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European Review for Medical and Pharmacological Sciences

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https://www.readbyqxmd.com/read/28485811/the-effects-of-second-messenger-camp-and-its-relative-components-on-the-contraction-of-uterine-smooth-muscle-of-rat
#1
S-J Shu, X-G Lei, J-H Liang, Y-H Song, Q Xu, X-D Chen, L-G Mao, Z-G Li
OBJECTIVE: To investigate the effect of second messenger pathways on the uterine smooth muscle contraction and their associated mechanisms, and compare the evaluation methods. MATERIALS AND METHODS: Preparation of uterine smooth muscle strips from healthy pregnant 18-21 d SD and non-pregnant rats. When the contraction of muscle strips was stable, we conducted gradient administration: PDE4 inhibitors (Z90), prostaglandin PGE2, adenylate cyclase inhibitor (SQ 22,530), cAMP analogs (dbcAMP) and AMPK agonists (AICAR), solvent dimethyl sulfoxide (DMSO) as controlled...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485810/expression-of-indoleamine-2-3-dioxygenase-in-pregnant-mice-correlates-with-cd4-cd25-foxp3-t-regulatory-cells
#2
L-L Yu, Y-H Zhang, F-X Zhao
OBJECTIVE: Indoleamine 2,3-dioxygenase (IDO) initiated tryptophan degradation in the placenta has a role in the prevention of allogeneic fetus rejection by T-cells. The present study aimed to investigate the relationship between IDO and CD4+CD25+Foxp3+ T cells in pregnant mice. MATERIALS AND METHODS: The percentage of CD4+CD25+Foxp3+ T cells in peripheral blood mononuclear cells (PBMC) and IDO mRNA levels were detected in pregnant mice. The non-pregnant mice were used as control in this study...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485809/overexpression-of-%C3%AE-arrestin2-induces-g1-phase-cell-cycle-arrest-and-suppresses-tumorigenicity-in-renal-cell-carcinoma
#3
Y-J Cao, Y-J Zhou, X-Z He, C-X Zhou, L Cui, Q-F Zhuang, R-F Xu
OBJECTIVE: The objective of this study was to investigate the role of β-arrestin2 in the proliferation, migration, apoptosis, cell cycle and clone formation of renal cell carcinoma (RCC) cell lines and to explore the possible mechanism of β-arrestin2 in RCC invasion and metastasis to find a new therapeutic target. MATERIALS AND METHODS: Cell proliferation, migration, apoptosis, cell cycle and clone formation were analyzed after RCC cell lines (786-0 and CaKi) and transfected with β-arrestin2 overexpression plasmid...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485808/influences-of-rfa-combined-with-tace-on-the-hif-1%C3%AE-and-egr-level-of-patients-with-primary-hepatic-carcinoma
#4
G Yuan, C-L Zeng, D-D Zhu, X-J Shi
OBJECTIVE: To discuss the influences of radiofrequency ablation (RFA) combined with hepatic arterial chemoembolization on the expression level of immunity and hypoxia-inducible factor (HIF-1a) and early growth response protein2 (EGR2) of patients with hepatocarcinoma. PATIENTS AND METHODS: Patients with primary hepatic carcinoma treated in our hospital from 2011 to 2014 were divided into research group (RFA+TACE) and control group (TACE) according to different therapy methods, with 72 patients in each group...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485807/effect-of-zeb2-silencing-on-cisplatin-resistance-in-gastric-cancer
#5
D-M Geng, X-M Kan, W-W Zhang
OBJECTIVE: To investigate the effect of ZEB2 silencing on cisplatin resistance in gastric cancer. MATERIALS AND METHODS: The resulting cell line, SGC7901/DDP, was transfected with ZEB2 siRNA, non-specific siRNA, or vehicle control. The effectiveness of ZEB2 silencing was evaluated by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot. MTT viability assay was used to determine the cisplatin-sensitivity of cells. Cell apoptosis was measured by flow cytometry...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485806/microrna-200c-represses-migration-and-invasion-of-gastric-cancer-sgc-7901-cells-by-inhibiting-expression-of-fibronectin-1
#6
H-B Chen, H-T Zheng
OBJECTIVE: Gastric cancer remains a worldwide burden as a leading cause of cancer-related death. Drug resistance of chemotherapy looms as a major clinical challenge to effective treatment. Recent research data has suggested that microRNAs could be a potential gastric cancer treatment strategy. To further evaluate the role of microRNAs on gastric cancer cells and its underlying possible mechanism, we transfected human gastric cancer SGC-7901 cells with microRNA-200c. MATERIALS AND METHODS: The cell proliferation, migration and invasion of SGC-7901 were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, Transwell assay and cell invasion assay...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485805/microrna-217-suppressed-epithelial-to-mesenchymal-transition-in-gastric-cancer-metastasis-through-targeting-ptpn14
#7
Y-P Liu, X-H Sun, X-L Cao, W-W Jiang, X-X Wang, Y-F Zhang, J-L Wang
