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European Review for Medical and Pharmacological Sciences

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https://www.readbyqxmd.com/read/30229854/molecular-basis-of-trigeminal-nerve-disorders-and-healing
#1
H Mohammed, L Rimondini, V Rocchetti
OBJECTIVE: This review aims to describe trigeminal neuralgia and the molecular basis contributing to the pathophysiology of this condition by focusing on the state of the art. PATIENTS AND METHODS: An electronic search of PubMed was performed using the following keywords: "trigeminal neuralgia" AND "classification", "pathophysiology," "molecular basis" and "mitochondrial role." RESULTS: Mitochondrial abnormality, whether functional or morphological, can contribute to neurological disorders...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229853/childhood-multiple-sclerosis-clinical-features-and-recent-developments-on-treatment-choices-and-outcomes
#2
Q An, C-H Fan, S-M Xu
Multiple sclerosis (MS) is an inflammatory idiopathic autoimmune disease causing demyelination of central nervous system (CNS). The incidence of pediatric MS is relatively rare, affecting 0.2 to 0.64/100,000 subjects; cases with MS onset before age 10-12 years, account for less than 1% of all MS cases, while 2.7 to 10.5% of all MS cases worldwide are seen in children <18 years of age, with a strong female preponderance. The disease course of MS varies from a benign type with relatively low level of disability after a long duration (15 years) of the disease, to a malignant type of MS with severe disability or even death within few months following onset...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229852/clinical-treatment-efficiency-of-mechanical-thrombectomy-combined-with-rhpro-uk-thrombolysis-for-acute-moderate-severe-cerebral-infarction
#3
Q-S Zhao, W Li, D Li, T Liu, J-H Wang, Y Gao, L Yi, R-K Zhao
OBJECTIVE: This study aims to compare clinical efficiency of mechanical thrombectomy combined with rhPro-UK thrombolysis on moderate or severe acute brain infarction. PATIENTS AND METHODS: A total of 90 acute cerebral infarction patients due to artery stenosis or blockade from May 2016 to May 2017 were recruited and randomly assigned into thrombolysis group (N = 30), mechanical thrombectomy (N = 30), and combined treatment group (N = 30). Clinical information was collected...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229851/effectiveness-of-antimicrobial-coated-sutures-for-the-prevention-of-surgical-site-infection-a-review-of-the-literature
#4
M G Onesti, S Carella, N Scuderi
OBJECTIVE: Surgical site infections (SSIs) are the third most common hospital-acquired infections and account for 14% to 16% of all such infections, and suture material may play a role in SSI rate. Given this risk of infection, sutures with antimicrobial activity have been developed. Both in vitro and in vivo experiments have shown that triclosan-coated sutures (TCS) are effective in the prevention of SSIs. Our aim is to analyze currently available RCTs, comparing the effect of antimicrobial-coated suture (ACS) with uncoated suture on the occurrence of SSIs following surgical procedures, we highlighted major contributions of most significant studies and evaluate the current "state of the art" on antimicrobial-coated sutures...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229850/effects-of-ulinastatin-on-myocardial-oxidative-stress-and-inflammation-in-severely-burned-rats
#5
F He, Y Song, W-J Ying, X-Y Jin, Z-X Wang, J-D Su, G-Y Wang
OBJECTIVE: By constructing the severe burns model in rat, we explored the effects of different doses of Ulinastatin (UTI) on protecting myocardium from oxidative stress and inflammatory reaction. MATERIALS AND METHODS: The severe burns model in rat was first constructed. Burned rats were intervened with different doses of UTI. Contents of cardiac troponin I (cTnI), Interleukin-1 (IL-1), Interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in rat serum and heart homogenate were detected by enzyme-linked immunosorbent assay (ELISA)...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229849/protective-effect-of-ulinastatin-combined-with-dexmedetomidine-on-lung-injury-after-cold-ischemia-reperfusion-in-rats
