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Transplantation Proceedings

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November 27, 2018: Transplantation Proceedings
V M Arantes, R T Bueno, R P Módolo, M A C Domingues, L R de Carvalho, P do Nascimento Junior, N S P Módolo
BACKGROUND: Ischemia-reperfusion injury is an unavoidable aspect of transplantation, as well as an important cause of acute kidney injury in clinical practice. Pre- and post-ischemic conditioning are strategies that may provide organs with resistance to major ischemic events. This study evaluates the effects of ischemic preconditioning and ischemic postconditioning, either separately or in combination, after an acute ischemia-reperfusion kidney injury. METHODS: Forty Wistar rats received isoflurane anesthesia and were randomized into 5 groups: 1...
November 27, 2018: Transplantation Proceedings
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No abstract text is available yet for this article.
October 25, 2018: Transplantation Proceedings
K Shimizu, S Miyagi, K Maida, W Nakanishi, Y Hara, K Tokodai, C Nakanishi, Y Umeda, S Satomi, M Goto, M Unno, T Kamei
BACKGROUND: With the current disparity between the donor organ availability and recipient needs, various marginal organs with anatomical variations or concomitant diseases have begun to be used. We present a case of simultaneous pancreas-kidney transplantation (SPKTx) from a marginal donor with a giant abdominal aortic aneurysm who was incidentally found to be an organ donor after brain death. CASE PRESENTATION: The donor was a 66-year-old man who died of brain hemorrhage...
November 2018: Transplantation Proceedings
I H Hii, N-H Chi, Y-S Chen, C-I Tsao, B-C Cheng, S-S Wang
We report a heart transplantation in a patient with no heart. A 60-year-old man suffered from severe infective endocarditis, and due to extensive involvement of the myocardium, only minimal myocardium was left after debridement of the necrotic myocardium and aortic annulus. We finally excised the entire heart to eradicate the infection source and employed 2 extracorporeal membrane oxygenations for full life support. The infection was controlled with strong antibiotics. The patient underwent successful heart transplantation 16 days following the excision and the patient fully recovered without any complications...
November 2018: Transplantation Proceedings
H Kato, M Usui, A Nakatsuka, A Hayasaki, T Ito, Y Iizawa, Y Murata, A Tanemura, N Kuriyama, Y Azumi, M Kishiwada, S Mizuno, H Sakurai, S Isaji
Isolated biliary leakage is difficult to manage, and afflicted patients often develop refractory fistula. The present case was a 43-year-old male donor whose wife developed acute fulminant liver failure. Computed tomography (CT) volumetry showed that the estimated remnant liver volume was only 394 mL (31%) if his right lobe would be harvested. Since remnant liver volume was marginal, our proposed cut line for the right hepatectomy was set in order to preserve branches of the middle hepatic vein draining segments 4b+8 and 5...
November 2018: Transplantation Proceedings
K-S Jeng, C-C Huang, C-S Chung, C-K Lin, C-J Teng, P-W Shueng, K-H Chen
The effective treatment for hepatocellular carcinoma (HCC) with American Joint Committee on Cancer stage IIIB remains controversial and challenging because of the high recurrence rate after resection and low survival rate. The median survival of those with macroscopic portal vein tumor thrombus (PVTT) is short. We reported such a case which received liver transplantation (LT) after successful consecutive downstaging therapies. A 40-year-old man with alcohol related liver cirrhosis and repeated esophageal varices bleeding had HCC with tumor thrombi in right main portal vein and the second portal branch of segment VI (stage IIIB)...
November 2018: Transplantation Proceedings
B-H Jung, J-I Park, S-G Lee
BACKGROUND: Fibrosing cholestatic hepatitis (FCH) is an aggressive form of hepatitis C virus (HCV) recurrence after liver transplantation (LT). Most FCH cases are fatal, occurring as a secondary disease following rapidly progressive liver dysfunction and graft failure. We report a case of early-onset FCH after LT that was successfully treated using daclatasvir and asunaprevir. CASE REPORT: A 59-year-old woman underwent living donor LT for HCV-related liver cirrhosis...
