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European Review for Medical and Pharmacological Sciences

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https://www.readbyqxmd.com/read/28083867/the-healthcare-service-in-italy-regional-variability
#1
A Cicchetti, A Gasbarrini
The Italian health system is highly decentralized, with most administrative and organizational powers governed by Regions and rather limited powers at national level. The state has full control over the definition of the core benefit package (LEA) but there is evidence that the actual provision of these services varies greatly across Regions.
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28083866/hcv-treatment-ratio-and-governance-footprints-analysis-of-regional-differentiation-in-italy
#2
E Lanati, A Marcelli
Due to the strongly fragmented reality of HCV treatment in the various Regions of Italy, effectiveness of access to treatment is difficult to gather. The aim of this paper was to analyze regional differences in healthcare governance models regarding HCV, in order to understand the ability of each Region to give access to HCV diagnosed patients. The analysis was performed by comparing treatment ratios (TR) across all Regions (treated patients/diagnosed patients). Furthermore, the study provides insight to regional regulatory environment and to all HCV treatments entering the market in each Region...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28083865/hcv-estimation-of-the-number-of-diagnosed-patients-eligible-to-the-new-anti-hcv-therapies-in-italy
#3
I Gardini, M Bartoli, M Conforti, F S Mennini, A Marcellusi, E Lanati
OBJECTIVE: The present research wants to take a picture of the current epidemiological scenario regarding HCV infection in Italy. Studies used to estimate HCV burden of illness in Italy were so far local and performed a number of years ago, not mirroring the state of the art. EpaC wanted to provide a real number of diagnosed patients, eligible to new anti-HCV therapies. PATIENTS AND METHODS: EpaC is the most important Italian NGO for hepatopathic patients. A number of sources were cross-checked...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28083864/the-hcv-sicily-network-a-web-based-model-for-the-management-of-hcv-chronic-liver-diseases
#4
F Cartabellotta, V Di Marco
OBJECTIVE: Epidemiological studies report that in Sicily reside about 30,000 citizens with a diagnosis of chronic hepatitis due to HCV. The availability of direct antiviral action (DAA) is a real therapeutic breakthrough, but the high cost of the therapeutic regimes limits their use and forced the National Health System to establish clinical priority for the treatment. MATERIALS AND METHODS: The HCV Sicily Network is a web-based model of best medical practice, which was designed to improve the management and the treatment of HCV chronic hepatitis and cirrhosis...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28083863/treatment-of-patients-with-chronic-hepatitis-c-infection-in-lombardia-a-report-by-the-lombardia-hepatitis-network
#5
A Aghemo, R Bruno, M Colombo, M Medagli, M Puoti, G Rizzardini, S Fagiuoli
The arrival of potent directly acting antivirals (DAAs) for the treatment of chronic Hepatitis C virus (HCV) infection was a challenge for the regional health system of the Lombardia Region. Lombardia represents roughly 8% of the Italian territory but includes nearly 16% of the Italian population. In 2014, nearly 37,600 HCV patients were routinely followed-up in liver centers across the region; nearly 16,000 were classified as having advanced fibrosis or cirrhosis (Metavir F3-F4). The creation of a regional network was necessary to ensure uniformity in treatment access and treatment management...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28051273/neural-stem-cells-in-lead-toxicity
#6
W-W Chen, X Zhang, W-J Huang
Lead (Pb) exposure in the early stages of neurodevelopment results in long-lasting alterations that ultimately cognitive function and behaviour. The prime targets of lead toxicity are the multipotent neural stem cells (NSCs). The present review will discuss the basic molecular physiology involved in the toxicity mechanisms induced by lead and its resultant counter effects on nervous system and physiology. The article shall help researchers working in the area to design new drugs and therapeutics for the efficient management of neuro-toxic states especially upon prenatal exposure to lead...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28051272/tgf-%C3%AE-1-factor-in-the-cerebrovascular-diseases-of-alzheimer-s-disease
#7
X Zhang, W-J Huang, W-W Chen
Transforming growth factor betas (TGF-βs) belong to three isoforms (TGF-β1, TGF-β2 and TGF-β3) members of a large pleiotropic superfamily of around 100 distinct proteins participating in the regulation of key events of development and disease, and tissue repair. In the central nervous system (CNS), all the three isoforms are produced by both glial and neuronal cells and are involved in essential tissue functions such as cell-cycle control, regulation of early development and differentiation, neuronal survival and astrocytes differentiation...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28051271/study-on-correlation-between-liver-ultrasonic-appearance-of-patients-with-chronic-hepatitis-b-and-cirrhosis-and-hydrothorax
#8
L-L Sun, Y-H Li, F Chen, S Wang, H Shi
The article "Study on correlation between liver ultrasonic appearance of patients with chronic hepatitis B and cirrhosis and hydrothorax" by L.-L. Sun, Y.-H. Li, F. Chen, S. Wang, H. Shi, published in Eur Rev Med Pharmacol Sci 2015; 20 (17): 3412-3605-3608 has been withdrawn.
