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Ye Xiaolong, Han Xiaoyan, Wei Bo, Huang Jianglong, Yang Xiaofeng, Tang Xiao, Zheng Zongheng, Luo Linbo, Zhan Zefeng, Wei Hongbo
AIM: In the present study, we combined a nanofibrous polylactic acid (PLA) scaffold fabricated by electrospinning with a polypropylene (PP) material to generate a new type of mesh for hernia repair. MATERIALS & METHODS: The PLA/PP mesh was tested with tensile testing, in vitro cytocompatibility and degradation. A total of 90 rats were randomly allocated to PLA/PP, PP and polyester (PE) mesh groups for the in vivo study to evaluate the properties of PLA/PP mesh...
July 12, 2018: Nanomedicine
Valentín Ceña, Pablo Játiva
No abstract text is available yet for this article.
July 12, 2018: Nanomedicine
Chun-Han Chen, Chih-Jung Chen, Ahmed O Elzoghby, Ta-Sen Yeh, Jia-You Fang
AIM: Whether the obesity prevention by chemicals or surgeries in already obese patients is the better choice remains controversial. We aimed to compare the effect of orally silibinin-loaded nanocarriers and Roux-en-Y gastric bypass surgery on hepatic fibrosis in high-fat feeding-induced obese rats. METHODOLOGY: The developed nanocarriers included self-emulsifying drug delivery system (SNEDDS) and nanostructured lipid carriers (NLC). RESULTS: A significant decrease in collagen production and lipid droplet formation was observed upon nanosystem and bariatric surgery than the rats treated with silibinin control suspension...
July 12, 2018: Nanomedicine
Fatemeh Nowroozi, Simin Dadashzadeh, Hoorieh Soleimanjahi, Azadeh Haeri, Soraya Shahhosseini, Jaber Javidi, Hesam Karimi
AIM: For simultaneous bioimaging and drug delivery via direct intratumoral injection, doxorubicin and Ag2 S quantum dots co-loaded multifunctional niosomes were prepared and fully characterized. MATERIALS & METHODS: Various theranostic niosomes were prepared and investigated regarding cytotoxicity, in vivo imaging, drug accumulation in breast cancer tumor and antitumor activity. RESULTS: Niosomes composed of Tween-60, Tween-80 or Span 60 produced strong and more durable detectable fluorescence signals...
July 11, 2018: Nanomedicine
Shaymaa W El-Far, Maged W Helmy, Sherine N Khattab, Adnan A Bekhit, Ahmed A Hussein, Ahmed O Elzoghby
AIM: Monascin and ankaflavin, the major fractions of the fungal-derived monascus yellow pigments, were incorporated with the herbal drug, resveratrol (RSV) within the core of folate-conjugated casein micelles (FA-CAS MCs, F1) for active targeting. PEGylated RSV-phospholipid complex bilayer enveloping casein-loaded micelles (PEGPC-CAS MCs) were also developed as passive-targeted nanosystem. RESULTS: FA- and PEGPC-CAS MCs demonstrated a proper size with monomodal distribution, sustained drug release profiles and good hemocompatibility...
June 29, 2018: Nanomedicine
Hardi Jogi, Rahul Maheshwari, Nidhi Raval, Kaushik Kuche, Vishakha Tambe, Kit-Kay Mak, Mallikarjuna Rao Pichika, Rakesh Kumar Tekade
Cancer is estimated to be a significant health problem of the 21st century. The situation gets even tougher when it comes to its treatment using chemotherapy employing synthetic anticancer molecules with numerous side effects. Recently, there has been a paradigm shift toward the adoption of herbal drugs for the treatment of cancer. In this context, a suitable delivery system is principally warranted to deliver these herbal biomolecules specifically at the tumorous site. To achieve this goal, carbon nanotubes (CNTs) have been widely explored to deliver anticancer herbal molecules with improved therapeutic efficacy and safety...
June 15, 2018: Nanomedicine
Mónica Vicente-Pascual, Andrea Albano, María Á Solinís, Loredana Serpe, Alicia Rodríguez-Gascón, Federica Foglietta, Elisabetta Muntoni, Josune Torrecilla, Ana Del Pozo-Rodríguez, Luigi Battaglia
AIM: Inflammation is a process that underlies sight-threatening ocular surface diseases, and gene supplementation with the plasmid that encodes for p-IL10 will allow the sustained de novo synthesis of the cytokine to occur in corneal cells, and provide a long-term anti-inflammatory effect. This work describes the development of solid lipid nanoparticle systems for the delivery of p-IL10 to transfect the cornea. RESULTS: In vitro, vectors showed suitable features as nonviral vectors (size, ζ-potential, DNA binding, protection and release), and they were able to enter and transfect human corneal epithelial cells...
