516/the-association-between-plasma-mir-122-5p-release-pattern-at-admission-and-all-cause-mortality-or-shock-after-out-of-hospital-cardiac-arrest
#1
Patrik Gilje, Martin Frydland, John Bro-Jeppesen, Josef Dankiewicz, Hans Friberg, Malin Rundgren, Yvan Devaux, Pascal Stammet, Mariam Al-Mashat, Jonas Jögi, Jesper Kjaergaard, Christian Hassager, David Erlinge
BACKGROUND: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA. METHODS: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls...
July 17, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30015514/obesity-is-an-independent-determinant-of-elevated-c-reactive-protein-in-healthy-women-but-not-men
#2
Xinyan Bi, Yi Ting Loo, Shalini D/O Ponnalagu, Christiani Jeyakumar Henry
BACKGROUND AND AIMS: High-sensitivity C-reactive protein (hs CRP) has emerged as an inflammatory biomarker to predict metabolic syndrome. Here, we investigate the association of hs CRP with metabolic variables and determine the risks for elevated hs CRP levels in healthy Singaporean adults. METHODS: We conducted a cross-sectional study of 225 participants (104 men). The levels of hs CRP and fasting lipid parameters were analyzed by COBAS. Body composition was determined with dual-energy X-ray absorptiometry...
July 17, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30015513/a-novel-microrna-mir-1165-3p-as-a-potential-diagnostic-biomarker-for-allergic-asthma
#3
Chaojie Wu, Kun Xu, Zhengxia Wang, Zhongqi Chen, Zhixiao Sun, Wenqing Yu, Ningfei Ji, Mao Huang, Mingshun Zhang
CONTEXT: A further examination of a novel potential miRNA asthma biomarker, miR-1165-3p, which was previously implicated in helper T cells (Th2) in a murine asthma model. OBJECTIVE: To determine whether serum miR-1165-3p can serve as a potential diagnostic biomarker for allergic asthma. METHODS: Serum miR-1165-3p was quantified via quantitative real-time PCR (qRT-PCR) in asthmatic and control samples. Serum miR-1165-3p levels were compared between groups and the clinical diagnostic abilities of miR-1165-3p were evaluated...
July 17, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30015512/influence-of-il-6-il-10-ifn-%C3%AE-and-tnf-%C3%AE-genetic-variants-on-susceptibility-to-diabetic-kidney-disease-in-type-2-diabetes-mellitus-patients
#4
Shadia A Fathy, Mohamed R Mohamed, Mohamed A M Ali, Ashraf E El-Helaly, Abdulnabi T Alattar
BACKGROUND: Data from previous studies on the role of inflammatory cytokines as biomarkers for diabetic kidney disease (DKD) are contradictory. The association of a particular inflammatory cytokine single nucleotide polymorphism (SNP) with susceptibility to DKD has not been consistently replicated. We aimed to investigate the utility of inflammatory cytokines as biomarkers for DKD in type 2 diabetes mellitus (T2DM) patients. Association of inflammatory cytokine gene SNPs with the development of DKD was also explored...
July 17, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30010434/recurrence-prediction-using-microrna-expression-in-hormone-receptor-positive-breast-cancer-during-tamoxifen-treatment
#5
Chungyeul Kim, Eun Jin Go, Aeree Kim
PURPOSE: To identify miRNAs associated with distant recurrence during tamoxifen treatment and build a recurrence prediction model. MATERIALS AND METHODS: We measured the expression of five miRNAs (miR-134, miR-125b-5P, miRNA-30a, miR-10a-5p, and miR-222). A total of 176 tumor tissues from 176 patients who had hormone receptor positive breast cancer with tamoxifen treatment were used to measure miRNA expression using quantitative real-time PCR (qRT-PCR). RESULTS: The five miRNAs were all up-regulated in distant recurrence cases within 5 years after surgery and during tamoxifen treatment...
July 16, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30010432/validation-of-a-proteomic-biomarker-panel-to-diagnose-minor-stroke-and-transient-ischaemic-attack-phase-2-of-spectra-a-large-scale-translational-study
#6
Andrew M Penn, Maximilian B Bibok, Viera K Saly, Shelagh B Coutts, Mary L Lesperance, Robert F Balshaw, Kristine Votova, Nicole S Croteau, Anurag Trivedi, Angela M Jackson, Janka Hegedus, Evgenia Klourfeld, Amy Y X Yu, Charlotte Zerna, Jayesh Modi, Philip A Barber, Gordon Hoag, Christoph H Borchers
OBJECTIVE: To validate our previously developed 16 plasma-protein biomarker panel to differentiate between transient ischaemic attack (TIA) and non-cerebrovascular emergency department (ED) patients. METHOD: Two consecutive cohorts of ED patients prospectively enrolled at two urban medical centres into the second phase of SpecTRA study (training, cohort 2A, n = 575; test, cohort 2B, n = 528). Plasma samples were analysed using liquid chromatography/multiple reaction monitoring-mass spectrometry...
