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Nanomedicine

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https://www.readbyqxmd.com/read/30421644/how-nanomedicine-can-be-used-in-the-treatment-of-tumors-an-interview-with-dr-gang-zheng
#1
Gang Zheng, Marta Overchuk
Dr Zheng received his PhD in 1999 from SUNY Buffalo in Medicinal Chemistry. Following 2 years of postdoctoral training in photodynamic therapy at the Roswell Park Cancer Institute, he joined the University of Pennsylvania in 2001 as an Assistant Professor of Radiology, where he established the molecular imaging chemistry program and introduced photodynamic molecular beacons and lipoprotein-like nanoparticles. Since moving to Canada in 2006, his research has been focused on developing clinically translatable technology platforms to combat cancer...
November 13, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30411997/the-%C3%AF-%C3%AF-stacking-guided-supramolecular-self-assembly-of-nanomedicine-for-effective-delivery-of-antineoplastic-therapies
#2
Dongjuan Yang, Shan Gao, Yan Fang, Xiaojie Lin, Xuechao Jin, Xiyan Wang, Liyuan Ke, Kai Shi
In traditional nano drug-delivery systems, the complex chemical bonds between drug and carrier often complicate the preparation process and are less prone to rupture upon entry into the target, which is detrimental to the timely release of the drug. The π-π stacking provides us with a promising alternative as it is a weak interaction between the aromatic rings. Since most antitumor drugs are hydrophobic molecules with complex aromatic π-π-conjugated structures, the construction of self-assembly based on π-π stacking between drugs and carriers has the advantage of improving the stability and drug loading capacity as well as the improvement of hydrophilicity and biosafety...
November 9, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30398388/chemosensitizer-and-docetaxel-loaded-albumin-nanoparticle-overcoming-drug-resistance-and-improving-therapeutic-efficacy
#3
Jagdish P Desale, Rajan Swami, Varun Kushwah, Sameer S Katiyar, Sanyog Jain
AIM: Investigated strategy exploits the utilization of quercetin as a chemosensitizer for docetaxel (DTX), which was incorporated into albumin nanoparticles (NPs; bovine serum albumin NPs [BSA-NPs]). MATERIAL & METHODS: BSA-NPs containing both drugs were optimized, extensively characterized for different quality attributes and performance was investigated using series of in vitro and in vivo investigations. RESULTS: Co-encapsulated BSA-NPs exhibited size: 209...
November 6, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30398084/ultrasonic-assisted-synthesis-and-dna-interaction-studies-of-two-new-ru-complexes-ruo-2-nanoparticles-preparation
#4
Jun-Jie Xue, Fahime Bigdeli, Jian-Ping Liu, Mao-Lin Hu, Ali Morsali
AIM: To study of the interactions of two new ruthenium(II) complexes (C1 and C2) with calf thymus (CT)-DNA; production of RuO2 nanoparticles using the complexes precursor. MATERIALS & METHODS: Complex C1 was characterized by x-ray crystallography. The binding of the complexes with (CT)-DNA was studied using techniques that include electronic absorption spectra, fluorescence and redox behavior. The preparation of RuO2 nanoparticles was carried out by thermal decomposition...
November 6, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30394201/as1411-aptamer-decorated-cisplatin-loaded-poly-lactic-co-glycolic-acid-nanoparticles-for-targeted-therapy-of-mir-21-inhibited-ovarian-cancer-cells
#5
Somayeh Vandghanooni, Morteza Eskandani, Jaleh Barar, Yadollah Omidi
AIM: The overexpression of miRNA-21 correlates with the cisplatin (CIS) resistance in the ovarian cancers. METHODS: AS1411 antinucleolin aptamer-decorated PEGylated poly(lactic-co-glycolic acid) nanoparticles containing CIS (Ap-CIS-NPs) and anti-miR-21 (Ap-anti-miR-21-NPs) were prepared, physicochemically investigated and their cancer-targeting ability was confirmed. CIS-resistant A2780 cells (A2780 R) were infected with anti-miR-21 using Ap-anti-miR-21-NPs to decrease the drug resistance and sensitize the cells to CIS...
