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Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals

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https://www.readbyqxmd.com/read/28862880/club-cell-protein-cc16-in-plasma-bronchial-brushes-bal-and-urine-following-an-inhaled-allergen-challenge-in-allergic-asthmatics
#1
Henning Stenberg, Erik Wadelius, Subhabrata Moitra, Ida Åberg, Jaro Ankerst, Zuzana Diamant, Leif Bjermer, Ellen Tufvesson
BACKGROUND: Club cell protein (CC16) is a pneumoprotein secreted by epithelial club cells. CC16 possesses anti-inflammatory properties and is a potential biomarker for airway epithelial damage. We studied the effect of inhaled allergen on pulmonary and systemic CC16 levels. METHODS: Thirty-four subjects with allergic asthma underwent an inhaled allergen challenge. Bronchoscopy with bronchoalveolar lavage (BAL) and brushings was performed before and 24 h after the challenge...
September 18, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28862876/quantification-of-cotinine-in-dried-blood-spots-as-a-biomarker-of-exposure-to-tobacco-smoke
#2
Daniel Ladror, Bruce Pitt, William Funk
OBJECTIVE: We present an ultra-sensitive, minimally-invasive method for quantifying cotinine in dried blood spot (DBS) samples as a biomarker of exposure to tobacco smoke that can be collected using a simple heel or finger prick to obtain blood samples. METHODS: Cotinine levels were measured in matched plasma and reconstituted DBS samples from smokers and nonsmokers to evaluate assay parameters. In addition, we applied this new method to finger-prick DBS samples that were collected from infants, children and young adults ages 1-21 to estimate exposure to tobacco smoke...
September 18, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28901783/quantification-of-manganese-and-mercury-in-toenail-in-vivo-using-portable-x-ray-fluorescence-xrf
#3
Xinxin Zhang, Aaron J Specht, Linda H Nie
BACKGROUND AND OBJECTIVE: Toenail is an advantageous biomarker to assess exposure to metals such as manganese and mercury. Toenail Mn and Hg are in general analyzed by chemical methods such as ICP-MS and AAS. In this project, a practical and convenient technology - portable x-ray florescence (XRF) - is studied for the non-invasive in vivo quantification of manganese and mercury in toenail. MATERIALS AND METHODS: The portable XRF method has advantages in that it does not require toenail clipping and it can be done in 3 minutes, which will greatly benefit human studies involving the assessment of manganese and mercury exposures...
September 13, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28749186/correlation-between-cat-polymorphism-and-susceptibility-to-dmac-induced-abnormal-liver-function-a-case-control-study-of-chinese-population
#4
Xianping Song, Wei Gong, Huanxi Shen, Xiuting Li, Lu Ding, Lei Han, Hengdong Zhang, Baoli Zhu, Xin Liu
CONTEXT: Acute or chronic exposure of N,N-Dimethylacetamide (DMAc) is responsible for abnormal liver function. It appears that DMAc is mainly metabolized by cytochrome P450 in the liver and thereby produces reactive oxygen species (ROS). The elimination of ROS and the repairing of ROS-induced DNA damage are relevant to the ultimate toxicity of DMAc. OBJECTIVE: To investigate whether the polymorphisms in the CAT (rs564250, rs769214 and rs7943316), hOGG1 (rs2072668 and rs159153) and XRCC1 (rs25487 and rs1799782) genes are associated with susceptibility to DMAc-induced abnormal liver function in Chinese population...
July 27, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28748734/biochemical-alterations-induced-by-nickel-oxide-nanoparticles-in-female-wistar-albino-rats-after-acute-oral-exposure
#5
Naresh Dumala, Bhanuramya Mangalampalli, Kalyan Kamal Srinivasa Sarika, Paramjit Grover
CONTEXT: Nickel oxide (NiO) nanoparticles (NPs) with appropriate surface chemistry have been widely used for their potential new applications in biomedical industry. Increased usage of these NPs, enhances the chance of exposure of personnel involved in the work place. OBJECTIVE: This study was designed to assess the ability of NiO NPs to cause biochemical alterations post-acute oral exposure in female Wistar rats. MATERIALS AND METHODS: Rats were administered with 125, 250, and 500 mg/kg doses of NiO NPs for haematological, biochemical and histopathological studies...