July 16, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29993290/commentary-on-modarresi-a-et-al-2018-n-acetylcysteine-decreases-urinary-level-of-neutrophil-gelatinase-associated-lipocalin-in-deceased-donor-renal-transplant-recipients-a-randomized-clinical-trial
#7
David Paul Lovell
No abstract text is available yet for this article.
July 11, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29987966/attending-a-social-event-and-consuming-alcohol-is-associated-with-changes-in-serum-microrna-a-before-and-after-study-in-healthy-adults
#8
Paul Wl Ten Berg, Jonathan Shaffer, A D Bastiaan Vliegenthart, Jame McCrae, Noel Sharkey, David J Webb, James W Dear
PURPOSE: Circulating microRNAs represent a reservoir for biomarker discovery. Our objective was to profile the change in human circulating microRNA associated with recreational use of alcohol at a social event. MATERIAL AND METHODS: Blood was collected from healthy volunteers (N = 16) before and after recreational consumption of alcohol (ethanol). Biochemistry, haematology and ethanol measurements were performed. The change in the serum small RNA fraction was quantified by RNA sequencing...
July 10, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29976112/possible-mechanisms-behind-cardiac-troponin-elevations
#9
Ola Hammarsten, Johannes Mair, Martin Möckel, Bertil Lindahl, Allan S Jaffe
Cardiac-specific troponins are elevated in blood following cardiac injury and are the preferred diagnostic biomarkers when acute myocardial infarction is suspected clinically. Cardiac troponin elevations are also observed in clinical conditions without obvious connection to cardiac injury. Irrespective of the underlying condition, cardiac troponin elevation is linked to a poor prognosis, even if the elevation is stable over time. Here, we explore mechanisms that may lead to cardiac troponin elevations, including necrosis, apoptosis, necroptosis, cell wounds and decreased clearance...
July 6, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29962242/impdh2-is-highly-expressed-in-breast-cancer-and-predicts-unfavourable-prognosis
#10
Yueming Zhao, Yawen Yang, Jixing Dai, Dejun Xing, Ying Dong
Inosine monophosphate dehydrogenase type II (IMPDH2) is reported to be associated with tumor formation. However, the correlation between IMPDH2 and breast cancer has never been reported. In this study, IMPDH2 expression was measured in 40 cases of breast cancer tissues and matched adjacent normal tissues by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting assays. Then, IMPDH2 expression was further detected in 153 cases of breast cancer tissues by immunohistochemistry (IHC). The correlation between IMPDH2 expression and clinicopathological characteristics and patients' prognosis was investigated in breast cancer...
July 2, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29943660/methods-used-to-assess-the-performance-of-biomarkers-for-the-diagnosis-of-acute-kidney-injury-a-systematic-review-and-meta-analysis
#11
Anaïs Codorniu, Léa Lemasle, Matthieu Legrand, Alice Blet, Alexandre Mebazaa, Etienne Gayat
PURPOSE: Methods used to explore biomarkers for acute kidney injury (AKI) might have a major impact on the results and the use of these biomarkers. We evaluated the methods used to investigate biomarkers of AKI. MATERIALS AND METHODS: A systematic review and meta-analysis were performed using a computerized search of the MEDLINE and the EMBASE databases (PROSPERO CRD42017059618). Articles reporting biomarker's performance to diagnose AKI were included. The outcome included a description of the methods used to assess the performance of biomarkers to diagnose AKI...
June 26, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29943653/improving-clinical-prediction-rules-in-acute-kidney-injury-with-the-use-of-biomarkers-of-cell-cycle-arrest-a-pilot-study
#12
Luke E Hodgson, Richard M Venn, Steve Short, Paul J Roderick, Duncan Hargreaves, Nicholas Selby, Lui G Forni
INTRODUCTION: Early recognition of patients developing acute kidney injury is of considerable interest, we report the first use of a combination of a clinical prediction rule with a biomarker in emergent adult medical patients to improve AKI recognition. METHODS: Single-centre prospective pilot study of medical admissions without AKI identified as high risk by a clinical prediction rule. Urine samples were obtained and tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) - biomarkers associated with cell cycle arrest, were measured...
June 26, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29786448/serum-rbp4-positively-correlates-with-triglyceride-level-but-not-with-bmi-fat-mass-and-insulin-resistance-in-healthy-obese-and-non-obese-individuals
#13
Emilia Korek, Magdalena Gibas-Dorna, Zuzanna Chęcińska-Maciejewska, Hanna Krauss, Małgorzata Łagiedo-Żelazowska, Barbara Kołodziejczak, Paweł Bogdański
PURPOSE: Retinol binding protein 4 (RBP4) has recently been identified as an adipokine possibly involved in the development of impaired glucose metabolism. We aimed to test serum RBP4 in healthy non-obese individuals and in patients with well-characterized phenotype: obesity without confounding effects of diabetes, metabolic syndrome or dyslipidaemia. Additionally, we examined whether serum RBP4 is associated with anthropometric parameters, insulin resistance and blood lipid parameters...
