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A new N-methoxyl-carbonyl benzylisoquinoline from Litsea cubeba.

Bin Tang, Hua Tu, Han-An Long, Jun Du, Jian-Min Guo, Hong-Jin Liu, Xin Hu, Li Yang, Xi Du
Journal of Asian Natural Products Research 2017 September
A new benzylisoquinoline alkaloid (•)-N-methoxycarbonyl-norjuziphine (1) was isolated from Litsea cubeba. Its structure was identified by extensively spectroscopic techniques and confirmed by the single-crystal X-ray diffraction analysis. Compound 1 showed cytotoxicity against HL-60 and MCF-7 cells, with IC50 values of 18.1 and 15.0 μM, respectively, comparable to 3.1 and 17.5 μM of the cisplatin (positive control).

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