July 27, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28675313/values-of-vanillylmandelic-acid-and-homovanillic-acid-in-the-urine-as-potential-prognostic-biomarkers-in-ischaemic-stroke-patients
#6
David Bonifačić, Merica Aralica, Vlatka Sotošek Tokmadžić, Valentino Rački, Lidija Tuškan-Mohar, Natalia Kučić
BACKGROUND: Suitable biomarkers that have prognostic values are one of the key points of interest in ischaemic stroke. Increased sympathetic nervous system activity in ischaemic stroke causes multiple local and systemic effects that can be detrimental to outcome. The mechanism of action is increased secretion and activity of catecholamines, whose end metabolic products are vanillylmandelic acid and homovanilic acid. Aim of our study was to determine whether these compounds can be used as potential prognostic biomarkers in ischaemic stroke, as a unique insight into the activity of the sympathetic nervous system...
July 4, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28675303/plasma-mir-200b-3p-level-for-oral-squamous-cell-carcinoma-diagnosis
#7
Guo-Ming Zhang
No abstract text is available yet for this article.
July 4, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28675064/differential-expression-of-circulating-vascular-cell-adhesion-molecule-1-in-subjects-with-coronary-artery-disease-and-cardiac-syndrome-x-without-known-diabetes-mellitus
#8
Kae-Woei Liang, Wayne H-H Sheu, Wen-Jane Lee, Wen-Lieng Lee, Chia-Po Fu, Jun-Sing Wang
CONTEXT: Inflammation is one of the mechanisms underlying cardiac syndrome X (CSX). OBJECTIVES: Few studies have compared the expression of inflammatory or adhesion molecules between coronary artery disease (CAD) vs. CSX. MATERIALS AND METHODS: Ninety-two CSX and 145 CAD subjects without known diabetes mellitus underwent coronary angiogram for angina. RESULTS: Vascular cell adhesion molecule (VCAM)-1 (median, 507 vs...
July 4, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28678539/histone-3-modifications-and-blood-pressure-in-the-beijing-truck-driver-air-pollution-study
#9
Jacob K Kresovich, Zhou Zhang, Fang Fang, Yinan Zheng, Marco Sanchez-Guerra, Brian T Joyce, Jia Zhong, Yana Chervona, Sheng Wang, Dou Chang, John P McCracken, Anaite Díaz, Matteo Bonzini, Michele Carugno, Petros Koutrakis, Choong-Min Kang, Shurui Bian, Tao Gao, Hyang-Min Byun, Joel Schwartz, Andrea A Baccarelli, Lifang Hou
CONTEXT: Histone modifications regulate gene expression; dysregulation has been linked with cardiovascular diseases. Associations between histone modification levels and blood pressure in humans are unclear. OBJECTIVE: We examine the relationship between global histone concentrations and various markers of blood pressure. MATERIALS AND METHODS: Using the Beijing Truck Driver Air Pollution Study, we investigated global peripheral white blood cell histone modifications (H3K9ac, H3K9me3, H3K27me3, and H3K36me3) associations with pre- and post-work measurements of systolic (SBP) and diastolic (DBP) blood pressure, mean arterial pressure (MAP), and pulse pressure (PP) using multivariable mixed-effect models...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28583029/p-gp-expression-levels-in-the-erythrocytes-of-brown-trout-a-new-tool-for-aquatic-sentinel-biomarker-development
#10
Emeline Valton, Ivan Wawrzyniak, Christian Amblard, Bruno Combourieu, Marie-Laure Bayle, François Desmolles, Fabrice Kwiatkowski, Frédérique Penault-Llorca, Mahchid Bamdad
CONTEXT: P-glycoprotein (P-gp) is a ubiquitous membrane detoxification pump involved in cellular defence against xenobiotics. Blood is a hub for the trade and transport of physiological molecules and xenobiotics. Our recent studies have highlighted the expression of a 140-kDa P-gp in brown trout erythrocytes in primary cell culture and its dose-dependent response to Benzo[a]pyrene pollutant. OBJECTIVE: The purpose of this study was focused on using P-gp expression in brown trout erythrocytes as a biomarker for detecting the degree of river pollution...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28581828/biomarkers-used-in-studying-air-pollution-exposure-during-pregnancy-and-perinatal-outcomes-a-review
#11
Gauri Desai, Li Chu, Yanjun Guo, Ajay A Myneni, Lina Mu