#6
G Wang, J-Y Li, Y-Q Weng, M Ding, H-L Yu, Q Wang, H-C Ren, R-B Xu, W-L Yu
OBJECTIVE: We investigated the protective effect of ulinastatin combined with dexmedetomidine on lung injury after hepatic ischemia-reperfusion in rats. MATERIALS AND METHODS: A total of 60 healthy and clean male Sprague Dawley (SD) rats were divided into the blank control group (group O), the model control group (group K), the ulinastatin and dexmedetomidine group (group F) according to random number table with 20 rats in each group. RESULTS: The plasma concentrations of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8) and malondialdehyde (MDA) at T1, T2 and T3 time points in rats of the three groups were significantly higher than those of the T0 time point (p<0...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229848/regulation-by-pink1-on-the-mitochondrial-dysfunction-in-endothelial-cells-post-the-hypoxia-mimetic-agent-cocl2-treatment
#7
G-H Liu, Y Wen, P Yang, G-F Liu
OBJECTIVE: To explore the role of miR-451a in the migration and invasion of non-small cell lung cancer (NSCLC) cells. MATERIALS AND METHODS: Quantitative Real time-polymerase chain reaction (qRT-PCR) and Western blot were performed to detect the levels of miR-451a and activating transcription factor 2 (ATF2) in NSCLC. Transwell assay was employed to analyze the migratory and invasive abilities in NSCLC cells. Dual-luciferase reporter assay was applied to confirm the binding condition of miR-451 and its target gene in NSCLC cells...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229847/effects-of-hydromorphone-and-morphine-intravenous-analgesia-on-plasma-motilin-and-postoperative-nausea-and-vomiting-in-patients-undergoing-total-hysterectomy
#8
Y Liu, L Yang, S-J Tao
OBJECTIVE: To observe the effects of hydromorphone and morphine intravenous analgesia on plasma motilin and postoperative nausea and vomiting in patients undergoing a total hysterectomy. PATIENTS AND METHODS: 80 patients who underwent hysterectomy from April 2015 to June 2016 were randomly divided into two groups, with 40 patients in each group. The two groups received an intravenous infusion of hydromorphone or morphine for analgesia. The VAS pain score and Ramsey sedation score were recorded 4, 8, 12, 24, and 48 hours after the first dose of analgesia...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229846/mifepristone-alleviates-cerebral-ischemia-reperfusion-injury-in-rats-by-stimulating-ppar-%C3%AE
#9
X-J Wu, X-H Sun, S-W Wang, J-L Chen, Y-H Bi, D-X Jiang
OBJECTIVE: To investigate the changes of peroxisome proliferator-activated receptor gamma (PPAR γ) in focal cerebral ischemia-reperfusion injury, and to explore the effect and mechanism of mifepristone on the cerebral ischemia-reperfusion injury. MATERIALS AND METHODS: Male Sprague-Dawley (SD) rats were selected, and the middle cerebral artery occlusion and reperfusion (MCAO/R) rat model was constructed using the longa's suture-occluded method. The sham operation group was not inserted with occlusion sutures...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229845/dixdc1-prevents-oxygen-glucose-deprivation-reoxygenation-induced-injury-in-hippocampal-neurons-in-vitro-by-promoting-wnt-%C3%AE-catenin-signaling
#10
T Li, Y-C Wan, L-J Sun, S-J Tao, P Chen, C-H Liu, K Wang, C-Y Zhou, G-Q Zhao
OBJECTIVE: Dishevelled-Axin (DIX) domain containing 1 (DIXDC1), a novel DIX domain-containing protein and a positive regulator of Wingless (Wnt) signaling, has previously been reported to play multiple roles in neurodevelopment and neurological disorders. However, whether DIXDC1 plays a role during cerebral ischemia/reperfusion injury remains unknown. In this study, we investigated the potential role of DIXDC1 in neuronal injury induced by oxygen-glucose deprivation and reoxygenation (OGD/R), an in vitro model of cerebral ischemia/reperfusion injury...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229844/fasudil-alleviates-hepatic-fibrosis-in-type-1-diabetic-rats-involvement-of-the-inflammation-and-rhoa-rock-pathway
