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Kheireddine El-Boubbou
Magnetic nanoparticles (MNPs), particularly made of iron oxides, have been extensively studied as diagnostic imaging agents and therapeutic delivery vehicles. In this review, special emphasis is set on the 'recent advancements of drug-conjugated MNPs used for therapeutic applications'. The most prevalent preparation methods and chemical functionalization strategies required for translational biomedical nanoformulations are outlined. Particular attention is, then, devoted to the tailored conjugation of drugs to the MNP carrier according to either noncovalent or covalent attachments, with advantages and drawbacks of both pathways conferred...
March 16, 2018: Nanomedicine
Xiaju Cheng, Xiaohu Ni, Renfei Wu, Yu Chong, Xingfa Gao, Cuicui Ge, Jun-Jie Yin
AIM: To develop the potential application of carbon nanomaterials as antioxidants calls for better understanding of how the specific structure affects their antioxidant activity. MATERIALS & METHODS: Several typical carbon nanomaterials, including graphene quantum dots and fullerene derivatives were characterized and their radical scavenging activities were evaluated; in addition, the in vitro and in vivo radioprotection experiments were performed. RESULTS: These carbon nanomaterials can efficiently scavenge free radicals in a structure-dependent manner...
March 15, 2018: Nanomedicine
Yawen Li, Fangming Xiu, Zezhong Mou, Zhiwei Xue, Huanhui Du, Chunxue Zhou, Yan Li, Yongyu Shi, Shenyi He, Huaiyu Zhou
AIM: Exosomes are nanoscale membranous vesicles secreted by most cell types able to transfer bioactive molecules among cells, which play crucial roles in intercellular communication. We characterized the exosomes derived from Toxoplasma gondii (T. gondii) and detected the immune response in macrophages. METHODS: We used transmission electron microscopy, nanotracking analysis and western blotting to identify T. gondii exosomes. Functional experiments were performed in RAW264...
March 15, 2018: Nanomedicine
Huanan Li, Deping Zeng, Zhenyu Wang, Liaoqiong Fang, Faqi Li, Zhibiao Wang
AIM: To build up a combined therapy strategy to address limitations of the enhanced permeability and retention (EPR) effect and improve the efficiency of tumor therapy. MATERIALS & METHODS: A pH-sensitive nanocomplex for co-delivery of doxorubicin (DOX) and all-trans retinoic acid (ATRA) was developed based on nanodiamonds (DOX/ATRA-NDs) to enhance intracellular retention of drugs. Meanwhile, ultrasound was employed to enhance tumor vascular penetration of DOX-ATRA-NDs...
March 14, 2018: Nanomedicine
Kanika Thakur, Gajanand Sharma, Bhupinder Singh, Ashay Jain, Rajeev Tyagi, Sanjay Chhibber, Om P Katare
AIM: The aim of the current study was to investigate the therapeutic efficacy of cationic-charged bilayered nanoemulsion for topical delivery of fusidic acid in eradicating methicillin-resistant Staphylococcus aureus (MRSA) bacterial burn wound infection. MATERIALS & METHODS: The developed carriers were characterized for particle size, antibacterial activity, cell viability assay in HaCat cell lines, rheological profile, ex vivo and in vivo studies, namely, full thickness MRSA 33591 murine burn wound infection via topical route...
March 12, 2018: Nanomedicine
Qing Hu, Qing Chen, Xiuyun Yan, Bomei Ding, Dawei Chen, Lifang Cheng
AIM: To develop a nanocarrier for targeted delivery of agents to the cartilage. MATERIALS & METHODS: Chondrocyte affinity peptide modified PEGylated polyamidoamine conjugates (CAP-PEG-PAMAM) were prepared and rhodamine B isothiocyanate (RB) fluorophore was linked on them for comparative biological tracing and profiling. RESULTS: CAP4-PP-RB exhibited much more efficient cellular uptake in vitro than that of PEG-PAMAM-RB. Both the conjugates were likely internalized by chondrocytes via clathrin and caveolin co-mediated endocytosis, and delivered to lysosomes...