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28051270/the-approach-of-retroperitoneal-laparoscopic-partial-dissection-of-adipose-renal-capsule-plus-ligation-of-renal-pedicle-lymphatic-vessels-to-the-treatment-of-chyluria
#9
Y-D Zhang, R-F Cao, Z-J Jiang
OBJECTIVE: To compare the clinical effect of two surgical methods of treating chyluria, namely, retroperitoneal laparoscopic partial dissection of adipose renal capsule plus ligation of renal pedicle lymphatic vessels and retroperitoneal laparoscopic complete dissection of adipose renal capsule plus ligation of renal pedicle lymphatic vessels. PATIENTS AND METHODS: Thirty-eight cases have been divided into A and B groups. Retroperitoneal laparoscopic partial dissection of adipose renal capsule plus ligation of renal pedicle lymphatic vessels has been performed on Group A patients and retroperitoneal laparoscopic complete dissection of adipose renal capsule plus ligation of renal pedicle lymphatic vessels has been performed on Group B cases, and then their respective clinical efficacy has been compared...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28051269/disturbed-endometrial-nf-%C3%AE%C2%BAb-expression-in-women-with-recurrent-implantation-failure
#10
A Ersahin, M Acet, T Acet, Y Yavuz
OBJECTIVE: This study was planned to investigate whether expression levels of endometrial NF-κB1 and NFκB p65 changes in women with recurrent implantation failure (RIF). PATIENTS AND METHODS: The study group consists of 30 RIF patients having at least three previous failed IVF cycles. The control group comprises of 30 patients having one or no previous failed attempt. Endometrial samples were obtained from all participants during hysteroscopy at the late follicular phase...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28051268/immunoregulatory-effect-of-neuronal-like-cells-in-inducting-differentiation-of-bone-marrow-mesenchymal-stem-cells
#11
J Xu, H Lu, Z-N Miao, W-J Wu, Y -Z Jiang, F Ge, W-F Fang, A-H Zhu, G Chen, J-H Zhou, Y-Z Lu, Z-F Tang, Y Wang
OBJECTIVE: To evaluate the immune activity of bone marrow mesenchymal stem cells (BMSCs), and explore the biological characteristics and capabilities of BMSCs and the potential to be differentiated into neuronal cells in vitro. MATERIALS AND METHODS: The BMSCs were isolated and proliferated in vitro to generate the xenogeneic mixed lymphocyte reaction. Moreover, peripheral BMSCs (pBMSCs) were added according to different ratios, which methods were stated as follows: 1: Dulbecco's Modified Eagle Medium (DMEM) + 10% Fetal Bovine Serum (FBS) + 1 μmol/L all-trans-retinoic acid (ATRA) + 20 μg/L basic fibroblast growth factor (bFGF) + 20 μg/L epidermal growth factor (EGF); 2: DMEM + 2% dimethyl sulfoxide (DMSO) + 100 μmol/L butylated hydroxyanisole (BHA)...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28051267/reduced-expression-of-scf-in-serum-and-follicle-from-patients-with-polycystic-ovary-syndrome
#12
J Tan, X-Y Wen, Q Su, Z-H Huang, J-X He, C-L Xin, Q-F Wu, Y Zou
OBJECTIVE: In humans, stem cell factor (SCF), produced by cumulus granulosa cells during the follicular phase, plays a crucial role in follicular development. Remarkably, polycystic ovary syndrome (PCOS), one of the main reasons affecting women fertility, is accompanied by some abnormal follicles. Is there a relationship between SCF and PCOS? This study aimed to compare the expression of SCF in follicle and serum from patients with and without PCOS undergoing in vitro fertilization (IVF) treatment and to investigate the potential relationship between aberrant SCF expression and PCOS...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28051266/one-stage-breast-reconstruction-techniques-in-elderly-patients-to-preserve-quality-of-life
#13
M Maruccia, M Mazzocchi, L A Dessy, M G Onesti
OBJECTIVE: The aim of this study was to review one-stage breast reconstruction techniques performed in elderly patients at our institution to identify the criteria of selection of each in terms of outcomes and quality of life. PATIENTS AND METHODS: Patients older than 65 years who underwent one-stage breast reconstruction between January 2004 and July 2014 at our hospital were included. Patients and procedure-related data were collected from the medical records...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28051265/the-role-of-hypoxia-inducible-factor-in-nasal-inflammations
#14
K-J Cheng, Y-Y Bao, S-H Zhou
OBJECTIVE: Hypoxia-inducible factor (HIF) is considered an important transcription factor due to its roles in glycolysis, angiogenesis, cell differentiation, apoptosis, and other cellular pathways. It takes the role in various physiological and pathological states, such as solid tumors, vascular injury, and atherosclerotic lesion progression. In recent studies, HIF is found as a master regulator of body inflammation and immunity, not only in hypoxia but also in normoxia. Nasal inflammation has a close relationship with anoxia...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28051264/homogenization-versus-homogenization-free-method-to-measure-muscle-glycogen-fractions
