We have located links that may give you full text access.
Journal Article
Meta-Analysis
[Polymorphism of Glutathione S-Transferases and Genetic Sensitivity of Childhood Acute Lymphoblastic Leukemia: A Meta-Analysis].
Zhongguo Shi Yan Xue Ye Xue za Zhi 2017 Februrary
OBJECTIVE: To analyze the relationship between GST polymorphism and childhood acute lymphoblastic leukemia(ALL) risk.
METHODS: The relevant references of this relationship in English or Chinese were extensively searched through PubMed, Embase, China National Knowledge Internet(CNKI) and Wanfang Database up to August 2015 based on the inclusion and exclusion criteria. GST polymorphism-specific odd ratios(OR) with corresponding 95% confidence intervals(CI) were calculated with the STATA statistical package. Heterogeneity across studies was assessed, and funnel plots were constructed to test the publication bias.
RESULTS: A total of 27 studies concerning the GST polymorphisms and the risk of ALL were evaluated, which included 3736 cases of childhood acute lymphoblastic leukemia and 5549 controls. Significant summary OR of ALL were obtained for GSTM1 (OR=1.41, 95% CI=1.21-1.65) and GSTT1 (OR=1.26, 95% CI=1.05-1.50). Subgroup analysis showed that GSTM1 variant was associated with increased susceptibility to ALL in group of Blacks, Asians, PB (Population-based controls), HB (Hospital-based controls) '≥ 100 cases' and '< 100 cases'. Regarding GSTT1 polymorphism, significant relation with ALL risk was found in subgroup of Asians, PB and '≥ 100 cases'.
CONCLUSION: The GSTM1 and GSTT1 polymorphisms may be cerrelated with an increased risk of ALL. Further investigations are needed to confirm the conclusions.
METHODS: The relevant references of this relationship in English or Chinese were extensively searched through PubMed, Embase, China National Knowledge Internet(CNKI) and Wanfang Database up to August 2015 based on the inclusion and exclusion criteria. GST polymorphism-specific odd ratios(OR) with corresponding 95% confidence intervals(CI) were calculated with the STATA statistical package. Heterogeneity across studies was assessed, and funnel plots were constructed to test the publication bias.
RESULTS: A total of 27 studies concerning the GST polymorphisms and the risk of ALL were evaluated, which included 3736 cases of childhood acute lymphoblastic leukemia and 5549 controls. Significant summary OR of ALL were obtained for GSTM1 (OR=1.41, 95% CI=1.21-1.65) and GSTT1 (OR=1.26, 95% CI=1.05-1.50). Subgroup analysis showed that GSTM1 variant was associated with increased susceptibility to ALL in group of Blacks, Asians, PB (Population-based controls), HB (Hospital-based controls) '≥ 100 cases' and '< 100 cases'. Regarding GSTT1 polymorphism, significant relation with ALL risk was found in subgroup of Asians, PB and '≥ 100 cases'.
CONCLUSION: The GSTM1 and GSTT1 polymorphisms may be cerrelated with an increased risk of ALL. Further investigations are needed to confirm the conclusions.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app