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European Review for Medical and Pharmacological Sciences

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https://www.readbyqxmd.com/read/28429367/can-type-1-diabetes-progression-be-halted-possible-role-of-high-dose-vitamin-d-and-omega-3-fatty-acids
#1
F Cadario, S Savastio, A M Rizzo, D Carrera, G Bona And C Ricordi
In Type 1 Diabetes (T1D) in children, close to the onset the requirements of insulin are often reduced. This represents a transient recovery of endogenous insulin secretion named "honeymoon" because transient and followed by a progressive decline in C-peptide secretion. This case report describes the effect of administration of high dose vitamin D and Ω-3 fatty acids on T1D progression in a 8-year-old child. At today after one year and a half from the onset of T1D, the subject shows a near-normal blood glucose with the administration of 1...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429366/analysis-of-transcriptional-activities-of-angiogenic-biomarkers-during-intrauterine-complications-leading-to-preterm-birth
#2
M Rabajdová, R Dudič, P Urban, V Dudičová, P Urdzík, M Mareková
OBJECTIVE: Pre-eclampsia, growth retardation and preterm delivery are the most common reasons leading to increased maternal and perinatal mortality. The increased expression of hypoxia induced factors, such as HIF-1, triggers the overexpression of anti-angiogenic genes. The aim of this study was to determine the transcriptional activity of individual pro- and anti-angiogenic markers (VEGF, HIF-1, sEng, Flt-1, PlGF-1) in maternal blood samples from patients with spontaneous preterm labor, preterm labor in combination with pre-eclampsia and fetal growth restriction in comparison with physiologically terminated pregnancies...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429365/a-randomized-clinical-trial-about-presence-of-pathogenic-microflora-and-risk-of-peri-implantitis-comparison-of-two-different-types-of-implant-abutment-connections
#3
F Mencio, F De Angelis, P Papi, D Rosella, G Pompa, S Di Carlo
OBJECTIVE: The aim of this in vivo study was to evaluate two different types of implant-abutment connections: screwed connection and cemented connection, analyzing peri-implant bacteria microflora as well as other clinical parameters. PATIENTS AND METHODS: Twenty implants were selected, inserted in 20 patients, 10 with a screwed implant-abutment connection (Group 1) and 10 with a cemented implant-abutment connection (Group 2). The peri-implant microflora was collected, after at least 360 days from the prosthetic rehabilitation, using paper points inserted in peri-implant sulcus for 30 s...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429364/application-of-gene-detection-technique-in-the-antenatal-diagnosis-of-hereditary-hearing-loss
#4
Y Fang, M-S Gu, F Suo, C-X Wang, X-H Liu, F-M Liu
OBJECTIVE: Gene chip and gene sequencing techniques were used to detect the main pathogenic genes in pregnant women with hereditary hearing loss. PATIENTS AND METHODS: From May 2015 to May 2016, 1080 pregnant in Xuzhou Maternal and Child Health Hospital were enrolled in this study. Women age range was 18 to 40 years. 4 genes and 9 mutation sites, including 4 sites (35delG, 176, 235delC and 299) in GJB2 gene, 2 sites (2168A>G and IVS-7-2A>G) in SLC26A4 (PDS) gene, 2 sites (1494C>T and 1555A>G) in 12s rRNA gene and 1 site (538C>T) in GJB3 gene, were detected using the GeeDom® 9-item hereditary hearing loss gene detection kit...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429363/two-unilateral-puncturation-comparative-analyses-of-multiple-level-fresh-osteoporotic-vertebral-body-compression-fractures-treated-with-percutaneous-vertebroplasty-guided-by-c-arm-fluoroscopy-or-in-senile-patients
#5
J-C Xu, G-H Wu, L-L Zhou, X-J Yang, J-T Liu
