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Transplantation Proceedings

S D Hwang, J H Lee, S W Lee, J K Kim, M-J Kim, J H Song
BACKGROUND: Reactivation of BK polyomavirus causes destructive virus allograft nephropathy; however, treatment options are limited. Herein, we report a case in which a patient with T cell-mediated rejection was treated with steroid therapy. The patient subsequently developed BK viremia and was successfully treated by using intravenous immunoglobulin (IVIG) after failing to respond to conventional treatment. CASE PRESENTATION: A 54-year-old man had been undergoing peritoneal dialysis for 3 years before kidney transplantation...
June 2, 2018: Transplantation Proceedings
S D Hwang, J H Lee, S W Lee, J K Kim, M-J Kim, J H Song
BACKGROUND: Valganciclovir is widely used to prevent post-transplant cytomegalovirus (CMV) infection in kidney transplant patients. However, the currently used dose remains controversial because the continuous use of this drug decreases kidney function and can induce leukopenia. OBJECTIVE: The purpose of this study was to measure the appropriate dose of valganciclovir required to prevent CMV infection. METHODS: A systematic review and meta-analysis were performed by using a random effects model...
June 2, 2018: Transplantation Proceedings
W Cai, Q Cai, N Xiong, Y Qin, L Lai, X Sun, Y Hu
PURPOSE: To assess the pharmacokinetic properties of mycophenolate mofetil (MMF) dispersible tablets and capsules by the enzyme multiplied immunoassay technique (EMIT) in Chinese kidney transplant recipients in the early post-transplantation phase and to develop the equations to predict mycophenolic acid (MPA) area under the 12-hour concentration-time curve (AUC0-12h ) using a limited sampling strategy (LSS). METHODS: Forty patients who underwent renal transplantation from brain-dead donors were randomly divided into dispersible tablets (Sai KE Ping; Hangzhou Zhongmei Huadong Pharma) and capsules (Cellcept; Roche Pharma, Why, NSW, Australia) groups, and treated with MMF combined with combination tacrolimus and prednisone as a basic immunosuppressive regimen...
May 4, 2018: Transplantation Proceedings
D Birtan, M K Arslantas, G T Altun, P C Dincer, S Gecegormez, A Demirel, H O Ayanoglu
Serum catecholamine levels and peripheral vascular resistance decrease after brain death. Vasoactive drugs are used to control these hemodynamic changes and to improve perfusion of the organs. These drugs might have a role in rejection or loss of the graft organ. We aimed to investigate the effects of vasoactive drugs used in the cadaveric donor care on post-transplant renal graft functions. In this retrospective study, medical records of 135 cadaveric donors (270 kidneys) and recipients of these kidneys were evaluated...
May 4, 2018: Transplantation Proceedings
S H Song, S H Lim, J Lee, J G Lee, K H Huh, S I Kim, Y S Kim, M S Kim
BACKGROUND: The shortage of donor organs has been a major challenge in transplantation. In an effort to reduce the donor shortage, kidney transplantation (KT) using expanded criteria donors (ECD) was encouraged. In Korea, transplantation centers used the Korea Network for Organ Sharing (KONOS) ECD criteria, which is different from the United Network for Organ Sharing (UNOS) criteria. The aim of this study is to evaluate the predictive power of KONOS criteria on delayed graft function (DGF) in comparison to UNOS criteria...
April 28, 2018: Transplantation Proceedings
K Szymanek-Majchrzak, A Mlynarczyk, M Bilinska, M Rownicki, K Majchrzak, A Chmura, A Kwiatkowski, M Durlik, D Deborska-Materkowska, L Paczek, G Mlynarczyk
INTRODUCTION: Staphylococcus aureus infection, and health care-associated-methicillin resistant S aureus (HA-MRSA) in particular, is a serious risk for patients treated with organ transplantation. The frequent combined resistance of these bacteria to macrolides, lincosamides, and streptogramin-B (MLS-B) limits the use of these drugs in therapy. AIM: Evaluation of the mechanism of MLS-B resistance among HA-MRSA strains derived from patients treated in surgical-transplantation wards, over a 24-year period, and assessment of correlation of clindamycin use and resistance phenotype...
April 27, 2018: Transplantation Proceedings
Y S Ordin, B A Söylemez
BACKGROUND: Nurses play an effective role in the identification of donors and in the families' decision-making processes related to organ donation. It is recommended that nursing students be offered specific education regarding organ donation and transplantation. The aim of this study was to examine the effects of peer education on attitudes toward organ donation and the rate of attaining a donor card in undergraduate nursing students. METHODS: This study was a quasi-experimental trial in a single group conducted between February 2016 and October 2016...
