journal
MENU ▼
Read by QxMD icon Read
search

Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals

journal
https://www.readbyqxmd.com/read/28581828/biomarkers-used-in-studying-air-pollution-exposure-during-pregnancy-and-perinatal-outcomes-a-review
#1
Gauri Desai, Li Chu, Yanjun Guo, Ajay A Myneni, Lina Mu
PURPOSE: This review focuses on studies among pregnant women that used biomarkers to assess air pollution exposure, or to understand the mechanisms by which it affects perinatal outcomes. METHODS: We searched PubMed and Google scholar databases to find articles. RESULTS AND CONCLUSIONS: We found 29 articles, mostly consisting of cohort studies. Interpolation models were most frequently used to assess exposure. The most consistent positive association was between polycyclic aromatic hydrocarbon (PAH) exposure during entire pregnancy and cord blood PAH DNA adducts...
June 21, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28583029/p-gp-expression-levels-in-the-erythrocytes-of-brown-trout-a-new-tool-for-aquatic-sentinel-biomarker-development
#2
Emeline Valton, Ivan Wawrzyniak, Christian Amblard, Bruno Combourieu, Marie-Laure Bayle, François Desmolles, Fabrice Kwiatkowski, Frédérique Penault-Llorca, Mahchid Bamdad
CONTEXT: P-glycoprotein (P-gp) is a ubiquitous membrane detoxification pump involved in cellular defence against xenobiotics. Blood is a hub for the trade and transport of physiological molecules and xenobiotics. Our recent studies have highlighted the expression of a 140-kDa P-gp in brown trout erythrocytes in primary cell culture and its dose-dependent response to Benzo[a]pyrene pollutant. OBJECTIVE: The purpose of this study was focused on using P-gp expression in brown trout erythrocytes as a biomarker for detecting the degree of river pollution...
June 19, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28532247/high-sensitivity-cardiac-troponin-t-in-patients-not-having-an-acute-coronary-syndrome-results-from-the-trapid-ami-study
#3
Richard Nowak, Christian Mueller, Evangelos Giannitsis, Michael Christ, Jordi Ordonez-Llanos, Christopher DeFilippi, James McCord, Richard Body, Mauro Panteghini, Tomas Jernberg, Mario Plebani, Franck Verschuren, John K French, Robert Christenson, Gordon Jacobsen, Carina Dinkel, Bertil Lindahl
PURPOSE: To describe the baseline, 1 hr and delta high sensitivity cardiac troponin (hs-cTnT) values in patients with suspected acute myocardial infarction (AMI) but without a final acute coronary syndrome (ACS) diagnosis. MATERIALS AND METHODS: hs-cTnT assay for RAPID rule out of acute myocardial infarction (TRAPID-AMI) was a prospective diagnostic trial that enrolled emergency department (ED) patients with suspected AMI. Final patient diagnoses were adjudicated by a clinical events committee and subjects placed in different clinical groups: AMI, unstable angina, non-ACS cardiac, non-cardiac and unknown origin...
June 14, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28602143/mutation-in-the-beta3-subunit-of-guanine-nucleotide-binding-protein-gnb3-gene-is-not-associated-with-type-ii-diabetes-mellitus-risk-a-case-control-study-of-a-north-indian-population
#4
Saliha Rizvi, Syed Tasleem Raza, Qamar Rahman, Farzana Mahdi, Zeashan Haider Zaidi, Alina Zaidi
CONTEXT: Genetics play major role in development and pathophysiology of Type 2 diabetes mellitus (T2DM). OBJECTIVE: To asses association of GNB3 (C825T) gene's polymorphism with T2DM. MATERIALS AND METHODS: A case-control study including 400 North Indians was performed using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) approach to analyze genetic polymorphism. RESULTS: No significant difference was observed in genotype and allele frequencies of GNB3 gene on comparing cases with controls...
June 12, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28545334/head-to-head-comparison-of-cardiac-troponin-t-and-troponin-i-in-patients-without-acute-coronary-syndrome-a-systematic-review
#5
Ásthildur Árnadóttir, Christine Falk Klein, Kasper Iversen
BACKGROUND: Cardiac-specific troponin T (cTnT) and troponin I (cTnI) are considered diagnostically equal in patients with acute coronary syndrome (ACS). The aim of this systematic review was to compare the prevalence and prognostic strength of elevations of cTnT and cTnI in patients with other conditions than ACS. METHODS: A systemic review was conducted in concordance with the PRISMA guidelines. The studies were identified by searching PubMed, EMBASE and Cochrane Central Register, from May to August 2016...
