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European Review for Medical and Pharmacological Sciences

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https://www.readbyqxmd.com/read/29461619/microrna-200c-suppressed-cervical-cancer-cell-metastasis-and-growth-via-targeting-map4k4
#1
J Mei, D-H Wang, L-L Wang, Q Chen, L-L Pan, L Xia
OBJECTIVE: To dissect the functioning mode of miR-200c on cervical cancer cell metastasis and growth and provide therapeutic targets for cervical cancer. PATIENTS AND METHODS: By quantitative Real-time polymerase chain reaction, the miR-200c expression level in 42 pairs of cervical cancer tissue samples and six cervical cancer-derived cell lines were examined. Using miR-200c mimics, we analyzed the effects of miR-200c over-expression on cell proliferation, invasion, and migration...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461618/tms-as-tool-to-investigate-the-effect-of-pharmacological-medications-on-cortical-plasticity
#2
A Caipa, M Alomar, S Bashir
The application of medications with a well-defined mode of action on a neurotransmitter or neuromodulator of the central nervous system (CNS) can be utilized to test the pharmaco-physiological properties of transcranial magnetic stimulation (TMS) on cortical excitability and plasticity. Similarly, a physiologically well-defined TMS measure of cortical excitability may be exploited to study a particular drug's effect at the level of the cerebrum. In this review, we aim to assess the impact of calcium channel blockers, Selective Serotonin Reuptake Inhibitors (SSRIs), and GABAergic agents on cortical excitability and plasticity while concurrently investigating how TMS can enhance this understanding...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461617/jak-stat5-signaling-pathway-inhibitor-ruxolitinib-reduces-airway-inflammation-of-neutrophilic-asthma-in-mice-model
#3
R-F Li, G-F Wang
OBJECTIVE: The aim of this study was to explore the role of JAK/STAT signaling pathway inhibitor Ruxolitinib in neutrophilic airway inflammation and its possible immunological mechanism. MATERIALS AND METHODS: A total of 60 female C57BL/6 mice were randomly divided into neutrophilic asthma (NA) group, Ruxolitinib-treated (Ruxo) group and control (Con) group. Mice in NA and Ruxo groups were sensitized with ovalbumin (OVA) and excited to establish mice models of asthma...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461616/leukotriene-receptor-antagonists-do-not-improve-lung-function-decline-in-copd-a-meta-analysis
#4
L Liu, J-L Wang, X-Y Xu, M Feng, Y Hou, L Chen
OBJECTIVE: Leukotriene receptor antagonists (LTRA), the anti-inflammatory agents, have been reported new therapeutic value in chronic obstructive pulmonary disease (COPD). However, the effects of LTRA on lung function decline in COPD were determined with inconsistent results and a meta-analysis is needed. MATERIALS AND METHODS: Published cohort or randomized controlled studies were retrieved from PubMed and Embase databases. RESULTS: Pooled standardized mean difference (SMD) with 95% confidence interval (CI) was calculated in a random effects model...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461615/bilastine-safety-in-drivers-who-need-antihistamines-new-evidence-from-high-speed-simulator-driving-test-on-allergic-patients
#5
A Demonte, M B Guanti, S Liberati, A Biffi, F Fernando, M Fainello, P Pepe
OBJECTIVE: Bilastine is a highly selective, non-sedating antihistamine, indicated for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria. Available data suggest that bilastine interferes neither with driving ability nor with flying-related performance. However, no data are available on the effect of bilastine on the driving ability in extreme conditions. Here we analyzed the effect of 7 days treatment with 20 mg bilastine in patients with allergic rhinitis and/or chronic urticaria, on psychophysical performance assessed by the Formula One (F1) high-speed simulator-driving test...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461614/mitochondria-mediated-disturbance-of-fatty-acid-metabolism-in-proximal-tubule-epithelial-cells-leads-to-renal-interstitial-fibrosis
#6
W Shen, X-X Jiang, Y-W Li, Q He
OBJECTIVE: To investigate the role of mitochondria-mediated fatty acid metabolism in proximal tubule cells in renal interstitial fibrosis. MATERIALS AND METHODS: Intraperitoneal injection of folate was performed to induce renal interstitial fibrosis in mice. Polymerase chain reaction (PCR) was used to detect the expression of cytochrome c oxidase subunit IV (COX4IL) and phosphoenolpyruvate carboxykinase 1 (PCK1) in samples. Electron microscope was used to detect the activity of mitochondria...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461613/paraquat-promotes-the-epithelial-mesenchymal-transition-in-alveolar-epithelial-cells-through-regulating-the-wnt-%C3%AE-catenin-signal-pathway
#7
S-D Su, S-G Cong, Y-K Bi, D-D Gao
