journal
MENU ▼
Read by QxMD icon Read
search

Nanomedicine

journal
https://www.readbyqxmd.com/read/28635562/nanoformulated-natural-therapeutics-for-management-of-streptozotocin-induced-diabetes-potential-use-of-curcumin-nanoformulation
#1
Yousra M El-Far, Mahmoud M Zakaria, Mahmoud M Gabr, Amal M El Gayar, Laila A Eissa, Ibrahim M El-Sherbiny
AIM: The goal of this study was to improve curcumin (CUR) aqueous solubility and bioavailability via nanoformulation, and then study its activity and mechanism of action as an antidiabetic agent. METHODS: CUR-loaded pluronic nanomicelles (CURnp) were prepared and characterized. Biochemical assessments were performed as well as histological, confocal and RTPCR studies on pancreatic target tissues. RESULTS: CURnp with a diameter of 333 ± 6 nm and ζ potential of -26...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28635551/new-strategies-in-melanoma-therapy-can-nanoparticles-overcome-chemoresistance
#2
Ildiko Badea
No abstract text is available yet for this article.
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28635550/peptide-grafted-and-self-assembled-poly-%C3%AE-glutamic-acid-phenylalanine-nanoparticles-targeting-camptothecin-to-glioma
#3
Hitesh Kulhari, Srinivasa R Telukutla, Deep Pooja, Ravi Shukla, Ramakrishna Sistla, Vipul Bansal, David J Adams
AIM: To synthesize cRGDfK peptide conjugated poly(γ-glutamic acid)-phenylalanine nanoparticles to improve the therapeutic efficacy of camptothecin (CPT) against glioblastoma multiforme. METHODS: Peptide-conjugated, drug-loaded nanoparticles (cRGDfK-conjugated camptothecin-loaded PGA-PA nanoparticles [RCPN]) were prepared and physico-chemically characterized using different techniques. Nanoparticles were evaluated for in vitro anticancer activity, cellular uptake, induction of apoptosis and wound healing cell migration against U87MG human glioblastoma cells...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28635544/heparin-new-life-for-an-old-drug
#4
Carlos Raúl Aláez-Versón, Elena Lantero, Xavier Fernàndez-Busquets
Heparin is one of the oldest drugs, which nevertheless remains in widespread clinical use as an inhibitor of blood coagulation. The history of its identification a century ago unfolded amid one of the most fascinating scientific controversies turning around the distribution of credit for its discovery. The composition, purification and structure-function relationship of this naturally occurring glycosaminoglycan regarding its classical role as anticoagulant will be dealt with before proceeding to discuss its therapeutic potential in, among other, inflammatory and infectious disease, cancer treatment, cystic fibrosis and Alzheimer's disease...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28635419/multimodal-imaging-gd-nanoparticles-functionalized-with-pittsburgh-compound-b-or-a-nanobody-for-amyloid-plaques-targeting
#5
Jonathan Pansieri, Marie Plissonneau, Nathalie Stransky-Heilkron, Mireille Dumoulin, Laurence Heinrich-Balard, Pascaline Rivory, Jean-François Morfin, Eva Toth, Maria Joao Saraiva, Eric Allémann, Olivier Tillement, Vincent Forge, François Lux, Christel Marquette
AIM: Gadolinium-based nanoparticles were functionalized with either the Pittsburgh compound B or a nanobody (B10AP) in order to create multimodal tools for an early diagnosis of amyloidoses. MATERIALS & METHODS: The ability of the functionalized nanoparticles to target amyloid fibrils made of β-amyloid peptide, amylin or Val30Met-mutated transthyretin formed in vitro or from pathological tissues was investigated by a range of spectroscopic and biophysics techniques including fluorescence microscopy...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28635380/inorganic-nanoparticles-as-potential-regulators-of-immune-response-in-dendritic-cells
#6
Silvia Fogli, Costanza Montis, Sara Paccosi, Angela Silvano, Elena Michelucci, Debora Berti, Alberto Bosi, Astrid Parenti, Paolo Romagnoli
AIM: The spontaneous adsorption of proteins on nanoparticles (NPs) in biological media is exploited to prepare complexes of NPs and proteins from cancer cells' lysates for application in cancer immunotherapy. MATERIALS & METHODS: Gold (Au) and silica NPs were synthesized, incubated with cancer cells' lysates and characterized. Dendritic cells (DCs) were challenged with protein-coated NPs, their maturation, viability and morphology were evaluated and lymphocytes T proliferation was determined...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28635377/how-are-we-applying-nanogel-composites-in-biomedicine
#7
Mrityunjoy Kar, Maria Molina, Marcelo Calderón
No abstract text is available yet for this article.