PURPOSE: This review focuses on studies among pregnant women that used biomarkers to assess air pollution exposure, or to understand the mechanisms by which it affects perinatal outcomes. METHODS: We searched PubMed and Google scholar databases to find articles. RESULTS AND CONCLUSIONS: We found 29 articles, mostly consisting of cohort studies. Interpolation models were most frequently used to assess exposure. The most consistent positive association was between polycyclic aromatic hydrocarbon (PAH) exposure during entire pregnancy and cord blood PAH DNA adducts...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28434254/association-of-gstt1-null-xpd-751%C3%A2-cc-and-xpc-939%C3%A2-cc-genotypes-with-increased-levels-of-genomic-damage-among-hospital-pathologists
#12
Alfredo Santovito, Marta Delsoglio, Eleonora Manitta, Giulia Picco, Giulia Meschiati, Michela Chiarizio, Claudio Gendusa, Piero Cervella
CONTEXT: Hospital workers are at risk for genotoxic damage following occupationally exposure to xenobiotics. Pathologists are exposed to chemicals during their use in health care environments, particularly throughout inhalation of airborne agents, absorption through skin or contact with the patient's body fluids. OBJECTIVE: We evaluated the level of genomic damage in a sample of 61 hospital pathologists (occupationally exposed to antineoplastic drugs and sterilizing agents) and 60 control subjects...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28393561/hsp72-is-an-early-biomarker-to-detect-cisplatin-and-acetaminophen-nephrotoxicity
#13
Rosalba Pérez-Villalva, Jonatan Barrera-Chimal, Juan Carlos Aguilar-Carrasco, Ixchel Lima-Posada, Cristino Cruz, Victoria Ramírez, Yvett González-Bobadilla, Norma Uribe, Laura Trumper, Norma A Bobadilla
OBJECTIVE: To evaluate whether the urinary HSP72 levels (uHSP72) are a useful biomarker for early diagnosis of acute kidney injury (AKI) induced by two widely used drugs: cisplatin and acetaminophen. MATERIALS AND METHODS: To analyze the time-course of nephrotoxic injury and uHSP72 levels, male Wistar rats were administered a single high dose of cisplatin (7 mg/kg) or acetaminophen (750 mg/kg) and were assessed at 6, 12, 24, 48, 72, 96 and 120 h. RESULTS: AKI induced by cisplatin was characterized by tubular injury that started at 6 h and was enhanced after 48 h...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28368680/transcriptional-variations-in-biomarkers-of-mytilus-galloprovincialis-sampled-from-central-adriatic-coastal-waters-marche-region-italy
#14
Paolo Cocci, Martina Capriotti, Gilberto Mosconi, Francesco Alessandro Palermo
OBJECTIVE: this work evaluates the expression of several biomarker genes (i.e. CAT, HSPs, MT10, p53, GSTpi, ER1/2) in Mytilus galloprovincialis native specimens to identify pollution related transcriptional changes. METHODS: gene expression levels were analysed in the gills of mussels from five sites along a coastal area of the central Adriatic Sea, using qPCR. RESULTS: we observed higher expression levels of biomarker genes in mussels from the local harbour or river mouths than in mussels from the reference site and offshore platform...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28330376/determination-of-air-pollution-related-biomarkers-of-exposure-in-urine-of-travellers-between-germany-and-china-using-liquid-chromatographic-and-liquid-chromatographic-mass-spectrometric-methods-a-pilot-study
#15
Xiao Wu, Jutta Lintelmann, Sophie Klingbeil, Jie Li, Hao Wang, Evelyn Kuhn, Sebastian Ritter, Ralf Zimmermann
OBJECTIVE: The influence of different exposures to PM2.5 (particulate matter with an aerodynamic diameter below 2.5 μm) on the concentrations of biomarkers of exposure and oxidative stress should be investigated. For this purpose, urine samples from individuals travelling from Germany to China were collected and analysed. MATERIALS: Robust LC and LC-MS/MS methods were established for the determination of biomarkers including 8-hydroxy-2'-deoxyguanosine, malondialdehyde, F2α-isoprostanes and hydroxylated polycyclic aromatic hydrocarbons...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28298141/using-multiple-biomarkers-and-determinants-to-obtain-a-better-measurement-of-oxidative-stress-a-latent-variable-structural-equation-model-approach
#16