March 12, 2018: Nanomedicine
Yili Hu, Xiaoyang Zhu, Ruifang Zhao, Jin Wang, Yipeng Song, Guangjun Nie, Huiru Tang, Yulan Wang
AIM: To evaluate the advantages of nanomaterial methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) (mPEG-PLGA) encapsulated doxorubicin (D/DOX) and paclitaxel (T/TAX; mPEG-PLGA-DT) over free form of DOX and TAX (DOX/TAX). MATERIALS & METHODS: Metabonomics was conducted to characterize the systemic metabolic response of allograft breast cancer model mice to mPEG-PLGA-DT and DOX/TAX treatments. RESULTS: Breast tumor growth induced metabolic reprogram in serum and multiple organs...
March 12, 2018: Nanomedicine
Gergely Hetényi, Janine Griesser, Simon Fontana, Anja Martinez Gutierrez, Helmut Ellemunter, Katharina Niedermayr, Péter Szabó, Andreas Bernkop-Schnürch
AIM: The aim of the study was to develop self-emulsifying delivery systems (SEDDS) exhibiting improved permeation rate for pulmonary delivery of amikacin for treatment of cystic fibrosis (CF) patients. MATERIALS & METHODS: Solubility of amikacin in lipids was improved by hydrophobic ion pairing with sodium myristyl sulfate. The complex was loaded into SEDDS. Drug-release studies were performed and the permeation properties of SEDDS through human CF mucus were examined...
February 28, 2018: Nanomedicine
Antonella Antonelli, Severina Pacifico, Carla Sfara, Marialuisa Tamma, Mauro Magnani
AIM: The encapsulation of superparamagnetic iron oxide contrast agents in red blood cells (RBCs) could overcome their rapid removal by reticulo-endothelial system improving their stability in blood circulation. MATERIALS & METHODS: Murine ferucarbotran-loaded RBCs were tested in vivo as new contrasting agents in MRI application. RESULTS: A superior visualization of organs and cerebral vessels was evidenced in ferucarbotran-loaded RBCs-treated mice compared with the controls...
February 28, 2018: Nanomedicine
Ajeet Kaushik, Rahul D Jayant, Madhavan Nair
No abstract text is available yet for this article.
February 27, 2018: Nanomedicine
Anna Cifuentes-Rius, Lisa M Butler, Nicolas H Voelcker
No abstract text is available yet for this article.
February 27, 2018: Nanomedicine
Sherif M Gadoue, Piotr Zygmanski, Erno Sajo
AIM: In nanoparticle-aided radiotherapy, the computational paradigm has been that inside the cell, nanoparticles are distributed sparsely and solitarily. However, experiments reveal significant cluster formation, which affects radiosensitization and must be considered in clinical treatment planning. We characterize the impact of gold nanoparticle agglomeration on the predicted radiation dose enhancement as function of size, geometry, morphology and incident beam energy. MATERIALS & METHODS: Next-generation coupled electron-photon deterministic computations were performed using subnanometric unstructured spatial mesh...
February 27, 2018: Nanomedicine
Mario D Martinez, David Q Trac, Milton E Brown, Kevin O Maher, Michael E Davis
AIM: Current diagnostic tests for myocarditis are invasive and have low diagnostic value. Our aim was to identify potential targeting peptides to detect early myocarditis following intravenous delivery. MATERIALS & METHODS: We used an animal model of experimental autoimmune myocarditis and a phage display library to identify potential targeting peptides. After several steps, we selected two peptides, MyH-PhD-05 and MyH-PhD-120, for in vivo screening using fluorescent imaging...
February 23, 2018: Nanomedicine
Yuanyuan Xie, Xiaofan Zeng, Xian Wu, Jun Hu, Yanhong Zhu, Xiangliang Yang
AIM: To study the effects of combinational treatment of hyperbaric oxygen (HBO) and nanotemozolomide in glioma. MATERIALS & METHODS: Temozolomide (TMZ)-loaded porous silicon nanoparticles (TMZ/PSi NPs) were prepared. In vitro and in vivo evaluations were performed. RESULTS: The cell uptake of TMZ/PSi NPs could be tracked by autofluorescence of porous silicon. The concentration of oxygen in tumor was improved and the antitumor rate was increased to 84...
