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Nanomedicine

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https://www.readbyqxmd.com/read/28884615/resveratrol-loaded-nanoparticles-conjugated-with-kidney-injury-molecule-1-as-a-drug-delivery-system-for-potential-use-in-chronic-kidney-disease
#1
Yuh-Feng Lin, Yu-Hsuan Lee, Yung-Ho Hsu, Yi-Jie Chen, Yuan-Feng Lin, Fong-Yu Cheng, Hui-Wen Chiu
AIM: We used resveratrol (Res)-loaded nanoparticles (Res NPs) as a novel method for improving the pharmacokinetic properties of Res and analyzed the effect of Res NPs in chronic kidney disease (CKD). MATERIALS & METHODS: We coupled anti-kidney injury molecule-1 antibodies to Res NPs and analyzed safety and efficacy. RESULTS: Res NPs had low toxicity and induced autophagy. Res NPs inhibited the NLRP3 inflammasome and IL-1β secretion. Higher NLRP3 expression levels were observed in peripheral blood monocytic cells of CKD patients than healthy individuals...
September 8, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28882086/improving-gold-nanorod-delivery-to-the-central-nervous-system-by-conjugation-to-the-shuttle-angiopep-2
#2
Carolina Velasco-Aguirre, Francisco Morales-Zavala, Edison Salas-Huenuleo, Eduardo Gallardo-Toledo, Oscar Andonie, Luis Muñoz, Ximena Rojas, Gerardo Acosta, Macarena Sánchez-Navarro, Ernest Giralt, Eyleen Araya, Fernando Albericio, Marcelo Javier Kogan
AIM: To improve the in vivo delivery of gold nanorods (GNRs) to the central nervous system of rats, these gold nanoparticles were conjugated to Angiopep-2, a shuttle peptide that can cross the blood-brain barrier. MATERIALS & METHODS: GNRs were synthesized and modified using polyethylene glycol and Angiopep-2 (GNR-PEG-Angiopep-2). The physicochemical properties, in vitro cytotoxicity and ex vivo biodistribution of the conjugate were examined. RESULTS: GNR-PEG-Angiopep-2 was stable over the following days, and the different concentrations that were tested did not affect the viability of microvascular endothelial cells...
September 8, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28875744/folic-acid-conjugated-cationic-ag2s-quantum-dots-for-optical-imaging-and-selective-doxorubicin-delivery-to-hela-cells
#3
Fatma Demir Duman, Merve Erkisa, Rouhullah Khodadust, Ferda Ari, Engin Ulukaya, Havva Yagci Acar
AIM: We aim to develop folic acid (FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region. MATERIALS & METHODS: Cationic Ag2S NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells...
September 6, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28868980/nanoparticle-based-strategies-for-cancer-immunotherapy-and-immunodiagnostics
#4
Anna Maria Grimaldi, Mariarosaria Incoronato, Marco Salvatore, Andrea Soricelli
Although recent successes in clinical trials are strengthening research focused on cancer immunology, the poor immunogenicity and off-target side effects of immunotherapeutics remain major challenges in translating these promising approaches to clinically feasible therapies in the treatment of a large range of tumors. Nanotechnology offers target-based approaches, which have shown significant improvements in the rapidly advancing field of cancer immunotherapy. Here, we first discuss the chemical and physical features of nanoparticulate systems that can be tuned to address the anticancer immune response, and then review recent, key examples of the exploited strategies, ranging from nanovaccines to NPs revising the tumor immunosuppressive microenvironment, up to immunotherapeutic multimodal NPs...
September 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28868972/realizing-the-therapeutic-potential-of-rare-earth-elements-in-designing-nanoparticles-to-target-and-treat-glioblastoma
#5
Victor M Lu, Kerrie L McDonald, Helen E Townley
The prognosis of brain cancer glioblastoma (GBM) is poor, and despite intense research, there have been no significant improvements within the last decade. This stasis implicates the need for more novel therapeutic investigation. One such option is the use of nanoparticles (NPs), which can be beneficial due to their ability to penetrate the brain, overcome the blood-brain barrier and take advantage of the enhanced permeation and retention effect of GBM to improve specificity. Rare earth elements possess a number of interesting natural properties due to their unique electronic configuration, which may prove therapeutically advantageous in an NP formulation...