November 5, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30394178/effects-of-zno-nanoparticles-on-intestinal-function-and-structure-in-normal-high-fat-diet-fed-rats-and-caco-2-cells
#6
Ebrahim Abbasi-Oshaghi, Fatemeh Mirzaei, Amir Mirzaei
AIM: The present study was carried out to determine the effects of ZnO nanoparticles (ZnO-NPs) on intestinal function and pathophysiological alteration. MATERIALS & METHODS: ZnO-NPs were synthesized and their characterizations were performed using various techniques. The Wistar male rats fed with normal diet and/or high fat diet (HFD) for 8 weeks and then orally received ZnO-NPs (5, 50 and 100 mg/kg bodyweight) for 28 days. The oxidative stress (SOD, CAT, GPx), inflammatory (TNF-α, iNOS) and apoptosis pathways (Bcl2, Bax and p53) genes expression and protein levels were measured by real-time polymerase chain reaction and available kit, respectively...
November 5, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30394176/zn-doped-cuo-nanocomposites-inhibit-tumor-growth-by-nf-%C3%AE%C2%BAb-pathway-cross-linked-autophagy-and-apoptosis
#7
Huanli Xu, Ru Yuan, Xiaohui Liu, Xiao Li, Gan Qiao, Cong Li, Aharon Gedanken, Xiukun Lin
AIM: To investigate the antitumor effects and action mechanism of Zn-doped CuO nanocomposites (Zn-CuONPs). MATERIALS & METHODS: Therapeutic effects and mechanisms of Zn-CuONPs were investigated both in vitro and in vivo. RESULTS: Zn-CuONPs could inhibit tumor growth both in vitro and in vivo significantly. Zn-CuONPs treatment resulted in cytotoxicity, reactive oxygen species (ROS) production, DNA damage, apoptosis and autophagy. ROS scavenger N-acetylcysteine attenuated all of the above effects induced by Zn-CuONPs...
November 5, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30362877/pre-analytical-influences-on-the-population-heterogeneity-of-human-extracellular-vesicles-sourced-for-nanomedicine-uses
#8
Joshua L Hood
No abstract text is available yet for this article.
October 26, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30354963/nanoparticles-for-postinfarct-ventricular-remodeling
#9
Caijuan Dong, Aiqun Ma, Lijun Shang
In recent years, tremendous progress has been made in the treatment of acute myocardial infarction, but pathological ventricular remodeling often causes survivors to suffer from fatal heart failure. Currently, there is no effective therapy to attenuate ventricular remodeling. Recently, nanoparticle-based drug delivery systems are widely applied in biomedicine especially in cancer and liver fibrosis, owing to its excellent physical, chemical and biological properties. Therefore, the use of nanoparticles as delivery vehicles of small molecules, polypeptides, etc...
October 24, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30346253/polyethylene-glycol-coated-zinc-oxide-nanoparticle-an-efficient-nanoweapon-to-fight-against-herpes-simplex-virus-type-1
#10
Ahmad Tavakoli, Angila Ataei-Pirkooh, Gity Mm Sadeghi, Farah Bokharaei-Salim, Peyman Sahrapour, Seyed J Kiani, Mohsen Moghoofei, Mohammad Farahmand, Davod Javanmard, Seyed H Monavari
AIM: We aimed to determine the possible inhibitory effects of zinc oxide nanoparticles (ZnO-NPs) and polyethylene glycol (PEG)-coated ZnO-NPs (ZnO-PEG-NPs) on herpes simplex virus type 1 (HSV-1). MATERIALS & METHODS: PEGylated ZnO-NPs were synthesized by the mechanical method. Antiviral activity was assessed by 50% tissue culture infectious dose (TCID50 ) and real-time PCR assays. To confirm the antiviral activity of ZnO-NPs on expression of HSV-1 antigens, indirect immunofluorescence assay was also conducted...
October 22, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30338723/-19-f-mri-in-orthotopic-cancer-model-via-intratracheal-administration-of-%C3%AE-%C3%AE-%C3%AE-3-targeted-perfluorocarbon-nanoparticles
#11
Xiuan Xu, Ruixin Zhang, Fang Liu, Jiaqi Ping, Xiaofei Wen, Hongbin Wang, Kai Wang, Xilin Sun, Hongyan Zou, Baozhong Shen, Lina Wu
AIM: To demonstrate the feasibility of intratracheal administration in orthotopic lung cancer model with 19 F MRI. MATERIALS & METHODS: αv β3 -integrin targeting ability of the perfluorocarbon (PFC) nanoparticles was tested. Orthotopic lung cancer model was established in rabbits under computed tomography guidance. αv β3 -targeted PFC nanoparticles were administrated intratracheally or intravenously, and 19 F MRI was performed before and up to 24 h after administration...