June 20, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29799276/microarray-analysis-of-mirna-expression-profiles-following-whole-body-irradiation-in-a-mouse-model
#14
Molykutty J Aryankalayil, Sunita Chopra, Adeola Makinde, Iris Eke, Joel Levin, Uma Shankavaram, Laurel MacMillan, Claire Vanpouille-Box, Sandra Demaria, C Norman Coleman
CONTEXT: Accidental exposure to life-threatening radiation in a nuclear event is a major concern; there is an enormous need for identifying biomarkers for radiation biodosimetry to triage populations and treat critically exposed individuals. OBJECTIVE: To identify dose-differentiating miRNA signatures from whole blood samples of whole body irradiated mice. METHODS: Mice were whole body irradiated with X-rays (2 Gy-15 Gy); blood was collected at various time-points post-exposure; total RNA was isolated; miRNA microarrays were performed; miRNAs differentially expressed in irradiated vs...
June 19, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29781727/se-cadherin-and-sve-cadherin-indicate-active-epithelial-endothelial-to-mesenchymal-transition-emt-and-endomt-in-smokers-and-copd-implications-for-new-biomarkers-and-therapeutics
#15
Mathew Suji Eapen, Stephen Myers, Wenying Lu, Chloé Tanghe, Pawan Sharma, Sukhwinder Singh Sohal
No abstract text is available yet for this article.
June 19, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29911898/pneumoproteins-and-markers-of-inflammation-and-platelet-activation-in-the-blood-of-grain-dust-exposed-workers
#16
A Straumfors, W Eduard, K K Heldal, M Skogstad, L Barregård, D G Ellingsen
PURPOSE: To investigate if blood biomarkers could indicate early signs of lung damage or cardiovascular risk due to exposure to grain dust. MATERIALS AND METHODS: Pneumoproteins and markers of inflammation and platelet activation were analyzed in blood samples of 102 grain elevator and compound feed mill workers. Differences between exposed (n = 67) and controls (n = 35), and associations with exposure measurements and respiratory health were investigated by multiple linear regression analyses...
June 18, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29909697/identification-of-candidate-microrna-biomarkers-in-renal-fibrosis-a-meta-analysis-of-profiling-studies
#17
Alieh Gholaminejad, Hossein Abdul Tehrani, Mohammad Gholami Fesharaki
CONTEXT: The prognostic, diagnostic and therapeutic value of microRNA (miRNA) expression aberrations in renal fibrosis has been studied in recent years. However, the miRNA expression profiling efforts have led to inconsistent results between the studies. OBJECTIVE(S): The aim of this study was to perform a meta-analysis on the renal fibrosis miRNA expression profiling studies to identify candidate diagnostic biomarkers. MATERIALS AND METHODS: We performed comprehensive literature searches in several databases to identify miRNA expression studies of renal fibrosis in animal models and humans...
June 18, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29871536/bulky-dna-adduct-levels-in-normal-appearing-colon-mucosa-and-the-prevalence-of-colorectal-adenomas
#18
Vikki Ho, Sarah Peacock, Thomas E Massey, Roger W L Godschalk, Frederik J van Schooten, Janet E Ashbury, Stephen J Vanner, Will D King
PURPOSE: Examine the association between bulky DNA adduct levels in colon mucosa and colorectal adenoma prevalence, and explore the correlation between adduct levels in leukocytes and colon tissue. METHODS: Bulky DNA adduct levels were measured using 32 P-postlabelling in biopsies of normal-appearing colon tissue and blood donated by 202 patients. Multivariable logistic regression was used to examine associations between DNA adducts, and interactions of DNA adduct-DNA repair polymorphisms, with the prevalence of colorectal adenomas...
June 6, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29871526/effects-of-endogenous-serum-neuregulin-1%C3%AE-on-morbidity-and-mortality-in-patients-with-heart-failure-and-left-ventricular-systolic-dysfunction
#19
Jennifer Miao, Shi Huang, Yan Ru Su, Carrie A Lenneman, Meera Wright, Frank E Harrell, Douglas B Sawyer, Daniel J Lenihan
CONTEXT: Improved left ventricular ejection fraction (LVEF) following administration of recombinant human Neuregulin-1β (NRG), epidermal growth factor (EGF) involved in cardiomyocyte repair/survival, has been observed in patients with systolic heart failure (HF). METHODS: Serum NRG was measured by ELISA in 248 patients with NYHA class I-IV HF. RESULTS: NRG exhibited a marginally significant effect on LVEF trajectory over 11 months (p = 0...
June 6, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29862847/association-between-circulating-irisin-levels-and-epicardial-fat-in-patients-with-treatment-na%C3%A3-ve-overt-hyperthyroidism
#20
Mustafa Şahin, Asena Gökçay Canpolat, Demet Çorapçioğlu, Uğur Canpolat, Rıfat Emral, Ali Rıza Uysal
BACKGROUND: Hyperthyroidism is associated with increased metabolic activity and thermogenesis. Irisin is a key molecule in thermogenesis and energy expenditure via adipose tissue browning. Epicardial fat was previously defined as brown-like fat. Thus, here we aimed to evaluate the association between serum irisin level and epicardial fat thickness (EFT) in patients with hyperthyroidism. METHODS: A total of 25 hyperthyroid patients and 24 age-, sex-, and BMI-matched healthy controls were enrolled...
June 4, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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