OBJECTIVE: Gastric cancer (GC) is the third leading cause of cancer-related deaths while the mechanisms underlying its metastasis are not fully understood. In this study, we aimed to explore the relationship between miR-217 and GC metastasis. PATIENTS AND METHODS: We examined miR-217 level in gastric tumor tissues of 48 patients with GC and in cell lines including gastric mucosa epithelial cell line (GES-1), gastric cancer cell line (BGC-823), and gastric cancer cell line (SGC-7901)...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485804/the-structure-and-functions-of-paxillin-and-its-roles-in-neovascularization
#8
W-J Yang, J Zhong, J-G Yu, F Zhao, Y Xiang
Identifying and studying the molecular mechanisms of neovascularization biomarkers are critical for conquering many diseases, such as corneal diseases and cancer. Paxillin is an important cell scaffold and cellular signaling protein, especially a key molecule of the Integrin-mediated downstream signaling transduction. This review summarizes the structure and functions of paxillin, and the research progress of its roles in neovascularization. Although there are still some problems to be solved, paxillin may become an important target of anti-neovascularization therapies...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485803/clinical-efficacy-of-gamma-knife-and-surgery-treatment-of-mesial-temporal-lobe-epilepsy-and-their-effects-on-ef-tumt-and-ef-tsmt-expression
#9
X-Q Wang, X-D Zhang, Y-M Han, X-F Shi, Z-B Lan, X-X Men, Y-W Pan
OBJECTIVE: To study the clinical efficacy of gamma knife and surgery treatment of mesial temporal lobe epilepsy (MTLE) and their effects on EF-Tumt and EF-Tsmt expression. PATIENTS AND METHODS: The data of 78 cases of MTLE patients treated in our hospital from April 2011 to March 2013 were retrospectively analyzed. The patients were divided into two groups according to the treatment methods: the surgery group (including 41 cases) and the gamma knife group (including 37 cases)...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485802/nogo-a-antibody-treatment-enhances-neuron-recovery-after-sciatic-nerve-transection-in-rats
#10
Z-W Zhang, J-J Jiang, M-C Luan, Z-J Ma, F Gao, S-J Yu
OBJECTIVE: The use of an antibody to block the neurite outgrowth inhibitor Nogo-A has been of great interest for promoting axonal recovery as a treatment for peripheral nerve injuries. The present study aimed to investigate the signaling pathway of p75 neurotrophin receptor (NTR) and Nogo receptor (NgR) in a sciatic nerve transection (SNT) rat model and evaluate the underlining mechanisms. MATERIALS AND METHODS: Seventy-five Sprague-Dawley (SD) rats were randomly divided into 3 groups (n=25), namely the sham group, sciatic nerve transection (model) group and Nogo-A-pAb group...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485801/insulin-resistance-in-alzheimer-s-disease-ad-mouse-intestinal-macrophages-is-mediated-by-activation-of-jnk
#11
Y-L Zhou, Y-F Du, H Du, P Shao
OBJECTIVE: Alzheimer's disease (AD) has been considered as a metabolic disorder disease, which closely related to insulin signaling impairment. Therefore, identifying the potential mechanism of insulin resistance is important for AD treatment. MATERIALS AND METHODS: An APP/PS1 double transgenic AD mouse model was introduced to study insulin resistance in gut. The expressions of AD markers and key elements of insulin signaling were detected in ileum and intestinal macrophages of AD mice by immunohistochemistry...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485800/gdf11-does-not-improve-the-palmitate-induced-insulin-resistance-in-c2c12
#12
Y-Y Jing, D Li, F Wu, L-L Gong, R Li
OBJECTIVE: GDF11 (Growth Differentiation factor 11) has been reported to rejuvenate skeletal muscle, heart and brain in aged mice, and the aged skeletal muscle is closely related to insulin resistance. We wondered whether GDF11 has an effect on skeletal muscle insulin resistance. MATERIALS AND METHODS: High fat diet induced obese mice with insulin resistance were established in vivo. Palmitate-induced insulin resistance in C2C12 myotubes was established in vitro...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485799/decreased-microrna-146a-in-cd4-t-cells-promote-ocular-inflammation-in-thyroid-associated-ophthalmopathy-by-targeting-numb
#13
Z-J Hu, J-F He, K-J Li, J Chen, X-R Xie
OBJECTIVE: The aim of the study was to explore the functional role of miR-146a in CD4+T cells of active thyroid-associated ophthalmopathy (TAO) patients and to identify the possible molecular mechanism for the modulation of miR-146a in TAO. PATIENTS AND METHODS: The experimental group collected six cases of peripheral venous blood of patients with active TAO. The healthy control group collected six cases of normal peripheral venous blood. All specimens excluded other eye diseases and autoimmune diseases, tumors, asthma, chronic inflammation, Human Immunodeficiency Virus (HIV), recent history of trauma, infection, and showed normal thyroid function...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485798/immune-complexes-induce-tnf-%C3%AE-and-baff-production-from-u937-cells-by-hmgb1-and-rage
#14
X-J Gao, Y-Y Qu, X-W Liu, M Zhu, C-Y Ma, Y-L Jiao, B Cui, Z-J Chen, Y-R Zhao