May 24, 2018: Nanomedicine
Huawei Cai, Fang Xie, Aditi Mulgaonkar, Lihong Chen, Xiankai Sun, Jer-Tsong Hsieh, Fangyu Peng, Rong Tian, Lin Li, Changqiang Wu, Hua Ai
AIM: To synthesize and evaluate the imaging potential of Bom-PEG-[64 Cu]CuS nanoparticles (NPs) in orothotopic prostate tumor. MATERIALS & METHODS: [64 Cu]CuS NPs were synthesized in aqueous solution by 64 CuCl2 and Na2 S reaction. Then PEG linker with or without bombesin peptide were conjugated to the surface of [64 Cu]CuS NPs to produce Bom-PEG-[64 Cu]CuS and PEG-[64 Cu]CuS NPs. These two kinds of NPs were used for testing specific uptake in prostate cancer cells in vitro and imaging of orthotopic prostate tumor in vivo...
May 22, 2018: Nanomedicine
Jan Martel, Cheng-Yeu Wu, Hsin-Hsin Peng, John D Young
We observed earlier that mineralo-organic nanoparticles form in human body fluids when the concentrations of calcium, carbonate and phosphate exceed saturation. The particles have been shown to represent mineral precursors in developing bones and teeth as well as in ectopic calcification and kidney stones. Recent studies suggest that the mineral particles may also be involved in other physiological processes, including immune tolerance against the gut microbiota and food antigens. We review here the involvement of mineralo-organic nanoparticles in physiological and pathological processes and discuss recent findings that reveal novel and unexpected roles for these particles in the human body...
May 22, 2018: Nanomedicine
Matte Kasi Viswanadh, Madaswamy S Muthu
No abstract text is available yet for this article.
June 2018: Nanomedicine
Yanchun Wei, Li Quan, Chao Zhou, Qiuqiang Zhan
Nanoparticles have promising biomedical applications for drug delivery, tumor imaging and tumor treatment. Pharmacokinetics are important for the in vivo application of nanoparticles. Biodistribution and clearance are largely defined as the key points of pharmacokinetics to maximize therapeutic efficacy and to minimize side effects. Different engineered nanoparticles have different biodistribution and clearance processes. The interactions of organs with nanoparticles, which are determined by the characteristics of the organs and the biochemical/physical properties of the nanoparticles, are a major factor influencing biodistribution and clearance...
June 2018: Nanomedicine
Simón Guerrero, Victor Manuel Díaz-García, Pamela Contreras-Orellana, Pablo Lara, Sujey Palma, Fanny Guzman, Lorena Lobos-Gonzalez, Areli Cárdenas, Ximena Rojas-Silva, Luis Muñoz, Lisette Leyton, Marcelo J Kogan, Andrew Fg Quest
AIM: To track early events during lung metastasis, we labeled cells expressing (B16F10CAV1 ) or lacking CAV1 (B16F10mock ) with gold nanoparticles conjugated to the peptide TAT (AuNPs-PEG-TAT). METHODS: B16F10 expressing or lacking CAV1 were labeled with AuNPs-PEG-TAT. The physicochemical properties and cytotoxicity of these nanoparticles, as well as their effects on migration and invasiveness of B16F10 cells in vitro were evaluated. Ex vivo lung distribution of the labeled cells after tail vein injection into C57BL/6 mice was examined...
June 2018: Nanomedicine
Sanyog Jain, Dnyaneshwar P Kale, Rajan Swami, Sameer S Katiyar
AIM: Current study investigates therapeutic efficacy and tolerability of benzoyl peroxide (BPO)- and adapalene (AD)-loaded modified liposomal gel (BPO-AD-mLipo gel) for improved acne therapy. MATERIALS & METHOD: BPO-AD-mLipo were optimized and loaded in Carbopol gel. Both BPO-AD-mLipo and BPO-AD-mLipo-gel were extensively characterized for different quality attributes. Ex vivo dermal bioavailability, dermal distribution, in vivo anti-acne efficacy and skin irritation studies were performed and compared with marketed formulation (Epiduo® , Galderma Laboratories LP, TX, USA)...
June 2018: Nanomedicine
Sin-Ge Wang, Yen-Chun Chen, Yu-Chie Chen
AIM: The extensive use of vancomycin has given rise to vancomycin-resistant bacterial strains, such as vancomycin-resistant Enterococci (VRE). We aim to explore potent medical treatments that can inhibit the growth of VRE. MATERIALS & METHODS: Vancomycin-immobilized gold nanoparticles (Au@Van NPs) with polygonal shapes from one-pot reactions were generated within approximately 7 min. RESULTS & DISCUSSION: The as-prepared Au NPs exhibit not only antibacterial capability but also photothermal competence...
