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Sayantani Basu, Settimio Pacelli, Jinxi Wang, Arghya Paul
No abstract text is available yet for this article.
November 17, 2017: Nanomedicine
Agustin S Picco, Larissa F Ferreira, Michelle S Liberato, Gabriela B Mondo, Mateus B Cardoso
AIM: To study freeze-drying of silica nanoparticles (SiO2NPs) in order to find suitable conditions to produce lyophilized powders with no aggregation after resuspension and storage. METHODS: SiO2NPs were synthesized using a Stöber-based procedure, and characterized by scanning electron microscopy, dynamic light scattering and nitrogen adsorption/desorption isotherms. SiO2NPs hydrodynamic diameters were compared prior and after freeze-drying in the presence/absence of carbohydrate protectants...
November 15, 2017: Nanomedicine
Ke Kang, Jin Ma, Qiangying Yi, Zhongwei Gu
AIM: To build up a remote triggering drug delivery system with hyperthermia-responsive ammonium bicarbonate salt and investigate its effects on tumor therapy. MATERIALS & METHODS: This hybrid nanocapsule system was prepared by a different strategy, doxorubicin (DOX) was encapsulated in the heparin shell first and then ammonium bicarbonate was diffused into the nanocapsules to generate DOX-bicarbonate salt, its characterizations and effects on tumor therapy were investigated...
November 14, 2017: Nanomedicine
Amr Hefnawy, Islam A Khalil, Ibrahim M El-Sherbiny
AIM: Facile development of polysaccharides-based carrier system for efficient delivery of doxorubicin (DOX) to the brain. METHODS: DOX was nanocomplexed with alginate (Alg) followed by incorporation into chitosan (Cs) nanomatrices. The resulting carriers were optimized to have a net positive charge improving their delivery across the blood-brain barrier. The optimum DOX-loaded nanosystem was targeted to brain tissue via loading into various nasal dosage forms. RESULTS: The pH-dependent ionization of both DOX and Alg was found to have a significant effect on DOX entrapment efficiency which was improved from 4% at slightly acidic media to 85% using different pHs...
November 14, 2017: Nanomedicine
Alexandre Cc Vieira, Joana Magalhães, Sónia Rocha, Marcos S Cardoso, Susana G Santos, Margarida Borges, Marina Pinheiro, Salette Reis
AIM: This work aims to develop a mannosylated nanostructured lipid carrier (NLC) loaded with rifampicin to improve tuberculosis treatment. MATERIALS & METHODS: An active targeting strategy was used and the nanoparticles were characterized. Effects on cell viability and the antimycobacterial activity of the nanoformulations were evaluated. RESULTS: The nanoparticles developed exhibited a size of about 315 nm and polydispersity <0.2. The drug encapsulation efficiency was higher than 90% and its release was sensitive to pH...
November 9, 2017: Nanomedicine
Jessica M Kelly, Amanda L Gross, Douglas R Martin, Mark E Byrne
AIM: Polymersomes are created to deliver an enzyme-based therapy to the brain in lysosomal storage disease patients. MATERIALS & METHODS: Polymersomes are formed via the injection method using poly(ethylene glycol)-b-poly(lactic acid) (PEGPLA) and bound to apolipoprotein E, to create a brain-targeted delivery vehicle. RESULTS: Polymersomes have a smallest average diameter of 145 ± 21 nm and encapsulate β-galactosidase at 72.0 ± 12...
November 7, 2017: Nanomedicine
Raphael S Bonadio, Ana Carolina Arcanjo, Emilia Cd Lima, Alline T Vasconcelos, Renata C Silva, Frederico H Horst, Ricardo B Azevedo, Marcio José Poças-Fonseca, João Paulo F Longo
AIM: To evaluate the DNA methylation profile of MCF-7 cells during and after the treatment with maghemite nanoparticles (MNP-CIT). MATERIALS & METHODS: Noncytotoxic MNP-CIT concentrations and cell morphology were evaluated by standard methods. DNA methylation was assessed by whole genome bisulfite sequencing. DNA methyltransferase (DNMT) genes expression was analyzed by qRT-PCR. RESULTS: A total of 30 and 60 µgFeml(-1) MNP-CIT accumulated in cytoplasm but did not present cytotoxic effects...
