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Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
The Boosting Potential of Bacteria in Cancer Immunotherapy.
Trends in Molecular Medicine 2017 July
Salmonella Typhimurium, engineered to express flagellin B, recently demonstrated unprecedented tumor control through a TLR-dependent mechanism. Here, we review new observations that support the potential of utilizing modified bacteria to enhance antitumor immunity. We also discuss the implications of these findings for clinical applications, including immune checkpoint blockade therapies.
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