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European Review for Medical and Pharmacological Sciences

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https://www.readbyqxmd.com/read/28770971/apolipoprotein-a1-and-neuronal-nitric-oxide-synthase-gene-polymorphisms-and-hormone-related-osteonecrosis-of-the-femoral-head
#1
L Chen, P Wei, K Jiang, X-X Xia
OBJECTIVE: This study was designed to investigate the influence of several polymorphisms in neuronal NOS genes and apolipoprotein AI on the hormone-related osteonecrosis of the femoral head (ONFH) risk. PATIENTS AND METHODS: Peripheral blood mononuclear cell (PBMCs) samples extracted from hormone-related ONFH patients and controls were used to amplify fragments of the apolipoprotein A1 and neuronal NOS exon 7 and intron 4 using specific PCR primers. The products were analyzed by DNA sequencing and mapped to find the genotype distributions...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770970/oxtr-and-zeb1-expression-before-and-after-progesterone-dosing-in-pregnant-women-with-threatened-premature-labor
#2
Y-J Xu, L-D Ren, S-S Zhai, L-M Ran, L-L Hu, X-H Luo, T Hong, R Liu, Y-R Yu, Y-J Ban
OBJECTIVE: To investigate changes in the peripheral blood mRNA levels of oxytocin receptor (OXTR) and Zinc finger E-box-binding homeobox 1 (ZEB1) before and after progesterone dosing in pregnant women with threatened premature labor. PATIENTS AND METHODS: Blood samples were collected from 30 healthy pregnant women with 28- to 33+6-week gestational age and singleton pregnancy (group A) and from 30 pregnant women with singleton pregnancy and threatened premature labor before and 48 hours after progesterone dosing (groups B and C, respectively) for quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) assay to assess the OXTR and ZEB1 mRNA levels...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770969/long-non-coding-rna-cps1-it1-is-a-positive-prognostic-factor-and-inhibits-epithelial-ovarian-cancer-tumorigenesis
#3
Y-S Wang, L-N Ma, J-X Sun, N Liu, H Wang
OBJECTIVE: The aim of the present study was to explore the prognostic value of long non-coding RNA CPS1-IT1 (CPS1-IT1) expression in epithelial ovarian cancer (EOC) patients and identify the effect of CPS1-IT1 on cell proliferation and apoptosis of EOC cells. PATIENTS AND METHODS: Expression levels of CPS1-IT1 in tissues and cells were detected by the Real-time quantitative RT-PCR assay. The χ2-test was used to analyze the relationship between CPS1-IT1 expression and the clinicopathological characteristics...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770968/lncrna-malat1-promotes-proliferation-and-metastasis-in-epithelial-ovarian-cancer-via-the-pi3k-akt-pathway
#4
Y Jin, S-J Feng, S Qiu, N Shao, J-H Zheng
OBJECTIVE: The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA (lncRNA) that plays a key role in the malignant phenotype of tumors. Although abnormal regulation of lncRNA MALAT1 impacts clinical prognostic and tumor metastasis, its function remains unclear in ovarian cancer. PATIENTS AND METHODS: We collected 64 samples of surgical EOC tissues and 30 samples of normal ovarian tissues at the Department of Gynecology of Harbin Medical University (Harbin, China)...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770967/suppression-of-adriamycin-resistance-in-osteosarcoma-by-blocking-wnt-%C3%AE-catenin-signal-pathway
#5
B-Q Wu, Y Cao, Z-G Bi
OBJECTIVE: Wnt/β-catenin signal pathway plays a role in regulating cell proliferation and apoptosis, and is correlated with tumor onset, progression and drug resistance. B-cell lymphoma 2 (Bcl-2) is an anti-apoptotic factor inducing tumor cell drug resistance. Wnt/β-catenin signal pathway can modulate Bcl-2 expression. This study established a cell model of drug resistance using adriamycin (ADM) treatment. Wnt/β-catenin signal pathway was intervened to discuss its role in drug resistance of osteosarcoma cells...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770966/inhibition-of-mir-221-influences-bladder-cancer-cell-proliferation-and-apoptosis
#6
H Liu, J-K Chang, J-Q Hou, Z-H Zhao, L-D Zhang
OBJECTIVE: Janus kinase (JAK) - signal transducer and activator of transcription (STAT) signaling pathway participate in cell proliferation and apoptosis. Suppressors of cytokine signaling 3 (SOCS3) are negative regulators of JAK-STAT3. SOCS3 was found significantly declined, while microRNA-221 (miR-221) obviously up-regulated in bladder cancer tissue. Bioinformatics analysis revealed the complementary binding site between miR-221 and 3'-UTR of SOCS3. This study investigated the role of miR-221 in regulating SOCS3/JAK-STAT3 signaling pathway and bladder cancer cell proliferation and apoptosis...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770965/mir-455-3p-acts-as-a-prognostic-marker-and-inhibits-the-proliferation-and-invasion-of-esophageal-squamous-cell-carcinoma-by-targeting-fam83f
#7
H Yang, Y-N Wei, J Zhou, T-T Hao, X-L Liu