October 19, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30338706/caveolin-1-containing-extracellular-vesicles-transport-adhesion-proteins-and-promote-malignancy-in-breast-cancer-cell-lines
#12
America Campos, Carlos Salomon, Rocio Bustos, Jorge Díaz, Samuel Martínez, Veronica Silva, Constanza Reyes, Natalia Díaz-Valdivia, Manuel Varas-Godoy, Lorena Lobos-González, Andrew Fg Quest
Breast cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths in women worldwide, whereby mortality is largely attributable to the development of distant metastasis. Caveolin-1 (CAV1) is a multifunctional membrane protein that is typically upregulated in the final stages of cancer and promotes migration and invasion of tumor cells. Elevated levels of CAV1 have been detected in extracellular vesicles (EVs) from advanced cancer patients. EVs are lipid enclosed vesicular structures that contain bioactive proteins, DNA and RNAs, which can be transferred to other cells and promote metastasis...
October 19, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30338705/lactoferrin-tagged-quantum-dots-based-theranostic-nanocapsules-for-combined-cox-2-inhibitor-herbal-therapy-of-breast-cancer
#13
Ahmed S AbdElhamid, Dina G Zayed, Maged W Helmy, Shaker M Ebrahim, Mohammed Bahey-El-Din, Esmat A Zein-El-Dein, Sanaa A El-Gizawy, Ahmed O Elzoghby
AIM: Herein, tumor-targeted quantum dots (QDs)-based theranostic nanocapsules (NCs) coloaded with celecoxib and honokiol were developed. Materials & methodology: The anionic CD44-targeting chondroitin sulfate and cationic low density lipoprotein (LDL)-targeting lactoferrin (LF) were sequentially assembled onto the surface of the positively charged oily core. As an imaging probe, highly fluorescent mercaptopropionic acid-capped cadmium telluride QDs were coupled to LF. RESULTS: In vitro, fluorescence of QDs was quenched (OFF state) due to combined electron/energy transfer-mediated processes involving LF...
October 19, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30338704/highly-efficient-and-biocompatible-nanoparticle-based-photosensitizer-for-treatment-of-acne-vulgaris
#14
Peng Wang, Hong Tang, Peng Zhang
AIM: Nanoparticle-based photosensitizers containing silver core and mesoporous silica shell with hematoporphyrin IX embedded were developed to treat vulgaris photodynamically. MATERIALS & METHODS: The hybrid photosensitizers were dispersed in 30% polyethylene glycol (PEG-200) solution and used for the photodynamic treatment of Staph epidermidis and Propionibacterium acnes under the illumination of a portable LED (∼410 nm). RESULTS: After a 5 min illumination by the LED, the hybrid photosensitizers of 50 μg/ml displayed killing efficacy of approximately 5-log for S...
October 19, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30334683/development-of-poly-2-ethyl-2-oxazoline-coated-gold-core-silica-shell-nanorods-for-cancer-chemo-photothermal-therapy
#15
André F Moreira, Carolina F Rodrigues, Catarina A Reis, Elisabete C Costa, Paula Ferreira, Ilídio J Correia
AIM: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. METHODS: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ silane derivative. RESULTS: The PEOZ chemical grafting on the surface of AuMSS nanorods allowed the neutralization of nanodevices' surface charge, from -30 to -15 mV, which improved nanoparticles' biocompatibility, namely by decreasing the blood hemolysis to negligible levels...
