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Nanomedicine

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https://www.readbyqxmd.com/read/28322607/can-a-nanoparticle-that-mimics-salmonella-effectively-combat-tumor-chemotherapy-resistance
#1
Regino Mercado-Lubo, Beth A McCormick
No abstract text is available yet for this article.
March 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28322605/differential-dose-dependent-effects-of-zinc-oxide-nanoparticles-on-oxidative-stress-mediated-pancreatic-%C3%AE-cell-death
#2
Swati C Asani, Rinku D Umrani, Kishore M Paknikar
AIM: To study the effects of zinc oxide nanoparticles (ZON) on oxidative stress-mediated pancreatic β-cell death. METHODS: Cellular uptake of ZON, effects on antioxidant factors and apoptosis were studied. RESULTS: ZON get internalized by endocytosis and increase intracellular zinc ion levels. ZON treatment (30 and 100 μg/ml) to RIN5f cells resulted in cytotoxicity, oxidative stress and apoptosis. ZON (1, 3, 10 μg/ml, subcytotoxic concentrations) increased super oxide dismutase activity and levels of reduced glutathione in RIN5f cells...
March 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28322126/prenatal-exposure-to-nanosized-zinc-oxide-in-rats-neurotoxicity-and-postnatal-impaired-learning-and-memory-ability
#3
Feng Xiaoli, Wu Junrong, Lai Xuan, Zhang Yanli, Wei Limin, Liu Jia, Shao Longquan
AIM: To examine the neurotoxicity of prenatal exposure to ZnO nanoparticles on rat offspring. MATERIALS & METHODS: Pregnant Sprague-Dawley rats were exposed to ZnO nanoparticles (NPs) by gavage. Toxicity was assessed including zinc biodistribution, cerebral histopathology, antioxidant status and learning and memory capability. RESULTS: A significantly elevated concentration of zinc was detected in offspring brains. Transmission electron microscope observations showed abnormal neuron ultrastructures...
March 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28322118/evaluation-of-boron-nitride-nanotubes-and-hexagonal-boron-nitrides-as-nanocarriers-for-cancer-drugs
#4
Melis Emanet, Özlem Şen, Mustafa Çulha
AIM: Boron nitride nanotubes (BNNTs) and hexagonal boron nitrides (hBNs) are novel nanostructures with high mechanical strengths, large surface areas and excellent biocompatibilities. Here, the potential use of BNNTs and hBNs as nanocarriers was comparatively investigated for use with cancer drugs. MATERIALS & METHODS: Doxorubicin (Dox) and folate are used as model drugs and targeting agents, respectively. RESULTS & DISCUSSION: The obtained results indicate that BNNTs have about a threefold higher Dox loading capacity than hBNs...
March 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28322116/expanding-the-potential-of-mri-contrast-agents-through-multifunctional-polymeric-nanocarriers
#5
Ioana Craciun, Gesine Gunkel-Grabole, Andrea Belluati, Cornelia G Palivan, Wolfgang Meier
MRI is a sought-after, noninvasive tool in medical diagnostics, yet the direct application of contrast agents to tissue suffers from several drawbacks. Hosting the contrast agents in polymeric nanocarriers can solve many of these issues while creating additional benefit through exploitation of the intrinsic characteristics of the polymeric carriers. In this report, the versatility is highlighted with recent examples of dendritic and hyperbranched polymers, polymer nanoparticles and micelles, and polymersomes as multifunctional bioresponsive nanocarriers for MRI contrast agents...
March 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28322109/tio2-nanorod-arrays-as-a-photocatalytic-coating-enhanced-antifungal-and-antibacterial-efficiency-of-ti-substrates
#6
Lu Jia, Jichuan Qiu, Lingqian Du, Zhi Li, Hong Liu, Shaohua Ge
AIM: To investigate the photocatalytic inactivation of fungi and bacteria mediated by TiO2 nanorod arrays (TNRs). MATERIALS & METHODS: The features of TNRs were characterized by scanning electron microscopy, atomic force microscopy, transmission electron microscopy, x-ray diffraction (XRD) and contact angle measurement. The antimicrobial efficiency was detected on biofilm and planktonic forms of Candida albicans, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis by crystal violet and XTT (2,3-bis [2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-caboxanilide) assay, confocal laser scanning microscope and colony-forming assay...