September 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28868971/mucoadhesive-solid-lipid-microparticles-for-controlled-release-of-a-corticosteroid-in-the-chronic-obstructive-pulmonary-disease-treatment
#6
Erika Amore, Maria Ferraro, Maria Letizia Manca, Mark Gjomarkaj, Gaetano Giammona, Elisabetta Pace, Maria Luisa Bondì
AIM: Therapeutic efficacy of pulmonary diseases is often limited and drug delivery systems offer new solutions to clinical problems. Solid lipid microparticles (SLMs) are suggested as systems for the delivery of therapeutics to the lung as, because of their size, they are able to deposit into secondary bronchi. MATERIALS & METHODS: Here, we describe two novel different SLMs using chitosan and alginate such as mucoadhesive polymers and we also studied their biocompatibility and their effectiveness compared with the free drug in controlling senescence and inflammatory processes in cigarette smoke extracts...
September 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28868970/the-use-of-nanoparticulates-to-treat-breast-cancer
#7
Xiaomeng Tang, Welley S Loc, Cheng Dong, Gail L Matters, Peter J Butler, Mark Kester, Craig Meyers, Yixing Jiang, James H Adair
Breast cancer is a major ongoing public health issue among women in both developing and developed countries. Significant progress has been made to improve the breast cancer treatment in the past decades. However, the current clinical approaches are invasive, of low specificity and can generate severe side effects. As a rapidly developing field, nanotechnology brings promising opportunities to human cancer diagnosis and treatment. The use of nanoparticulate-based platforms overcomes biological barriers and allows prolonged blood circulation time, simultaneous tumor targeting and enhanced accumulation of drugs in tumors...
September 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28868968/can-regenerative-medicine-and-nanotechnology-combine-to-heal-wounds-the-search-for-the-ideal-wound-dressing
#8
Payam Zarrintaj, Abolfazl Salehi Moghaddam, Saeed Manouchehri, Zhaleh Atoufi, Anahita Amiri, Mohammad Amir Amirkhani, Mohammad Ali Nilforoushzadeh, Mohammad Reza Saeb, Michael R Hamblin, Masoud Mozafari
Skin is the outermost covering of the human body and at the same time the largest organ comprising 15% of body weight and 2 m(2) surface area. Skin plays a key role as a barrier against the outer environment depending on its thickness, color and structure, which differ from one site to another. The four major types of problematic wounds include ulcers (diabetic, venous, pressure) and burn wounds. Developing novel dressings helps us to improve the wound healing process in difficult patients. Recent advances in regenerative medicine and nanotechnology are revolutionizing the field of wound healing...
September 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28868966/core-shell-hybrid-nanostructured-delivery-platforms-for-advanced-rnai-therapeutics
#9
S Sajeesh, Jeong Yong Choe, Dong Ki Lee
AIM: Study was aimed at combining the advantages of nonclassical RNAi-triggering oligonucleotides with nanoparticle-based advanced delivery platforms for developing efficient therapeutic systems. MATERIALS & METHODS: We utilized a core-shell hybrid nanostructured platform for effectively delivering nonclassical RNAi triggers, namely long double stranded interfering RNA and tripodal interfering RNA. Core-shell structure was prepared by stably anchoring thiol-modified cationic polymer on the surface of growing crystal gold (Au) seeds, and the resulting particles were further complexed with nonclassical RNAi candidates via electrostatic interactions...
September 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28868964/poly-%C3%AF%C2%B5-caprolactone-chitosan-nanoparticles-provide-strong-adjuvant-effect-for-hepatitis-b-antigen
#10
Sandra Jesus, Edna Soares, Gerrit Borchard, Olga Borges
AIM: This work aims to investigate the adjuvant effect of poly-ϵ-caprolactone/chitosan nanoparticles (NPs) for hepatitis B surface antigen (HBsAg) and the plasmid DNA encoding HBsAg (pRC/CMV-HBs). METHODS: Both antigens were adsorbed onto preformed NPs. Vaccination studies were performed in C57BL/6 mice. Transfection efficiency was investigated in A549 cell line. RESULTS: HBsAg-adsorbed NPs generated strong anti-HBsAg IgG titers, mainly of IgG1 isotype, and induced antigen-specific IFN-γ and IL-17 secretion by spleen cells...