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28635372/peptide-functionalized-nanoparticles-for-the-selective-induction-of-apoptosis-in-target-cells
#8
Nicole Remaliah S Sibuyi, Ntevheleni Thovhogi, Kwazikwakhe B Gabuza, Miche D Meyer, Mustafa Drah, Martin O Onani, Amanda Skepu, Abram M Madiehe, Mervin Meyer
AIM: The study developed a prohibitin (PHB) targeted nanotherapy for selective induction of apoptosis in target cells. METHODS: Gold nanoparticles (AuNPs) were bifunctionalized with adipose homing and proapoptotic peptides. The efficacy and mode of cell death induced by the AuNPs were investigated in vitro on three cancer cell lines. RESULTS: The antiproliferative activity of PHB-targeted bifunctionalized AuNPs was more pronounced on cells that express the PHB receptor, and demonstrated receptor-mediated targeting and selectivity...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28635366/redox-biology-of-leishmania-and-macrophage-targeted-nanoparticles-for-therapy
#9
Hafiz Shoaib Sarwar, Sohail Akhtar, Muhammad Farhan Sohail, Zaeema Naveed, Muhammad Rafay, Akhtar Nadhman, Masoom Yasinzai, Gul Shahnaz
Intramacrophage parasite 'Leishmania' has developed various mechanisms for proficient uptake into macrophages and phagosome regulation to avoid macrophage's oxidative burst induced by peroxide, hydroxyl radical, hypochlorous acid and peroxynitrite production. One major barrier for impairing the accession of old fashioned anti-Leishmanial drugs is intrinsic incapability to pass through cell membranes and limiting their abilities to ultimately destroy intracellular pathogens. Receptor-mediated targeted drug delivery to the macrophages by using nanoparticles emerges as promising strategy to improve therapeutic efficacy of old-fashioned drug...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28621632/how-can-nanoparticles-be-used-in-sentinel-node-detection
#10
Muneer Ahmed, Mirjam Cl Peek, Michael Douek
No abstract text is available yet for this article.
June 16, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28621615/molecular-determinants-for-cyclo-oligosaccharide-based-nanoparticle-mediated-effective-sirna-transfection
#11
Darío Manzanares, Ingrid Araya-Durán, Laura Gallego-Yerga, Pablo Játiva, Valeria Márquez-Miranda, Jonathan Canan, José Luis Jiménez Blanco, Carmen Ortiz Mellet, Fernando Danilo González-Nilo, José Manuel García Fernández, Valentín Ceña
AIM: To study the structural requirements that a cyclooligosaccharide-based nanoparticle must fulfill to be an efficient siRNA transfection vector. MATERIALS & METHODS: siRNA protection from degradation by RNAses, transfection efficiency and the thermodynamic parameters of the nanoparticle/siRNA interactions were studied on pairs of amphiphilic molecules using biochemical techniques and molecular dynamics. RESULTS: The lower the siRNA solvent accessible surface area in the presence of the nanoparticle, higher the protection from RNAse-mediated degradation in the corresponding nanocomplex; a moderate nanoparticle/siRNA binding energy value further facilitates reversible complexation and binding to the target cellular mRNA...