#11
Y Xie, T Song, M Huo, Y Zhang, Y-Y Zhang, Z-H Ma, N Wang, J-P Zhang, L Chu
OBJECTIVE: Rho-associated kinases (ROCKs) are recognized to be involved in many pathophysiological processes caused by hyperglycemia. We performed experiments to evaluate the effects of fasudil, the Rho/ROCK inhibitor, on preventing hepatic fibrosis in type 1 diabetic rats and to elucidate the underlying mechanisms. MATERIALS AND METHODS: Sprague-Dawley (SD) rats were randomly divided into five groups: normal control (NC), untreated diabetic (DM), low-dose fasudil-treated (L-Fas), high-dose fasudil-treated (H-Fas) and captopril-treated (Cap) groups...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229843/the-involvement-of-p38mapk-in-the-rat-model-of-lower-extremity-arterial-ischemia-reperfusion-injury
#12
H-L Guan, S-Y Xie, F Zhang, X Jin
OBJECTIVE: This study aims to investigate the regulatory role of p38 mitogen-activated protein kinase (p38MAPK) in rats with lower-extremity arterial ischemia-reperfusion injury. MATERIALS AND METHODS: A total of 60 Sprague-Dawley (SD) rats were randomly divided into four groups: control group (Group A), lower-extremity arterial ischemia-reperfusion group (Group B), lower-extremity arterial ischemic postconditioning group (Group C), and lower-extremity arterial ischemic postconditioning + SB203580 group (Group D, 5 μmol/L SB203580, the inhibitor of MAPK pathway, was injected after lower-extremity arterial ischemic postconditioning)...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229842/mechanism-of-vasoactive-peptide-intermedin-in-vascular-collagen-remodeling-during-angiotensin-ii-induced-hypertention
#13
J-D Li, W-S An, Y Xu, X-X Zhao, Z-F Li, Y Mu, L-S Jing
OBJECTIVE: Renin-angiotensin axis plays a pivotal role in the cardiovascular system, and Angiotensin II (Ang II) is of great importance in the progression of hypertension. Vasoactive peptide intermedin (IMD) belongs to calcitonin gene-related peptide (CGRP) family, which is involved in the regulation of the cardiovascular function. This study aims to determine the effect of vasoactive peptide intermedin on vascular collagen remodeling caused by angiotensin II-induced hypertension. MATERIALS AND METHODS: 12-week old rats were randomly assigned into three groups, and each group consisted of 12 rats...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229841/long-non-coding-rna-h19-protects-acute-myocardial-infarction-through-activating-autophagy-in-mice
#14
M Zhou, Y-G Zou, Y-Z Xue, X-H Wang, H Gao, H-W Dong, Q Zhang
OBJECTIVE: We investigate the effect of long non-coding RNA H19 in acute myocardial infarction (AMI) and the underlying mechanism. MATERIALS AND METHODS: C57BL/6 mice were subjected to AMI and injected with lentivirus pcDNA-H19. After AMI procedures for 3 weeks, cardiac function was detected by echocardiography. The infarct size was stained by triphenyltetrazolium chloride. H19 expression in mice was measured by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR)...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229840/relations-of-hepatic-steatosis-with-liver-functions-inflammations-glucolipid-metabolism-in-chronic-hepatitis-b-patients
#15
X-L Chen, Y-D Han, H Wang
OBJECTIVE: To investigate the relations between the steatosis and liver functions, inflammations, and glucolipid metabolism in chronic hepatitis B patients. PATIENTS AND METHODS: A total of 144 chronic hepatitis B patients who were admitted to our hospital from January 2015 to April 2017 were selected and divided into the steatosis group (n=73) and the non-steatosis group (n=71) according to the detection of hepatic puncture biopsy. The general information of the patients including age, sex, and body mass index (BMI) was collected, and patients' liver functions, inflammations, and glucolipid metabolism indicators were determined and compared between the chronic hepatitis patients with steatosis and without steatosis...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229839/correlations-of-25-hydroxyvitamin-d3-level-in-patients-with-ulcerative-colitis-with-inflammation-level-immunity-and-disease-activity
