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European Review for Medical and Pharmacological Sciences

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https://www.readbyqxmd.com/read/30402876/combined-treatment-with-myo-inositol-alpha-lipoic-acid-folic-acid-and-vitamins-significantly-improves-sperm-parameters-of-sub-fertile-men-a-multi-centric-study
#1
P Canepa, A Dal Lago, C De Leo, M Gallo, C Rizzo, E Licata, P Anserini, R Rago, P Scaruffi
OBJECTIVE: Reduction in motility and number of spermatozoa and change in their morphology are some of the most relevant causes of male infertility. Production of reactive oxygen species may affect motility, morphology and DNA stability of spermatozoa. This study aimed at evaluating the effect of combined treatment with myo-inositol, alpha-lipoic acid, folic acid, betaine and vitamins (namely, Sinopol®) on semen parameters of sub-fertile men. PATIENTS AND METHODS: We recruited 143 sub-fertile men, 26-53 years aged, no-smokers, without any testicular pathologies, with a normal endocrinological/metabolic profile, and no concomitant consumption of drugs...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402875/vitamin-d3-promotes-cerebral-angiogenesis-after-cerebral-infarction-in-rats-by-activating-shh-signaling-pathway
#2
G-Q Bao, J-Y Yu
OBJECTIVE: This study aims at investigating the neuroprotective role of Vitamin D3 (VitD3) in rats with cerebral infarction and its molecular mechanisms. MATERIALS AND METHODS: Male Sprague- Dawley (SD) rats were selected and randomly divided into sham operation group, middle cerebral artery occlusion (MCAO) model group, and VitD3 treatment group. The therapeutic effect of VitD3 was evaluated via neurobehavioral scoring and triphenyltetrazolium chloride (TTC) staining...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402874/charged-molecular-silica-trigger-in-vitro-netosis-in-human-granulocytes-via-both-oxidative-and-autophagic-pathways
#3
M Rizzi, F Carniato, S Tonello, M Migliario, M Invernizzi, V Rocchetti, L Marchese, F Renò
OBJECTIVE: Neutrophils play a key role in immunity and are known to respond to exogenous threats by releasing neutrophil extracellular traps (NETs) through NETosis, a process involving the release of neutrophils nuclear DNA decorated with proteins into the extracellular space. In this study, attention has been focused on the ability of differently charged molecular systems polyhedral oligomeric silsesquioxanes (POSS) to induce NETosis. MATERIALS AND METHODS: NETs formation was induced by phorbol myristate acetate (PMA) (positive control) and POSS treatment and visualized by confocal microscopy...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402873/targeting-patients-microbiota-with-probiotics-and-natural-fibers-in-adults-and-children-with-constipation
#4
E R Ceresola, R Ferrarese, A Preti, F Canducci
OBJECTIVE: Functional constipation (FC) is a common condition in which the gut microbiota composition plays a fundamental role. The increasing knowledge on the role of gut microbes in the regulation of gut motility and stool consistency has allowed reconsidering, with a new scientific-based approach, the possibility to target the composition of intestinal bacterial populations for FC treatment. In this review, we evaluate recent attempts that used prebiotics, natural fibers or probiotics to treat FC, with a deep microbiome-based focus...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402872/preterm-birth-after-loop-electrosurgical-excision-procedure-leep-how-cone-features-and-microbiota-could-influence-the-pregnancy-outcome
#5
A Frega, M Santomauro, F Sesti, J Di Giuseppe, C Colombrino, R Marziani, A Catalano, M Pavone, C Leone, M Mallozzi, E D'Adamo, A Ciavattini, D Caserta