April 26, 2018: Transplantation Proceedings
A Oruc, A Ersoy
OBJECTIVE: Besides severe organ shortage, hepatitis C virus (HCV) infection is an important obstacle for kidney transplantation because of long waiting times on deceased kidney donor waiting lists. We aimed to evaluate calling number of candidates according to HCV serology. METHOD: A total of 404 adults on the deceased donor waiting list invited for cadaveric transplantation was evaluated. Demographic data, waiting time, calling number for transplantation, and viral serology were obtained during the 6-year period...
April 18, 2018: Transplantation Proceedings
H Zhang, S Gao, L Yan, G Zhu, Q Zhu, Y Gu, F Shao
BACKGROUND: The goal of this study was to analyze the protective role of ARA290 in early renal allograft injury by using a rat model of renal allograft. METHODS: Lewis rats were divided into 3 groups: sham, University of Wisconsin solution (UW), and ARA290. A rat model of renal allograft was established by anastomosis using a titanium ring pin stapler. The kidneys were removed 24 hours after transplantation to accomplish the following: (1) examine the protective effect of ARA290 on renal morphology and function; (2) investigate the underlying mechanism by determining the binding affinity of nuclear factor-κB (NF-κB) to DNA by using an electrophoretic mobility shift assay; (3) observe the effect of ARA290 on macrophage infiltration using immunohistochemistry; and (4) detect messenger RNA (mRNA) expression of inflammatory mediators by using reverse transcriptase polymerase chain reaction...
June 2018: Transplantation Proceedings
E A Lendermon, J M Dodd-O, T A Coon, X Wang, C R Ensor, N Cardenes, C L Koodray, H L Heusey, M F Bennewitz, P Sundd, G C Bullock, I Popescu, L Guo, C P O'Donnell, M Rojas, J F McDyer
BACKGROUND: Cellular and molecular mechanisms of acute and chronic lung allograft rejection have yet to be clearly defined, and obliterative bronchiolitis (OB) remains the primary limitation to survival in lung transplant recipients (LTRs). We have previously shown that T-bet-deficient recipients of full major histocompatibility complex (MHC)-mismatched, orthotopic left lung transplants develop accelerated obliterative airway disease (OAD) in the setting of acute cellular rejection characterized by robust alloimmune CD8+ interleukin (IL)-17 and interferon (IFN)-γ responses that are attenuated with neutralization of IL-17...
June 2018: Transplantation Proceedings
X-F Zou, B Song, J-H Duan, Z-D Hu, Z-L Cui, T Yang
BACKGROUND: Previously, high levels of CXCR3+ T-cell recruitment was demonstrated in the prolonged ischemia-accelerated acute allograft rejection in rat kidney transplant. In the present study, the effect of chemokine IP-10 was investigated and the expression of chemokine-related PRINS (Psoriasis susceptibility-related RNA gene induced by stress) lncRNA determined in the allografts subjected to ischemia. METHODS: F344-to-Lewis rat kidney transplantation was performed, and renal grafts were stored for 2 hours or 16 hours...
June 2018: Transplantation Proceedings
Y Chen, L Zhao, S Jiang, Z Hu, B Hu, F Tong, R Shen
BACKGROUND: The aim of this study was to determine whether the protective effects of brief and repeated ischemic postconditioning (IPoC) are associated with the modulation of cystathionine γ-lyase (CSE) expression after renal ischemia/reperfusion (I/R) injury in diabetes mellitus (DM). METHODS: We subjected diabetic rats to 45 minutes of ischemia followed by reperfusion at 24 hours. Before reperfusion, diabetic rats were treated with 3 cycles of 6 seconds of reperfusion, followed by 6 seconds of ischemia...
June 2018: Transplantation Proceedings
V Opatrný, J Moláček, V Třeška, R Matějka, O Hes
INTRODUCTION: There is still a lack of organs for kidney transplantation. The aim of our experimental animal study was to improve the quality of the kidney grafts from donors after cardiac death (DCD) using immediate start of machine perfusion instead of perfusion based on hydrostatic pressure. METHODS: Ten rabbits were used as an experimental model. In group A, 5 kidneys after ischemic injury were perfused in situ using hydrostatic pressure. In group B, 5 kidneys were perfused in situ using machine pulsatile perfusion...
June 2018: Transplantation Proceedings
M Li, G Peng, Q Ye, Y Wang, Y Xiong, R Wang, Z Yang
The mechanisms of autophagy during liver ischemia-reperfusion injury are not completely understood. This study aimed to assess the role of high-mobility group box 1 protein (HMGB1) in autophagy in LO2 cells following anoxia-reoxygenation injury. LO2 cells were pretreated with the HMGB1 inhibitor ammonium glycyrrhizinate (1000 μmol/L) or the HMGB1 agonist recombinant HMGB1 (rHMGB1, 10 ng/mL) at proper concentrations before induction of anoxia-reoxygenation injury. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and cell viability were evaluated...