June 16, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28621606/nano-targeting-of-mucosal-addressin-cell-adhesion-molecule-1-identifies-bowel-inflammation-foci-in-murine-model
#12
Marta Truffi, Miriam Colombo, Jesus Peñaranda-Avila, Luca Sorrentino, Francesco Colombo, Matteo Monieri, Veronica Collico, Pietro Zerbi, Erika Longhi, Raffaele Allevi, Davide Prosperi, Fabio Corsi
AIM: We investigate MAdCAM-1 as a reliable target to detect active bowel inflammation for selective noninvasive nanodiagnostics. MATERIALS & METHODS: We coupled anti-MAdCAM-1 antibodies to manganese oxide nanoparticles, and analyzed nanoconjugate biodistribution and safety in murine model of inflammatory bowel disease by imaging and histology. RESULTS: Nanoparticles were stable and nontoxic. Upon administration in colitic mice, anti-MAdCAM-1 functionalized nanoparticles preferentially localized in the inflamed bowel, whereas untargeted nanoparticles were more rapidly washed out...
June 16, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28621581/self-assembling-protein-nanoparticles-a-promising-tool-against-lethal-influenza
#13
Peter Burkhard, Christopher P Karch
No abstract text is available yet for this article.
June 16, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28621578/the-effect-of-nanoparticle-size-on-the-ability-to-cross-the-blood-brain-barrier-an-in-vivo-study
#14
Oshra Betzer, Malka Shilo, Renana Opochinsky, Eran Barnoy, Menachem Motiei, Eitan Okun, Gal Yadid, Rachela Popovtzer
AIM: Our goal was to develop an efficient nanoparticle-based system that can overcome the restrictive mechanism of the blood-brain barrier (BBB) by targeting insulin receptors and would thus enable drug delivery to the brain. METHODS: Insulin-coated gold nanoparticles (INS-GNPs) were synthesized to serve as a BBB transport system. The effect of nanoparticle size (20, 50 and 70 nm) on their ability to cross the BBB was quantitatively investigated in Balb/C mice. RESULTS: The most widespread biodistribution and highest accumulation within the brain were observed using 20 nm INS-GNPs, 2 h post injection...
June 16, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28621567/-68-ga-radiolabeled-aguix-nanoparticles-as-dual-modality-imaging-agents-for-pet-mri-guided-radiation-therapy
#15
Penelope Bouziotis, Dimitris Stellas, Eloïse Thomas, Charles Truillet, Charalampos Tsoukalas, François Lux, Theodoros Tsotakos, Stavros Xanthopoulos, Maria Paravatou-Petsotas, Anastasios Gaitanis, Lia Angela Moulopoulos, Vassilis Koutoulidis, Constantinos D Anagnostopoulos, Olivier Tillement
AIM: The aim of this study was to develop a dual-modality positron emission tomography/magnetic resonance (PET/MR) imaging probe by radiolabeling gadolinium-containing AGuIX derivatives with the positron-emitter Gallium-68 ((68)Ga). MATERIALS & METHODS: AGuIX@NODAGA nanoparticles were labeled with (68)Ga at high efficiency. Tumor accumulation in an appropriate disease model was assessed by ex vivo biodistribution and in vivo PET/MR imaging. RESULTS:  (68)Ga-AGuIX@NODAGA was proven to passively accumulate in U87MG human glioblastoma tumor xenografts...
June 16, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28573926/curcumin-loaded-chitosan-cholesterol-micelles-evaluation-in-monolayers-and-3d-cancer-spheroid-model
#16
Omkara Swami Muddineti, Preeti Kumari, Eupa Ray, Balaram Ghosh, Swati Biswas
AIM: To improve the bioavailability and anticancer potential of curcumin by using a cholesterol-conjugated chitosan micelle. Methods & methods: Cholesterol was conjugated to chitosan (15 kDa) to form self-assembled micelles, which loaded curcumin. Physicochemical characterization and formulation optimization of the drug-loaded micelles (curcumin-loaded chitosan-cholesterol micelles [C-CCM]) were performed. In vitro cellular uptake and viability of C-CCM were investigated in melanoma and breast cancer cell lines...