OBJECTIVE: In the last years, the mean age of women who underwent cervical treatment for high-grade cervical intraepithelial neoplasia (CIN 2-3) is similar to the age of women having their first pregnancy. The aim of this study was to evaluate the risk of preterm birth in subsequent pregnancies after loop electrosurgical excision procedure (LEEP). PATIENTS AND METHODS: From January 2013 to January 2016 the study identified a total of 1435 women, nulliparous, who underwent LEEP for CIN 2-3, and who wished to have their first pregnancy...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402871/paraquat-poisoning-in-western-french-guyana-a-public-health-problem-persisting-ten-years-after-its-withdrawal-from-the-french-market
#6
A Flechel, A Jolivet, R Boukhari, C Misslin-Tritsch, M F Manca, E Wiel, B Megarbane, F Pousset
OBJECTIVE: Paraquat poisoning has almost disappeared from metropolitan France following its ban from the European market ten years ago. However, due to neighboring countries still authorizing paraquat use, French Guyana seems in a different situation. Here we aimed to report a series of paraquat-poisoned patients admitted to the emergency department of the Western French Guyana Hospital in Saint-Laurent du Maroni, to raise awareness of national health authorities on this persistent major issue...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402870/optimising-management-of-patients-with-hepatitis-c-virus-in-the-age-of-direct-acting-antivirals-results-of-a-delphi-consensus
#7
V Di Marco, A Alberti, G Angarano, M Colombo, G Di Perri, G B Gaeta, G Ippolito, A Mangia, P Pasqualetti, A Craxì
OBJECTIVE: To optimize the management of patients with chronic hepatitis C virus (HCV). MATERIALS AND METHODS: We developed two questionnaires to determine Italian healthcare professionals' opinions on the overall management of HCV chronic liver disease and the use of direct-acting antivirals (DAAs) in the treatment of HCV. A Delphi consensus method using the RAND/UCLA appropriateness method was used to determine opinions of an expert panel (EP) of specialists...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402869/oral-ulcer-healing-and-anti-candida-efficacy-of-an-alcohol-free-chitosan-curcumin-mouthwash
#8
S Mahattanadul, M W Mustafa, S Kuadkaew, S Pattharachayakul, S Ungphaiboon, K Sawanyawisuth
OBJECTIVE: The purpose of this study was to investigate oral ulcer healing and anti-Candida efficacy of an alcohol-free 0.1% chitosan-curcumin mouthwash. MATERIALS AND METHODS: A buccal mucosal ulcer was induced in hamster by topical application of acetic acid. The test mouthwash was applied to the ulcer twice a day for 7 consecutive days beginning on the fourth day after the ulcer induction. The anti-Candida efficacy of the mouthwash was determined against both free floating and biofilm forms of Candida albicans...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402868/endogenous-nerve-growth-factor-stimulation-effects-on-auditory-pathway-neural-cells-in-a-mouse-model
#9
F Salvinelli, V Frari, F Capuano, B Salvinelli, M L Rocco, L Aloe
OBJECTIVE: In the present study, we investigated whether high-pressure hypotonic saline solution (Hphss) affects the basal level of Nerve Growth Factor (NGF) and expression of receptors in the cochlea, bark earing, retina, and visual cortex. MATERIALS AND METHODS: For this study, we used three weeks old female Sprague Dawley (SD) rats (n = 12). Rats were housed in polypropylene cages and were kept under standard conditions (12 h light:12 h dark cycle) with free access to water and food (Purina chow food)...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402867/role-of-gspe-in-improving-early-cerebral-vascular-damage-by-inhibition-of-profilin-1-expression-in-a-ouabain-induced-hypertension-model
#10
J-P Hao, H Shi, J Zhang, C-M Zhang, Y-M Feng, L-Y Qie, M Dong, X Ji
OBJECTIVE: Grape seed proanthocyanidin extract (GSPE), as one of the most popular natural drug extracted from the grape, has been reported to improve endothelial function and arteriosclerosis. However, little is known about the influence of GSPE on hypertension and vascular remodeling. Profilin-1, an Actin-binding protein, is closely involved in the remodeling of large vessels in ouabain-induced hypertension. To date, there is no effective prevention or treatment in place for the high incidence of ischemic stroke associated with hypertension...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402866/hotair-alleviates-ox-ldl-induced-inflammatory-response-in-raw264-7-cells-via-inhibiting-nf-%C3%AE%C2%BAb-pathway
