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Luigi Battaglia, Elisabetta Muntoni, Daniela Chirio, Elena Peira, Laura Annovazzi, Davide Schiffer, Marta Mellai, Chiara Riganti, Iris Chiara Salaroglio, Michele Lanotte, Pierpaolo Panciani, Maria Teresa Capucchio, Alberto Valazza, Elena Biasibetti, Marina Gallarate
AIM: Methotrexate-loaded biocompatible nanoparticles were tested for preliminary efficacy in glioma treatment. MATERIALS & METHODS: Behenic acid nanoparticles, prepared by the coacervation method, were loaded with the ester prodrug didodecylmethotrexate, which was previously tested in vitro against glioblastoma human primary cultures. Nanoparticle conjugation with an ApoE mimicking chimera peptide was performed to obtain active targeting to the brain. RESULTS & CONCLUSION: Biodistribution studies in healthy rats assessed the superiority of ApoE-conjugated formulation, which was tested on an F98/Fischer glioma model...
February 10, 2017: Nanomedicine
Gajanand Sharma, Mandeep Kaur Saini, Kanika Thakur, Namarta Kapil, Neeraj Kumar Garg, Kaisar Raza, Vijay G Goni, Anil Pareek, Om Prakash Katare
AIM: The aim of present research was to complex aceclofenac with lysine (LYS) and the developed aceclofenac-LYS cocrystal was encapsulated in lipid bilayers of liposomes by employing dual carrier approach for the treatment of pain-related disorders in rheumatoid arthritis (RA). MATERIALS & METHODS: The developed carriers were characterized for particle size, drug release, ex vivo and in vivo studies, dermatokinetic modeling, complete freund's adjuvant (CFA)-induced RA rat model, radiant heat tail-flick method, formalin-induced paw-licking model, paw edema model and xylene-induced ear edema model in mice...
February 10, 2017: Nanomedicine
Mohammad Izadifar, Michael E Kelly, Xiongbiao Chen
AIM: Temporal control of growth-factor release from nanoparticles is essential to many tissue engineering applications, yet remains a challenge due to its complicated behavior. The interplay between nanoparticle characteristics and release mechanisms can be captured using computational models. This study aims to develop two novel models to represent the release of bilayer nanoparticles. MATERIALS & METHODS: Bilayer nanoparticles were prepared and characterized experimentally...
February 10, 2017: Nanomedicine
Mariana R Carvalho, F Raquel Maia, Joana Silva-Correia, Bruno M Costa, Rui L Reis, Joaquim M Oliveira
AIM: Develop a platform composed of labeled dendrimer nanoparticles (NPs) and a microfluidic device for real-time monitoring of cancer cells fate. MATERIALS & METHODS: Carboxymethylchitosan/poly(amidoamine) dendrimer NPs were labeled with fluorescein-5(6)-isothiocyanate and characterized using different physicochemical techniques. After, HeLa, HCT-116 and U87MG were cultured in the presence of NPs, and cell viability and internalization efficiency in static (standard culture) and dynamic (microfluidic culture) conditions were investigated...
February 10, 2017: Nanomedicine
Rini Rachel Joseph, Subbu S Venkatraman
Ocular drug delivery has seen several advances in the past few decades, with respect to new drugs, improved formulations, targeted delivery, as well as exploration of new routes of drug administration. New materials have been explored for encasing existing drugs, which can enhance treatment by increasing bioavailability, decreasing toxicity, providing better tissue adherence, targeted delivery as well as increased duration of action. The challenges and requirements are different for the anterior and posterior ocular segments...
February 10, 2017: Nanomedicine
Gashin Rezaei, Mahdi Habibi-Anbouhi, Morteza Mahmoudi, Kayhan Azadmanesh, Shima Moradi-Kalbolandi, Mahdi Behdani, Leila Ghazizadeh, Mohsen Abolhassani, Mohammad Ali Shokrgozar
AIM: To develop a novel anti-CD47 single-chain variable fragment (scFv) functionalized magnetic nanoparticles (MNPs) for targeting bladder cell lines and its applicability in thermotherapy. MATERIAL & METHODS: An immunized murine antibody phage display library was constructed and screened to isolate anti-CD47 binders. A scFv was selected and conjugated to MNPs which was then utilized to discriminate CD47(+) bladder cells along with assessing its efficacy in thermotherapy...
