Outcomes of Kidney Transplantation in Patients Exposed to Hepatitis B Virus: Analysis by Phase of Infection.

BACKGROUND: In kidney transplant recipients (KTRs) with hepatitis B virus (HBV) infection, immunosuppression may increase viral replication with increased risk for liver disease progression and HBV-related kidney diseases, factors that could adversely influence graft and patient outcomes. We aimed to analyze the impact of different phases of HBV infection on the outcomes in KTRs.

METHODS: Using the Organ Procurement and Transplant Network/United Network for Organ Sharing database, we selected adult KTRs from 2001 to 2011 who received peri-operative antibody induction followed by calcineurin inhibitor/mycophenolate mofetil maintenance with/without steroid. The cohort was divided into 4 groups, based on the presence/absence of hepatitis B surface antigen (HBsAg) and core antibody (HBcAb) at the time of transplantation: group 1: HBsAg+/HBcAb- (acute infection); group 2: HBsAg+/HBcAb+ (developing immune response); group 3; HBsAg-/HBcAb+ (resolving infection); and group 4: HBsAg-/HBcAb- (HBV-naive). Graft and patient survivals were compared among the groups in a multivariate Cox model.

RESULTS: Adjusted overall graft (hazard ratio [HR], 0.97; 95% confidence interval [CI], 0.90-1.10; P = .58) and patient (HR, 0.95; 95% CI, 0.83-1.09; P = .52) survival rates were similar between groups 1 and 2, with inferior death-censored graft survival in group 1 (HR, 0.83; 95% CI, 0.71-0.98; P = .02). Adjusted over all graft (HR, 1.0; 95% CI, 0.90-1.00; P = .46) and patient (HR, 1.03; 95% CI, 0.90-1.10; P = .10) survival rates were similar between groups 3 and 4, and death-censored graft survival trended inferior in group 3 (HR, 0.97; 95% CI, 0.90-1.00; P = .05).

CONCLUSIONS: Our analysis supports a practice of delaying kidney transplantation in HBV-infected patients until they develop an immune response and preferably until the infection is cleared.