March 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28322108/polymeric-glabrescione-b-nanocapsules-for-passive-targeting-of-hedgehog-dependent-tumor-therapy-in-vitro
#7
Cinzia Ingallina, Pedro M Costa, Francesca Ghirga, Rebecca Klippstein, Julie T Wang, Simone Berardozzi, Naomi Hodgins, Paola Infante, Steven M Pollard, Bruno Botta, Khuloud T Al-Jamal
AIM: With the purpose of delivering high doses of glabrescione B (GlaB) to solid tumors after systemic administration, long-circulating GlaB-loaded oil-cored polymeric nanocapsules (NC-GlaB) were formulated. MATERIALS & METHODS: Synthesis of GlaB and its encapsulation in nanocapsules (NCs) was performed. Empty and GlaB-loaded NCs were assessed for their physico-chemical properties, in vitro cytotoxicity and in vivo biodistribution. RESULTS: GlaB was efficiently loaded into NCs (∽90%), which were small (∽160 nm), homogeneous and stable upon storage...
March 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28322107/surface-modulation-of-polymeric-nanocarriers-enhances-the-stability-and-delivery-of-proteins-and-small-molecules
#8
Zohreh Amoozgar, Michael S Goldberg
AIM: We aimed to enhance the stability and therapeutic efficiency of protein-based therapeutic formulations. MATERIALS & METHODS: Proteins were immobilized on the surface of nanoparticles (NPs) to improve both protein stability and protein function, especially enzymatic activity. The modularity of the platform was demonstrated by coating proteins of varied molecular weights and functionalities on the surface of poly(lactic-co-glycolic acid)-based NPs. RESULTS: Coating proteins to the particle surface greatly enhanced the stability of the NPs, preventing particle aggregation and improving enzymatic potency, including in vivo...
March 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28327075/magnetic-nanobubbles-with-potential-for-targeted-drug-delivery-and-trimodal-imaging-in-breast-cancer-an-in-vitro-study
#9
Weixiang Song, Yindeng Luo, Yajing Zhao, Xinjie Liu, Jiannong Zhao, Jie Luo, Qunxia Zhang, Haitao Ran, Zhigang Wang, Dajing Guo
AIM: The aim of this study was to improve tumor-targeted therapy for breast cancer by designing magnetic nanobubbles with the potential for targeted drug delivery and multimodal imaging. MATERIALS & METHODS: Herceptin-decorated and ultrasmall superparamagnetic iron oxide (USPIO)/paclitaxel (PTX)-embedded nanobubbles (PTX-USPIO-HER-NBs) were manufactured by combining a modified double-emulsion evaporation process with carbodiimide technique. PTX-USPIO-HER-NBs were examined for characterization, specific cell-targeting ability and multimodal imaging...
March 13, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28186465/solid-lipid-nanoparticles-by-coacervation-loaded-with-a-methotrexate-prodrug-preliminary-study-for-glioma-treatment
#10
Luigi Battaglia, Elisabetta Muntoni, Daniela Chirio, Elena Peira, Laura Annovazzi, Davide Schiffer, Marta Mellai, Chiara Riganti, Iris Chiara Salaroglio, Michele Lanotte, Pierpaolo Panciani, Maria Teresa Capucchio, Alberto Valazza, Elena Biasibetti, Marina Gallarate
AIM: Methotrexate-loaded biocompatible nanoparticles were tested for preliminary efficacy in glioma treatment. MATERIALS & METHODS: Behenic acid nanoparticles, prepared by the coacervation method, were loaded with the ester prodrug didodecylmethotrexate, which was previously tested in vitro against glioblastoma human primary cultures. Nanoparticle conjugation with an ApoE mimicking chimera peptide was performed to obtain active targeting to the brain. RESULTS & CONCLUSION: Biodistribution studies in healthy rats assessed the superiority of ApoE-conjugated formulation, which was tested on an F98/Fischer glioma model...
