We have located links that may give you full text access.
Expression of serum microRNA-378 and its clinical significance in laryngeal squamous cell carcinoma.
European Review for Medical and Pharmacological Sciences 2016 December
OBJECTIVE: Studies have demonstrated that miRNA -378 expressed in various malignant tumors. In the present study, we aim to explore the expression of serum miRNA-378 and its clinical significance in laryngeal squamous cell carcinoma (LSCC) patients.
PATIENTS AND METHODS: A total of 127 LSCC patients, 127 vocal cord polyp (VCP) and 130 healthy controls were selected.
RESULTS: The miRNA-378 level in LSCC and VCP group was significantly higher compared to healthy control, and LSCC group has the highest miRNA-378 level. The miRNA-378 level was both decreased significantly in LSCC and VCP group when compared with the same group after surgery. When compared with healthy control, VCP group has a higher miRNA-378 level but has no statistical difference (p>0.05) while LSCC group has a statistical difference (p<0.05) higher miRNA-378 compare with healthy control. The miRNA-378 expression is correlated with clinical stage and differentiation degree, but did not correlate with patient's age, gender distribution, operation mode, and tumor diameter. The AUC of miRNA-378 was 0.888, 95% confidence interval was 0.849 to 0.929, and AUC hypothesis testing was statistically significant (p<0.001).
CONCLUSIONS: miRNA-378 could be used in the diagnosis and the prediction of the postoperative curative effect of laryngeal cancer (LSCC).
PATIENTS AND METHODS: A total of 127 LSCC patients, 127 vocal cord polyp (VCP) and 130 healthy controls were selected.
RESULTS: The miRNA-378 level in LSCC and VCP group was significantly higher compared to healthy control, and LSCC group has the highest miRNA-378 level. The miRNA-378 level was both decreased significantly in LSCC and VCP group when compared with the same group after surgery. When compared with healthy control, VCP group has a higher miRNA-378 level but has no statistical difference (p>0.05) while LSCC group has a statistical difference (p<0.05) higher miRNA-378 compare with healthy control. The miRNA-378 expression is correlated with clinical stage and differentiation degree, but did not correlate with patient's age, gender distribution, operation mode, and tumor diameter. The AUC of miRNA-378 was 0.888, 95% confidence interval was 0.849 to 0.929, and AUC hypothesis testing was statistically significant (p<0.001).
CONCLUSIONS: miRNA-378 could be used in the diagnosis and the prediction of the postoperative curative effect of laryngeal cancer (LSCC).
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices 
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app