#11
J-L Pang, J-W Wang, P-Y Hu, J-S Jiang, C Yu
OBJECTIVE: To investigate the possible role of hox transcript antisense intergenic RNA (HOTAIR) in the pathogenesis of atherosclerosis and its underlying mechanism. PATIENTS AND METHODS: The expression of HOTAIR in peripheral blood lymphocytes of atherosclerosis (AS) and healthy controls was detected by quantitative Real-time-polymerase chain reaction (qRT-PCR). In vitro AS model was established by ox-LDL induction in Raw264.7 cells. Viability of Raw264.7 cells after ox-LDL induction was detected by cell counting kit-8 (CCK-8) assay...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402865/hotair-promotes-myocardial-fibrosis-through-regulating-uri1-expression-via-wnt-pathway
#12
S-C Pan, H-H Cui, C-G Qiu
OBJECTIVE: To investigate whether HOX transcript antisense RNA (HOTAIR) regulates myocardial fibrosis via promoting proliferation of cardiac fibroblasts (CFs) and upregulating the expression levels of fibrotic proteins through activating Wnt signaling pathway. MATERIALS AND METHODS: The expression level of HOTAIR in Ang II-induced cardiac fibroblasts was detected by quantitative Real-time-polymerase chain reaction (qRT-PCR). Overexpression or knockdown of HOTAIR expression was achieved by lentivirus transfection...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402864/clinical-efficacy-of-different-side-branch-protection-techniques-on-patients-receiving-coronary-intervention-and-prognostic-analysis
#13
J-X Lai, Z-Q Mo, A-J Song, W-F Tan
OBJECTIVE: To investigate and analyze the clinical efficacy of different side branch protection techniques on patients receiving coronary intervention and the patient's prognosis. PATIENTS AND METHODS: A total of 80 patients with coronary heart disease treated in Jiangmen Central Hospital from January 2014 to January 2017 were collected. According to different side branch protection strategies selected during operation, they were divided into jailed wire technique (JWT) group (n=20), jailed balloon technique (JBT) group (n=20), balloon-stent kissing technique (BSKT) group (n=20), and BSKT+RW group (n=20)...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402863/suppression-of-microrna-101-attenuates-hypoxia-induced-myocardial-h9c2-cell-injury-by-targeting-dimt1-sp1-survivin-pathway
#14
Z-X Guo, F-Z Zhou, W Song, L-L Yu, W-J Yan, L-H Yin, H Sang, H-Y Zhang
OBJECTIVE: MicroRNAs (miRNAs) are small single-stranded RNAs in eukaryotic cells, which play important regulatory roles in the pathogenesis of various diseases. We aimed to investigate the effects of miRNA-101 (miR-101) on hypoxia-induced myocardial infarction (MI) cell injury model (myocardial H9c2 cell injury model). The possible target gene of miR-101 was also analyzed. MATERIALS AND METHODS: H9c2 cells were exposed to hypoxia treatment. Cell viability, migration, invasion, apoptosis and the expression of miR-101 were detected using CCK-8 assay, transwell assay, flow cytometer analysis, Western blotting and qRT-PCR, respectively...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402862/gpiib-iiia-expression-changes-in-atrial-fibrillation-post-radiofrequency-ablation
#15
Y-Q Song, W-J Xu, C-L Lin, Q-M Wu
OBJECTIVE: Atrial fibrillation (AF) is one of the most common arrhythmias affecting the patient's quality of life, and its complications of thromboembolism can lead to serious consequences. AF patients are often in hypercoagulation status that can affect the prognosis. GPIIb/IIIa is a fibrinogen receptor that can bind to the ligands of platelet and cause aggregation. Therefore, GPIIb/IIIa can be treated as a marker of hemagglutination. This work aims to analyze the changes of GPIIb/IIIa after radiofrequency ablation of atrial fibrillation, and to investigate its relationship with recurrence...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402861/homocysteine-induced-oxidative-stress-in-human-umbilical-vein-endothelial-cells-via-regulating-methylation-of-sorbs1
