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Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Fragile phagocytes: FMRP positively regulates engulfment activity.
Journal of Cell Biology 2017 March 7
Defective immune system function is implicated in autism spectrum disorders, including Fragile X syndrome. In this issue, O'Connor et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607093) demonstrate that phagocytic activity of systemic immune cells is compromised in a Drosophila melanogaster model of Fragile X, highlighting intriguing new mechanistic connections between FMRP, innate immunity, and abnormal development.
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