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Journal Article
Research Support, Non-U.S. Gov't
Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors.
Bioorganic & Medicinal Chemistry Letters 2017 May 16
We accomplished divergent synthesis of potent kinase inhibitor BAY 61-3606 (1) and 27 derivatives via conjugation of imidazo[1,2-c]pyrimidine and indole ring compounds with aromatic (including pyridine) derivatives by means of palladium-catalyzed cross-coupling reaction. Spleen tyrosine kinase (Syk) and germinal center kinase (Gck, MAP4K2) inhibition assays showed that some of the synthesized compounds were selective Gck inhibitors.
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