November 2018: Transplantation Proceedings
Y-X Zhang, L-P Liu, M Li, J-L Huang, H Xu, X-D Chen, W-Y Zhu, Y-P Cai, N-N Guo, Z-Q Chen, Y-W Zheng, Y-M Li
OBJECTIVE: Presently, interesting research related to induced pluripotent stem cells (iPSCs) is emerging. However, the development of new therapies and techniques for treatment of refractory diseases is still required in dermatology. We are exploring novel methods to provide stem cell therapy and elucidate research mechanisms underlying troublesome diseases by reprogramming iPSCs from the fibroblasts of keloid lesions from patients in vitro. METHOD: Here, we identified the expression of fibroblastic genes in the fibroblast derived from diseased individuals...
November 2018: Transplantation Proceedings
L-Y Wang, L-P Liu, J-Y Ge, Y-Y Yuan, L-L Sun, H Xu, P-Y Huang, L-J Hui, H Isoda, N Ohkohchi, Y-M Li, Y-W Zheng
OBJECTIVES: The difficulty in proliferation and availability and the rapid loss functions of primary human hepatocytes highlight the need to develop an alternative, preferably renewable source of human induced hepatocytes in regenerative medicine. Liver organoids generated on a multiple-cell microenvironment in a 3-dimensional (3D) system can provide a highly efficient solution to this issue. METHODS: Human hepatocytes were induced from fibroblasts by the lentiviral expression of FOXA3, HNF1A, and HNF4A...
November 2018: Transplantation Proceedings
T-H Chen, J-J Wang
BACKGROUND: Lung injury subsequent to pancreatic ischemia and reperfusion (PIR) due to shock, revascularization, and pancreas transplantation is a major clinical problem. In addition to proteases, massive production and release of reactive oxygen species (ROS) and induction of inflammatory cytokines have been implicated in remote lung injury. Niacin, also known as vitamin B3 , is both antioxidative and anti-inflammatory. In this study, we examined the protective effectiveness of niacin pretreatment against PIR-induced pancreatic and remote lung injury...
November 2018: Transplantation Proceedings
C S Park, H J Jang, J H Lee, M Y Oh, H J Kim
BACKGROUND: Calcineurin inhibitors are effective immunosuppressive agents, but associated adverse effects such as nephrotoxicity may limit efficacy. Tacrolimus (FK506) is an immunosuppressive drug used mainly to lower the risk of organ rejection after allogeneic organ transplant. Adverse effects of FK-506 can prompt patients to end treatment despite the efficacy. In the present study, we investigated the protective effect and mechanism of tetrahydrocurcumin (THC) on FK506-induced renal damage, apoptosis, and oxidative stress to evaluate its possible use for kidney protection...
November 2018: Transplantation Proceedings
S S Kim, H J Jang, M Y Oh, J H Lee, K S Kang
BACKGROUND: The transplantation of isolated pancreatic islets is a promising treatment for diabetes. Curcumin has been used for its pharmacologic effects, such as antidiabetic and anti-inflammatory activities. Tetrahydrocurcumin (THC), one of the major metabolites of curcumin, has been reported to have antioxidant and anti-inflammatory activities. This study examines the hypothesis that preoperative THC treatment can attenuate ischemic damage and apoptosis before islet transplantation...
November 2018: Transplantation Proceedings
G Ramis, L Martínez-Alarcón, E Medina-Moreno, J M Abellaneda, J J Quereda, B Febrero, A Sáez-Acosta, A Ríos, A Muñoz, P Ramírez, M J Majado
INTRODUCTION: The immunorejection in xenotransplantation has mostly been studied from the host's immune system activation point of view and there is very little information about the graft-vs-host reaction. OBJECTIVES: To validate an enzyme-linked immunosorbent assay (ELISA) test for porcine IgM and IgG quantitation, the assessment of porcine IgG and IgM in sera samples from baboons after liver orthotopic xenotransplantation or in human plasma after xenotransfusion through pig organs, and to assess the presence of porcine immunoglobulin in a baboon after plasmapheresis to a complete change of plasma after 4 passages through pig liver...
