We have located links that may give you full text access.
Journal Article
Observational Study
Maternal and Fetal Folate, Vitamin B 12 , and Homocysteine Concentrations and Childhood Kidney Outcomes.
American Journal of Kidney Diseases 2017 April
BACKGROUND: Folate, vitamin B12 , and homocysteine concentrations during pregnancy are important factors for early development and may persistently influence kidney function in the offspring. We examined the associations of folate, vitamin B12 , and homocysteine concentrations during pregnancy with kidney outcomes in school-aged children.
STUDY DESIGN: Population-based prospective cohort study from fetal life onward.
SETTINGS & PARTICIPANTS: This study was performed among 4,226 pregnant women and their children.
PREDICTORS: Folate, vitamin B12 , and homocysteine blood concentrations measured in early pregnancy (median gestational age, 13.2 [IQR, 12.2-14.8] weeks) and at birth (cord blood).
OUTCOMES & MEASUREMENTS: At the median age of 6.0 (IQR, 5.9-6.3) years, we measured combined kidney volume with ultrasound, estimated glomerular filtration rate based on creatinine (eGFRcr ) and cystatin C (eGFRcys ) concentrations, and microalbuminuria.
RESULTS: We observed that higher maternal folate concentrations were associated with larger childhood combined kidney volume, whereas higher maternal vitamin B12 concentrations were associated with higher childhood eGFRcys (P for both <0.05). These associations were independent of homocysteine concentrations. Higher maternal homocysteine concentrations were associated with smaller combined kidney volume and lower childhood eGFRcys (P for both < 0.05). The association of maternal homocysteine concentrations with childhood eGFRcys was largely explained by combined kidney volume. Higher cord blood homocysteine concentrations were associated with larger combined kidney volume and lower eGFRcys (P for both < 0.05). Folate, vitamin B12 , or homocysteine concentrations were not associated with microalbuminuria.
LIMITATIONS: Observational study, so causality cannot be established.
CONCLUSIONS: Our findings suggest that folate, vitamin B12 , and homocysteine concentrations during fetal life are associated with offspring kidney development. However, effect sizes are small. Further studies to replicate these findings and assess the causality and consequences for kidney health in later life are needed.
STUDY DESIGN: Population-based prospective cohort study from fetal life onward.
SETTINGS & PARTICIPANTS: This study was performed among 4,226 pregnant women and their children.
PREDICTORS: Folate, vitamin B12 , and homocysteine blood concentrations measured in early pregnancy (median gestational age, 13.2 [IQR, 12.2-14.8] weeks) and at birth (cord blood).
OUTCOMES & MEASUREMENTS: At the median age of 6.0 (IQR, 5.9-6.3) years, we measured combined kidney volume with ultrasound, estimated glomerular filtration rate based on creatinine (eGFRcr ) and cystatin C (eGFRcys ) concentrations, and microalbuminuria.
RESULTS: We observed that higher maternal folate concentrations were associated with larger childhood combined kidney volume, whereas higher maternal vitamin B12 concentrations were associated with higher childhood eGFRcys (P for both <0.05). These associations were independent of homocysteine concentrations. Higher maternal homocysteine concentrations were associated with smaller combined kidney volume and lower childhood eGFRcys (P for both < 0.05). The association of maternal homocysteine concentrations with childhood eGFRcys was largely explained by combined kidney volume. Higher cord blood homocysteine concentrations were associated with larger combined kidney volume and lower eGFRcys (P for both < 0.05). Folate, vitamin B12 , or homocysteine concentrations were not associated with microalbuminuria.
LIMITATIONS: Observational study, so causality cannot be established.
CONCLUSIONS: Our findings suggest that folate, vitamin B12 , and homocysteine concentrations during fetal life are associated with offspring kidney development. However, effect sizes are small. Further studies to replicate these findings and assess the causality and consequences for kidney health in later life are needed.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app