#16
P-N Feng, Y-R Liang, W-B Lin, Z-R Yao, D-B Chen, P-S Chen, J Ouyang
OBJECTIVE: The aim of the present study was to investigate the mechanism of homocysteine (Hcy) induced oxidative stress in the human umbilical vein endothelial cells (HUVECs). PATIENTS AND METHODS: The HUVECs were isolated from umbilical vein vascular wall of 12 patients and treated with Hcy. The malondialdehyde (MDA) level was measured using the thiobarbituric acid (TBA) method. The expressions of superoxide dismutase 2 (SOD2), endothelial nitric oxide synthase (eNOS), and intercellular adhesion molecule 1 (ICAM-1) were detected by Western blot and RT-PCR...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402860/long-non-coding-rna-expression-profile-in-permanent-atrial-fibrillation-patients-with-rheumatic-heart-disease
#17
B Mei, H Liu, S Yang, M-Y Liang, Y Yue, S-Q Huang, J Hou, G-X Chen, Z-K Wu
OBJECTIVE: Atrial fibrillation (AF) is the most common type of arrhythmia, especially in rheumatic heart disease (RHD) patients. The differences in structural remodeling and electrical remodeling between the left and right atrium associated with AF in RHD patients are well known, and alterations in the expression profiles of long noncoding RNAs (lncRNAs) in the left atrium have also been investigated. However, the role of lncRNAs in the right atrium (RA) remains largely unknown. PATIENTS AND METHODS: We identified differentially expressed lncRNAs in RA tissues of RHD patients with AF or a normal sinus rhythm (NSR) using microarray analysis...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402859/obesity-in-the-european-region-social-aspects-epidemiology-and-preventive-strategies
#18
G Ricci, D Tomassoni, I Pirillo, A Sirignano, M Sciotti, S Zaami, I Grappasonni
Obesity related to metabolic syndrome is gaining an increasing importance as the main risk factor for diseases and disability in the European region. We herein review the increasing trend of obesity and overweight in males and females from Europe, preventive programs addressed to children, youngsters, adult population and subjects with particular diseases which can profit from healthy nutrition. The main feature is that some European countries have implemented programs on World Health Organization (WHO) proposals, while some others have focused attention only on some aspects...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402858/tug1-promotes-diabetic-atherosclerosis-by-regulating-proliferation-of-endothelial-cells-via-wnt-pathway
#19
H-Y Yan, S-Z Bu, W-B Zhou, Y-F Mai
OBJECTIVE: To explore the specific role of TUG1 in regulating the occurrence and progression of diabetic atherosclerosis and its underlying mechanism. PATIENTS AND METHODS: TUG1 expressions in coronary artery disease (CAD) tissues, normal arterial tissues, endothelial cells induced by high-dose glucose and tumor necrosis factor-α (TNF-α) were detected by quantitative Real-time polymerase chain reaction (qRT-PCR). The effects of TUG1 on proliferation, migration and cell cycle of human umbilical vein endothelial cells (HUVECs) were detected by cell counting kit-8 (CCK-8), transwell assay and flow cytometry, respectively...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30402857/hoxa11-as-regulates-diabetic-arteriosclerosis-related-inflammation-via-pi3k-akt-pathway
#20
Q-S Jin, L-J Huang, T-T Zhao, X-Y Yao, L-Y Lin, Y-Q Teng, S H Kim, M-S Nam, L-Y Zhang, Y-J Jin
OBJECTIVE: This study aims to explore whether homeobox A11 antisense RNA (HOXA11-AS) could regulate inflammation induced by diabetic arteriosclerosis (DAA) via PI3K/AKT pathway. PATIENTS AND METHODS: Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was used to detect expressions of HOXA11-AS and proinflammatory genes in carotid endarterectomy samples of symptomatic and asymptomatic atherosclerosis (AS) patients, diabetes mellitus (DM), and non-DM patients...
October 2018: European Review for Medical and Pharmacological Sciences
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