October 18, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30334677/as1411-aptamer-targeted-gold-nanoclusters-effect-on-the-enhancement-of-radiation-therapy-efficacy-in-breast-tumor-bearing-mice
#16
Fatemeh Ghahremani, Amirhosein Kefayat, Daryoush Shahbazi-Gahrouei, Hasan Motaghi, Masoud A Mehrgardi, Shaghayegh Haghjooy-Javanmard
AIM: Herein, the AS1411 aptamer-targeted ultrasmall gold nanoclusters (GNCs) were assessed at different aspects as a radiosensitizer. MATERIALS & METHODS: AS1411 aptamer-conjugated gold nanoclusters (Apt-GNCs) efficacy was evaluated at cancer cells targeting, radiosensitizing effect, tumor targeting, and biocompatibility in breast tumor-bearing mice. RESULTS: Flow cytometry and fluorescence microscopy exhibited more cellular uptake for Apt-GNCs in comparison with GNCs...
October 18, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30334671/aurora-kinase-b-sirna-loaded-lactoferrin-nanoparticles-potentiate-the-efficacy-of-temozolomide-in-treating-glioblastoma
#17
Sonali Kumari, Dwaipayan Bhattacharya, Nandini Rangaraj, Sumana Chakarvarty, Anand K Kondapi, Nalam M Rao
AIM: To investigate the efficacy of lactoferrin nanoparticles (LfNPs) in delivering siRNA across the blood-brain barrier to treat glioblastoma multiforme (GBM) and with an additional objective of potentiation of conventional temozolomide (TMZ) chemotherapy. METHODS: Aurora Kinase B (AKB) siRNA-loaded nanoparticles (AKB-LfNPs) were prepared with milk protein, lactoferrin, by water in oil emulsion method. AKB-LfNPs were tested in cell lines and in GBM orthotopic mouse model with and without TMZ treatment...
October 18, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30334476/modulation-of-gene-expression-in-rat-muscle-cells-following-treatment-with-nanoceria-in-different-gravity-regimes
#18
Giada Graziana Genchi, Andrea Degl'Innocenti, Alice Rita Salgarella, Ilaria Pezzini, Attilio Marino, Arianna Menciassi, Sara Piccirillo, Michele Balsamo, Gianni Ciofani
AIM: Oxidative stress (OS) is strictly associated with senescence/pathogenesis of biological systems. As putative countermeasure to environmental OS, cerium oxide nanoparticles (nanoceria [NC]) were administered to muscle cells on ground and aboard the International Space Station. MATERIALS & METHODS: Transcriptional analyses were conducted through microarray technology and hierarchical clustering. Venn diagram and gene ontology analyses were also performed on selected gene lists...
October 18, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30334470/understanding-the-elusive-protein-corona-of-thermoresponsive-nanogels
#19
Enrico Miceli, Benno Kuropka, Christine Rosenauer, Ernesto R Osorio Blanco, Loryn E Theune, Mrityunjoy Kar, Christoph Weise, Svenja Morsbach, Christian Freund, Marcelo Calderón
AIM: We analyzed the protein corona of thermoresponsive, poly(N-isopropylacrylamide)- or poly(N-isopropylmethacrylamide)-based nanogels. MATERIALS & METHODS: Traces of protein corona detected after incubation in human serum were characterized by proteomics and dynamic light scattering in undiluted serum. RESULTS: Apolipoprotein B-100 and albumin were the main components of the protein coronae. For dendritic polyglycerol-poly(N-isopropylacrylamide) nanogels at 37°C, an increase in adsorbed immunoglobulin light chains was detected, followed by partially reversible nanogel aggregation...
October 18, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30328369/vitamin-b12-conjugated-sericin-micelles-for-targeting-cd320-overexpressed-gastric-cancer-and-reversing-drug-resistance
#20
Weihong Guo, Lizhi Deng, Zhaoyu Chen, Zhian Chen, Jiang Yu, Hao Liu, Tuanjie Li, Tian Lin, Hao Chen, Mingli Zhao, Liming Zhang, Guoxin Li, Yanfeng Hu
AIM: Our previous research has introduced sericin micelles to reverse drug resistance. However, these micelles could not selectively bind to gastric cancer (GC) cells. We developed vitamin B12 (VB12) conjugated sericin micelles for targeted GC therapy. MATERIALS & METHODS: We used VB12, sericin, synthetic poly(γ-benzyl-L-glutamate) (PBLG) and paclitaxel (PTX) to develop VB12-conjugated and PTX-loaded micelles (VB12-sericin-PBLG-PTX). Then we explored their physicochemical properties, cellular uptake and antitumor mechanism...
October 17, 2018: Nanomedicine
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