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Journal Article
Research Support, Non-U.S. Gov't
Synthesis of a GlcNAcylated arginine building block for the solid phase synthesis of death domain glycopeptide fragments.
Bioorganic & Medicinal Chemistry 2017 June 2
Herein we describe the synthesis of glycopeptide fragments from the death domains of TRADD and FADD bearing the recently discovered Nω-GlcNAc-β-arginine post-translational modification. TRADD and FADD glycopeptides were accessed through the use of a suitably protected synthetic glycosylamino acid 'cassette' that could be directly incorporated into conventional solid phase peptide synthesis (SPPS) protocols.
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