February 10, 2017: Nanomedicine
Luis J Cruz, Paul J Tacken, Christina Eich, Felix Rueda, Ruurd Torensma, Carl G Figdor
AIM: Dendritic cells rapidly capture nanoparticles and induce a potent cellular immune response. It is yet unknown whether the immunological response induced by slow release of encapsulated versus soluble antigen and adjuvant is superior. MATERIALS & METHODS: The kinetics of poly(lactic-co-glycolic acid) PLGA nanoparticles antigen release was studied by the DQ-bovine serum albumin (BSA) self-quenching antigen model. The immunological response induced was evaluated by means of dendritic cell activation/maturation markers, cytokine production and their ability to drive antigen-specific T-cell proliferation...
February 9, 2017: Nanomedicine
Javier Campos, Manuel Varas-Godoy, Ziyad Samir Haidar
AIM: To investigate the potential of modified solid lipid nanoparticles (SLN) for the delivery of paclitaxel (PAX). MATERIALS & METHODS: SLN loaded with PAX were prepared via modified high-pressure hot homogenization. Formulation parameters were optimized to obtain a high-quality delivery system. SLN cores were coated, layer-by-layer, with a chitosan and hyaluronan (HA) shell. Selectivity toward HA receptors was tested in a breast cancer cell line, MCF-7. RESULTS: Stable and reproducible nano-sized and negatively charged nanoparticles resulted...
February 9, 2017: Nanomedicine
Duarte de Melo-Diogo, Cleide Pais-Silva, Elisabete C Costa, Ricardo O Louro, Ilídio J Correia
AIM: To evaluate the therapeutic capacity of D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized nanographene oxide (nGO) in breast cancer cells. METHODS: TPGS-functionalized nGO-based materials were obtained through two different approaches: a simple sonication method and a one-pot hydrothermal treatment. RESULTS: TPGS coating successfully improved the stability of the nGO-based materials. The nanomaterials that underwent the hydrothermal procedure generated a 1...
February 9, 2017: Nanomedicine
Seyed-Iman Roohani-Esfahani, Hala Zreiqat
No abstract text is available yet for this article.
February 9, 2017: Nanomedicine
Shuguftha Naz, James Beach, Blaze Heckert, Tanuja Tummala, Oleksandra Pashchenko, Tuhina Banerjee, Santimukul Santra
Despite advances in understanding the factors that cause many neurodegenerative diseases (NDs), no current therapies have yielded significant results. Cerium oxide nanoparticles (CeONPs) have recently emerged as therapeutics for the treatment of NDs due to their antioxidant properties. This report summarizes the recent findings regarding CeONPs in treatment of various NDs, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, ischemic stroke and amyotrophic lateral sclerosis. Interest in CeONPs as a potential nanomedicine for NDs has increased due to: their ability to alter signaling pathways, small diameter allowing passage through the blood-brain barrier and scavenging of reactive oxygen species...
February 9, 2017: Nanomedicine
Min Wu, Lei Gu, Qiyong Gong, Jiayu Sun, Yiqi Ma, Haoxing Wu, Yu Wang, Gang Guo, Xue Li, Hongyan Zhu
Mesenchymal stem cells (MSCs) have a significant self-renewal capacity and can differentiate into a variety of cell types. Cell labeling is crucial as it is difficult to detect cell fate after transplantation in vivo. MSCs labeled with iron oxide nanoparticles (IONPs), which can be tracked by MRI, have tremendous potential in regenerative medicine and oncological research. As a part of nanoparticle, the iron oxide core is a key aspect that can exhibit adverse or beneficial effects on MSCs labeled for tracking...
February 9, 2017: Nanomedicine
Vijay Raghavan, Cathal O'Flatharta, Roisin Dwyer, Aedán Breathnach, Haroon Zafar, Peter Dockery, Antony Wheatley, Ivan Keogh, Martin Leahy, Malini Olivo
AIM: To fabricate multimodal nanoconstruct that act as a single node for photoacoustic imaging (PAI) and photothermal therapy (PTT) in the fight against cancer. MATERIALS & METHODS: Dual plasmonic gold nanostars (DPGNS) were chemically synthesized by reducing gold precursor using ascorbic acid and silver ions as shape directing agent. PAI and PTT were performed using commonly available 1064 nm laser source on DPGNS embedded tumor xenografts on mice. RESULTS & CONCLUSION: Photoacoustic amplitude increase with longer wavelength source and with silica coating of DPGNS...
