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European Review for Medical and Pharmacological Sciences

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https://www.readbyqxmd.com/read/28617563/regulatory-mechanism-of-mir-29-over-tgf-%C3%AE-1-and-col1-in-scar-cells
#1
S Bi, C Cao, L-L Chai, S-R Li, D-Y Yang
OBJECTIVE: To study the regulatory mechanism of miR-29 over TGF-β1 and COL1 in scar cells. PATIENTS AND METHODS: 5 clinical cases of hypertrophic scar (HS) skin and adjacent normal skin tissues were separated into fibroblast for primary culture and subculture before being observed morphologically and standard HE staining under an ordinary optical microscope. RT-PCR method was applied to test the expression level of miR-29, TGF-β1, and COL1 mRNA. ELISA method was applied to test the expression level of extracellular matrix COL1, fibronectin (FN) and α-SMA...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617562/5-aminolevulinic-acid-photodynamic-therapy-stimulates-local-immunity-in-patients-with-condylomata-acuminata-via-activation-of-t-lymphocytes
#2
J Du, Q Cheng, Z Zhang, J-F Wu, F Li, S-Y Chen, Y-L Wang, X-N Lu, J-H Xu
The article "5-Aminolevulinic acid photodynamic therapy stimulates local immunity in patients with condylomata acuminata via activation of T lymphocytes" by J. Du, Q. Cheng, Z. Zhang, J.-F. Wu, F. Li, S.-Y. Chen, Y.-L. Wang, X.-N. Lu, J.-H. Xu, published in Eur Rev Med Pharmacol Sci 2017; 21 (5): 1125-1135 has been withdrawn.
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617561/cervicovaginal-bacteria-and-fungi-in-pregnant-diabetic-and-non-diabetic-women-a-multicenter-observational-cohort-study
#3
A Lukic, A Napoli, I Santino, P Bianchi, F Nobili, G Ciampittiello, M R Nardone, M Santomauro, M Di Properzio, D Caserta
OBJECTIVE: We evaluated the prevalence of cervicovaginal Bacteria, group B Streptococcus (GBS), Gardnerella vaginalis (GV), Candida spp., Chlamydia trachomatis (CT), Mycoplasma hominis (MH) and Ureaplasma urealyticum (UU) in pregnant women with and without diabetes mellitus (DM). PATIENTS AND METHODS: Cervicovaginal swabs were gathered from 473 pregnant patients divided into 127 diabetic and 346 non-diabetic. The results were correlated to gestational age, parity and glycemic control...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617560/influence-of-vegf-bmp-2-on-the-proliferation-and-osteogenetic-differentiation-of-rat-bone-mesenchymal-stem-cells-on-plga-gelatin-composite-scaffold
#4
G An, W-B Zhang, D-K Ma, B Lu, G-J Wei, Y Guang, C-H Ru, Y-S Wang
OBJECTIVE: To investigate the influence of VEGF/BMP-2 on the proliferation and osteogenic differentiation of rat bone mesenchymal stem cells BMSCs) on PLGA/gelatin composite scaffold. MATERIALS AND METHODS: Randomly-oriented nanofibers with different ratios of Poly Lactic-co-Glycolic Acid (PLGA)/gelatin were produced through electrospinning. The mixture of nanofibers and BMSCs was pipetted onto the surface of the scaffolds, and BMSCs/PLGA/gelatin composite was obtained...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617559/blockade-of-il-17-alleviated-inflammation-in-rat-arthritis-and-mmp-13-expression
#5
X-L Shui, W Lin, C-W Mao, Y-Z Feng, J-Z Kong, S-M Chen
OBJECTIVE: Rheumatoid arthritis (RA) is one systemic auto-immune disorder featured as chronic synovitis and can destruct joint cartilage. Fibroblast-like synoviocyte (FLS) secretes various factors affecting chondrocyte matrix and degradation. This study thus investigated the effect of interleukin-17A (IL-17A) on FLS and osteoclast. MATERIALS AND METHODS: Type II collagen-induced arthritis (CIA) rats were assigned to CIA model, CIA + IgG1 isotype, and CIA + Anti-Rat IL-17A groups...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617558/up-regulation-of-mir-124-inhibits-invasion-and-proliferation-of-prostate-cancer-cells-through-mediating-jak-stat3-signaling-pathway
#6
Z Wu, W Huang, B Chen, P-D Bai, X-G Wang, J-C Xing
OBJECTIVE: Signal transducer and activator of transcription 3 (STAT3) is an important protein in Janus kinase (JAK)-STAT signaling pathway, and can facilitate expression of Bcl-2 and Cyclin D1 gene, thus playing a role in tumor pathogenesis. Bioinformatics analysis revealed targeted binding sites between mircroRNA-124 (miR-124) and 3'-UTR of STAT3 mRNA. This study aims to investigate the role of miR-124 in regulating STAT3 expression and proliferation, cycle, apoptosis and invasion of prostate cancer cells...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617557/expression-of-microrna-142-3p-in-cervical-cancer-and-its-correlation-with-prognosis
#7
M Li, B-Y Li, H Xia, L-L Jiang
