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European Review for Medical and Pharmacological Sciences

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https://www.readbyqxmd.com/read/28975997/mechanisms-of-ogt2115-inhibition-of-invasion-and-migration-in-kb-oral-cancer-cells
#1
S Shen, J-X Tang
The article "Mechanisms of OGT2115 inhibition of invasion and migration in KB oral cancer cells" by S. Shen, J.-X. Tang, published in Eur Rev Med Pharmacol Sci 2017; 21 (1): 55-60 has been withdrawn.
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975996/laparoscopic-pancreaticoduodenectomy-for-tumors-of-the-head-of-pancreas-10-cases-for-a-single-center-experience
#2
F Caruso, G Alessandri, G Cesana, G Castello, M Uccelli, F Ciccarese, R Giorgi, R Villa, B Scotto, S Olmi
OBJECTIVE: The tumors of the head of the pancreas are one of the leading causes of cancer-related death in Western countries. The current gold standard for these tumors is a Whipple procedure. This procedure did not change in its surgical steps since when it was initially introduced in 1935. More recently, a laparoscopic approach with similar outcomes has been described. The aim of this paper is to describe the laparoscopic surgical technique performed in our unit, reporting single center postoperative outcomes...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975995/mir-146a-inhibits-proliferation-and-induces-apoptosis-in-murine-osteoblastic-mc3t3-e1-by-regulating-bcl2
#3
B Zhang, J Yi, C-L Zhang, Q-H Zhang, J-F Xu, H-Q Shen, D-W Ge
OBJECTIVE: The dysregulation of proliferation and apoptosis plays a significant role in the pathogenesis of hormone-induced osteonecrosis of femoral head (ONFH). The research aimed to explore the regulatory role of miR-146a in dexamethasone (DEX)-induced proliferation and apoptosis change in MC3T3-E1 cells from murine osteoblastic. MATERIAL AND METHODS: In this study, MC3T3-E1 was co-cultured with 10-7 DEX for 6 h, then RT-PCR was employed to test the expression level of miR-146a and Bcl2...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975994/mir-145-silencing-promotes-steroid-induced-avascular-necrosis-of-the-femoral-head-repair-via-upregulating-vegf
#4
Z-J Tian, B-Y Liu, Y-T Zhang, X-Z Chen, G-Y Qiao, S Wang, Z-L Ma
OBJECTIVE: To investigate the role of miR-145 silencing in the expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), B-cell lymphoma-2 (Bcl-2), BCL2-Associated X(bax) and caspase-3 in avascular necrosis of femoral head (ANFH). MATERIALS AND METHODS: A total of 12 healthy wild-types (the control group) and 12 miR-145 knock-out (miR-145-/-) (the experimental group) adult New Zealand white rabbits were selected to construct ANFH model with a steroid...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975993/lncrna-h19-polymorphisms-associated-with-the-risk-of-oscc-in-chinese-population
#5
Q-Y Guo, H Wang, Y Wang
OBJECTIVE: H19, a maternally expressed imprinted gene transcribing a long noncoding RNA, has previously been reported to be involved in tumorigenesis and cancer progression. The relationship between H19 and susceptibility of multiple tumors is inconsistent, and currently there is a lack of association of H19 with the risk of oral squamous cell carcinoma (OSCC). The objective to design this research is to investigate and discuss the association of H19 with susceptibility to oral squamous cell carcinoma in Chinese population...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975992/association-between-h19-polymorphisms-and-osteosarcoma-risk
#6
T-D He, D Xu, T Sui, J-K Zhu, Z-X Wei, Y-M Wang
OBJECTIVE: The long non-coding RNA (lncRNA) H19, a maternally expressed imprinted gene, has involvement in cancer susceptibility and disease progression. However, the association between H19 polymorphisms and osteosarcoma susceptibility has remained elusive. We designed this case-control study to explore the association between H19 polymorphism and osteosarcoma risk. PATIENTS AND METHODS: In this study, we genotyped 4 tagger SNPs of the H19 gene in a case-control study including 193 osteosarcoma cases and 393 cancer-free controls...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975991/downregulation-of-sash1-correlates-with-poor-prognosis-in-cervical-cancer
#7
J Xie, W Zhang, J Zhang, Q-Y Lv, Y-F Luan
OBJECTIVE: The aim of this study was to analyze the association of SASH1 expression with clinicopathological features and prognosis in patients suffering cervical cancer. PATIENTS AND METHODS: The expressions of SASH1 mRNA and protein in cervical cancer tissues and matched normal cervical tissues were detected by Real-time PCR and Immunohistochemistry. Based on the above findings, the association among SASH1 expression and clinicopathological features was analyzed...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975990/mir-326-regulates-emt-and-metastasis-of-endometrial-cancer-through-targeting-twist1