June 9, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28532220/the-adipokine-tartrate-resistant-acid-phosphatase-5a-in-serum-correlates-to-adipose-tissue-expansion-in-obesity
#6
Christina Patlaka, Laia Mira Pascual, Staffan Paulie, Anni-Frid Henriksson, Peter Arner, Pernilla Lång, Göran Andersson
PURPOSE: Tartrate-resistant acid phosphatase (TRAP) exists as two isoforms, 5a and 5b. TRAP 5a is elevated in adipose tissue of obese women, interacts with pre-adipocytes and is linked to insulin-sensitive hyperplastic obesity when overexpressed in mice. The aim of this study was to investigate the relation between serum TRAP 5a, adiposity indices and metabolic syndrome risk markers in lean and obese women, using a newly developed TRAP 5a-specific ELISA. MATERIALS AND METHODS: A TRAP 5a sandwich ELISA was optimized using TRAP 5a-specific monoclonal antibodies and tested in sera of healthy males...
June 8, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28562101/methionine-metabolism-and-multiple-sclerosis
#7
Zuzana Bystrická, Lucia Laubertová, Monika Ďurfinová, Zuzana Paduchová
CONTEXT: Methylation reactions are particularly important in the brain and their inhibition can lead to a number of serious pathologies. Multiple sclerosis is one of the most common neurological disorders caused by interaction of genetic and environmental factors, but little is known about its cause or factors that contribute to the disorder. Although multiple sclerosis is primarily regarded as demyelinating disorder, there are no many articles focusing on methionine determination. OBJECTIVE: The aim of this work was to investigate whether serum methionine and its related compounds like homocysteine, cysteine, glutathione and asymmetric dimethylarginine were changed in multiple sclerosis patients...
June 6, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28562097/a-simple-point-of-care-test-can-indicate-the-need-for-periodontal-therapy-to-reduce-the-risk-for-adverse-pregnancy-outcomes-in-mothers-attending-antenatal-clinics
#8
Mervyn Sydney Turton, Ralf Reinhold Henkel, Charlene Wilma Joyce Africa
INTRODUCTION: Although the association between periodontal disease (PD) and adverse pregnancy outcomes has gained recognition amongst antenatal healthcare workers, not much has changed in practice to address it. This prospective study tested the hypothesis that BANA (N-benzoyl-DL-arginine-2-naphthylamide), a diagnostic test for PD, may inform obstetricians and other antenatal healthcare practitioners, of the risk of adverse pregnancy outcomes in mothers attending antenatal clinics. METHODS: At first visit, the presence of suspected periodontopathogens was assessed by BANA testing of dental plaque from 443 mothers attending antenatal clinics in KwaZulu-Natal, South Africa and an association later sought with pregnancy outcomes...
June 6, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28554261/plasma-alpha-1-acid-glycoprotein-as-a-potential-predictive-biomarker-for-non-haematological-adverse-events-of-docetaxel-in-breast-cancer-patients
#9
Rafid Salim Jabir, Gwo Fuang Ho, Muhammad Azrif Bin Ahmad Annuar, Johnson Stanslas
CONTEXT: Rash and oral mucositis are major non-haematological adverse events (AEs) of docetaxel, in addition to fatigue, nausea, vomiting and diarrhoea, which restrict the use of the drug in cancer therapy. Alpha-1-acid glycoprotein (AAG) is an acute phase reactant glycoprotein and is a primary carrier of docetaxel in the blood. Docetaxel has extensive binding (>98%) to plasma proteins such as AAG, lipoproteins and albumin. OBJECTIVE: To study the association between plasma AAG level and non-haematological AEs of docetaxel in Malaysian breast cancer patients of three major ethnic groups (Malays, Chinese and Indians)...
June 6, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28434254/association-of-gstt1-null-xpd-751%C3%A2-cc-and-xpc-939%C3%A2-cc-genotypes-with-increased-levels-of-genomic-damage-among-hospital-pathologists
#10
Alfredo Santovito, Marta Delsoglio, Eleonora Manitta, Giulia Picco, Giulia Meschiati, Michela Chiarizio, Claudio Gendusa, Piero Cervella
CONTEXT: Hospital workers are at risk for genotoxic damage following occupationally exposure to xenobiotics. Pathologists are exposed to chemicals during their use in health care environments, particularly throughout inhalation of airborne agents, absorption through skin or contact with the patient's body fluids. OBJECTIVE: We evaluated the level of genomic damage in a sample of 61 hospital pathologists (occupationally exposed to antineoplastic drugs and sterilizing agents) and 60 control subjects...