OBJECTIVE: To investigate whether paraquat (PQ)-induced rat alveolar type II cells (RLE-6TN) epithelial-mesenchymal transition (EMT) and to explore the underlying molecular mechanism. MATERIALS AND METHODS: In the present study, RLE-6TN cells were treated by 20 μmol/L PQ, and then the morphology was observed under an inverted microscope; RT-PCR and Western blot were performed to detect the expression level of EMT related markers, E-cadherin, and vimentin, as well as Wnt/β-catenin signaling pathway...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461612/the-hyperthermic-intraoperative-intraperitoneal-chemotherapy-in-the-treatment-of-advanced-abdominopelvic-cancer-personal-experience-on-103-procedures-during-a-seventeen-year-period-in-a-single-italian-center
#8
D Di Miceli, C Cina, C Fiorillo, G B Doglietto, S Alfieri
OBJECTIVE: Integration of different therapeutic strategies in cancer surgery in the last years has led from treating primary lesions to the surgical treatment of metastases. The purpose of this paper is to report a single Italian center experience of treatment of peritoneal carcinosis of the abdominopelvic malignancies. PATIENTS AND METHODS: 103 HIPEC procedures were performed in 17 years on 94 selected patients affected by abdominopelvic cancer. The PCI score was calculated at laparotomy...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461611/leptin-inhibits-apoptosis-of-nucleus-pulposus-cells-via-promoting-autophagy
#9
W Zhang, Z-L Li, Q Zhang
OBJECTIVE: To investigate whether leptin can regulate the apoptosis of nucleus pulposus cells by adjusting the autophagy of human degenerative nucleus pulposus cells and its possible molecular mechanism. PATIENTS AND METHODS: The human degenerative nucleus pulposus cells were extracted and cultured, then treated with leptin, leptin inhibitor and leptin neutralizing antibody; the expressions of light chain 3 (LC3) II/I and Beclin-1 were detected by Western blot, and the change of apoptosis rate was detected by flow cytometer...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461610/the-effect-of-dc-cik-combined-therapy-on-rat-liver-cancer-model-and-its-modulatory-effect-on-immune-functions
#10
W He, Z Huang, S Zhou, L Huang, B Wang, L Zhu, Y Ding, Y-L Yu, S Zhang
OBJECTIVE: Primary liver cancer is a sort of the most common solid tumors occurred in the digestive system. The incidence and mortality rate maintain at a high level, thus leading to heavy economic and psychological burdens for patients. Next-generation biological therapy, such as cellular immune treatment, improves the medicine efficacy. Cytokine-induced killer (CIK) cells can effectively clear residual tumor lesion and inhibit metastasis or recurrence. Dendritic cells (DCs) can specifically eliminate tumor cells via modulating cellular immune function of the host...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461609/the-effects-of-recombinant-human-growth-hormone-rhgh-on-survival-of-slender-narrow-pedicle-flap-and-expressions-of-vascular-endothelial-growth-factor-vegf-and-classification-determinant-34-cd34
#11
W Sun, W-Y Yu, D-J Yu, T-L Zhao, L-J Wu, W-Y Han
OBJECTIVE: To explore the effects of recombinant human growth hormone (rHGH) on the survival of the mouse slender narrow pedicle flap and the expressions of vascular endothelial growth factor (VEGF) and classification determinant 34 (CD34). MATERIALS AND METHODS: A total of 20 BALB/c mice were randomly divided into the experimental group (n=10) and control group (n=10). The flaps were transplanted for mice in two groups respectively. 6 h after the operation, the mice in the experimental group were administrated with rHGH via local subcutaneous injection, while the mice in the control group were injected with the same amount of normal saline...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461608/high-expression-of-lnc-crnde-presents-as-a-biomarker-for-acute-myeloid-leukemia-and-promotes-the-malignant-progression-in-acute-myeloid-leukemia-cell-line-u937
#12
Y Wang, Q Zhou, J-J Ma
OBJECTIVE: To detect the expression of long non-coding RNA-CRNDE in patients with acute myeloid leukemia and its effect on proliferation and apoptosis in acute myeloid leukemia cell line U937. PATIENTS AND METHODS: 81 cases of newly diagnosed acute myeloid leukemia (AML) were enrolled, and 35 non-malignant hematological patients were selected as controls. Quantitative RT-PCR (qRT-PCR) was performed to detect the expression of lncRNA-CRNDE in the bone marrow specimens of the subjects, and the difference between the two groups was also compared...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461607/assessment-of-atrial-fibrillation-and-ventricular-arrhythmia-risk-in-patients-with-asthma-by-p-wave-corrected-qt-interval-dispersion
#13
H E Bozkurt Yilmaz, M Yilmaz, N Şen, C Altin, Z E Ünsal, A Tekin, Ş Akçay
OBJECTIVE: Although the relationship between obesity-asthma, obesity-atrial fibrillation (AF) and obesity-sudden cardiac death is clearly known, the risk of AF and ventricular arrhythmia has not been clearly determined in asthmatic patients. The aim of this study was to investigate whether AF, ventricular arrhythmia, and sudden cardiac death risk were increased in asthmatic patients using P wave dispersion (PWD) and corrected QT interval dispersion (CQTD). PATIENTS AND METHODS: The study was designed as a cross-sectional study...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461606/daylight-saving-time-and-myocardial-infarction-should-we-be-worried-a-review-of-the-evidence
#14
R Manfredini, F Fabbian, A De Giorgi, B Zucchi, R Cappadona, F Signani, N Katsiki, D P Mikhailidis