#8
W Liu, B Zhang, N Xu, M-J Wang, Q Liu
OBJECTIVE: Endometrial carcinoma is the most common malignancy of the female genital tract. Therefore, there is an urgent need to understand the molecular mechanism of its metastasis. This study is aimed to explore the function and underlying mechanism of miR-326 in endometrial cancer (EC). PATIENTS AND METHODS: RT-PCR was used to evaluate the miR-326 expression in EC tissues and cell lines. The CKK-8 was used to detect the EC cells proliferation. Transwell assay was performed to evaluate the metastasis of EC cells...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975989/mir-577-inhibits-papillary-thyroid-carcinoma-cell-proliferation-migration-and-invasion-by-targeting-sphk2
#9
K-C Xue, D-D Hu, L Zhao, N Li, H-Y Shen
OBJECTIVE: MiRNAs are small, noncoding RNA molecules that serve as important regulators of cancer-related processes. Abnormal expression of miR-577 has been found in several tumors. However, the expression pattern and biological function of miR-577 in progression of papillary thyroid cancer (PTC) remain unknown. This study is aimed to determine its expression pattern and explore the function underlying the mechanism of miR-577 in PTC. PATIENTS AND METHODS: Using quantitative RT-PCR, we detected miR-577 expression in PTC cell lines and primary tumor tissues...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975988/risk-factors-for-predicting-central-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma-cn0-a-study-of-273-resections
#10
M Li, X-Y Zhu, J Lv, K Lu, M-P Shen, Z-L Xu, Z-S Wu
OBJECTIVE: The role of routine central lymph node dissection (CLND) for clinically central lymph node negative (CN0) papillary thyroid microcarcinoma (PTMC) remains uncertain. We aim to determine the predictive factors for central lymph node metastasis (CLNM) in papillary thyroid microcarcinoma. PATIENTS AND METHODS: A total of 273 patients diagnosed with clinically central lymph node negative PTMC from 2014 to 2016 were included. The predictive risk factors for CLNM were analyzed with respect to age, sex, tumor size, tumor multifocal, lymphadenectasis of lateral neck, capsular invasion, extra capsular spread (ECS), coexistence of chronic lymphocytic thyroiditis (Hashimoto thyroiditis, HT) and nodular goiter (NG), BRAFV600E mutation and subtype of papillary thyroid carcinoma (PTC)...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975987/long-non-coding-rna-loc344887-is-a-potential-prognostic-biomarker-in-non-small-cell-lung-cancer
#11
B Wu, X-J Zhang, X-G Li, L-S Jiang, F He
OBJECTIVE: Long non-coding RNA NmrA-like family domain containing 1 pseudogene (Loc344887) has been shown to be aberrantly expressed in non-small cell lung cancer (NSCLC). However, the biological function of Loc344887 in NSCLC remains unknown. The present study aimed to explore the prognosis value of Loc344887 in NSCLC patients. PATIENTS AND METHODS: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to detect the expression level of Loc344887 in NSCLC tissues and adjacent non-tumor lung tissues...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975986/csr1-suppresses-tumor-growth-and-metastasis-of-human-hepatocellular-carcinoma-via-inhibition-of-hpip
#12
L Jiang, G Hu, F-F Chen, X-Y Du, B Liu, C Liu
OBJECTIVE: Cellular stress response 1 (CSR1) is a tumor suppressor gene that was frequently down-regulated in prostate cancer. CSR1 has critical roles in the regulation of cell apoptosis via inactivation of CPSF3 or preventing the interaction of XIAP with caspases. However, whether CSR1 plays a role in human hepatocellular carcinoma (HCC) is completely unknown. PATIENTS AND METHODS: The expression of CSR1 in HCC clinic samples and cell lines was detected by Real-time PCR and Western blot...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975985/sox12-upregulation-is-associated-with-metastasis-of-hepatocellular-carcinoma-and-increases-cdk4-and-igf2bp1-expression
#13
P Yuan, L Meng, N Wang
OBJECTIVE: In this study, we studied the expression profile of SOX12 gene in different pathological stages of hepatocellular carcinoma (HCC) and explored the possible downstream genes related to its regulation of HCC invasion and migration. MATERIALS AND METHODS: Bioinformatic data mining was performed in liver cancer cohort in TCGA. HepG2 cells were used as in vitro cell model to assess the effect of SOX12 on CDK4 and IGF2BP1 expression. The association between the expression of SOX12, CDK4 or IGF2BP1 and survival time in HCC patients was also assessed based on the data in TCGA...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975984/levels-of-hbx-vegf-and-ceacam1-in-hbv-related-hepatocellular-carcinoma-and-their-correlation-with-cancer-prognosis
#14
C-S Mao, H Yin, H-B Ning, Z Peng, K Li, G-Q Ding