OBJECTIVE: The aim of the current study was to elucidate the role of miR-455-3p in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and its prognostic value in patients with ESCC. PATIENTS AND METHODS: Expression levels of miR-455-3p and FAM83F mRNA in ESCC tissues and adjacent normal tissues were detected by quantitative RT-PCR. The X2-test was used to assess miR-455-3p expression on clinicopathological parameters. The association with overall survival of patients was analyzed by Kaplan-Meier survival analysis...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770964/cancer-stem-cell-markers-in-glioblastoma-an-update
#8
H-S Xu, X-L Qin, H-L Zong, X-G He, L Cao
The glioblastoma includes brain tumors, which are very aggressive in nature and are among the most common brain tumors in adults. Latest therapeutic avenues involve combination approach. However, the observed median survival is still no more than 15 months. Moreover, there is a scarcity of accurate pre-clinical model systems, which in turn resulted in limited treatment options for this disease. Cancer stem cells are attractive avenues in anticancer research against glioblastoma. Most of the recent studies are focused towards the identification of novel markers for cancer stem cells...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770963/characteristic-analysis-of-pulmonary-ground-glass-lesions-with-the-help-of-64-slice-ct-technology
#9
Y-G Lv, J-H Bao, D-U Xu, Q-H Yan, Y-J Li, D-L Yuan, J-H Ma
OBJECTIVE: With the help of new technologies like 64-slice spiral CT, including latest AW4.4, 2D nodule comparing and analyzing technology, MPR and 3D technology, MIP technology and the technology of analyzing pulmonary vascular density by the method of perfusion scanning, we performed characteristic analysis of ground-glass opacities (GGO) for the early diagnosis of lung cancer. PATIENTS AND METHODS: We selected 62 patients suspected of lung cancer, whose conventional CT showed that they were patients with GGO...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770962/research-on-the-a549-cell-apoptosis-mechanism-of-the-nude-mouse-model-using-mensc-strail
#10
H Ding, J Wang, F-P Jia, J Yi, M Zhang
OBJECTIVE: To investigate the inhibitory effect of MenSC-sTRAIL on the apoptosis of A549 cells of lung cancer in a nude mouse model and the relevant molecular mechanism. MATERIALS AND METHODS: The tumorigenesis curve of A549 cells in the nude mouse model was assayed using the growth curve plotted by the growth rate of tumor of the A549 cell nude mouse model. Cellular apoptosis was assayed using flow cytometer and Annexin V-FITC, and the effect of MenSC-sTRAIL on the expression of Bax was measured using Western blot...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770961/the-mir-224-promotes-non-small-cell-lung-cancer-cell-proliferation-by-directly-targeting-rassf8
#11
L Wang, W Liu, Y-P Zhang, X-R Huang
OBJECTIVE: The purpose of this study was to explore the mechanism of microRNA-224 (miR-224) in NSCLC. PATIENTS AND METHODS: Quantitative RT-PCR (qRT-PCR) was used to evaluate expression levels of miR-224. The association of miR-224 with the clinicopathologic features of NSCLC was evaluated in 56 patients. The roles of miR-224 in cell proliferation were analyzed in vivo and in vitro with pre-miR-224 transfected cells. Also, the regulation of RASSF8 by miR-224 was evaluated by qRT-PCR, Western blotting and luciferase reporter assays...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770960/expression-of-mir-195-in-laryngeal-squamous-cell-carcinoma-and-its-effect-on-proliferation-and-apoptosis-of-hep-2
#12
Y Shuang, C Li, X Zhou, Y-W Huang, L Zhang
OBJECTIVE: To investigate the expression of miR-195 and its relationship with clinicopathological characteristics in laryngeal squamous cell carcinoma (LSCC), and to explore its effect and possible mechanism on proliferation and apoptosis of Hep-2. PATIENTS AND METHODS: Real-time fluorescence quantitative PCR was used to detect the expression of miR-195 in laryngeal carcinoma tissues and adjacent normal tissues from 98 cases. Dual-luciferase reporter plasmid with Bcl-2 wild type and mutant type 3' untranslated region was created to verify the target of miR-195 by luciferase assay...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770959/the-expression-and-function-of-long-noncoding-rna-lncrna-atb-in-papillary-thyroid-cancer
#13
X-M Fu, W Guo, N Li, H-Z Liu, J Liu, S-Q Qiu, Q Zhang, L-C Wang, F Li, C-L Li
OBJECTIVE: This study aimed to investigate the expression and clinical significances of long noncoding RNA-ATB (lncRNA-ATB) in papillary thyroid cancer (PTC), and to explore the roles of lncRNA-ATB in PTC cell proliferation and migration. PATIENTS AND METHODS: The expression of lncRNA-ATB in 64 PTC tissues and paired adjacent noncancerous thyroid tissues was measured. The association between lncRNA-ATB expression and clinicopathological characteristics was analyzed by Pearson X2...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770958/the-role-of-mitochondrial-dna-mutations-in-a-han-chinese-population-on-sepsis-pathogenesis
#14
G-X Han, Y Song, L Chen, Y-Z Zhai, J Dong, T-S Li, H-Y Zhu
