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Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals

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https://www.readbyqxmd.com/read/29786448/serum-rbp4-positively-correlates-with-triglyceride-level-but-not-with-bmi-fat-mass-and-insulin-resistance-in-healthy-obese-and-non-obese-individuals
#1
Emilia Korek, Magdalena Gibas-Dorna, Zuzanna Chęcińska-Maciejewska, Hanna Krauss, Małgorzata Łagiedo-Żelazowska, Barbara Kołodziejczak, Paweł Bogdański
PURPOSE: Retinol binding protein 4 (RBP4) has recently been identified as an adipokine possibly involved in the development of impaired glucose metabolism. We aimed to test serum RBP4 in healthy non-obese individuals and in patients with well-characterized phenotype: obesity without confounding effects of diabetes, metabolic syndrome or dyslipidemia. Additionally, we examined whether serum RBP4 is associated with anthropometric parameters, insulin resistance and blood lipid parameters...
May 22, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29781727/se-cadherin-and-sve-cadherin-indicate-active-epithelial-endothelial-to-mesenchymal-transition-emt-and-endomt-in-smokers-and-copd-implications-for-new-biomarkers-and-therapeutics
#2
Mathew Suji Eapen, Stephen Myers, Wenying Lu, Chloé Tanghe, Pawan Sharma, Sukhwinder Singh Sohal
No abstract text is available yet for this article.
May 21, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29771158/global-methylation-profiles-in-buccal-cells-of-long-term-smokers-and-moist-snuff-consumers
#3
Walter J Jessen, Michael F Borgerding, G L Prasad
PURPOSE: Alternations in gene methylation and other epigenetic changes regulate normal development as well as drive disease progression. The aim of this study is to investigate global methylation changes in the buccal cells of smokers and smokeless tobacco users. MATERIALS AND METHODS: Generally healthy adult male subjects were recruited into Smoker (SMK), Moist Snuff Consumer (MSC) and Non-Tobacco Consumer (NTC) cohorts (40 subjects/cohort) (ClinicalTrials.gov Identifier: NCT01923402)...
May 17, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29741401/comparison-of-%C3%AE-2-microglobulin-serum-level-between-alzheimer-s-patients-cognitive-healthy-and-mild-cognitive-impaired-individuals
#4
Roberto Dominici, Dario Finazzi, Letizia Polito, Emanuela Oldoni, Giovanna Bugari, Alessandro Montanelli, Elio Scarpini, Daniela Galimberti, Antonio Guaita
BACKGROUND: Several studies performed in the last years on the brain, showed that beta2-microglobulin (β2m) and MHC can act independently of their canonical immune function to regulate normal brain development, synaptic plasticity and behaviour. Increased systemic levels of soluble β2m have been implicated in cognitive impairments like that associated with chronic hemodialysis, or aortic valve replacement. Increased soluble β2m has also been detected in the cerebral spinal fluid (CSF) of patients with HIV-associated dementia and Alzheimer's disease...
May 9, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29737876/microrna-221-222-expression-in-atherosclerotic-coronary-artery-plaque-and-peripheral-blood
#5
Aslıhan Esra Bildirici, Serdal Arslan, Nil Özbilüm Şahin, Öcal Berkan, Osman Beton, Mehmet Birhan Yılmaz
BACKGROUND: Atherosclerosis is a disease of the arterial wall with predilection to some sites on others. MicroRNAs (miRNAs) are a class of the non-coding RNAs regulating the target gene expression at post-transcriptional level. Different miRNAs were found at distinct stages of plaque development and expression of miRNAs' might play an important role in the local behaviour of atherosclerotic plaques. OBJECTIVE: We aimed to investigate and compare mirR-221/222 expression levels in tissues and in circulation in patients with and without overt atherosclerosis...
May 8, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29737875/the-discovery-of-protein-biomarkers-in-pre-eclmmpsia-the-promising-role-of-mass-spectrometry
#6
Lina A Dahabiyeh
CONTEXT: Pre-eclampsia (PE) is a common hypertensive disorder of pregnancy that substantially affects maternal and neonatal morbidity and mortality worldwide. The etiology of the disease remains poorly understood with lack of reliable diagnostic tests. PE is a multisystem disorder so it is very unlikely that a single or a small group of biomarkers will accurately predict the disease. Mass spectrometry (MS) is indispensable analytical tool in protein analysis studies. MS-based proteomics have the ability to detect the entire protein complement to provide a useful window into a range of biological processes and allow the identification of differentially expressed proteins between samples...