November 7, 2017: Nanomedicine
Muhammad Ovais, Akhtar Nadhman, Ali Talha Khalil, Abida Raza, Fazli Khuda, Muhammad Farhan Sohail, Nazar Ul Islam, Hafiz Shoaib Sarwar, Gul Shahnaz, Irshad Ahmad, Muthupandian Saravanan, Zabta Khan Shinwari
Many recent key innovations in nanotechnology have greatly fascinated scientists to explore new avenues in treatment and diagnosis of emerging diseases. Due to extensive utilization of metallic nanoparticles (NPs) in diverse biomedical applications, scientists are looking forward to green synthesis of NPs as safer, simple, fast, and low-cost method over chemical and physical methods. Due to enriched phytochemistry, no need for maintenance and ready availability, plants are preferred for green synthesis of silver (AgNPs) and gold NPs (AuNPs)...
November 7, 2017: Nanomedicine
Jessica Fernanda Affonso de Oliveira, Larissa Brentano Capeletti, Mateus Borba Cardoso
No abstract text is available yet for this article.
November 3, 2017: Nanomedicine
Stefan Lyer, Christina Janko, Ralf P Friedrich, Marina Pöttler, Iwona Cicha, Christoph Alexiou
No abstract text is available yet for this article.
November 3, 2017: Nanomedicine
Santosh Gupta, Piyush Kumar Gupta, Gunasekaren Dharanivasan, Rama Shanker Verma
Management of prostate cancer is currently being pursued by systemic delivery of anticancer drugs, but it has drawbacks like nonspecific distribution, decreased bioavailability, coupled with adverse side effects. These problems have been resolved using nanomedicine-based anticancer drug delivery to improve the therapeutic index with higher drug dose and reduced nonspecific distribution. Targeting prostate tumor by delivering nanomedicine through locoregional route is more effective, than the systemic delivery, which can decrease systemic exposure of the therapeutics significantly...
November 3, 2017: Nanomedicine
Charles B Chesson, Andrew Zloza
The major goal of immunity is maintaining host survival. Toward this, immune cells recognize and eliminate targets that pose a danger. Primarily, these are external invaders (pathogens) and internal invaders (cancers). Their recognition relies on distinguishing foreign components (antigens) from self-antigens. Since cancer cells are the host's own cells that are harmfully altered, they are difficult to distinguish from normal self. Furthermore, the antigens least resembling the host are often sequestered in parts of the tumor least accessible to immune responses...
November 3, 2017: Nanomedicine
Min Zhang, Jing Hu, Ying Zou, Junwen Wu, Yun Yao, Hua Fan, Kehai Liu, Jun Wang, Shen Gao
AIM: To increase in vivo DNA transfection efficiency of a nonviral delivery vehicle, its tumor targeting and nuclear delivery ability was improved. MATERIALS & METHODS: A novel bifunctional peptide tLyP-1-NLS (named K12) was prepared by coupling a tumor-targeting peptide (tLyP-1) with a nuclear localization signal (NLS), and then was used to modify a degradable polyethyleneimine (PEI) derivative called "N-octyl-N-quaternary chitosan (OTMCS)-PEI". The carrier OTMCS-PEI-K12 was characterized in terms of the physicochemical properties, in vitro gene transfection and antitumor effect in vivo...