OBJECTIVE: The aim of current study was to assess the association between miR-142-3p expression and the prognosis of patients with cervical cancer. PATIENTS AND METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to assess the expression level of miR-142-3p in cervical cancer tissues and matched normal tissues. Then, statistical analysis was performed to determine the associations of miR-142-3p expression with the clinical features and the prognosis of cervical cancer...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617556/correlation-between-methylation-of-the-p16-promoter-and-cervical-cancer-incidence
#8
F-L Wang, Y Yang, Z-Y Liu, Y Qin, T Jin
OBJECTIVE: To study the methylation of the promoter of the p16 gene in cervical cancer patients and explore the correlation between methylation and the incidence of cervical cancer. PATIENTS AND METHODS: We recruited 78 patients with cervical cancer and 48 healthy individuals. The methylation-specific PCR was used to detect the methylation status in the promoter of the p16 gene. The mRNA expression of p16 was studied by quantitative fluorescence PCR. The protein expression of p16 was monitored by Enzyme-linked immunosorbent assay (ELISA) and Western blot...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617555/correlation-analysis-of-mir-200b-mir-200c-and-mir-141-with-liver-metastases-in-colorectal-cancer-patients
#9
S-H Zhu, X-C He, L Wang
OBJECTIVE: To investigate correlation relationship between serum miR-200b, miR-200c, miR-141 levels with liver metastases in colorectal cancer patients. PATIENTS AND METHODS: A total of 85 colorectal cancer patients with liver metastases and 54 colorectal cancer patients without liver metastases were divided into experimental group and control. Serum sample was collected before surgery and tested by Real-time PCR to evaluate miR-200b, miR-200c, miR-141 expressions...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617554/the-study-on-specific-umbilical-blood-dc-vaccine-for-beige-nude-mice-loaded-human-colorectal-carcinoma-to-induce-anti-tumor-immunity
#10
Z-X Fu, J-S Han, F Liu, Z-L Zhao, D-B Li, L Shi, J-T Dong, Y Zhou, J-H Cai
OBJECTIVE: This study is to observe the immunosuppression of CD137L transfected umbilical blood Dcs (Dendritic cell) vaccine to tumor development of SCID/ Beige nude mice. MATERIALS AND METHODS: Samples of umbilical blood in the childbirth pregnant women were collected by density gradient centrifugation. Umbilical cord blood dendritic cells (Dcs) were transfected by specific CD137L via LipofectamineTM method and cells were harvested. Meanwhile, the peripheral blood of volunteers was collected to isolate Dcs, the Dcs were cultured for 5 days and hatched with SW-1116 cells antigen...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617553/higher-rabex-5-mrna-predicts-unfavourable-survival-in-patients-with-colorectal-cancer
#11
J-S Zhang, L-Q Yang, B-R Du, H Gao
OBJECTIVE: The aim of the present study was to clarify the expression pattern and prognostic role of RABEX-5 mRNA in colorectal cancer (CRC) patients. PATIENTS AND METHODS: RABEX-5 mRNA levels in 187 CRC were examined by Real-time polymerase chain reaction. Then, the association of RABEX-5 mRNA levels with clinicopathological features was analyzed. Survival curves were plotted using the Kaplan-Meier method and differences in survival rates were analyzed using the log-rank test...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617552/long-non-coding-rna-tug1-can-promote-proliferation-and-migration-of-pancreatic-cancer-via-emt-pathway
#12
C-F Qin, F-L Zhao
OBJECTIVE: This paper aimed to investigate the effect of long non-coding RNA TUG1 (lncRNA TUG1) on cell proliferation, as well as cell migration in pancreatic cancer. PATIENTS AND METHODS: The mRNA levels of Taurine-up-regulated gene 1 (TUG1) in three kinds of pancreatic cancer cells BxPC3, PaTu8988 and SW1990 was detected by RT-qPCR. Meantime, RT-qPCR was used to examine the mRNA levels of TUG1 in 20 cases of human pancreatic cancer tissues and its para-carcinoma tissues...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617551/mir-222-promotes-proliferation-migration-and-invasion-of-lung-adenocarcinoma-cells-by-targeting-ets1
#13
Q Sun, C-W Jiang, Z-H Tan, L-Y Hou, H Dong, K Liu, G Sun, Y-J Liu, Y-Q Wang, X-C Lu, H Liu
OBJECTIVE: The lung adenocarcinoma is a type of lung cancer. This research is to investigate the effects of miR-222 on the proliferation, migration and invasion of the lung adenocarcinoma cells. MATERIALS AND METHODS: At the beginning, MiR-222 and the controls were transfected to the lung adenocarcinoma cell line A549 for CCK-8 proliferation, transwell migration and Matrigel invasion, and then observed the effect of miR-222 on the proliferation, migration and invasion of lung adenocarcinoma cells...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617550/prognostic-and-diagnostic-significance-of-long-non-coding-rna-agap2-as1-levels-in-patients-with-non-small-cell-lung-cancer
#14
K-J Fan, Y Liu, B Yang, X-D Tian, C-R Li, B Wang