May 8, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29737871/circulating-biomarkers-of-hypertrophy-and-fibrosis-in-patients-with-hypertrophic-cardiomyopathy-assessed-by-cardiac-magnetic-resonance
#7
Monika Gawor, Mateusz Śpiewak, Agata Kubik, Aleksandra Wróbel, Anna Lutyńska, Magdalena Marczak, Jacek Grzybowski
PURPOSE: Myocardial fibrosis in hypertrophic cardiomyopathy (HCM) is associated with worse clinical outcomes. The availability of circulating biomarkers of myocardial fibrosis and hypertrophy would be helpful in clinical practice. METHODS: Levels of biomarkers: soluble ST2 (sST2), galectin-3, growth differentiation factor-15 (GDF-15), NT-proBNP, and high-sensitivity cardiac troponin T (hs-cTnT) were measured in 60 patients with HCM. All patients underwent cardiac magnetic resonance imaging to calculate parameters of hypertrophy and fibrosis...
May 8, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29733687/prognostic-and-diagnostic-significance-of-mid-regional-pro-atrial-natriuretic-peptide-in-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-and-acute-heart-failure-data-from-the-ace-2-study
#8
Mohammad Osman Pervez, Jacob A Winther, Jon Brynildsen, Heidi Strand, Geir Christensen, Arne Didrik Høiseth, Peder L Myhre, Ragnhild Røysland, Magnus Nakrem Lyngbakken, Torbjørn Omland, Helge Røsjø
PURPOSE: To compare the diagnostic and prognostic value of mid-regional pro-ANP (MR-proANP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with acute dyspnea. METHODS: MR-proANP and NT-proBNP were measured with commercial immunoassays at hospital admission (n = 313), on day 2 (n = 234), and before discharge (n = 91) and compared for diagnosing acute heart failure (HF; n = 143) and to predict mortality among patients with acute HF and acute exacerbation of chronic obstructive pulmonary disease (AECOPD; n = 84) separately...
May 7, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29732934/no-association-between-the-vitamin-d-pathway-gene-polymorphisms-and-bone-biomarkers-response-to-calcium-and-low-dose-calcitriol-supplementation-in-postmenopausal-chinese-women-a-one-year-prospective-study
#9
Jiemei Gu, Chun Wang, Hao Zhang, Hue Yue, Weiwei Hu, Jinwei He, Wenzhen Fu, Zhenlin Zhang
INTRODUCTION: The aim of the study was to explore the association between the Vitamin D pathway gene variations and the bone biomarkers response to calcium and low dose calcitriol supplementation in postmenopausal Chinese women. METHODS: A total of 110 healthy postmenopausal Chinese women (61.51±6.93 years) were enrolled. The participants were supplemented with calcium (600 mg/d) and calcitriol (0.25 μg/d), for 1 year. Four biomarkers, serum levels of beta C-terminal cross-linked telopeptides of type I collagen (β-CTX), amino-terminal propeptide of type I collagen (P1NP), parathyroid hormone (PTH) and 25-hydroxyvitamin D [25(OH)D] were measured at baseline and 12-month follow-up...
May 7, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29730953/low-density-lipoprotein-associated-variables-and-the-severity-of-coronary-artery-disease-an-untreated-chinese-cohort-study
#10
Xi Zhao, Di Sun, Rui-Xia Xu, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Yan Zhang, Sha Li, Ying Gao, Geng Liu, Qian Dong, Jian-Jun Li
BACKGROUND AND AIMS: Elevated low-density lipoprotein cholesterol (LDL-C) is causal risk for coronary artery disease (CAD) and LDL-associated variables including LDL-C, apolipoprotein B (apoB), non-high-density lipoprotein cholesterol (non-HDL-C), lipoprotein a [Lp(a)], small dense LDL (sd-LDL) and oxidized LDL (ox-LDL) have been widely used for predicting the risk of CAD. The present study was aimed to compare the values of six LDL-related variables for predicting the severity of CAD using untreated patients undergoing coronary angiography (CAG)...