OBJECTIVE:  To compare the curative effects of two unilateral puncturation percutaneous vertebroplasty (PVP) for the pain caused by multiple-level osteoporotic vertebral body compression fractures (OVCF) in senile patients. PATIENTS AND METHODS: From June 2008 to November 2014, eighty-nine cases suffering from fresh multiple-level OVCF were randomly divided into experimental group (n=51) and control group (n=38). Patients underwent PVP guided by C-arm fluoroscopy in the prone position...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429362/wnt11-overexpression-promote-adipose-derived-stem-cells-differentiating-to-the-nucleus-pulposus-like-phenotype
#6
H-T Chen, A-B Huang, Y-L He, J Bian, H-J Li
OBJECTIVE: Our present study aimed to evaluate the effects of Wnt11 overexpression on the adipose-derived stem (ADSCs) cells differentiation to the nucleus pulposus (NP) cells and its function in the ADSCs cells growth, proliferation and induction of the NP cells markers. MATERIALS AND METHODS: The cell growth was detected using the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) (MTT) assay and the cell cycle was assessed by the flow cytometry...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429361/pathologic-character-and-diagnosis-of-female-primary-genital-system-diffuse-large-b-cell-lymphoma
#7
H Cheng, X Tang, J Cheng, B Zhang, Y-L Zhang, W-Q Wang, P Teng
OBJECTIVE: We investigated the clinicopathological characteristics and immunophenotype of female genital system diffuse large B-cell lymphoma (DLBCL) in order to improve diagnosis and therapy efficacy. PATIENTS AND METHODS: The clinicopathologic features of 13 cases with primary DLBCL of the female genital system were studied retrospectively. According to the immunophenotypes, 10 cases were classified as germinal center B-cell-like DLBCL and the other 3 as non-center B-cell-like DLBCL...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429360/effects-of-silencing-annexin-a5-on-proliferation-and-invasion-of-human-cholangiocarcinoma-cell-line
#8
X-M Ding, J-X Li, K Wang, Z-S Wu, A-H Yao, C-Y Jiao, J-J Qian, D-S Bai, X-C Li
OBJECTIVE: We investigated the expression of annexin A5 (ANXA5) in human cholangiocarcinoma (CCA) cell line and its effect on proliferation, migration, and apoptosis of human CCA cells. MATERIALS AND METHODS: Expression of ANXA5 was detected by fluorescent quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) and western blotting method in 2 human CCA cell lines, QBC939 and RBE. 3 shRNA plasmids for ANXA5 silencing (ANXA5-sh1, ANXA5-sh2, ANXA5-sh3) and 1 negative control plasmid were constructed to infect QBC939 cells...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429359/the-role-of-angiogenesis-inhibitors-re-challenge-in-colorectal-cancer-previously-treated-with-bevacizumab-a-meta-analysis-of-randomized-controlled-trials
#9
Y-X Xiong, L Ren, Z-Q Wang, X-W Huang, Y-J Zhou
OBJECTIVE: The potential usefulness of angiogenesis inhibitors (AIs) re-challenge in the treatment of metastatic colorectal cancer (CRC) who previously treated with bevacizumab has not been established yet. MATERIALS AND METHODS: We identified relevant clinical studies through searching databases up to October 2016. Prospective clinical trials investigating AIs re-challenge in metastatic CRC were included for analysis. The primary endpoint was overall survival with secondary endpoint progression-free survival...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429358/slpi-promotes-the-gastric-cancer-growth-and-metastasis-by-regulating-the-expression-of-p53-bcl-2-and-caspase-8
#10
X-Y Du, X Liu, Z-J Wang, Y-Y Wang
OBJECTIVE: The incidence of gastric cancer is very high all over the world, but the mechanism of the occurrence and development of gastric cancer is unclear. Secretory leukocyte protease inhibitor (SLPI) is overexpressed in gastric, lung and ovarian cancers, which accelerates the metastasis of cancer cells. In this research, we mainly explored the expression level and possible mechanism of SLPI in gastric cancer. PATIENTS AND METHODS: The expression and clinical significance of SLPI in 68 cases of gastric cancer tissues and adjacent tissues were detected by qRT-PCR...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429357/inhibition-of-pulmonary-carcinoma-proliferation-or-metastasis-of-mir-218-via-down-regulating-cdcp1-expression