OBJECTIVE: Individual susceptibility to sepsis has received increasing attention in recent years, and the study of genetic variations has become a hotspot regarding sepsis pathogenesis. We, therefore, investigated the association between mitochondrial genotype and sepsis susceptibility. PATIENTS AND METHODS: One hundred patients admitted with sepsis and registered by five intensive care units (ICUs) in the People's Liberation Army Hospital and the Beijing Aerospace Center Hospital between January 2015 and January 2016 were enrolled as a case group, and 100 healthy persons were recruited as a control group...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770957/can-procalcitonin-be-used-to-diagnose-gram-negative-bloodstream-infection-evidence-based-on-a-meta-analysis
#15
C He, B Wang, Y-F Wang, Y-C Shen
OBJECTIVE: Procalcitonin (PCT) is a useful biomarker for systemic bacterial infection, and many studies have described the correlation between high serum PCT level and Gram-negative bloodstream infection (BSI), whereas the diagnostic accuracy of PCT for this kind of episode has not been summarized. This study aimed to estimate the overall accuracy of serum PCT for diagnosing Gram-negative BSI through a meta-analysis. MATERIALS AND METHODS: We searched PubMed, EMBASE, Web of Science, and Scopus database for studies that met the inclusion criteria...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770956/investigation-into-the-correlations-of-expressions-of-cav-3-and-smad3-with-pathogenesis-and-prognosis-of-viral-myocarditis
#16
Ch-L Jia, J Liu
OBJECTIVE: To investigate the correlations of expressions of Caveolae-3 (Cav-3) and sma and mad homologue (Smad3) with the pathogenesis and prognosis of viral myocarditis (VMC). MATERIALS AND METHODS: VMC animal models were prepared and divided into the control group, the virus group and the Shenmai group. We detected the levels of creatine kinase isoenzyme (CK-MB) in the serum that was associated with the myocardial injuries, investigated the pathological features of VMC in BALB/C mice via hematoxylin-eosin (HE) staining, measured the mRNA expressions of Cav-3 and Smad3 via Real-time polymerase chain reaction (RT-PCR) and determined the protein expressions of Cav-3 and Smad3 through Western blotting method...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770955/the-regulatory-role-of-dopamine-receptor-d1-on-pp2a-via-sumo-1-modification
#17
C-Q Yu, L-Q Yin, Z-T Tu, D-W Liu, W-P Luo
OBJECTIVE: Renal dopamine receptor D1 played a critical role in the regulation of body blood pressure. Under hypertension, over-phosphorylation of D1 receptor impaired its function. G protein kinase 4 (GRK4) and protein phosphatase 2A (PP2A) exerted the effect to phosphorylate and de-phosphorylate D1 receptor. A current study revealed that the inhibition of GRK4 cannot normalize the phosphorylation level of D1 receptor. Meanwhile, the PP2A was activated under hypertension, indicating abnormal de-phosphorylation function of D1 receptor, the reason for which remains unknown...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770954/assessment-of-obestatin-and-arginine-vasopressin-avp-levels-in-acute-renal-failure-and-acute-heart-failure
#18
X-Y Miao, Z Li, Z Hui, F Liu, X-W Zhang
OBJECTIVE: We conducted this study to assess the clinical application of obestatin and arginine vasopressin (AVP) levels in cases of acute renal failure (ARF) and acute heart failure (AHF). PATIENTS AND METHODS: 30 cases of ARF, 30 cases of AHF, 30 cases of ARF complicated with AHF, and 30 cases of healthy subjects (control group) were successively selected. An ELISA test was conducted to detect levels of obestatin and AVP. Routine biochemistry testing was applied to detect the levels of serum creatinine and calculate the glomerular filtration rate (GFR)...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770953/microrna-200c-exacerbates-the-ischemia-reperfusion-injury-of-heart-through-targeting-the-glutaminase-gls-mediated-glutamine-metabolism
#19
F Liu, Y Li, G Liu
OBJECTIVE: Cardiac ischemia and reperfusion, the common pathophysiological processes during cardiovascular surgery, are followed by oxidative stresses during the restoration of blood flow to the tissue, known as ischemia/reperfusion (IR) injury. microRNAs (miRNAs) are a group of endogenous, short and noncoding RNAs that post-transcriptionally repress their target mRNA expressions. Currently, the roles of microRNAs in the IR are still under investigated. This study will investigate the roles and mechanisms of miRNAs in the ischemia/reperfusion injury of the heart...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770952/an-effective-indicator-in-predicting-cardiovascular-events-urine-albumin-to-creatinine-ratio
#20
H Zhao, Y-F Jiang, X-C Zhou, L Yao, J Chen, D Wang, D-Y Fu
OBJECTIVE: To study elderly hypertensive patients with trace albuminuria (urine albumin to creatinine ratio (UACR)) and the relationship between the occurrence of new cardiovascular events, to provide a basis for early prevention in elderly patients with high blood pressure. PATIENTS AND METHODS: A total of 3564 elderly patients with high blood pressure were enrolled in the study. Based on UACR, patients were divided into four groups (group A: 0.05-3.20 mg/g; group B:3...
July 2017: European Review for Medical and Pharmacological Sciences
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