OBJECTIVE: The purpose of this study was to explore whether long non-coding RNA AGAP2-AS1 (AGAP2-AS1) could serve as a novel biomarker for non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Cancer and matched normal lung tissues were collected from 198 patients. AGAP2-AS1 levels were examined by RT-PCR, and the associations of AGAP2-AS1 levels with clinicopathological characteristics evaluated. Overall survival was evaluated using the Kaplan-Meier method...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617549/identification-of-genes-associated-with-lung-cancer-by-bioinformatics-analysis
#15
J Li, H Yu, Y-F Ma, M Zhao, J Tang
OBJECTIVE: This study was aimed to explore the underlying genes associated with lung cancer (LC) by bioinformatics analysis. DATA AND METHODS: Gene expression profile GSE2514 was downloaded from the Gene Expression Omnibus database. Twenty lung and nineteen para-carcinoma tissue samples were used to identify the differentially expressed genes (DEGs) by paired t-test. Pathway enrichment analysis of DEGs was performed, followed by the construction of protein-protein interaction (PPI) network...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617548/bioinformatic-analysis-of-prognostic-value-of-arap3-in-breast-cancer-and-the-associated-signaling-pathways
#16
J-J Han, B-R Du, C-H Zhang
OBJECTIVE: In this study, we tried to pool previous annotated genomic data to assess the association between ARAP3 expression and metastatic relapse (MR) risk in patients with breast cancer. Moreover, we also investigated the signaling pathways in which ARAP3 might be involved in breast cancer. MATERIALS AND METHODS: The raw microarray data (GDS5666) that compared gene transcriptional profiles of 4T1 derived lung-aggressive explant and primary tumor explant were reanalyzed to identify the dysregulated genes...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617547/mastl-is-a-potential-poor-prognostic-indicator-in-er-breast-cancer
#17
B-Z Zhuge, B-R Du, X-L Meng, Y-Q Zhang
OBJECTIVE: In this study, we aimed to explore prognostic value of MASTL (microtubule-associated serine/threonine kinase-like) in breast cancer patients on the basis of ER status and molecular subtypes. MATERIALS AND METHODS: The raw microarray data (GDS5666) of 4T1 derived bone-aggressive explant and primary tumor explant were reanalyzed to identify the dysregulated genes. To pool previous annotated genomic data that assessed the association between MASTL expression and metastatic relapse (MR) risk, MR-free survival, any event (AE, defined as any relapse or death) risk, and AE-free survival in breast cancer patients, a meta-analysis was performed by bc-GenExMiner 4...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617546/down-expression-of-mir-373-predicts-poor-prognosis-of-glioma-and-could-be-a-potential-therapeutic-target
#18
S-Y Jing, S-Q Jing, L-L Liu, L-F Xu, F Zhang, J-L Gao
OBJECTIVE: MicroRNAs (miRNAs) are epigenetic regulators of gene expression, and their deregulation plays an important role in human cancer, including glioma. The main objective of this work was to investigate the expression level of miR-373 and its clinical significance in glioma. PATIENTS AND METHODS: The expression levels of miR-373 in glioma tissues and non-neoplastic brain tissues were measured by the qRT-PCR assay. Patients were divided into two groups based on the median miR-373 expression...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617545/fluid-status-of-patients-during-the-early-stages-of-continuous-ambulatory-peritoneal-dialysis
#19
L Wang, W Yu, T Wang
OBJECTIVE: The purpose of this paper is to investigate the fluid status of patients in the early stages of continuous ambulatory peritoneal dialysis (CAPD). PATIENTS AND METHODS: A total of 36 patients (13 males and 23 females), hospitalized in the Nephrology CAPD Center, Peking University Third Hospital, and undergoing intubation and CAPD treatment, were recruited in this study. By utilize a bioelectrical impedance analyzer, changes in extracellular fluid and intracellular fluid within the patients' cells, and overall fluid changes were monitored throughout six months following CAPD treatment...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617544/the-relationship-between-quality-of-life-and-clinical-phenotype-in-patients-with-treatment-resistant-and-non-treatment-resistant-depression
#20
J Qiao, L-J Qian, H-F Zhao, G-H Gong, D-Q Geng
OBJECTIVE: The purpose of this investigation is to determine the differences in quality of life (QOL) and clinical phenotype between patients with treatment resistant (TRD) and non-treatment resistant depression (NTRD). PATIENTS AND METHODS: The severity, QOL, and cognitive function of 107 TRD and 173 NTRD patients were evaluated and calculated by the Hamilton Depression Scale-17 (HAMD-17), the 36-Item Short Form Health Survey (SF-36), and the P300 component of event-related potentials (ERP), respectively...
May 2017: European Review for Medical and Pharmacological Sciences
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