November 2, 2017: Nanomedicine
Pascale Schwinté, Alexandre Mariotte, Priya Anand, Laetitia Keller, Ysia Idoux-Gillet, Olivier Huck, Florence Fioretti, Henri Tenenbaum, Philippe Georgel, Wolfgang Wenzel, Silvia Irusta, Nadia Benkirane-Jessel
AIM: We developed polymeric membranes for local administration of nonsoluble anti-inflammatory statin, as potential wound patch in rheumatic joint or periodontal lesions. METHODS: Electrospun polycaprolactone membranes were fitted with polysaccharide-atorvastatin nanoreservoirs by using complexes with poly-aminocyclodextrin. Characterization methods are UV-Visible and X-ray photoelectron spectroscopy, molecular dynamics, scanning and transmission electron microscopy...
November 2, 2017: Nanomedicine
Ahmed O Elzoghby, Sarah A El-Lakany, Maged W Helmy, Marwa M Abu-Serie, Nazik A Elgindy
AIM: Oral administration of exemestane (EXM) and resveratrol (RES) for breast cancer therapy has been limited by their poor solubility and low permeability. METHODS: In this study, these issues were tackled using zein nanocapsules (ZNCs) for oral EXM/RES codelivery combining drug solubilization within oily core and resistance to digestion via hydrophobic protein shell. Furthermore, higher oral stability and sustained release could be enabled by glutaraldehyde crosslinking of zein shell...
November 2, 2017: Nanomedicine
Pramod Kumar, Gajanand Sharma, Rajendra Kumar, Ruchi Malik, Bhupinder Singh, Om Prakash Katare, Kaisar Raza
AIM: Dimethyl fumarate is a frequent prescription for the management of numerous neurological disorders. Despite immense promises, DMF is associated with various problems such as multiple dosing (2-3 oral doses daily) and lower brain permeability. Our aim was to enhance the oral bioavailability and increase the brain concentrations of dimethyl fumarate. METHODS: Solid lipid nanoparticles were systematically formulated by optimizing the composition based on the desired attributes viz...
November 2, 2017: Nanomedicine
Laura Rubio, Jordi Bach, Ricard Marcos, Alba Hernández
AIM: Since controversial results have been obtained in studies dealing with nanoceria usefulness in biomedical applications, the transforming effects of long-term exposure to nanoceria in lung epithelial cells, alone or together with cigarette smoke condensate (CSC), were evaluated. MATERIALS & METHODS: In vitro cell transformation techniques were used to study several hallmarks of carcinogenesis. Morphology, cell proliferation, gene expression, cell migration, anchorage-independent cell growth and cell secretome were analyzed...
November 2, 2017: Nanomedicine
Anil Parsram Bidkar, Pallab Sanpui, Siddhartha Sankar Ghosh
AIM: To develop selenium nanoparticles (SeNPs)-based delivery systems for paclitaxel (PTX) and assess their antiproliferative efficacy against cancer cells in vitro with potential mechanistic insight. METHODS: Pluronic F-127 stabilized SeNPs were prepared and characterized. Effects of PTX-loaded SeNPs on lung (A549), breast (MCF7), cervical (HeLa) and colon (HT29) cancer cells were studied by viability assay complemented with flow-cytometric analyses of cell cycle, apoptosis, mitochondrial membrane potential, intracellular reactive oxygen species and caspase activity...
October 18, 2017: Nanomedicine
Tian-Xu Zhang, Guan-Yin Zhu, Bo-Yao Lu, Chao-Liang Zhang, Qiang Peng
AIM: A comprehensive understanding of nanoparticle (NP)-protein interaction (protein corona formation) is required. So far, many factors influencing this interaction have been investigated, like size and ζ potential. However, NPs exposure concentration has always been ignored. Herein, we aim to disclose the correlation of NPs exposure concentration with protein adsorption. MATERIALS & METHODS: Four polymeric NPs systems possessing similar sizes (230 ± 20 nm) but varied ζ potentials (-30 ∼ +40 mv) were prepared...
October 10, 2017: Nanomedicine
Md Masud Parvez Arnob, Wei-Chuan Shih
No abstract text is available yet for this article.
October 10, 2017: Nanomedicine
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