May 7, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29716428/the-subset-of-patients-with-acute-heart-failure-able-to-secrete-relaxin-2-at-pregnancy-concentrations-could-have-a-longer-survival-a-pilot-study
#11
Òscar Miró, Pablo Herrero-Puente, Belén Prieto, María García-García, Pablo García-Hernández, Francisco J Martín-Sánchez, Javier Jacob, José Ríos, Rodolfo Romero, Víctor Gil, Étienne Gayat, Pere Llorens, Alexandre Mebazaa
OBJECTIVE: To investigate how many patients with acute heart failure (AHF) hypersecrete relaxin-2 concentrations similar to those of pregnant women and determine their long-term outcome. METHODS: In consecutive AHF patients relaxin-2 was quantified by ELISA sandwich method. Patients were divided into pregnancy-like group (PLG, relaxin-2 ≥ 500 pg/mL) and control group (CG, relaxin-2 < 500 pg/mL). The primary outcome was all-cause death during follow-up...
May 1, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29708443/maternal-association-and-influence-of-dhfr-19bp-deletion-variant-predisposes-fetus-to-anencephaly-susceptibility-a-family-based-triad-study
#12
K R Prasoona, T Sunitha, B Srinadh, T Muni Kumari, A Jyothy
PURPOSE: Previous studies have not used family-based methods to evaluate maternal-paternal genetic effects of the folate metabolising enzyme, dihydro folate reductase (DHFR) essential during embryogenesis. Present study focused on evaluating the association and influence of parental genetic effects of DHFR 19bp deletion in the development of fetal Neural Tube Defects (NTDs) using family-based triad approach. MATERIALS AND METHODS: The study population (n = 924) including 124 NTD case-parent trios (n = 124x3 = 372) and 184 healthy control-parent trios (n = 184x3 = 552) from Telangana, India were genotyped for DHFR 19bp deletion...
April 30, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29697271/correction-to-cho-y-s-et-al-association-of-plasma-neutrophil-gelatinase-associated-lipocalin-with-acute-kidney-injury-and-clinical-outcome-in-cardiac-arrest-survivors-depends-on-the-time-of-measurement
#13
(no author information available yet)
No abstract text is available yet for this article.
April 26, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29697001/nestin-is-highly-expressed-in-fetal-spinal-cord-isolated-from-placenta-previa-patients-and-promotes-inflammation-by-enhancing-nf-%C3%AE%C2%BAb-activity
#14
Ling Li, Jing Zhang, Huahe Gao, Yuyan Ma
Purpose Nestin is expressed in various tissues of the embryo in patients with placenta previa, while the regulatory mechanism still unknown. Materials and methods All participants terminated pregnancy. Among them, 75 patients with placenta previa were assigned to the case group and 80 healthy pregnant women with normal placenta were assigned to the control group. Expression of nestin and CDK5 in fetal spinal cord tissues was detected by Western Blot and RT-qPCR methods. The enzyme-linked immunosorbent assay (ELISA) was used to determine the serum expression of some pro-inflammatory cytokines in placenta previa patients...
April 26, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29683755/n-acetylcysteine-decreases-urinary-level-of-neutrophil-gelatinase-associated-lipocalin-in-deceased-donor-renal-transplant-recipients-a-randomized-clinical-trial
#15
Atieh Modarresi, Mohsen Nafar, Zahra Sahraei, Jamshid Salamzadeh, Samira Chaibakhsh, Shadi Ziaie, Mahmoud Parvin, Yunes Panahi, Behzad Einollahi
CONTEXT: Acute kidney injury (AKI) is a common complication after kidney transplantation (KT), especially in recipients from deceased donors. Urinary neutrophil gelatinase-associated lipocalin (u-NGAL) is an early and sensitive marker of AKI after transplantation. OBJECTIVES: We assessed the renoprotective effect of N-acetylcysteine (NAC) on u-NGAL levels as an early prognostic marker of graft function immediately after transplantation. MATERIALS AND METHODS: A double-blind, randomized, placebo-controlled trial was conducted on 70 deceased-donor KT recipients ( www...