November 2018: Transplantation Proceedings
R Sakai, M Watanabe, A Maeda, P C Lo, H T Wang, R Matsuura, T Kodama, H Eguchi, T Ueno, R Inoue, H Nagashima, H Okuyama, S Miyagawa
Pigs have recently become very popular for use not only in xenotransplantation field, but in regeneration studies as well, sometimes with pigs being used as the scaffold. We have already presented our findings related to the pig immune system against human cells, including the complement systems, natural antibodies (NAs), and NK cells. In this study, we investigated the pig innate immunological reaction against human cells further. Our investigations included issues such as the production of NAs in newborns, day 0 and day 1, and sow colostrum...
November 2018: Transplantation Proceedings
N C Wu, J J Wang
PURPOSE: Alveolar-capillary barrier dysfunction, characterized by alveolar protein leak and lung edema, is a common scenario following cardiopulmonary surgery and thoracic organ transplantation. Reactive oxygen species generated through lung ischemia and reperfusion (I/R) injury during surgery plays a crucial role. Niacin, also known as vitamin B3, has been demonstrated to possess antioxidative and anti-inflammatory capacity. In this study, we examine the pulmonary barrier function via capillary filtration coefficient (Kfc ) following lung I/R injury with and without niacin treatment...
November 2018: Transplantation Proceedings
H Obara, N Morito, N Matsuno, R Yoshikawa, M Gouchi, M Otani, T Shonaka, H Takahashi, S Enosawa, T Hirano, H Furukawa
INTRODUCTION: Subnormothermic machine perfusion (SNMP) shows some advantages for the preservation of grafts donated after cardiac death (DCD) and improvements in machine perfusion (MP) technology are important to enhance organ preservation outcomes for liver transplantation. In this study, we focused on purified subnormothermic machine perfusion (PSNMP) and volumes of perfusate removed to substitute for purification and replaced by modified University of Wisconsin-gluconate after the start of perfusion and investigated, in particular, the optimum perfusate purification volume...
November 2018: Transplantation Proceedings
R Yoshikawa, H Obara, N Matsuno, N Morito, M Gouchi, M Otani, T Shonaka, H Takahashi, S Enosawa, T Hirano, H Furukawa
BACKGROUND: Machine perfusion (MP) techniques are expected to prove useful for preserving the organ viability and recovering organ function for organ transplantation. Furthermore, an accurate assessment of organ viability using MP is important for expanding the donor criteria. In this study, an ex vivo reperfusion model (ERM) simulating transplantation using diluted autologous blood under normothermic conditions was evaluated for its utility of MP under subnormothermic conditions for livers donated after cardiac death (DCD)...
November 2018: Transplantation Proceedings
T Shonaka, N Matsuno, H Obara, R Yoshikawa, Y Nishikawa, M Gouchi, M Otani, H Takahashi, H Azuma, H Sakai, H Furukawa
Oxygenation is necessary for aerobic metabolism, which maintains adenosine triphosphate within the graft organ. In recent years, some studies have demonstrated that subnormothermic machine perfusion (SNMP) with hemoglobin-based oxygen carriers has the potential to improve oxygen metabolism. OBJECTIVE: The aim of this study was to evaluate the effectiveness of perfusate with human-derived hemoglobin vesicles (HbV) under SNMP in a pig model of donation after cardiac death. MATERIALS AND METHODS: In this study, pig livers were procured with a warm ischemic time of 60 minutes and were preserved in 3 groups for 240 minutes...
November 2018: Transplantation Proceedings
H Sasajima, S Miyagi, Y Kakizaki, T Kamei, M Unno, S Satomi, M Goto
BACKGROUND: Liver transplantation from donors after cardiac death (DCD) might increase the pool of available organs. Recently, some investigators reported the potential use of mesenchymal stem cells (MSCs) to improve the outcome of liver transplantation from DCD. The aim of this study was to evaluate the cytoprotective effects and safety of MSC transplantation on liver grafts from DCD. METHODS: Rats were divided into 4 groups (n = 5) as follows: 1. the heart-beating group, in which liver grafts were retrieved from heart-beating donors; 2...
November 2018: Transplantation Proceedings
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