Self-targeted salinomycin-loaded DSPE-PEG-methotrexate nanomicelles for targeting both head and neck squamous cell carcinoma cancer cells and cancer stem cells.

Minhui Zhu, Shicai Chen, Libo Hua, Caiyun Zhang, Mengjie Chen, Donghui Chen, Yinmei Dong, Yingying Zhang, Meng Li, Xianmin Song, Huaiwen Chen, Hongliang Zheng

Nanomedicine 2017 Februrary

AIM: To target both head and neck squamous cell carcinoma (HNSCC) cells and cancer stem cells (CSCs) by salinomycin-loaded DSPE-PEG-MTX (synthesized using DSPE-PEG2000-NH2 and methotrexate) nanomicelles (M-SAL-MTX).

MATERIALS & METHODS: The characterization, antitumor activity and mechanism of M-SAL-MTX were evaluated.

RESULTS & CONCLUSION: M-SAL-MTX showed enhanced inhibitory effect toward both HNSCC CSCs and non-CSCs compared with a single treatment of methotrexate and salinomycin. In nude mice-bearing HNSCC xenografts, M-SAL-MTX suppressed tumor growth more effectively than other controls including combination of methotrexate and salinomycin. Therefore, M-SAL-MTX may provide a strategy for treating HNSCC by targeting both HNSCC CSCs and HNSCC cells.

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