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Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
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The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family.

Jerry Edward Chipuk, Mark P A Luna-Vargas
Journal of Cell Biology 2017 March 7
Within the mitochondrial pathway of apoptosis, VDAC2 controls both the localization and proapoptotic activity of BAK. In this issue, Hosoi et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605002) find that loss of VDAC2 diverts BAK into peroxisome membranes, revealing the ability of BAK to control peroxisome membrane integrity and the release of soluble peroxisomal matrix proteins.

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