#11
X-J Zeng, Y-H Wu, M Luo, P-G Cong, H Yu
OBJECTIVE: Pulmonary carcinoma is one common malignant tumor with a high risk of recurrence and metastasis. Non-small cell lung cancer (NSCLC) is the most common subtype. As one tumor biomarker, microRNA (miR) has tissue sensitivity and can facilitate oncogene or inhibit tumor suppressor gene. MiR-218 has abnormal expression and can work as one molecular marker for tumors. However, its expression and function mechanism in lung cancer cells have not been fully illustrated. MATERIALS AND METHODS: In vitro cultured pulmonary adenoma A549 cells and normal bronchial epithelial cell line 16HBE were tested for miR-218 expression...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429356/thrombolysis-in-acute-stroke-without-angiographically-documented-occlusion
#12
M-C Shi, F-N Chu, C Li, S-C Wang
OBJECTIVE: The aim of this study was to evaluate the safety and efficacy of intra-arterial thrombolysis (IAT) using urokinase (UK) in acute stroke patients without angiographically-documented occlusion, and to define predictors of clinical outcome. PATIENTS AND METHODS: We analyzed clinical and radiological data of acute ischemic stroke patients whose angiography did not show an arterial occlusion within six hours of symptom onset and who were further treated with IAT using UK...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429355/lewy-pathological-study-on-%C3%AE-synuclein-in-gastrointestinal-tissues-of-prodromal-parkinson-s-disease
#13
Q-B Lu, Z-F Zhu, H-P Zhang, W-F Luo
OBJECTIVE: In the gastrointestinal neural system, the emergence of Lewy Body (LB) is usually earlier than the clinical diagnosis of Parkinson (PD) motor symptoms. Therefore, this study is aimed to explore whether the LB in the gastrointestinal tract of prodromal PD patients. PATIENTS AND METHODS: 98 paraffin embedded tissue specimens from 57 PD patients were collected in the Second Affiliated Hospital of Soochow University archives, as well as 98 tissue specimens of 90 non-PD patients undergone surgical resection...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429354/the-role-of-the-hippocampus-and-the-function-of-calcitonin-gene-related-peptide-in-the-mechanism-of-traumatic-brain-injury-accelerating-fracture-healing
#14
Y Song, G-X Han, L Chen, Y-Z Zhai, J Dong, W Chen, T-S Li, H-Y Zhu
OBJECTIVE: This research attempts to identify the part the hippocampus plays in accelerated fracture-healing after traumatic brain injury as well as to test functions of calcitonin gene-related peptide (CGRP) during this process. MATERIALS AND METHODS: Experiments were carried out on Male Sprague-Dawley rats that were split into four groups at random: TBI-fracture group, fracture-only group, TBI-only group, and control group. In the first week, blood specimen would be drawn from rats among the groups except those of the control group at three-time points (24, 72 and 168 hours) post-damage...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429353/roles-of-the-nrf2-ho-1-pathway-in-the-anti-oxidative-stress-response-to-ischemia-reperfusion-brain-injury-in-rats
#15
L-J Jiang, S-M Zhang, C-W Li, J-Y Tang, F-Y Che, Y-C Lu
OBJECTIVE: The aim of this study was to investigate the roles of the Nrf2/HO-1 pathway in the responses to the oxidative stress created by ischemia-reperfusion brain injury in rats. MATERIALS AND METHODS: 54 healthy, adult, male SD rats were included in the study. Eighteen (18) rats were placed in the sham group. The ischemia-reperfusion model was created in the other 36 rats, among which 18 received injections of Nrf2 agonist before the surgery. The suture method was used to create artery occlusions in the right brain of the rats; and reperfusion was done after 90-minute ischemia (MCAO); while no suture was inserted in the sham group...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429352/difference-in-resting-state-fractional-amplitude-of-low-frequency-fluctuation-between-bipolar-depression-and-unipolar-depression-patients