February 9, 2017: Nanomedicine
Fei Liu, Fen-Fen Kong, Qing-Po Li, Hong Yuan, Yong-Zhong Du, Fu-Qiang Hu, Ji-Hong Sun, Jian You
AIM: Whether PEI2k-HAuNS could promote gene transfection efficiency controlled by near-infrared (NIR) light. MATERIALS & METHODS: This safe nonviral gene delivery system was obtained by conjugating low molecular weight (2 kDa) polyethylenimine (PEI) onto hollow gold nanospheres (PEI2k-HAuNS). Upon NIR laser irradiation, there was a conspicuous increase both in the in vitro and in vivo transfection achieved by the nanocomplexes. Furthermore, a plasmid encoding the tumor suppressor TP53 (pTP53) was applied to test antitumor activity...
February 9, 2017: Nanomedicine
Thangirala Sudha, Dhruba J Bharali, Murat Yalcin, Noureldien He Darwish, Melis Debreli Coskun, Kelly A Keating, Hung-Yun Lin, Paul J Davis, Shaker A Mousa
AIM: Nano-diamino-tetrac (NDAT) targets a receptor on integrin αvβ3; αvβ3 is generously expressed by cancer cells and dividing endothelial cells and to a small extent by nonmalignant cells. The tetrac (tetraiodothyroacetic acid) of NDAT is covalently bound to a poly(lactic-co-glycolic acid) nanoparticle that encapsulates anticancer drugs. We report NDAT delivery efficiency of cisplatin to agent-susceptible urinary bladder cancer xenografts. MATERIALS & METHODS: Cisplatin-loaded NDAT (NDAT-cisplatin) was administered to xenograft-bearing nude mice...
January 19, 2017: Nanomedicine
Rainer Tietze, Christoph Alexiou
No abstract text is available yet for this article.
January 18, 2017: Nanomedicine
Marina Pöttler, Iwona Cicha, Stefan Lyer, Christina Janko, Ralf P Friedrich, Christoph Alexiou
No abstract text is available yet for this article.
January 17, 2017: Nanomedicine
Wongsakorn Suchaoin, Andreas Bernkop-Schnürch
Pre-uptake metabolism within the GI tract is responsible for the poor oral bioavailability of numerous drugs. As nanocarriers function as a 'shield', protecting incorporated drugs from enzymatic attack, there is an increasing interest in utilizing them as a tool for overcoming drug degradation. Degradation of carriers resulting in the release of incorporated drugs, mucus permeation, enzyme inhibitory properties and their toxicity are crucial factors that must be taken into account when designing proper nanocarriers...
January 17, 2017: Nanomedicine
Yu Wan, Peter M Moyle, Pei Z Gn, Istvan Toth
AIM: To develop a new synthetic peptide-based nanoparticulate siRNA delivery system. MATERIALS & METHODS: DEN-K(GALA)-TAT-K(STR) was generated by incorporating stearic acid into a multicomponent peptide (DEN-K(GALA)-TAT), containing a cationic poly-L-lysine dendron, an endosome-disrupting peptide GALA and a cell-penetrating peptide TAT(48-60). Its physicochemical characteristics, size, toxicity, cellular uptake and gene knockdown activity of the peptide/siRNA complexes were studied...
January 17, 2017: Nanomedicine
Stewart A Low, Chris V Galliford, Yava L Jones-Hall, Jyoti Roy, Jiyuan Yang, Philip S Low, Jindřich Kopeček
AIM: To evaluate the fracture healing capabilities of a GSK3β inhibitor, 6-bromoindirubin-3'-oxime, coupled with an aspartic acid octapeptide in a micellar delivery system. MATERIALS & METHODS: The efficacy of the intravenously administered micelles to accelerate healing of femoral fracture in mice was evaluated. Micro-computed tomography analysis was employed to obtain bone density, total volume, relative volume, trabecular thickness and trabecular spacing. RESULTS: Both fracture bone mineral density and volume were significantly higher in the micelle treatment groups when compared with controls...
January 17, 2017: Nanomedicine
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