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European Review for Medical and Pharmacological Sciences

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https://www.readbyqxmd.com/read/29164591/trend-of-decreasing-length-of-cervical-cone-excision-during-the-last-20-years
#1
F Sopracordevole, N Clemente, G Delli Carpini, G Giorda, A Del Fabro, L Moriconi, G De Piero, L Alessandrini, V Canzonieri, M Buttignol, M Nicodemo, A Ciavattini
OBJECTIVE: The aim of the present investigation was to evaluate the cervical conizations performed in the last 20 years in a single institution, with a particular interest in analyzing the trend of the length of cone excisions. PATIENTS AND METHODS: A retrospective cohort study of women who underwent a CO2-laser cervical conization between January 1996 and December 2015. Cytological abnormalities on referral pap smear, colposcopic findings and pertinent clinical and socio-demographic characteristics of each woman were collected...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164590/the-effect-of-abdominal-obesity-in-patients-with-polycystic-ovary-syndrome-on-metabolic-parameters
#2
G Franik, A Bizoń, S Włoch, D Pluta, Ł Blukacz, H Milnerowicz, P Madej
OBJECTIVE: Polycystic ovarian syndrome and obesity contribute to the metabolic complications for women of reproductive age. The aim of present study was to analyze the effect of abdominal obesity expressed using waist/hip ratio (WHR) in patients with polycystic ovary syndrome on metabolic parameters. PATIENTS AND METHODS: The study included 659 women with PCOS with WHR <0.8 and ≥0.8 aged between 17 and 44 years. Patients were tested for follicular stimulating hormone, luteinizing hormone, 17-beta-estradiol, dehydroepiandrosterone sulfate, androstenedione, sex hormone binding globulin, and total lipid profile during the follicular phase (within 3 and 5 days of their menstrual cycle)...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164589/mir-214-protects-mc3t3-e1-osteoblasts-against-h2o2-induced-apoptosis-by-suppressing-oxidative-stress-and-targeting-atf4
#3
X-Z Lu, Z-H Yang, H-J Zhang, L-L Zhu, X-L Mao, Y Yuan
OBJECTIVE: Fragility fracture is one of the common complications of osteoporosis. Elevated oxidative stress-induced apoptosis is thought to be one of the unfavorable factors to osteoblastic dysfunction, which increased the risk of bone fracture. However, the molecular mechanisms for oxidative stress-induced osteoblast cells apoptosis still need to be elucidated. This study aims to investigate the protective function of miR-214 in H2O2-induced apoptosis of MC3T3-E1 osteoblasts. MATERIALS AND METHODS: MC3T3-E1 cells were treated with 400 μM H2O2...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164588/lncrna-hoxa11-as-is-involved-in-fracture-healing-through-regulating-mir-124-3p
#4
X-N Wang, L-H Zhang, X-D Cui, M-X Wang, G-Y Zhang, P-L Yu
OBJECTIVE: Long noncoding RNAs (lncRNAs) have been reported to participate in many diseases. Fracture healing is one of these ordinary diseases. This study aims to identify how lncRNA HOXA11-AS affects the progression of fracture healing. MATERIALS AND METHODS: RT-qPCR was performed to detect the level of HOXA11-AS. Moreover, function assays including cell growth assay and cell apoptosis assay were performed to explore how HOXA11-AS functions in fracture healing...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164587/mir-214-inhibits-human-mesenchymal-stem-cells-differentiating-into-osteoblasts-through-targeting-%C3%AE-catenin
#5
J-P Li, H-T Zhuang, M-Y Xin, Y-L Zhou
OBJECTIVE: Wnt/β-catenin signaling pathway promotes osteoblasts (OBs) differentiation through up-regulating osteoblast-specific gene runt-related transcription factor 2 (RUNX2) expression. It was showed that microRNA-214 (miR-214) was abnormally increased in bone tissue from osteoporosis patients, suggesting its role in osteogenesis. Bioinformatics analysis revealed the complementary binding site between miR-214 and 3'-UTR of β-catenin. This study investigated the effects of miR-214 in regulating β-catenin expression and bone marrow mesenchymal stem cells (BMSCs) differentiating into OB...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164586/functions-of-micrornas-in-osteoporosis
#6
D-W Ge, W-W Wang, H-T Chen, L Yang, X-J Cao
Osteoporosis (OP) is a kind of disease with a 25% incidence, characterized by the bone mass loss, bone microstructure damage, increased bone fragility, and easy fracture. miRNA plays an important regulatory role in the process of bone remodeling, especially in the regulation of differentiation and function of osteoblasts and osteoclasts, and the development and progression of OP and other bone diseases. In the future, it is expected to delay the bone loss and promote the bone remodeling via the overexpression or inhibition of specific miRNAs in specific tissues, thereby treating OP...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164585/expression-and-clinical-significance-of-mir-181a-and-mir-203-in-systemic-lupus-erythematosus-patients