#16
P-L Sun, S Zhang
OBJECTIVE: To investigate the correlations between 25-hydroxyvitamin D3 (25-OHD3) level in patients with ulcerative colitis (UC) and inflammation level, immunity, disease activity. PATIENTS AND METHODS: The serum level of 25-OHD3, inflammation status, immunity level and disease activity in patients (n=122) with UC in our hospital from 2015 to October 2017 were evaluated and analyzed. RESULTS: The levels of inflammatory factors [C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α)] in low 25-OHD3 group were higher than those in non-low 25-OHD3 group (p<0...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229838/low-expression-of-mir-203-promoted-diabetic-nephropathy-via-increasing-tlr4
#17
Z-M Liu, H-Y Zheng, L-H Chen, Y-L Li, Q Wang, C-F Liao, X-W Li
OBJECTIVE: To investigate the relationship between microRNA-203 (miR-203) and diabetic nephropathy and its potential mechanism. MATERIALS AND METHODS: The expression of microRNA-203 in mice with diabetic nephropathy and M4200 cells cultured with high glucose was detected by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Toll-like receptor 4 (TLR4), the target gene of microRNA-203, was predicted and screened by bioinformatics method. Real-time quantitative PCR and Western blot were used to detect the endogenous TLR4 level in renal cortex of db/db mice with diabetic nephropathy and glomerular mesangial cells cultured in high glucose or low glucose...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229837/microrna-218-alleviates-sepsis-inflammation-by-negatively-regulating-vopp1-via-jak-stat-pathway
#18
J-M Li, H Zhang, Y-J Zuo
OBJECTIVE: To investigate the possible role of microRNA-218 in the pathogenesis of sepsis and its underlying mechanism. PATIENTS AND METHODS: MicroRNA-218 expression in peripheral blood mononuclear cells (PBMCs) of 53 sepsis patients and 20 healthy controls was detected by quantitative Real-Time Polymerase Chain Reaction (qRT-PCR). MicroRNA-218 expression in Treg cells of sepsis patients and healthy controls was also detected. The binding condition of microRNA-218 to VOPP1 was confirmed by dual-luciferase reporter gene assay and RNA binding protein immunoprecipitation (RIP) assay, respectively...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229836/il-10-targets-th1-th2-balance-in-vascular-dementia
#19
Q-Q Liu, D Zhong, X Zhang, G-Z Li
OBJECTIVE: The pathogenesis of vascular dementia (VD) is not fully elucidated. Th1/Th2 balance may change in VD, leading to numerous inflammatory cytokines secretion. Interleukin-10 (IL-10) is an immune suppressor, while its function in VD and correlation with Th1/Th2 balance are still unclear. MATERIALS AND METHODS: The healthy male rats were randomly divided into three groups, including sham group, model group, and IL-10 group. Th1 and Th2 cytokines IL-2, IL-4, IL-6, and tumor necrosis factor-α (TNF-α) expressions in the serum were tested by enzyme-linked immunosorbent assay (ELISA)...
September 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30229835/microrna-544-inhibits-inflammatory-response-and-cell-apoptosis-after-cerebral-ischemia-reperfusion-by-targeting-irak4
#20
R Fang, N-N Zhao, K-X Zeng, Q Wen, P Xiao, X Luo, X-W Liu, Y-L Wang
OBJECTIVE: Stroke remains the most common malignant cerebrovascular event in the world. The correlation between the expression of miR-544 and the degree of cerebral ischemia reperfusion (CIR) injury has not been well recognized in recent years. This study focuses on the effect of miR-544 on inflammation and apoptosis after CIR. PATIENTS AND METHODS: Plasma expression of miR-544 in ischemic stroke (IS) patients and healthy controls was determined by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR)...
September 2018: European Review for Medical and Pharmacological Sciences
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