February 10, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28186461/aceclofenac-cocrystal-nanoliposomes-for-rheumatoid-arthritis-with-better-dermatokinetic-attributes-a-preclinical-study
#11
Gajanand Sharma, Mandeep Kaur Saini, Kanika Thakur, Namarta Kapil, Neeraj Kumar Garg, Kaisar Raza, Vijay G Goni, Anil Pareek, Om Prakash Katare
AIM: The aim of present research was to complex aceclofenac with lysine (LYS) and the developed aceclofenac-LYS cocrystal was encapsulated in lipid bilayers of liposomes by employing dual carrier approach for the treatment of pain-related disorders in rheumatoid arthritis (RA). MATERIALS & METHODS: The developed carriers were characterized for particle size, drug release, ex vivo and in vivo studies, dermatokinetic modeling, complete freund's adjuvant (CFA)-induced RA rat model, radiant heat tail-flick method, formalin-induced paw-licking model, paw edema model and xylene-induced ear edema model in mice...
February 10, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28186439/computational-nanomedicine-for-mechanistic-elucidation-of-bilayer-nanoparticle-mediated-release-for-tissue-engineering
#12
Mohammad Izadifar, Michael E Kelly, Xiongbiao Chen
AIM: Temporal control of growth-factor release from nanoparticles is essential to many tissue engineering applications, yet remains a challenge due to its complicated behavior. The interplay between nanoparticle characteristics and release mechanisms can be captured using computational models. This study aims to develop two novel models to represent the release of bilayer nanoparticles. MATERIALS & METHODS: Bilayer nanoparticles were prepared and characterized experimentally...
February 10, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28186438/a-semiautomated-microfluidic-platform-for-real-time-investigation-of-nanoparticles-cellular-uptake-and-cancer-cells-tracking
#13
Mariana R Carvalho, F Raquel Maia, Joana Silva-Correia, Bruno M Costa, Rui L Reis, Joaquim M Oliveira
AIM: Develop a platform composed of labeled dendrimer nanoparticles (NPs) and a microfluidic device for real-time monitoring of cancer cells fate. MATERIALS & METHODS: Carboxymethylchitosan/poly(amidoamine) dendrimer NPs were labeled with fluorescein-5(6)-isothiocyanate and characterized using different physicochemical techniques. After, HeLa, HCT-116 and U87MG were cultured in the presence of NPs, and cell viability and internalization efficiency in static (standard culture) and dynamic (microfluidic culture) conditions were investigated...
February 10, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28186436/drug-delivery-to-the-eye-what-benefits-do-nanocarriers-offer
#14
Rini Rachel Joseph, Subbu S Venkatraman
Ocular drug delivery has seen several advances in the past few decades, with respect to new drugs, improved formulations, targeted delivery, as well as exploration of new routes of drug administration. New materials have been explored for encasing existing drugs, which can enhance treatment by increasing bioavailability, decreasing toxicity, providing better tissue adherence, targeted delivery as well as increased duration of action. The challenges and requirements are different for the anterior and posterior ocular segments...
February 10, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28186432/development-of-anti-cd47-single-chain-variable-fragment-targeted-magnetic-nanoparticles-for-treatment-of-human-bladder-cancer
#15
Gashin Rezaei, Mahdi Habibi-Anbouhi, Morteza Mahmoudi, Kayhan Azadmanesh, Shima Moradi-Kalbolandi, Mahdi Behdani, Leila Ghazizadeh, Mohsen Abolhassani, Mohammad Ali Shokrgozar
AIM: To develop a novel anti-CD47 single-chain variable fragment (scFv) functionalized magnetic nanoparticles (MNPs) for targeting bladder cell lines and its applicability in thermotherapy. MATERIAL & METHODS: An immunized murine antibody phage display library was constructed and screened to isolate anti-CD47 binders. A scFv was selected and conjugated to MNPs which was then utilized to discriminate CD47(+) bladder cells along with assessing its efficacy in thermotherapy...
