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Michael R King, Zeinab J Mohamed
No abstract text is available yet for this article.
November 25, 2016: Nanomedicine
Yang Li, Nancy A Monteiro-Riviere
AIM: To assess inflammation, cellular uptake and endocytic mechanisms of gold nanoparticles (AuNP) in human epidermal keratinocytes with and without a protein corona. MATERIALS & METHODS: Human epidermal keratinocytes were exposed to 40 and 80 nm AuNP with lipoic acid, polyethylene glycol (PEG) and branched polyethyleneimine (BPEI) coatings with and without a protein corona up to 48 h. Inhibitors were selected to characterize endocytosis. RESULTS & CONCLUSION: BPEI-AuNP showed the greatest uptake, while PEG-AuNP had the least...
November 24, 2016: Nanomedicine
Emanuela F Craparo, Barbara Porsio, Domenico Schillaci, Maria G Cusimano, Dario Spigolon, Gaetano Giammona, Gennara Cavallaro
AIM: Efficacy of antibiotics in cystic fibrosis (CF) is compromised by the poor penetration through mucus barrier. This work proposes a new 'nano-into-micro' approach, used to obtain a combinatorial effect: achieve a sustained delivery of tobramycin and overcome mucus barrier. METHODS: Mannitol microparticles (MPs) were loaded with a tobramycin polymeric nanocomplex and characterized in presence of CF artificial mucus. RESULTS & DISCUSSION: MPs are able to alter the rheological properties of CF artificial mucus, enhancing drug penetration into it and allowing a prolonged drug release...
November 23, 2016: Nanomedicine
Gul Shahnaz, Benson J Edagwa, JoEllyn McMillan, Sohail Akhtar, Abida Raza, Naveeda A Qureshi, Masoom Yasinzai, Howard E Gendelman
AIM: Our goal was to improve treatment outcomes for visceral leishmaniasis by designing nanocarriers that improve drug biodistribution and half-life. Thus, long-acting mannose-anchored thiolated chitosan amphotericin B nanocarrier complexes (MTC AmB) were developed and characterized. MATERIALS & METHODS: A mannose-anchored thiolated chitosan nanocarrier was manufactured and characterized. MTC AmB was examined for cytotoxicity, biocompatibility, uptake and antimicrobial activities...
November 23, 2016: Nanomedicine
Sri Vishnu Kiran Rompicharla, Prakruti Trivedi, Preeti Kumari, Pratyusha Ghanta, Balaram Ghosh, Swati Biswas
AIM: To improve the bioavailability and anticancer potential of suberoylanilide hydroxamic acid (SAHA) by developing a drug-loaded polymeric nanomicellar system. METHODS: SAHA-loaded Poly(ethylene glycol)-block-poly(caprolactone) (PEG-PCL) micelles were developed, and physico-chemically characterized. In vitro cellular uptake, viability and apoptosis-inducing ability of the SAHA-PEG-PCL micelles were investigated. In vivo anticancer activity was evaluated in C57BL/6 mice-bearing tumor...
November 23, 2016: Nanomedicine
Maria Vetro, Dodi Safari, Silvia Fallarini, Korrie Salsabila, Martina Lahmann, Soledad Penadés, Luigi Lay, Marco Marradi, Federica Compostella
AIM: Nanotechnology-based fully synthetic carbohydrate vaccines are promising alternatives to classic polysaccharide/protein conjugate vaccines. We have prepared gold glyco-nanoparticles (GNP) bearing two synthetic carbohydrate antigens related to serotypes 19F and 14 of Streptococcus pneumoniae and evaluated their immunogenicity in vivo. RESULTS: A tetrasaccharide fragment of serotype 14 (Tetra-14), a trisaccharide fragment of serotype 19F (Tri-19F), a T-helper peptide and d -glucose were loaded onto GNP in different ratios...
November 23, 2016: Nanomedicine
Maria Molina, Stefanie Wedepohl, Enrico Miceli, Marcelo Calderón
AIM: To develop nanogels (NG) able to modulate the encapsulation and release of drugs, in order to circumvent drug resistance mechanisms in cancer cells. MATERIALS & METHODS: Poly-N-isopropylacrylamide-dendritic polyglycerol NG were semi-interpenetrated with 2-acrylamido-2-methylpropane sulfonic acid or (2-dimethylamino) ethyl methacrylate. Physico-chemical properties of the NGs as well as doxorubicin (DOXO) loading and release were characterized. Drug delivery performance was investigated in vitro and in vivo in a multidrug-resistant tumor model...
November 23, 2016: Nanomedicine
Lei Zhu, Zhiyang Zhou, Hui Mao, Lily Yang
Recent advances in the development of magnetic nanoparticles (MNPs) have shown promise in the development of new personalized therapeutic approaches for clinical management of cancer patients. The unique physicochemical properties of MNPs endow them with novel multifunctional capabilities for imaging, drug delivery and therapy, which are referred to as theranostics. To facilitate the translation of those theranostic MNPs into clinical applications, extensive efforts have been made on designing and improving biocompatibility, stability, safety, drug-loading ability, targeted delivery, imaging signal and thermal- or photodynamic response...
November 23, 2016: Nanomedicine
Li Min Tay, Chenjie Xu
No abstract text is available yet for this article.
November 23, 2016: Nanomedicine
Hui Tan, Dengfeng Cheng
No abstract text is available yet for this article.
November 23, 2016: Nanomedicine
Max L Senders, Zahi A Fayad, Thomas Reiner, Willem Jm Mulder, Carlos Pérez-Medina
No abstract text is available yet for this article.