February 23, 2018: Nanomedicine
Bo Zheng, Lu Chen, Chun-Chun Pan, Jian-Zhang Wang, Guang-Rong Lu, Shou-Xing Yang, Zhan-Xiong Xue, Fang-Yan Wang, Chang-Long Xu
AIM: MiRNAs have been recognized for their potential in cancer therapeutics, and multiple miRNAs were suggested to affect target genes expression. To overcome limitations of free synthetic miRNAs, such as easily degraded in biofluids and limited in cellular uptake, novel miRNAs delivery systems need to be developed. MATERIALS & METHODS: Using surface-functionalizing technique, poly(D,L-lactide-co-glycolide)/poly(L-lactide)-block-poly(ethylene glycol)-folate polymer nanoparticle (PLGA/PLA-PEG-FA) loaded with miR-204-5p (FA-NPs-miR-204) was developed...
February 20, 2018: Nanomedicine
Rafał Pokrowiecki, Krzysztof Pałka, Agnieszka Mielczarek
AIM: The studies on tooth structure provided basis for nanotechnology-based dental treatment approaches known as nanodentistry which aims at detection and treatment of oral pathologies, such as dental caries and periodontal diseases, insufficiently being treated by conventional materials or drugs. This review aims at defining the role of nanodentistry in the medical area, its potential and hazards. MATERIALS & METHODS: To validate these issues, current literature on nanomaterials for dental applications was critically reviewed...
February 8, 2018: Nanomedicine
Paramita Paul, Soma Sengupta, Biswajit Mukherjee, Tapan K Shaw, Raghuvir H Gaonkar, Mita Chatterjee Debnath
AIM: Chitosan-coated polylactic-co-glycolic acid nanoparticles of voriconazole (VChNP) were developed to increase residence time and provide sustained drug release locally to treat recurrent lung-fungal infection. MATERIALS & METHODS: VChNP has been developed using a simple, unique technique and characterized. Pharmacokinetics, lung deposition with time and gamma imaging were conducted with optimized formulations. RESULTS: The deposition of fluorescein isothiocyanate-labeled VChNP in lung was confirmed by confocal microscopy...
January 31, 2018: Nanomedicine
Swapnil Singh, Varun Kushwah, Ashish Kumar Agrawal, Sanyog Jain
AIM: The present study reports insulin (INS)- and quercetin (QT)-lyotropic liquid crystalline nanoparticles (LCNPs) with improved bioavailability, antidiabetic and antioxidant efficacy following oral administration. MATERIALS & METHODS: The developed INS-QT-LCNPs were evaluated for simulated gastric fluid stability. In vitro Caco-2 uptake studies were also performed. Furthermore, in vivo pharmacokinetics and pharmacodynamics of INS-QT-LCNPs were evaluated. RESULTS & CONCLUSION: INS entrapped within LCNPs demonstrated excellent stability in simulated gastric fluid...
January 31, 2018: Nanomedicine
Melissa Togtema, Robert Jackson, Jessica Grochowski, Peter L Villa, Miranda Mellerup, Jyoti Chattopadhyaya, Ingeborg Zehbe
High-risk human papillomaviruses infect skin and mucosa, causing approximately 5% of cancers worldwide. In the search for targeted nanotherapeutic approaches, siRNAs against the viral E6 transcript have been molecules of interest but have not yet seen successful translation into the clinic. By reviewing the past approximately 15 years of in vitro literature, we identify the need for siRNA validation protocols which concurrently evaluate ranges of key treatment parameters as well as characterize downstream process restoration in a methodical, quantitative manner and demonstrate their implementation using our own data...
January 31, 2018: Nanomedicine
Sabrina Gioria, Fanny Caputo, Patricia Urbán, Ciarán Manus Maguire, Susanne Bremer-Hoffmann, Adriele Prina-Mello, Luigi Calzolai, Dora Mehn
The use of nanotechnology in medical products has been demonstrated at laboratory scale, and many resulting nanomedicines are in the translational phase toward clinical applications, with global market trends indicating strong growth of the sector in the coming years. The translation of nanomedicines toward the clinic and subsequent commercialization may require the development of new or adaptation of existing standards to ensure the quality, safety and efficacy of such products. This work addresses some identified needs, and illustrates the shortcomings of currently used standardized methods when applied to medical-nanoparticles to assess particle size, drug loading, drug release and in vitro safety...
January 30, 2018: Nanomedicine
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