May 4, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28406038/the-gala-study-relationship-between-galectin-3-serum-levels-and-short-and-long-term-outcomes-of-patients-with-acute-heart-failure
#11
Òscar Miró, Bernardino González de la Presa, Pablo Herrero-Puente, Rosa Fernández Bonifacio, Martin Möckel, Christian Mueller, Gregori Casals, Silvia Sandalinas, Pere Llorens, Francisco Javier Martín-Sánchez, Javier Jacob, José Luis Bedini, Víctor Gil
OBJECTIVE: We tested the hypothesis that early measurement of galectin-3 at the emergency department (ED) during an episode of acute heart failure (AHF) allows predicting short- and long-term outcomes. METHODS: We performed an exploratory study including 115 patients consecutively diagnosed with AHF in a single ED. Clinical and analytical variables were recorded. The primary endpoint was 30-day all-cause mortality, and secondary endpoints were 30-day composite outcome (death, rehospitalization or ED reconsultation, whichever first) and 1-year mortality...
May 2, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28393561/hsp72-is-an-early-biomarker-to-detect-cisplatin-and-acetaminophen-nephrotoxicity
#12
Rosalba Pérez-Villalva, Jonatan Barrera-Chimal, Juan Carlos Aguilar-Carrasco, Ixchel Lima-Posada, Cristino Cruz, Victoria Ramírez, Yvett González-Bobadilla, Norma Uribe, Laura Trumper, Norma A Bobadilla
OBJECTIVE: To evaluate whether the urinary HSP72 levels (uHSP72) are a useful biomarker for early diagnosis of acute kidney injury (AKI) induced by two widely used drugs: cisplatin and acetaminophen. MATERIALS AND METHODS: To analyze the time-course of nephrotoxic injury and uHSP72 levels, male Wistar rats were administered a single high dose of cisplatin (7 mg/kg) or acetaminophen (750 mg/kg) and were assessed at 6, 12, 24, 48, 72, 96 and 120 h. RESULTS: AKI induced by cisplatin was characterized by tubular injury that started at 6 h and was enhanced after 48 h...
April 19, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28374624/elevated-serum-leptin-levels-are-associated-with-low-vitamin-d-sarcopenic-obesity-poor-muscle-strength-and-physical-performance-in-knee-osteoarthritis
#13
Pacharee Manoy, Wilai Anomasiri, Pongsak Yuktanandana, Aree Tanavalee, Srihatach Ngarmukos, Thanathep Tanpowpong, Sittisak Honsawek
CONTEXT: The associations between serum leptin, vitamin D status, sarcopenic obesity, muscle strength and physical performance in osteoarthritis (OA) remain uncertain. OBJECTIVE: To analyse the relationships between serum leptin, vitamin D status, muscle strength and physical performance in OA patients. METHODS: A total of 208 knee OA patients were enrolled. Serum leptin, vitamin D, muscle strength and physical performance were evaluated. RESULTS: OA patients with sarcopenic obesity had significantly higher serum leptin levels than those with non-sarcopenic obesity...
April 19, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28368680/transcriptional-variations-in-biomarkers-of-mytilus-galloprovincialis-sampled-from-central-adriatic-coastal-waters-marche-region-italy
#14
Paolo Cocci, Martina Capriotti, Gilberto Mosconi, Francesco Alessandro Palermo
OBJECTIVE: this work evaluates the expression of several biomarker genes (i.e. CAT, HSPs, MT10, p53, GSTpi, ER1/2) in Mytilus galloprovincialis native specimens to identify pollution related transcriptional changes. METHODS: gene expression levels were analysed in the gills of mussels from five sites along a coastal area of the central Adriatic Sea, using qPCR. RESULTS: we observed higher expression levels of biomarker genes in mussels from the local harbour or river mouths than in mussels from the reference site and offshore platform...
April 19, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28330376/determination-of-air-pollution-related-biomarkers-of-exposure-in-urine-of-travellers-between-germany-and-china-using-liquid-chromatographic-and-liquid-chromatographic-mass-spectrometric-methods-a-pilot-study
#15
Xiao Wu, Jutta Lintelmann, Sophie Klingbeil, Jie Li, Hao Wang, Evelyn Kuhn, Sebastian Ritter, Ralf Zimmermann
OBJECTIVE: The influence of different exposures to PM2.5 (particulate matter with an aerodynamic diameter below 2.5 μm) on the concentrations of biomarkers of exposure and oxidative stress should be investigated. For this purpose, urine samples from individuals travelling from Germany to China were collected and analysed. MATERIALS: Robust LC and LC-MS/MS methods were established for the determination of biomarkers including 8-hydroxy-2'-deoxyguanosine, malondialdehyde, F2α-isoprostanes and hydroxylated polycyclic aromatic hydrocarbons...