#16
H-L Yu, W-B Liu, T Wang, P-Y Huang, L-Y Jie, J-Z Sun, C Wang, W Qian, M Xuan, Q-Q Gu, H Liu, F-L Zhang, M-M Zhang
OBJECTIVE: To investigate the difference in fractional amplitude of low-frequency fluctuation (fALFF) of localized brain activities in the resting-state between bipolar depression and unipolar depression patients and to find biological markers that differentiate the two groups of patients. PATIENTS AND METHODS: Thirteen patients with bipolar depression, 15 patients with unipolar depression, and 16 healthy control subjects that were matched in age and years of education were subjected to 3...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429351/tgf%C3%AE-1-protects-myocardium-from-apoptosis-and-oxidative-damage-after-ischemia-reperfusion
#17
Y-F Liu, Y-Y Chu, X-Z Zhang, M Zhang, F-G Xie, M Zhou, H-H Wen, A-H Shu
OBJECTIVE: Myocardial apoptosis is an important pathologic basis of ischemia-reperfusion injury (I/R). Transforming growth factor β1 (TGFβ1) participates in the regulation of oxidative damage and apoptosis. TGFβ1 is upregulated in the repair process of I/R injury. It is speculated that TGFβ1 over-expression is involved in the endogenous protective mechanism of I/R injury. This study explores the significance of TGFβ1 in myocardial cell apoptosis after I/R. MATERIALS AND METHODS: Rat myocardial I/R injury model was established...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429350/the-polymorphism-of-xrcc1-and-coronary-artery-disease-risk-a-meta-analysis
#18
S-J Guo, Y-T Zhou, W-Y Liu, Q-N Zuo, X-H Li
OBJECTIVE: Coronary artery disease (CAD) is a life-threatening disease and is caused by various factors, with genetic variation being an important risk factor. The association between X-ray repair cross-complementing group 1 (XRCC1) polymorphisms and CAD has been extensively studied with conflicting results. We performed a meta-analysis to investigate the overall association between XRCC1 polymorphisms and CAD risk. MATERIALS AND METHODS: We searched PubMed and Embase databases until October 19, 2016...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429349/association-between-the-severity-of-newly-diagnosed-obstructive-sleep-apnea-and-subclinical-carotid-atherosclerosis-in-patients-without-overt-cardiovascular-disease
#19
K Theodoropoulos, D Lykouras, K Karkoulias, D Damania, K Leou, O Lagiou, O A Meelu, A Rigopoulou, G D Dangas, G Hahalis, K Spiropoulos, I Starakis
OBJECTIVE: Obstructive Sleep Apnea (OSA) has been associated with both subclinical and accelerated atherosclerosis; however, it still remains unknown whether this association is unique or is mediated by the higher burden of co-existing cardio-metabolic disorders frequently seen in patients with OSA. PATIENTS AND METHODS: A total of 40 subjects without clinically diagnosed cardiovascular disease (CVD) referred for polysomnography test were included in the study. Subjects with apnea/hypopnea index (AHI > 15/h) were classified as moderate/severe OSA...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429348/diagnostic-value-of-copeptin-in-acute-myocardial-infarction
#20
M O Ay, A K Erenler, T Dogan, M Yetim
OBJECTIVE: The aim of this study was to investigate the effectiveness of copeptin in the early diagnosis of acute myocardial infarction (AMI), and to compare the diagnostic efficacy of copeptin with other cardiac markers. PATIENTS AND METHODS: A total of 160 cases were enrolled in the study. All were over 18 years of age, and consisted of 54 non-ST elevation MI (NSTEMI), 54 ST segment elevation MI (STEMI), and 52 healthy subjects (controls). Serum troponin-I, CK-MB mass, copeptin and CRP levels were measured in each of the cases, and were compared between the three groups for statistical differences...
April 2017: European Review for Medical and Pharmacological Sciences
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