Transitions into and out of Daylight Saving Time (DST) may disrupt circadian rhythms and lead to sleep disturbance and deprivation. A first report observed an association between DST and acute myocardial infarction (AMI), especially after the spring shift and in women. We tried to identify and evaluate the possible association between DST and AMI, using the MEDLINE, EMBASE and Google Scholar electronic database (years 2009-2016), with regards to the searching terms 'daylight saving time', 'daylight saving time' plus 'gender', and 'daylight saving time' plus 'acute myocardial infarction'...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461605/mir-210-protects-cardiomyocytes-from-ogd-r-injury-by-inhibiting-e2f3
#15
W-S Bian, P-X Shi, X-F Mi, Y-Y Sun, D-D Yang, B-F Gao, S-X Wu, G-C Fan
OBJECTIVE: To detect the change in miRNA-210 expression of cardiomyocytes under hypoxia/reoxygenation status. Also, the effect of miR-210 on the apoptosis of cardiomyocytes induced by oxygen-glucose deprivation/reperfusion (OGD/R) and its mechanism through establishing the OGD/R injury model of primary cardiomyocytes in this experiment were investigated. MATERIALS AND METHODS: The cell model of OGD/R injury was established. The cell apoptosis in each group was detected by methyl thiazolyl tetrazolium (MTT) assay and detection of Caspase-3 activity...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461604/a-novel-ultrasound-based-vascular-calcification-score-calcs-to-detect-subclinical-atherosclerosis
#16
R Flore, M A Zocco, M E Ainora, C Fonnesu, A Nesci, A Gasbarrini, F R Ponziani
OBJECTIVE: To quantify non-coronary vascular calcifications (VC) in asymptomatic patients at low-intermediate cardiovascular risk by a new color Doppler ultrasound (DUS)-based score (the carotid, aortic, lower limbs calcium score, CALCs), and to correlate this score with classical parameters associated with cardiovascular risk [carotid intima media thickness (IMT), and arterial stiffness (AS)]. PATIENTS AND METHODS: All consecutive asymptomatic patients who underwent a screening DUS of non-coronary circulation were evaluated and patients at low-intermediate cardiovascular risk were selected according to Framingham risk score (FRS)...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461603/correlations-of-25-oh-d-level-with-blood-lipid-inflammatory-factors-and-vascular-endothelial-function-in-diabetic-patients
#17
J-M Wang, S-D Ye, S-M Li, W Hu
OBJECTIVE: To investigate the correlation between 25-hydroxyvitamin D [25(OH)D] and the lipid profile, inflammatory cytokines, and endothelial function in diabetic patients. PATIENTS AND METHODS: A total of 77 patients with type 2 diabetes mellitus treated in our hospital from January 2015 to March 2017 and 73 healthy volunteers were selected. The 25(OH)D, lipids, inflammatory factors, and endothelial function were compared between the two groups. The levels of 25(OH)D in diabetic patients were also compared to detect the levels of serum lipids and inflammatory cytokines in different groups...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461602/expression-of-mir-146a-5p-in-patients-with-intracranial-aneurysms-and-its-association-with-prognosis
#18
H-L Zhang, L Li, C-J Cheng, X-C Sun
OBJECTIVE: The study aims to detect the association of miR-146a-5p with intracranial aneurysms (IAs). PATIENTS AND METHODS: The expression of miR-146a-5p was compared from plasma samples between 72 patients with intracranial aneurysms (IAs) and 40 healthy volunteers by quantitative Real-time polymerase chain reaction (qRT-PCR). Statistical analysis was performed to analyze the relationship between miR-146a-5p expression and clinical data and overall survival (OS) time of IAs patients...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461601/impact-of-serum-fgf23-levels-on-blood-pressure-of-patients-with-chronic-kidney-disease
#19
J-X Li, G-Q Yu, Y-Z Zhuang
OBJECTIVE: To investigate the impact of serum FGF23 levels on blood pressure of patients with chronic kidney disease (CKD). PATIENTS AND METHODS: 128 patients with chronic kidney disease were selected from February 2013 to January 2016. Using CKD staging method, all the patients were divided into 1 to 5 stages according to the glomerular filtration rate. Enzyme-Linked ImmunoSorbent Assay (ELISA) was used to detect serum FGF23 levels of CKD patients and healthy control subjects...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461600/evaluation-of-the-application-of-high-volume-hemofiltration-in-sepsis-combined-with-acute-kidney-injury
#20
S-Q Meng, W-B Yang, J-G Liu, J-Y Yuan, K Zhang, W-Y Ding, S-Q Yang, J-H Liu
OBJECTIVE: To investigate the safety and effectiveness of the application of high-volume hemofiltration (HVHF) in children with sepsis combined with acute kidney injury. PATIENTS AND METHODS: A total of 76 child patients were enrolled and randomly divided equally (n=38) into control and the observation groups respectively. The control group received conventional volume hemofiltration (the ultrafiltration rate of 35-50 ml/kg/h), and the observation group received HVHF (50-100 ml/kg/h)...
February 2018: European Review for Medical and Pharmacological Sciences
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