Ronald C Eldridge, W Dana Flanders, Roberd M Bostick, Veronika Fedirko, Myron Gross, Bharat Thyagarajan, Michael Goodman
PURPOSE: Since oxidative stress involves a variety of cellular changes, no single biomarker can serve as a complete measure of this complex biological process. The analytic technique of structural equation modeling (SEM) provides a possible solution to this problem by modelling a latent (unobserved) variable constructed from the covariance of multiple biomarkers. METHODS: Using three pooled datasets, we modelled a latent oxidative stress variable from five biomarkers related to oxidative stress: F2-isoprostanes (FIP), fluorescent oxidation products, mitochondrial DNA copy number, γ-tocopherol (Gtoc) and C-reactive protein (CRP, an inflammation marker closely linked to oxidative stress)...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27918196/riboflavin-as-an-independent-and-accurate-biomarker-for-adherence-in-a-randomized-double-blind-and-placebo-controlled-clinical-trial
#17
V-M S Ramanujam, Fatima Nayeem, Karl E Anderson, Yong-Fang Kuo, Nai-Wei Chen, Hyunsu Ju, Lee-Jane W Lu
BACKGROUND: Medication adherence is critical for success of clinical trials. OBJECTIVE: To assess oral riboflavin is an adherence marker. METHODS: Riboflavin was incorporated into active treatment and placebo pills for a clinical trial lasting for 2 years. RESULTS: The accuracy (area under the receiver operating curve) of urinary riboflavin was 0.91 as a binary classifier of adherence, and was similar or better than for two active study ingredients daidzein (0...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27805415/determination-of-natural-moisturizing-factors-in-the-skin-raman-microspectroscopy-versus-hplc
#18
S A Koppes, P Kemperman, I Van Tilburg, F Calkoen-Kwa, K A Engebretsen, G J Puppels, P J Caspers, S Kezic
BACKGROUND: Natural moisturizing factor (NMF) is used as genotypic and phenotypic biomarker in diagnostics. This study is a side-to-side comparison of two different methods to determine NMF in atopic dermatitis patients: Raman microspectroscopy and stratum corneum tape stripping followed by HPLC. RESULTS: Measured NMF values were significantly correlated (R(2) = .61; p < .0001), both methods demonstrated a concentration-depth dependence of NMF and reduced NMF levels in the carriers of filaggrin null mutations...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27775446/quantification-of-1-hydroxypyrene-1-and-2-hydroxynaphthalene-3-hydroxybenzo-a-pyrene-and-6-hydroxynitropyrene-by-hplc-ms-ms-in-human-urine-as-exposure-biomarkers-for-environmental-and-occupational-surveys
#19
Flavio Raponi, Lisa Bauleo, Carla Ancona, Francesco Forastiere, Enrico Paci, Daniela Pigini, Giovanna Tranfo
CONTEXT: Several urinary PAHs metabolites can be detected by HPLC-MS/MS for individual exposure assessment. OBJECTIVE: Quantitation of urinary metabolites of four PAHs, selected on the basis of their significance, with reduced costs and high sensitivity. MATERIALS AND METHODS: HPLC-MS/MS was used and pure standards and isotope-labeled internal analogs of the analytes. Two hundred samples were tested after enzymatic hydrolysis. RESULTS: Accuracy was higher than 90% and variability lower than 19%; LODs permit to measure 1-hydroxypyrene, 1 and 2-hydroxynaphthalene in all subjects, 6-hydroxynitropyrene in the 65% and 3-hydroxybenzo[a]pyrene in the 70%...
September 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27775440/assessment-of-genotoxicity-in-female-agricultural-workers-exposed-to-pesticides
#20
Rekhadevi Perumalla Venkata, M F Rahman, M Mahboob, S Indu Kumari, Srinivas Chinde, Bhanuramya M, Naresh Dumala, Paramjit Grover
OBJECTIVE: This study was designed to determine the genotoxic effect of exposure to a mixture of pesticides in 106 female agricultural workers employed in cotton fields from India. METHODS: Comet, micronucleus and chromosomal aberrations tests were carried out in peripheral blood lymphocytes. Micronucleus test was also performed in buccal epithelial cells. Levels of antioxidant enzymes, RBC acetylcholinesterase and hematological parameters were analyzed in the blood samples of the study subjects...
July 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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