#7
H-S Li, Y Ning, S-B Li, P-Y Shao, S-J Chen, Q Ye, X Heng
OBJECTIVE: MiR-181a plays a critical role in modulating T cell and B cell differentiation, as well as immune response. Its abnormal expression probably participates in the pathogenesis of systemic lupus erythematosus (SLE). MiR-203 is involved in regulating Toll-like receptor and inducing immune tolerance. Abnormal expression or function of miR-203 is related to multiple auto-immune diseases but its role in SLE remains unclear. This study, thus, investigated the serum level of miR-181a and miR-203, to analyze their roles in diagnosing and evaluating SLE...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164584/cardiac-magnetic-resonance-in-systemic-sclerosis-patients-with-cardiac-symptoms
#8
A Meduri, D V Di Molfetta, L Natale, R Manfredi
OBJECTIVE: Systemic sclerosis (SSc) is characterized by widespread vascular lesions and skin and internal organs fibrosis, including the heart; all cardiac layers, endocardium, myocardium, and pericardium, may be involved. We report the relevance of cardiac MRI findings in scleroderma patients with cardiac symptoms. PATIENTS AND METHODS: 50 patients, all fulfilling the ACR SSc criteria (19 with limited and 31 with diffused skin involvement) were evaluated using a 1...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164583/application-of-dynamic-ct-to-identify-lung-cancer-pulmonary-tuberculosis-and-pulmonary-inflammatory-pseudotumor
#9
X-L Wang, W Shan
OBJECTIVE: To determine the value of dynamic enhanced computed tomography (CT) scanning in diagnosing lung cancer, pulmonary tuberculosis, and pulmonary inflammatory pseudotumor. PATIENTS AND METHODS: We recruited 30 patients with pulmonary tuberculoma, 38 with lung cancer, and 16 with pulmonary inflammatory pseudotumor. All patients received CT scanning, dynamic enhanced CT scanning for 20, 30, 45, 60, 75, 90, and 120 s, and scanning for 3, 5, 8, 12, and 15 min...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164582/mir-15a-5p-suppresses-endometrial-cancer-cell-growth-via-wnt-%C3%AE-catenin-signaling-pathway-by-inhibiting-wnt3a
#10
Z-M Wang, X-H Wan, G-Y Sang, J-D Zhao, Q-Y Zhu, D-M Wang
OBJECTIVE: Endometrial cancer is one of the three most common types of gynecologic cancer. The global incidence has increased in recent years. microRNAs (miRNAs) regulate numerous biological processes by binding to the 3'UTR of target mRNA to down-regulate protein synthesis. PATIENTS AND METHODS: Endometrial cancer patients received surgeries in our hospital were enrolled. MiR-15a-5p mimic or miR-15a-5p inhibitor was transfected into HEC-1-A cells by lentivirus...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164581/microrna-30c-suppressed-giant-cell-tumor-of-bone-cell-metastasis-and-growth-via-targeting-hoxa1
#11
L-Y Ni, J-D Zhao, Y-H Lu, W Li, B-L Li, X-C Wang, Q-G Meng
OBJECTIVE: To dissect the functioning mode of miR-30c on giant cell tumor of bone cell metastasis and growth and provide therapeutic targets for giant cell tumor of bone. PATIENTS AND METHODS: By quantitative Real-time polymerase chain reaction (qRT-PCR), miR-30c expression level in 62 pairs of giant cell tumor of bone cells tissue samples and five breast cancer-derived cell lines. Using miR-30c mimics and inhibitors, we analyzed the effects of miR-30c over-expression and knockdown on cell proliferation, invasion, and migration...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164580/mir-564-inhibited-metastasis-and-proliferation-of-prostate-cancer-by-targeting-mllt3
#12
F-J Meng, F-M Meng, H-X Wu, X-F Cao
OBJECTIVE: MiR-564 has been discovered to be abnormally expressed in human malignancy. Two recent studies suggested that miR-564 plays a role in tumor inhibition in both lung and breast cancer. However, no evidence reported the mechanism and function of miR-564 in prostate cancer (PCa). PATIENTS AND METHODS: The PCa tissues and their adjacent normal tissues were collected from 50 PCa patients. Expressions of miR-564 in tissues and cells were evaluated with RT-qPCR...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164579/mir-181a-promotes-epithelial-to-mesenchymal-transition-of-prostate-cancer-cells-by-targeting-tgif2
#13
C Zhiping, T Shijun, W Linhui, W Yapei, Q Lianxi, D Qiang
OBJECTIVE: Prostate cancer is the most commonly diagnosed cancer, and metastatic prostate cancer often leads to poor outcomes for patients. During the metastasis processes, cancer cells acquire a migratory and invasive phenotype. Epithelial to mesenchymal transition (EMT) has been implicated in multiple processes of prostate cancer development including migration, chemoresistance, and carcinogenesis. PATIENTS AND METHODS: Expressions of miR-181a in prostate tumor samples and cancer cells were measured by qRT-PCR...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164578/mir-590-3p-promotes-colon-cancer-cell-proliferation-via-wnt-%C3%AE-catenin-signaling-pathway-by-inhibiting-wif1-and-dkk1
#14