OBJECTIVE: Hepatitis B virus X protein (HBx), vascular endothelial growth factor (VEGF) and carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM1), are related to HBV associated hepatocellular carcinoma (HCC). This study recruited HCC patients and employed the SMMC-7721 and L02 liver cell lines, to analyze the expression levels of HBx, VEGF and CEACAM1 in liver cancer and their correlation with the cancer prognosis. PATIENTS AND METHODS: HBV-related HCC patients were recruited from our hospital...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975983/hiv-patient-with-pseudomyxoma-peritonei-of-extra-appendiceal-origin-is-disease-free-and-alive-9-years-after-complete-cytoreductive-surgery
#15
A Tampakis, E C Tampaki, P Alexandrou, K Kontzoglou, G Kouraklis
OBJECTIVE: Pseudomyxoma peritonei (PMP) is a clinical syndrome that is mainly characterized by the presence of mucinous ascites that results from the rupture of a mucin-producing neoplasm. No reports exist so far regarding the management of this syndrome in HIV patients. CASE REPORT: A 54-year old male patient with a diagnosed atypical colitis developed additionally over time a complicated diverticulitis which was initially treated conservatively with antibiotics...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975982/increased-expression-of-long-non-coding-rna-sbdsp1-correlates-with-poor-survival-in-colorectal-cancer
#16
H-B Zhou, Q Li, M Liu, Y-Q Cao, J-Y Xu
OBJECTIVE: Long non-coding RNA SBDSP1 (SBDSP1) had been reported to be increased in colorectal cancer (CRC), but its effects on prognosis were still unclear. The aim of this study was to investigate the clinical significance and prognostic value of the SBDSP1 expression in CRC. PATIENTS AND METHODS: The expression levels of SBDSP1 in CRC tissues and adjacent normal tissues were detected using quantitative Real-time PCR (qRT-PCR). The association between SBDSP1 expression and clinicopathological factors as well as survival rates were analyzed...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975981/increased-lncrna-afap1-as1-expression-predicts-poor-prognosis-and-promotes-malignant-phenotypes-in-gastric-cancer
#17
Y Feng, Q Zhang, J Wang, P Liu
OBJECTIVE: The clinical significance and biological functions of long non-coding RNA AFAP1-AS1 in gastric cancer (GC) remain larger elucidated. The aim of the study is to investigate the role of lncRNA AFAP1-AS1 involved in GC progression. PATIENTS AND METHODS: Quantitative reverse transcription-polymerase chain reaction (QRT-PCR) assay was used to evaluate the expression of lncRNA AFAP1-AS1 in GC tissues, when compared with adjacent noncancerous tissues, respectively...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975980/lncrna-meg3-inhibit-proliferation-and-metastasis-of-gastric-cancer-via-p53-signaling-pathway
#18
G-H Wei, X Wang
OBJECTIVE: lncRNA MEG3 has been reported as a tumor suppressor gene in many different kinds of cancer, but its role in gastric cancer has not been fully understood. Then, we would like to explore its mechanism in gastric cancer. PATIENTS AND METHODS: We first used qRT-PCR to detect the expression of lncRNA MEG3, then CCK8 and wound healing assay were used to detect the effect of lncRNA MEG3 on gastric cancer cells. Western blot assay was used to measure the expression of p53 when lncRNA MEG3 was overexpressed...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975979/gli2-induces-pdgfrb-expression-and-modulates-cancer-stem-cell-properties-of-gastric-cancer
#19
J-X Wang, J-F Zhou, F-K Huang, L Zhang, Q-L He, H-Y Qian, H-L Lai
OBJECTIVE: In this study, we aimed to investigate the downstream effector of GLI2 in gastric cancer (GC) and their regulative effect on cancer stem cell (CSC) properties of GC. MATERIALS AND METHODS: Bioinformatic data mining was performed in TCGA-Stomach Adenocarcinoma (STAD), as well as in Kaplan-Meier plotter. Moderate-differentiated GC cell line SGC-7901 and poor-differentiated GC cell line MKN-45 were used as in-vitro model to investigate the regulative effect of GLI2 on PDGFRB expression...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28975978/down-regulation-of-lncrna-mir31hg-correlated-with-aggressive-clinicopathological-features-and-unfavorable-prognosis-in-esophageal-squamous-cell-carcinoma
#20
Z-P Ren, X-Y Chu, Z-Q Xue, L-B Zhang, J-X Wen, J-Q Deng, X-B Hou
OBJECTIVE: Long non-coding RNA MIR31HG (MIR31HG) has been shown to affect numerous tumorigenesis. However, the function of MIR31HG in esophageal squamous cell carcinoma (ESCC) remains unclear. The aim of this study was to investigate whether the levels of MIR31HG could be served as a prognostic factor in patients with ESCC. PATIENTS AND METHODS: MIR31HG expression was detected in 185 samples of surgically resected ESCC and matched normal tumor-adjacent tissues by qRT-PCR...
October 2017: European Review for Medical and Pharmacological Sciences
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