April 3, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28303731/the-value-of-microparticles-in-detecting-acute-rejection-episodes-after-liver-transplantation
#16
Mehmet Haluk Morgul, Katrin Splith, Christoph Leonhardt, Nathanael Raschzok, Anja Reutzel-Selke, Rosa Bianca Schmuck, Andreas Andreou, Georgi Atanasov, Christian Benzing, Felix Krenzien, Hans-Michael Hau, Philipp Felgendreff, Sergej Klunk, Johann Pratschke, Igor Maximillian Sauer, Moritz Schmelzle
CONTEXT: Non-invasive markers for diagnosis of acute rejection (AR) following liver transplantation have not been developed, yet. OBJECTIVE: We analyzed the correlation of plasma microparticle levels (MP) with AR. MATERIALS AND METHODS: MP (CD4, CD8, CD25, CD31, MHC) of 11 AR patients and 11 controls were analyzed within the first week after transplantation. RESULTS: CD4, CD8 and CD31 positive MP were higher in the AR, whereas overall MP count, CD25 and MHCI positive MP proportions did not differ between both groups...
April 3, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27775440/assessment-of-genotoxicity-in-female-agricultural-workers-exposed-to-pesticides
#17
Rekhadevi Perumalla Venkata, M F Rahman, M Mahboob, S Indu Kumari, Srinivas Chinde, Bhanuramya M, Naresh Dumala, Paramjit Grover
OBJECTIVE: This study was designed to determine the genotoxic effect of exposure to a mixture of pesticides in 106 female agricultural workers employed in cotton fields from India. METHODS: Comet, micronucleus and chromosomal aberrations tests were carried out in peripheral blood lymphocytes. Micronucleus test was also performed in buccal epithelial cells. Levels of antioxidant enzymes, RBC acetylcholinesterase and hematological parameters were analyzed in the blood samples of the study subjects...
July 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27775433/nickel-exposure-and-plasma-levels-of-biomarkers-for-assessing-oxidative-stress-in-nickel-electroplating-workers
#18
Yu-Chung Tsao, Po-Wen Gu, Su-Hsun Liu, I-Shiang Tzeng, Jau-Yuan Chen, Jiin-Chyuan John Luo
CONTEXT: The mechanism of nickel-induced pathogenesis remains elusive. OBJECTIVE: To examine effects of nickel exposure on plasma oxidative and anti-oxidative biomarkers. MATERIALS AND METHODS: Biomarker data were collected from 154 workers with various levels of nickel exposure and from 73 controls. Correlations between nickel exposure and oxidative and anti-oxidative biomarkers were determined using linear regression models. RESULTS: Workers with a exposure to high nickel levels had significantly lower levels of anti-oxidants (glutathione and catalase) than those with a lower exposure to nickel; however, only glutathione showed an independent association after multivariable adjustment...
July 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27685703/aberrant-methylation-of-nucleotide-excision-repair-genes-is-associated-with-chronic-arsenic-poisoning
#19
Aihua Zhang, Huiyao Li, Yun Xiao, Liping Chen, Xiaonian Zhu, Jun Li, Lu Ma, Xueli Pan, Wen Chen, Zhini He
OBJECTIVE: To define whether aberrant methylation of DNA repair genes is associated with chronic arsenic poisoning. METHODS: Hundred and two endemic arsenicosis patients and 36 healthy subjects were recruited. Methylight and bisulfite sequencing (BSP) assays were used to examine the methylation status of ERCC1, ERCC2 and XPC genes in peripheral blood lymphocytes (PBLs) and skin lesions of arsenicosis patients and NaAsO2-treated HaCaT cells. RESULTS: Hypermethylation of ERCC1 and ERCC2 and suppressed gene expression were found in PBLs and skin lesions of arsenicosis patients and was correlated with the level of arsenic exposure...
July 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27457054/micronuclei-as-a-marker-for-medical-screening-of-subjects-continuously-occupationally-exposed-to-low-doses-of-ionizing-radiation
#20
Jelena Pajic, Dubravka Jovicic, Aleksandar Ps Milovanovic
CONTEXT: Genotoxicity assays are widely employed in human biomonitoring studies to assess genetic damage inflicted by genotoxic agents. OBJECTIVE: Evaluation of micronuclei (MN) as a screening marker of occupational ionizing radiation (IR) exposure. MATERIALS AND METHODS: Using micronucleus test, peripheral blood lymphocytes (PBL) of 402 control and exposed subjects were screened for genetic damage. RESULTS: The mean frequencies of micronucleus test parameters were significantly higher in exposed persons...
July 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
journal
journal
32500
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"