#15
N Mojibi, M Rasouli
OBJECTIVE: The glycogen is extracted from animal tissues with or without homogenization using cold perchloric acid. Three methods were compared for determination of glycogen in rat muscle at different physiological states. MATERIALS AND METHODS: Two groups of five rats were kept at rest or 45 minutes muscular activity. The glycogen fractions were extracted and measured by using three methods. RESULTS: The data of homogenization method shows that total glycogen decreased following 45 min physical activity and the change occurred entirely in acid soluble glycogen (ASG), while AIG did not change significantly...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28051263/psychological-factors-associated-with-nafld-nash-a-systematic-review
#16
B Macavei, A Baban, D L Dumitrascu
OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) represents one of the most common chronic liver diseases worldwide. So far, the pathogenesis of NAFLD and its more severe variant nonalcoholic steatohepatitis (NASH) is yet unclear, with many mechanisms being proposed as possible causes. This article aims to review the psychological factors associated with NAFLD/NASH. MATERIALS AND METHODS: Three main categories of factors have been investigated: emotional, cognitive and behavioral...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28051262/bioinformatic-identification-of-igf1-as-a-hub-gene-in-hepatocellular-carcinoma-hcc-and-in-vitro-analysis-of-the-chemosensitizing-effect-of-mir-379-via-suppressing-the-igf1-igf1r-signaling-pathway
#17
D-J Huang, J-Z Huang, J Yang, Y-H Li, Y-C Luo, H-Y He, H-J Huang
OBJECTIVE: We investigated the interactions among the dysregulated genes in hepatocellular carcinoma (HCC) and identified the hub genes in the protein-protein interaction (PPI) network. Also, we also investigated the regulative effect of miR-379 on the IGF1/IGF1R signaling pathway and chemoresistance in HCC. MATERIALS AND METHODS: Raw data of a microarray that compared transcriptional gene profile between 3-paired HCC tissue samples and adjacent normal tissues were downloaded from Expression Atlas (E-GEOD-33006)...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28051260/the-application-value-of-the-detection-of-the-level-of-tissue-polypeptide-antigen-ovarian-cancer-antigen-x1-cathepsin-l-and-ca125-on-the-diagnosis-of-epithelial-ovarian-cancer
#18
X-L Lv, Y Zhu, J-W Liu, H Ai
OBJECTIVE: We investigated the value of the joint detection of tissue polypeptide antigen (TPA), ovarian cancer antigen X1 (OVX1), cathepsin L (CTSL) and CA125 on the early diagnosis of epithelial ovarian carcinoma (EOC). PATIENTS AND METHODS: From October 2011 to February 2015, 84 cases of patients under surgical treatment of epithelial ovarian cancer, 98 cases of patients with benign epithelial ovarian tumor and 51 subjects in healthy control group were selected to detect the level of TPA, OVX1 and CTSL in serum from the Obstetrics and Gynecology Department of the First Affiliated Hospital of Liaoning Medical University...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28051259/microrna-145-inhibits-tumour-growth-and-metastasis-in-osteosarcoma-by-targeting-cyclin-dependent-kinase-cdk6
#19
Y Li, J Liu, Z-Z Liu, W-B Wei
OBJECTIVE: Osteosarcoma (OS) is reported to be one of the most familiar forms of the primary malignant tumor to adolescents and adults, which is usually found in their long bones. Evidence and data have shown that abnormality in micro-RNA expression is closely related to tumorigenesis. The aim of this study is to investigate the expression, function and underlying mechanism of miR-145 in OS. MATERIALS AND METHODS: MiR-145 expression in tumor tissues of patients and cell lines were detected by SYBR green qPCR...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28051258/overexpression-of-long-noncoding-rna-zfas1-decreases-survival-in-human-nsclc-patients
#20
F-M Tian, F-Q Meng, X-B Wang
OBJECTIVE: The purpose of the current study was to characterize the expression of long-noncoding-RNA ZFAS1 (ZFAS1) and assess the clinical significance of ZFAS1 in non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: A total of 173 patients with NSCLC were addressed in the present retrospective study. Expression levels of ZFAS1 were detected by quantitative real-time PCR. We further analyzed the correlation between ZFAS1 and clinicopathologic features of NSCLC with X2-test...
December 2016: European Review for Medical and Pharmacological Sciences
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