February 10, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28181470/controlled-release-of-antigen-and-toll-like-receptor-ligands-from-plga-nanoparticles-enhances-immunogenicity
#16
Luis J Cruz, Paul J Tacken, Christina Eich, Felix Rueda, Ruurd Torensma, Carl G Figdor
AIM: Dendritic cells rapidly capture nanoparticles and induce a potent cellular immune response. It is yet unknown whether the immunological response induced by slow release of encapsulated versus soluble antigen and adjuvant is superior. MATERIALS & METHODS: The kinetics of poly(lactic-co-glycolic acid) PLGA nanoparticles antigen release was studied by the DQ-bovine serum albumin (BSA) self-quenching antigen model. The immunological response induced was evaluated by means of dendritic cell activation/maturation markers, cytokine production and their ability to drive antigen-specific T-cell proliferation...
February 9, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28181464/physicochemical-characterization-of-chitosan-hyaluronan-coated-solid-lipid-nanoparticles-for-the-targeted-delivery-of-paclitaxel-a-proof-of-concept-study-in-breast-cancer-cells
#17
Javier Campos, Manuel Varas-Godoy, Ziyad Samir Haidar
AIM: To investigate the potential of modified solid lipid nanoparticles (SLN) for the delivery of paclitaxel (PAX). MATERIALS & METHODS: SLN loaded with PAX were prepared via modified high-pressure hot homogenization. Formulation parameters were optimized to obtain a high-quality delivery system. SLN cores were coated, layer-by-layer, with a chitosan and hyaluronan (HA) shell. Selectivity toward HA receptors was tested in a breast cancer cell line, MCF-7. RESULTS: Stable and reproducible nano-sized and negatively charged nanoparticles resulted...
February 9, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28181461/d-%C3%AE-tocopheryl-polyethylene-glycol-1000-succinate-functionalized-nanographene-oxide-for-cancer-therapy
#18
Duarte de Melo-Diogo, Cleide Pais-Silva, Elisabete C Costa, Ricardo O Louro, Ilídio J Correia
AIM: To evaluate the therapeutic capacity of D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized nanographene oxide (nGO) in breast cancer cells. METHODS: TPGS-functionalized nGO-based materials were obtained through two different approaches: a simple sonication method and a one-pot hydrothermal treatment. RESULTS: TPGS coating successfully improved the stability of the nGO-based materials. The nanomaterials that underwent the hydrothermal procedure generated a 1...
February 9, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28181460/nanoparticles-a-promising-new-therapeutic-platform-for-bone-regeneration
#19
Seyed-Iman Roohani-Esfahani, Hala Zreiqat
No abstract text is available yet for this article.
February 9, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28181459/cerium-oxide-nanoparticles-a-radical-approach-to-neurodegenerative-disease-treatment
#20
Shuguftha Naz, James Beach, Blaze Heckert, Tanuja Tummala, Oleksandra Pashchenko, Tuhina Banerjee, Santimukul Santra
Despite advances in understanding the factors that cause many neurodegenerative diseases (NDs), no current therapies have yielded significant results. Cerium oxide nanoparticles (CeONPs) have recently emerged as therapeutics for the treatment of NDs due to their antioxidant properties. This report summarizes the recent findings regarding CeONPs in treatment of various NDs, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, ischemic stroke and amyotrophic lateral sclerosis. Interest in CeONPs as a potential nanomedicine for NDs has increased due to: their ability to alter signaling pathways, small diameter allowing passage through the blood-brain barrier and scavenging of reactive oxygen species...
February 9, 2017: Nanomedicine
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