September 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28853318/corrigendum
#11
(no author information available yet)
No abstract text is available yet for this article.
August 30, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28820020/multiple-emulsions-as-effective-platforms-for-controlled-anti-cancer-drug-delivery
#12
Ewa Dluska, Agnieszka Markowska-Radomska, Agata Metera, Barbara Tudek, Konrad Kosicki
AIM: Developing pH-responsive multiple emulsion platforms for effective glioblastoma multiforme therapy with reduced toxicity, a drug release study and modeling. MATERIALS & METHODS: Cancer cell line: U87 MG, multiple emulsions with pH-responsive biopolymer and encapsulated doxorubicin (DOX); preparation of multiple emulsions in a Couette-Taylor flow biocontactor, in vitro release study of DOX (fluorescence intensity analysis), in vitro cytotoxicity study (alamarBlue cell viability assay) and numerical simulation of DOX release rates...
August 18, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28818003/hybrid-a-cnh-tio2-tin-type-surface-layers-produced-on-niti-shape-memory-alloy-for-cardiovascular-applications
#13
Justyna Witkowska, Agnieszka Sowińska, Elżbieta Czarnowska, Tomasz Płociński, Janusz Kamiński, Tadeusz Wierzchoń
AIM: The goal was to improve the properties of NiTi shape memory alloy to make it suitable for cardiac applications. For this purpose, a hybrid a-CNH+TiO2+TiN-type surface layer was produced on NiTi alloy and characterized. MATERIALS & METHODS: The NiTi alloy subjected to hybrid process combining low-temperature oxynitriding under glow discharge conditions and radio frequency chemical vapor deposition process was examined for microstructure, surface topography, corrosion resistance, wettability and surface-free energy, Ni ion release and platelets adhesion, aggregation and activation...
August 18, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28816102/hydrodenticity-to-enhance-relaxivity-of-gadolinium-dtpa-within-crosslinked-hyaluronic-acid-nanoparticles
#14
Maria Russo, Alfonso Maria Ponsiglione, Ernesto Forte, Paolo Antonio Netti, Enza Torino
AIM: The efficacy of gadolinium (Gd) chelates as contrast agents for magnetic resonance imaging remains limited owing to poor relaxivity and toxic effects. Here, the effect of the hydration of the hydrogel structure on the relaxometric properties of Gd-DTPA is explained for the first time and called Hydrodenticity. RESULTS: The ability to tune the hydrogel structure is proved through a microfluidic flow-focusing approach able to produce crosslinked hyaluronic acid nanoparticles, analyzed regarding the crosslink density and mesh size, and connected to the characteristic correlation times of the Gd-DTPA...
August 17, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28814165/ag-implantation-induces-mechanical-properties-cell-adhesion-and-antibacterial-effects-of-tin-ag-multilayers-in-vitro
#15
Xiuhua Sun, Huanhuan Gong, Dejun Li, Lei Dong, Mengli Zhao, Rongxin Wan, Hanqing Gu
AIM: This study aims to investigate the effect of Ag(+) implantation dose on the structure, hardness, adhesion strength, friction resistance, cell adhesion and antibacterial effects of TiN/Ag multilayers. METHODS: Nanoscale TiN/Ag multilayers were deposited on Ti-6Al-4V substrates using multiarc ion plating. The multilayers were then implanted by Ag ions. RESULTS: A distinct multilayer structure and large titanium nitride grains with better (111) crystallinity were proved...