June 2018: Transplantation Proceedings
R Ito, M Ito, Y Asano, A Murakumo, N Yamamoto, A Horiguchi
INTRODUCTION: Hepatocyte transplantation is a promising alternate for the treatment of hepatic diseases. Hypothermic preservation of isolated human hepatocytes is potentially a simple and convenient strategy to provide on-demand hepatocytes in the quantity sufficient and the quality required for biotherapy. Isolated fresh hepatocytes include damaged cells that are also early apoptotic cells, which is not ideal for hepatocyte transplantation. However, this does not reflect cell viability, although it is considered that it adversely affects cell survival after transplantation...
June 2018: Transplantation Proceedings
L Huang, F Li, Q Fu, X Yang, S Deng, L Wei
BACKGROUND: Acute rejection is a significant challenge after organ transplantation. The CD4+ T-cell‒mediated immune response plays an important role in acute transplant rejection. It was also found that miR-449a microRNA regulates the alloimmune response in a model of heart transplantation in mice. Our goal was to determine the role of miR-449a in the regulation of CD4+ T cells. METHODS: We examined miR-449a expression in peripheral blood mononuclear cells (PBMCs) and graft-infiltrating lymphocytes (GILs) between syngeneic transplant and allogeneic transplant groups on day 7 post‒heart transplantation...
June 2018: Transplantation Proceedings
L Gao, Y Fan, Y Yang, R Xie, J Yang, Z Chen
OBJECTIVE: A preliminary investigation on the proliferation and cultivation process of natural killer T cells (NKT) was carried out. We provide reference data for future NKT-related research and development. METHODS: Peripheral blood mononuclear cells (PBMCs) were isolated from healthy people and were induced by α-galactosylceramide (α-GalCer). The phenotypic changes of the cells and the activation and apoptosis of Caspase-3 were recorded for 3-4 weeks. RESULTS: The proliferation of the NKT cells continued for approximately 3 weeks, and then apoptosis started to occur...
June 2018: Transplantation Proceedings
F Ekşi, T Karslıgil, I Gündeş, M Sağlam, M P Kırık, M S Büdeyri, H Haydaroğlu Şahin, M Pehlivan
INTRODUCTION: BK virus (BKV) is a common human polyomavirus and causes latent infection. Especially in immunosuppressive patients, early diagnosis and treatment are very important in reducing the high mortality rate. In this study, we investigated BKV DNA in serum and plasma and urine specimens by real-time polymerase chain reaction (PCR) method in allogeneic hematopoietic stem cell transplantation patients. MATERIALS AND METHODS: BKV DNA was isolated in QIAsymphony SP/AS (Hilden, Germany) equipment using QIAsymphony DSP Virus/Pathogen Midi Kit, Version 1 (QIAGEN, Hilden, Germany) in urine and serum samples collected from 100 patients post-transplantation...
June 2018: Transplantation Proceedings
V Kesherwani, L F Guzman Vinasco, M Awaji, R G Bociek, J Meza, V K Shostrom, A G Freifeld, C Gebhart
In a retrospective case-control study, we aimed to assess the utility of plasma BK viral load value to predict hemorrhagic cystitis (HC) symptoms after allogeneic hematopoietic stem cell transplantation (alloHSCT). During first 100 post-transplantation days of all adult AlloHSCT recipients at the University of Nebraska Medical Center from October 1, 2011, to June 30, 2014, 8 unexcluded cases of HC were identified and matched with 88 unexcluded unaffected control cases. Viral loads were determined for archived DNA extracted from plasma collected within 3 weeks before transplantation until ∼100 days after transplantation...
June 2018: Transplantation Proceedings
C A Quezada-Loaiza, A de Pablo Gafas, V Pérez, R Alonso, L Juarros, M I Real, E López, M Cortes, J C Meneses, I H González, V Díaz-Hellín Gude, P E Subías, P Gámez
BACKGROUND: Prognosis assessment of pulmonary hypertension (PH) is multifactorial and placement of patients on the lung transplantation (LT) waiting list requires the weighing of a complex set of criteria. The aim of this retrospective cohort study was to analyze a series of patients treated in our unit at the moment of their inclusion on the LT waiting list and long-term survival after LT. MATERIAL AND METHODS: Baseline characteristics, LT outcomes, and survival were evaluated in all patients diagnosed with pulmonary arterial hypertension (PAH) and pulmonary veno-occlusive disease (PVOD) who were included on the LT waiting list in 2011-2016...
June 2018: Transplantation Proceedings
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