November 23, 2016: Nanomedicine
Azadeh Haeri, Saeed Sadeghian, Shahram Rabbani, Shapour Shirani, Maryam Sotoudeh Anvari, Simin Dadashzadeh
AIM: To develop an ameliorated sirolimus (SIR) liposome for intramural delivery, the effects of various carrier physicochemical parameters on the antirestenosis efficacy were evaluated. MATERIALS & METHODS: Different liposomes were prepared, characterized and administered to balloon injured rats (12 animal groups). Their efficacies were investigated using morphometric, immunohistochemical and in vivo computed tomography imaging analyses. RESULTS: The antirestenosis efficacy of SIR liposomes decreased in the following order: cationic 100 nm vesicles ≥ cationic 60 nm vesicles > neutral 100 nm vesicles ≥ stealth 100 nm vesicles > anionic 100 nm vesicles...
November 23, 2016: Nanomedicine
Mauricio P Pinto, Maximiliano Arce, Basit Yameen, Cristian Vilos
Brain tumors display the highest mortality rates of all childhood cancers, and over the last decade its prevalence has steadily increased in elderly. To date, effective treatments for brain tumors and particularly for malignant gliomas remain a challenge mainly due to the low permeability and high selectivity of the blood-brain barrier (BBB) to conventional anticancer drugs. In recent years, the elucidation of the cellular mechanisms involved in the transport of substances into the brain has boosted the development of therapeutic-targeted nanoparticles (NPs) with the ability to cross the BBB...
November 23, 2016: Nanomedicine
Michael Evangelopoulos, Ennio Tasciotti
No abstract text is available yet for this article.
November 23, 2016: Nanomedicine
Yanjun Chen, Qiaoxin Yue, Gejing De, Jie Wang, Zhenzhen Li, Shuiming Xiao, Huatao Yu, Hai Ma, Feng Sui, Qinghe Zhao
AIM: Tumor metastasis is one of the leading causes of insufficient chemotherapy during cancer treatment. In this study, a poly(β-amino ester) derivate was developed to fabricate paclitaxel (PTX) entrapped pH-responsive copolymer micelles for inhibition of breast cancer metastasis. MATERIALS & METHODS: PTX-loaded micelles were fabricated by thin film hydration method. The inhibition efficacy of the as-prepared micelles was evaluated on MDA-MB-231 cells and tumor bearing mice...
November 17, 2016: Nanomedicine
Mohammad Izadifar, Michael E Kelly, Xiongbiao Chen
AIM: Cardiac tissue engineering aims to develop engineered constructs for myocardial infarction repair, where a challenge is the control of growth factor (GF) sequential release. Herein, bilayer polymeric nanoparticles composed of a GF-encapsulating core surrounded by rate-regulating shell were developed for sequential GF release. MATERIALS & METHODS: Single and bilayer polymeric nanoparticles were fabricated, characterized and biologically assessed. A novel 'Geno-Neural model' was developed and validated for rate-programming of the nanoparticles...
November 17, 2016: Nanomedicine
Jie Gao, Wei Li, Yajun Guo, Si-Shen Feng
Cancer stem cells (CSCs) are original cancer cells that are of characteristics associated with normal stem cells. CSCs are toughest against various treatments and thus responsible for cancer metastasis and recurrence. Therefore, development of specific and effective treatment of CSCs plays a key role in improving survival and life quality of cancer patients, especially those in the metastatic stage. Nanomedicine strategies, which include prodrugs, micelles, liposomes and nanoparticles of biodegradable polymers, could substantially improve the therapeutic index of conventional therapeutics due to its manner of sustained, controlled and targeted delivery of high transportation efficiency across the cell membrane and low elimination by intracellular autophagy, and thus provide a practical solution to solve the problem encountered in CSCs treatment...
November 17, 2016: Nanomedicine
Qiang Zhang, Zhengjie Zhou, Yitong Wang, Yiyun Cheng
No abstract text is available yet for this article.
November 15, 2016: Nanomedicine
Nirmal Marasini, Ashwini K Giddam, Zeinab G Khalil, Waleed M Hussein, Robert J Capon, Michael R Batzloff, Michael F Good, Istvan Toth, Mariusz Skwarczynski
AIM: To develop novel polymer-based nanoscale delivery system for lipopeptide-based vaccine against group A Streptococcus (GAS). MATERIALS & METHODS: Four types of lipopeptide antigen-loaded polymeric nanoparticles (NP) were prepared. NP were accessed for their capacity to be taken up by dendritic cells; effect on dendritic cell maturation; ability to induce mucosal and systemic immunity; and capability to induce antibody responses that opsonize GAS bacteria. RESULTS & DISCUSSION: The combination of adjuvanting properties of lipopeptides and dextran/trimethyl chitosan-based NP had a synergistic effect on humoral immunity, and the produced antibodies showed high opsonic activity against clinical GAS isolates...
November 10, 2016: Nanomedicine
Cátia Df Lopes, Carla P Gomes, Estrela Neto, Paula Sampaio, Paulo Aguiar, Ana P Pêgo
AIM: Propose a nanoparticle for neuron-targeted retrograde gene delivery and describe a microfluidic-based culture system to provide insight into vector performance and safety. METHODS: Using compartmentalized neuron cultures we dissected nanoparticle bioactivity upon delivery taking advantage of (quantitative) bioimaging tools. RESULTS: Targeted and nontargeted nanoparticles were internalized at axon terminals and retrogradely transported to cell bodies at similar average velocities but the former have shown an axonal flux 2...
November 10, 2016: Nanomedicine
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