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Adjunctive Corticosteroid Therapy in the Treatment of Coccidioidal Meningitis.

George R Thompson, Janis E Blair, Sharon Wang, Robert Bercovitch, Michael Bolaris, Dane Van Den Akker, Rodrigo Lopez, Arash Heidari, Antonino Catanzaro, Jose Cadena, Peter Chin-Hong, Brad Spellberg, Royce Johnson
Clinical Infectious Diseases 2017 July 16
Coccidioidal meningitis (CM) has high morbidity, and adjunctive measures to improve outcomes are needed. Using an established multicenter retrospective cohort study of CM (N = 221), we found that patients receiving adjunctive corticosteroids had a significant reduction in secondary cerebrovascular events (P = .0049). Those with CM-associated cerebrovascular events (8%) may benefit from short-term corticosteroids.

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