June 2018: Nanomedicine
Jiang Jiang, Yang Zhang, Arup K Indra, Gitali Ganguli-Indra, Mai N Le, Hongjun Wang, Ronald R Hollins, Debra A Reilly, Mark A Carlson, Richard L Gallo, Adrian F Gombart, Jingwei Xie
AIM: The aim of this study was to develop a nanofiber-based dressing capable of local sustained delivery of 1α,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ) and augmenting human CAMP induction. MATERIALS & METHODS: Nanofibrous wound dressings containing 1,25(OH)2 D3 were successfully prepared by electrospinning, which were examined in vitro, in vivo and ex vivo. RESULTS: 1,25(OH)2 D3 was successfully loaded into nanofibers with encapsulation efficiency larger than 90%...
June 2018: Nanomedicine
Pierre-Olivier Champagne, Harrison Westwick, Alain Bouthillier, Mohamad Sawan
Superparamagnetic iron oxide nanoparticles (SPIONs) consist of nanosized metallic-based particles with unique magnetic properties. Their potential in both diagnostic and therapeutic applications in the CNS is at the source of an expanding body of the literature in recent years. Colloidal stability of nanoparticles represents their ability to resist aggregation and is a central aspect for the use of SPION in biological environment such as the CNS. This review gives a comprehensive update of the recent developments and knowledge on the determinants of colloidal stability of SPIONs in the CNS...
June 2018: Nanomedicine
Kurtulus Gokduman, Furkan Bestepe, Lei Li, Martin L Yarmush, O Berk Usta
AIM: As a first study in literature, to investigate concentration-dependent (0-400 μg/ml) and exposure-dependent (single dosing vs cumulative dosing) effects of superparamagnetic iron oxide nanoparticles (d = 10 nm) on primary rat hepatocytes in a time-dependent manner. MATERIALS & METHODS: Sandwich-cultured hepatocyte model was used to evaluate viability, hepatocyte specific functions and reactive oxygen species level. RESULTS: In terms of all parameters, generally statistically more significant effects were observed in a concentration- and time-dependent manner...
June 2018: Nanomedicine
Cristian R Lillo, María Natalia Calienni, Roxana M Gorojod, María Belén Rivas Aiello, Damián Rodriguez Sartori, María Jimena Prieto, Silvia Del V Alonso, Mónica L Kotler, Mónica C Gonzalez, Jorge Montanari
Silicon blue-emitting nanoparticles (NPs) are promising effectors for photodynamic therapy and radiotherapy, because of their production of reactive oxygen species (ROS) upon irradiation. RESULTS: Amino-functionalized silicon NPs (NH2 SiNP) were intrinsically nontoxic below 100 μg/ml in vitro (on two tumor cell lines) and in vivo (zebrafish larvae and embryos). NH2 SiNP showed a moderate effect as a photosensitizer for photodynamic therapy and reduced ROS generation in radiotherapy, which could be indicative of a ROS scavenging effect...
June 2018: Nanomedicine
Ning Wu, Chunyun Zhang, Changhui Wang, Lairong Song, Weicheng Yao, Aharon Gedanken, Xiukun Lin, Dayong Shi
AIM: To assess the effect of zinc-doped copper oxide nanocomposites (nZn-CuO NPs) on glioblastoma therapy. MATERIALS & METHODS: nZn-CuO NPs were synthesized by sonochemical method and its antitumor effects and underlying molecular mechanisms were investigated both in vitro and in vivo. RESULTS: After nZn-CuO NPs treatment, cell proliferation was significantly inhibited in dividing cancer cells but less toxicity was observed in normal cells...
June 2018: Nanomedicine
Leiqiang Han, Tianqi Wang, Shengjun Mu, Xiaolan Yin, Shuang Liang, Hao Fang, Yongjun Liu, Na Zhang
AIM: To optimize the synergistic efficacy of combination therapy with controlled molar ratio, complex small molecule-based nanodrug (Co-SMND) of 5-fluorouracil (5-Fu)/vorinostat (SAHA) was developed. MATERIALS & METHODS: Co-SMND with various ratios of 5-Fu-D-α-tocopherol (VE)/SAHA-VE were prepared and characterized including co-assembly mechanism, hydrolytic stability, cytotoxicity, synergistic effect and apoptosis inducing ability. The antitumor activity, systematic toxicity and biodistribution of optimized Co-SMND were evaluated in CT-26 bearing BALB/c mouse...
June 2018: Nanomedicine
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