August 17, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28814163/protease-activated-nanomaterials-for-targeted-cancer-theranostics
#16
Yung-Chieh Chan, Michael Hsiao
Cancer metastasis accompanies irreversible proteolysis. Malignant cells that abnormally express extracellular proteases usually lead to a poor outcome during cancer progression. The development of protease-activated drugs is an important goal. Moreover, the specific proteolytic mechanism can be used as a diagnostic strategy. Currently, nanotechnology for use in medication has been extensively developed to exploit the physical and chemical properties of nanoparticles. For example, to improve the efficacy of cancer therapy drugs, targeted delivery has been attempted by combining a targeting ligand with a nanoparticle...
August 17, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28814149/n-implantation-induce-cytocompatibility-of-shape-controlled-three-dimensional-self-assembly-graphene
#17
Ye Cao, Dejun Li, Mengli Zhao, Huanhuan Gong, Rongxin Wan, Hanqing Gu
AIM: The aim of the present research was to synthesize N(+) implanted 3D self-assembly graphene (N(+)/3D-SGHs) to overcome the weaknesses of graphene (small sizes and poor hydrophilicity) in tissue engineering scaffolds. MATERIALS & METHODS: N(+)/3D-SGHs was achieved by ion implantation on one-step hydrothermal synthesized 3D self-assembly graphene (3D-SGHs), and N(+)/3D-SGHs with different doses of nitrogen ions (1 × 10(16) ions/cm(2), 1 × 10(18) ions/cm(2) and 1 × 10(20) ions/cm(2)), which adjusted by nitrogen ion beam intensity...
August 17, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28814137/pegylated-crosslinked-hyaluronic-acid-nanoparticles-designed-through-a-microfluidic-platform-for-nanomedicine
#18
Maria Russo, Anna Maria Grimaldi, Paolo Bevilacqua, Olimpia Tammaro, Paolo Antonio Netti, Enza Torino
AIM: A high versatile microfluidic platform is proposed to design, in a one-step strategy, PEGylated crosslinked hyaluronic acid nanoparticles (cHANPs) entrapping a magnetic resonance imaging contrast agent and a dye for multimodal imaging applications. MATERIALS & METHODS: Clinically relevant biomaterials were shaped in the form of spherical NPs through a microfluidic flow focusing approach. A comparison between post processing and simultaneous PEGylation is reported to evaluate the potentiality of the chemical decoration of the cHANPs in microfluidics...
August 17, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28814136/hybrid-core-shell-nanoparticles-entrapping-gd-dtpa-and-18-f-fdg-for-simultaneous-pet-mri-acquisitions
#19
Donatella Vecchione, Marco Aiello, Carlo Cavaliere, Emanuele Nicolai, Paolo Antonio Netti, Enza Torino
AIM: Although there has been an improvement in the hardware and software of the PET/MRI system, the development of the nanoprobes exploiting the simultaneous acquisition of the bimodal data is still under investigation. Moreover, few studies on biocompatible and clinically relevant probes are available. This work presents a core-shell polymeric nanocarrier with improved relaxometric properties for simultaneous PET/MRI acquisitions. MATERIALS & METHODS: Core-shell nanoparticles entrapping the Gd-DTPA and (18)F-FDG are obtained by a complex coacervation...
August 17, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28814127/carbon-nanotubes-functionalized-with-folic-acid-attached-via-biomimetic-peptide-linker
#20
Justyna Fraczyk, Malgorzata Walczak, Lukasz Szymanski, Zbigniew Kolacinski, Henryk Wrzosek, Ireneusz Majsterek, Karolina Przybylowska-Sygut, Zbigniew J Kaminski
AIM: Anchoring folic acid (FA) with a biomimetic peptidic linker resistant to proteolytic degradation to act as a homing device on functionalized carbon nanotubes. MATERIALS & METHODS: Ethylenediamine was attached to oxidized multiwalled carbon nanotubes (MWNTs) using 4-(4,6-dimethoxy-[1,3,5]triazin-2-yl)-4-methylmorpholinium tetrafluoroborate. FA was coupled with 6-aminohexanoic acid and derivatives of β-alanine, affording four intermediates, which connected to the MWNTs via peptidic linkers of various lengths...
August 17, 2017: Nanomedicine
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