June 2, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28573923/combined-photothermal-and-photodynamic-therapy-by-hyaluronic-acid-decorated-polypyrrole-nanoparticles
#17
Tuan Hiep Tran, Hanh Thuy Nguyen, Thi Thu Phuong Tran, Sae Kwang Ku, Jee-Heon Jeong, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
AIM: To develop a nanoparticle-based platform using polypyrrole and IR-780 for effective combined photothermal and photodynamic therapy. MATERIALS & METHODS: IR-780 was loaded in a poly(lactic-co-glycolic acid) core, decorated with polypyrrole shells and hyaluronic acid (IPPH). Physicochemical properties and in vitro and in vivo anticancer effects of these nanoparticles were evaluated. RESULTS: The resulting IPPHs were spherical, small and negatively charged...
June 2, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28565994/the-effects-of-silver-nanoparticles-on-behavior-apoptosis-and-nitro-oxidative-stress-in-offspring-wistar-rats
#18
Oana-Ofelia Dănilă, Alexandra Sevastre Berghian, Vlad Dionisie, Dan Gheban, Diana Olteanu, Flaviu Tabaran, Ioana Baldea, Gabriel Katona, Bianca Moldovan, Simona Clichici, Luminita David, Gabriela Adriana Filip
AIM: To investigate the comparative effects of prenatal exposure to silver nanoparticles (AgNPs) functionalized with citrate and polyphenols on spatial cognition and also on nitro-oxidative stress and apoptosis in the hippocampus and cerebellum of offsprings. MATERIALS & METHODS: Pregnant Wistar rats were orally administered substances from day 10 of gestation until day 21. Six weeks postpartum, six male offsprings from each group were used for behavioral evaluation and determination of oxidative stress and apoptosis...
June 1, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28565974/pnc27-anticancer-peptide-as-targeting-ligand-significantly-improved-antitumor-efficacy-of-doxil-in-hdm2-expressing-cells
#19
Shahrzad Amiri Darban, Ali Badiee, Mahmoud Reza Jaafari
AIM: To investigate the potential of PNC27 peptide, 12-26 of p53 with high affinity for HDM2 protein, as targeting ligand for Doxil to improve its antitumor activity. MATERIALS & METHODS: Doxil postinserted with 25, 50, 100 and 200 PNC27 peptides per liposome. Flow cytometry and confocal analysis were performed on C26 colon carcinoma (HDM2 positive) and B16F0 melanoma (HDM2 negative) cells. In vivo studies were performed on BALB/c mice bearing C26 and C57BL/6 mice bearing B16F0 tumor models...
June 1, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28524813/a-multifunctional-nanocomplex-for-enhanced-cell-uptake-endosomal-escape-and-improved-cancer-therapeutic-effect
#20
Patrick V Almeida, Mohammad-Ali Shahbazi, Alexandra Correia, Ermei Mäkilä, Marianna Kemell, Jarno Salonen, Jouni Hirvonen, Hélder A Santos
AIM: To evaluate the chemotherapeutic potential of a novel multifunctional nanocomposite encapsulating both porous silicon (PSi) and gold (Au) nanoparticles in a polymeric nanocomplex. MATERIALS & METHODS: The nanocomposite was physicochemically characterized and evaluated in vitro for biocompatibility, cellular internalization, endosomolytic properties, cytoplasmatic drug delivery and chemotherapeutic efficacy. RESULTS: The nanocomposites were successfully produced and exhibited adequate physicochemical properties and superior in vitro cyto- and hemocompatibilities...
May 19, 2017: Nanomedicine
journal
journal
41392
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"