OBJECTIVE: This study investigated the effects of immune complexes (ICs) on tumor necrosis factor α (TNF-α) and B cell-activating factor (BAFF) production from U937 cells and further explored the mechanism. MATERIALS AND METHODS: U937 cells were incubated with necrosis supernatant or systemic lupus erythematosus (SLE) sera alone, or their combination. The expression of TNF-α and BAFF was determined by Real-time polymerase chain reaction and enzyme-linked immunosorbent assay...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485797/hypoxia-increases-expression-of-cxc-chemokine-receptor-4-via-activation-of-pi3k-akt-leading-to-enhanced-migration-of-endothelial-progenitor-cells
#15
T Dai, Y Hu, H Zheng
OBJECTIVE: Recruitment of endothelial progenitor cells (EPCs) to the ischemia has recently been suggested as an important mechanism of neovascularization. Although tissue ischemia can mobilize EPCs from bone marrow, the effects of hypoxia on the migration of EPCs are little known. MATERIALS AND METHODS: In this study, migratory function of EPCs was examined by a modified Boyden chamber technique. The expression of CXCR4 was detected by reverse transcription PCR and flow cytometry assay...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485796/the-blood-genome-wide-dna-methylation-analysis-reveals-novel-epigenetic-changes-in-human-heart-failure
#16
B Li, Z-H Feng, H Sun, Z-H Zhao, S-B Yang, P Yang
OBJECTIVE: Epigenetic mechanisms, such as microRNA, histone modification, and DNA methylation, are critical for dysregulated gene expression in heart failure (HF). However, the relationship between DNA methylation and dysregulated gene expression of blood leukocytes during HF remains unclear. PATIENTS AND METHODS: In this study, DNA methylation status and gene expression in blood leukocytes from ischemic end-stage cardiomyopathy patients were compared to normal controls by using reduced representation bisulfite sequencing (RRBS), and the results were validated by quantitative MassARRAY analysis and RT-qPCR...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485795/correlation-study-between-interleukin-6-levels-and-coronary-reflow
#17
F-M Guo, X-H Han, Y-Y Guo, D-M Zhang, F-J Tang, L Zhao, L-L Ji, W-B Liu
OBJECTIVE: To analyze the correlation between local interleukin-6 (IL-6) levels in different parts of blood vessel and the record of Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) after myocardial ischemia-reperfusion (IR) model. MATERIALS AND METHODS: Establishment of IR model in Yorkshire pigs, the pigs were divided into two groups (n=6). Experiment group pigs were administrated with Shenfu injection (SF) intravenously (1 mL/kg), control group was given saline injection...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485794/effects-of-tumor-necrosis-factor-and-e-selectin-on-coronary-artery-flow
#18
W-B Liu, X-H Han, Y-Y Guo, D-M Zhang, F-J Tang, L Zhao, L-L Ji, F-M Guo
OBJECTIVE: The aim of the study is to investigate the correlation between tumor necrosis factor (TNF-α), E-selectin and coronary artery flow following myocardial ischemia-reperfusion model (IR) in Yorkshire pigs. MATERIALS AND METHODS: Establishment of IR model in pigs. Following the injury model, Experiment group was administrated intravenously Shenfu injection solution (SFI, 1 mL/kg). The control group received the same amount of saline. After 30 min of blood reflux, thrombolysis in myocardial infarction frame count (TFC) was recorded following surgery...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485793/lipoxin-a4-mitigates-experimental-autoimmune-myocarditis-by-regulating-inflammatory-response-nf-%C3%AE%C2%BAb-and-pi3k-akt-signaling-pathway-in-mice
#19
Y Shi, H Pan, H-Z Zhang, X-Y Zhao, J Jin, H-Y Wang
OBJECTIVE: Myocarditis, an acute inflammation disease of the heart, is a potentially lethal disease and can lead to sudden death. This study aims to investigate the therapeutic effect of lipoxin A4 (LXA4) on experimental autoimmune myocarditis (EAM) and to explore the underlying mechanism. MATERIALS AND METHODS: EAM was induced in BALB/c mice by injection of porcine cardiac myosin and LAX4 at doses of 10 or 50 μg/kg was administrated from day 1 to 21. The severity of myocarditis was evaluated by detection of heart weight/body weight (HW/BW) ratio and histopathological examination of the heart...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28485792/increased-expression-of-cxcr5-and-cxcl13-in-mice-with-experimental-autoimmune-myocarditis
#20
F-L Han, F Liang, T-C Jiang, M Liu
OBJECTIVE: Myocarditis is an inflammatory heart muscle disease associated with cardiac dysfunction, and autoimmunity is considered to play an important role in the pathogenesis of myocarditis. CXCL13 and its receptor CXCR5 have been reported to be associated with many diseases including some cancers and inflammatory diseases, but so far there has been no report on CXCR5/CXCL13 expression in myocarditis. MATERIALS AND METHODS: With a mouse experimental autoimmune myocarditis (EAM) model, it was found that the mRNA and protein expression of both CXCR5 and CXCL13 were increased in myocardial tissue in the EAM mice...
April 2017: European Review for Medical and Pharmacological Sciences
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