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Unprecedented highly efficient capture of glycopeptides by Fe 3 O 4 @Mg-MOF-74 core-shell nanoparticles.

Jie Li, Jiaxi Wang, Yun Ling, Zhenxia Chen, Mingxia Gao, Xiangmin Zhang, Yaming Zhou
Chemical Communications : Chem Comm 2017 April 5
Magnetic Fe3 O4 nanospheres coated with Mg-MOF-74 have been facilely prepared via epitaxial growth. Owing to the intrinsic hydrophilic pore surface and size-exclusive properties of Mg-MOF-74, the Fe3 O4 @Mg-MOF-74 core-shell nanoparticles show effective and selective enrichment of 441 N-glycosylation sites of 418 glycopeptides from 125 glycoproteins in 1 μL of human serum.

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