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Immune response to Vi-antigen of Salmonella typhi is dependent on introduction of positive charge and shape of charged group into polysaccharide.

A V Kolesnikov, A V Kozyr, A K Ryabko, I G Shemyakin, I A Dyatlov
Doklady. Biochemistry and Biophysics 2017 March
A model of a controlled conversion of polysaccharide Vi-antigen of S. typhi into zwitterionic antigen is proposed. The immunological properties of modifications of this antigen conjugated to a protein support were studied.

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