Z-Y Feng, X-H Xu, D-Z Cen, C-Y Luo, S-B Wu
OBJECTIVE: Colon cancer is one of the most common and deadly types of gastrointestinal tumor. Despite progressive treatments, the patient prognosis has not been improved effectively. MATERIALS AND METHODS: Expression of miRNA and mRNA were tested by Realtime PCR. Cell cycle was detected by flow cytometry. Cell viability was evaluated by MTT assay. Cell spheroid formation was determined by colony assay. Wnt signaling pathway activity was evaluated by TOP/FOP ratio...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164577/mir-150-alleviates-emt-and-cell-invasion-of-colorectal-cancer-through-targeting-gli1
#15
H Fan, X Liu, W-W Zheng, Z-H Zhuang, C-D Wang
OBJECTIVE: Epithelial-mesenchymal transition (EMT) is related to colorectal cancer invasion and metastasis. Glioma-associated oncogene homolog 1 (Gli1) abnormal expression is associated with EMT, invasion, and metastasis in various cancers. MiR-150 is found downregulated in colorectal cancer pathogenesis. Bioinformatics analysis shows the complementary targeted relationship between miR-150 and the 3'-UTR of Gli1 mRNA. This study explores the role of miR-150 in regulating Gli1 expression, colorectal cancer cell EMT, and invasion...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164576/potentiation-of-treatment-efficacy-against-colon-cancer-of-dopamine-via-elevating-klf2-expression-in-tumor-vascular-endothelial-cells
#16
S Chen, Y-M Zhang, Y-G Zhang, J Jia, R-W Zhu
OBJECTIVE: To investigate the anti-tumor effect and potential mechanism of dopamine combined with 5-FU in colon cancer. MATERIALS AND METHODS: Babl/c F1 generation male mice (N = 60) were inoculated with mouse C26 colon cancer cells below the pit to construct colon cancer model. Tumor-bearing mice were then divided into 4 groups (N = 8 each): model control group, dopamine group, 5-FU group and dopamine combined with 5-FU group. Dopamine (100 mg/kg/d) was intraperitoneally injected into mice...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164575/long-non-coding-rna-xloc_010235-correlates-with-poor-prognosis-and-promotes-tumorigenesis-of-hepatocellular-carcinoma
#17
F Yang, Y Jiang, L-Z Lv
OBJECTIVE: Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. Long non-coding RNAs (lncRNAs) are novel proposed non-coding RNAs, and play critical roles in tumorigenesis. However, the clinical significance, biological role and molecular mechanism of ncRNAs in HCC still remain largely elusive. The aim of this study was to uncover the clinical value and biological role of XLOC_010235 (XLOC), which has been demonstrated as an oncogene in gastric cancer, in HCC...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164574/mechanism-of-as2o3-induces-apoptosis-of-glioma-u87-cells
#18
G-B Wang, J-H Liu, J Hu, K Xue
OBJECTIVE: To investigate the mechanism of arsenic trioxide (As2O3)-induced apoptosis of glioma cells. MATERIALS AND METHODS: U87 cells were treated by different concentrations of As2O3 (8 μmol/L, 6 μmol/L, 4 μmol/L, 2 μmol/L, 1 μmol/L and 0.5 μmol/L) for 24 h, 48 h and 72 h, respectively. Cell viability was detected by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and the appropriate dosage and time were screened. Transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL) was used to stain cells, followed by an investigation on the apoptosis of cells...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164573/role-of-perfusion-ct-in-the-evaluation-of-metastatic-nodal-tumor-response-after-radiochemotherapy-in-head-and-neck-cancer-preliminary-findings
#19
S Ursino, L Faggioni, F Fiorica, D Delishaj, V Seccia, F Pasqualetti, I Desideri, C Colosimo, R Morganti, F Paiar, D Caramella
OBJECTIVE: To assess changes of CT perfusion parameters (ΔPCTp) of cervical lymph node metastases from head and neck cancer (HNC) before and after radiochemotherapy (RT-CT) and their association with nodal tumor persistence. PATIENTS AND METHODS: Eligibility criteria included HNC (Stage III-IV) candidates for RT-CT. Patients underwent perfusion CT (PCT) at baseline 3 weeks and 3 months after RT-CT. Blood volume (BV), blood flow (BF), mean transit time (MTT) and permeability surface (PS) were calculated...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164572/expression-of-glut-1-in-nasopharyngeal-carcinoma-and-its-clinical-significance
#20
J-C Zhou, J-J Zhang, W Zhang, Z-Y Ke, L-G Ma, M Liu
OBJECTIVE: To investigate the relationship between the expression of glucose transporter-1 (GLUT-1) and the clinicopathological features and prognosis of patients with nasopharyngeal carcinoma (NPC). PATIENTS AND METHODS: Sixty-three patients with NPC (the NPC group) and 24 patients with chronic nasopharyngitis (the control group) who were treated between December 2014 and February 2016 were selected for this study. Pathological nasopharyngeal tissues were collected from patients...
November 2017: European Review for Medical and Pharmacological Sciences
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