April 23, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29683727/bone-turnover-markers-and-novel-biomarkers-in-lung-cancer-bone-metastases
#16
Jiangli Lang, Qian Zhao, Yuedong He, Xijie Yu
CONTEXT: Lung cancer still remains the leading cause of cancer-related mortality worldwide. Bone is one of preferred metastatic sites for lung cancer cells. So far, both accurate diagnosis and effective treatment of lung cancer bone metastases are difficult. OBJECTIVE: This review aimed to evaluate roles of bone turnover markers (BTMs), microRNAs (miRNAs), dickkopf1 (DKK1) and insulin like growth factor binding protein 3 (IGFBP-3) in lung cancer bone metastases...
April 23, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29619842/high-sensitivity-cardiac-troponin-t-for-diagnosis-of-nstemi-in-the-elderly-emergency-department-patient-a-clinical-cohort-study
#17
Dorothee Riedlinger, Martin Möckel, Christian Müller, Fabian Holert, Julia Searle, Johannes von Recum, Anna Slagman
PURPOSE: The aim of this study is to evaluate the impact of age on the diagnostic performance of high-sensitivity troponin T (hsTnT) under routine conditions. MATERIALS AND METHODS: Data of 4118 consecutive emergency department (ED) patients who underwent a routine TnT measurement between 11 October 2012 and 30 November 2013 were analysed. Diagnostic accuracy of hsTnT was compared in four age categories (<50, 50-64, 65-74, ≥75 years of age) for different cut-off values...
April 18, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29498549/potential-of-serum-soluble-cd93-as-a-biomarker-for-asthma-in-an-ovalbumin-induced-asthma-murine-model
#18
Hye Jung Park, Eun-Yi Oh, Yoon Hee Park, Misuk Yang, Kyung Hee Park, Jung-Won Park, Jae-Hyun Lee
BACKGROUND: CD93 is a membrane-associated glycoprotein, which can be released in a soluble form (sCD93) into the serum. CD93 has received renewed attention as a candidate biomarker of inflammation in various inflammatory and immune-mediated diseases, including asthma. OBJECTIVE: We aimed to evaluate the effects of airway inflammation on CD93 levels in murine models. METHODS: We established an ovalbumin (OVA)-induced acute asthma murine model (OVA model) and a lipopolysaccharide (LPS)-induced airway inflammation murine model (LPS model)...
April 12, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29633866/triangular-gold-nanoparticles-modify-shell-characteristics-and-increase-antioxidant-enzyme-activities-in-the-clam-ruditapes-decussatus
#19
Khazri Abdelhafidh, Sellami Badreddine, Amine Mezni, Dellali Mouhamed, Saidani Wiem, Bouzidi Imen, Sheehan David, Ezzeddine Mahmoudi, Beyrem Hamouda
CONTEXT: Nanoparticles may cause adverse environmental effects but there is limited information on their interactions with marine organisms. OBJECTIVE: Our aim was to examine the effects of triangular gold nanoparticles (Tr-Au NPs) on the clam, Ruditapes decussatus. MATERIALS AND METHODS: Clams were exposed to Tr-Au1 = 5 µg/L and Tr-Au2 = 10 µg/L for 2 and 7 days. Effects on shell structure were investigated. Superoxide dismutase (SOD), catalase (CAT), glutathione transferase (GST) activities, protein carbonyl levels and malondialdehyde content were used to assess biochemical status...
April 10, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29631448/relationship-of-troponin-to-incident-atrial-fibrillation-occurrence-recurrence-after-radiofrequency-ablation-and-prognosis-a-systematic-review-meta-analysis-and-meta-regression
#20
Ying Bai, Shi-Dong Guo, Yue Liu, Chang-Sheng Ma, Gregory Y H Lip
Objective To explore the association between the levels of troponin (Tn) and incident atrial fibrillation (AF) occurrence, AF recurrence after radiofrequency ablation (RFA), and the risk trend of AF related prognosis(stroke, major bleeding, and mortality). Methods Twenty seven studies were included after a systematic search in PubMed from 2005 to 2017, including 13 associated with incident AF occurrence, 8 associated with AF recurrence after RFA, and 6 studies evaluating the risk trend of AF related prognosis with increased Tn levels...
April 10, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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