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Journals European Review for Medical an...

European Review for Medical and Pharmacological Sciences

https://read.qxmd.com/read/38497892/tocilizumab-treatment-in-covid-19-patients-therapy-s-side-effects-and-effect-on-mortality
#1
JOURNAL ARTICLE
P Ayvat, S Kayhan Omeroglu
OBJECTIVE: This study aimed to determine the effect of tocilizumab use on mortality and the potential side effects in COVID-19 patients. PATIENTS AND METHODS: The intensive care patients were divided into the tocilizumab group and the control group. Hemogram, biochemistry, acute phase reactant values, age, gender, comorbidity, and culture results were recorded on the 0th, 3rd, 7th, and 14th days. Factors affecting mortality between and within the groups and side effects were examined...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497891/dual-disorder-does-expert-clinical-experience-support-the-rationale-for-cariprazine-use
#2
JOURNAL ARTICLE
J Martinez-Raga, M Bajouco, D Kenzin, J Sahlsten, D De Berardis, G Tzeferakos, E Wagner, G França, J Johnsen, C Roncero, H Grunze
Comorbid substance use disorder (SUD) in patients with schizophrenia (dual disorder, DD) is a frequent occurrence in the psychiatric clinical practice and is positively associated with poorer outcomes. Despite a very high co-prevalence, clinical guidelines for SUD and severe mental illnesses tend to give limited consideration to co-existing disorders regarding diagnosis and management. This article is the result of a meeting held in February 2023 to discuss common challenges and best clinical practice initiatives for patients with schizophrenia and DD in different treatment settings...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497890/atypical-dermoid-cyst-of-the-corpus-callosum-a-case-report
#3
JOURNAL ARTICLE
A Spallone, K Ivanova, L Ferrante, A A Belogurov
BACKGROUND: Intracranial dermoid cysts (DCs) represent an infrequent subset of congenital ectodermal inclusion cysts predominantly observed near the midline structures. In spite of their benign nature, they can cause clinical manifestations, necessitating surgical removal as the main therapeutic measure. CASE REPORT: We present here an extremely rare case characterized by a radiologically atypical dermoid cyst located within the corpus callosum, an extremely rare location for such tumors...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497889/a-3-5-year-clinical-experience-with-perampanel-for-refractory-epilepsy
#4
JOURNAL ARTICLE
T Bin Teni, N A Almutairi, S Abuhaimed, S Alaskar, G Alkhamis, B A Alsfouk, M R Almarzouqi, S Alageel, A Alsemari
OBJECTIVE: This study aimed to evaluate the efficacy and tolerability of perampanel, which was used in a cohort of patients with refractory epilepsy for up to 3.5 years in a real-world setting in Saudi Arabia. PATIENTS AND METHODS: Data from the medical records of patients treated with perampanel between March 13th, 2017, and September 6th, 2020, at neurology clinics at King Faisal Specialist Hospital and Research Centre (KFSHRC), Riyadh and Jeddah, Saudi Arabia, was collected...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497888/unveiling-the-antinociceptive-mechanisms-of-methyl-2-4-chloro-phenyl-5-benzoxazoleacetate-insights-from-nociceptive-assays-in-mice
#5
JOURNAL ARTICLE
Q Jarrar, R Ayoub, Y Jarrar, H Jaffal, K W Goh, L C Ming, S Moshawih, A Sirhan
OBJECTIVE: Methyl-2-(4-chloro- phenyl)-5-benzoxazoleacetate (MCBA), a synthetic benzoxazole derivative with established antipsoriatic efficacy, was investigated for potential antinociceptive effects. This study employs various nociceptive assays in mice to elucidate MCBA's antinociceptive mechanisms. MATERIALS AND METHODS: MCBA's antinociceptive potential was tested against various nociception models induced by formalin, glutamate, capsaicin, a transient receptor potential vanilloid 1 (TRPV1) receptor agonist, and phorbol 12-myristate 13-acetate, a protein kinase C (PKC) activator...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497887/a-rare-case-of-takotsubo-cardiomyopathy
#6
JOURNAL ARTICLE
O Fiste, C Trika, N K Syrigos, E A Kotteas
BACKGROUND: The recent advent of the cyclin-dependent kinase (CDK) 4/6 inhibitors has considerably evolved hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer treatment. Palbociclib, an orally administered pyridopyrimidine derivative, was the first CDK4/6 inhibitor to be introduced into daily clinical practice in combination with classic endocrine backbone, based on progression-free survival (PFS) benefit assessed in the pivotal PALOMA series of randomized clinical trials...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497886/5-signature-genes-revealed-by-single-cell-profiling-identified-unique-immune-subtypes-affecting-the-prognosis-of-ovarian-cancer
#7
JOURNAL ARTICLE
S-Y Xiang, Q-K Li, Z Yang, Q Yi
OBJECTIVE: Ovarian cancer (OC) ranks among the most prevalent gynecological malignancies, with surgery, chemotherapy, and immunotherapy constituting primary treatment modalities. However, despite advancements, immunotherapy, particularly immune checkpoint inhibitors, has yielded suboptimal outcomes. The pressing need to identify biomarkers predictive of clinical prognosis underscores our objective. We aim to discern gene signatures and establish prognostic subgroups, specifically in the context of immunotherapy and chemotherapy, guiding clinical decision-making...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497885/identification-and-validation-of-a-novel-cuproptosis-signature-for-stratifying-different-prognostic-immune-metabolic-and-therapeutic-landscapes-in-pancreatic-adenocarcinoma
#8
JOURNAL ARTICLE
X Yan, W Zheng, F-S Xu, H-L Chang, Y Zhang, Z-Y Zhang, Y-H Zhang
OBJECTIVE: Pancreatic adenocarcinoma (PAAD) is a highly malignant cancer that urgently needs more effective therapeutic strategies. The discovery of cuproptosis brings great inspiration for the treatment and clinical assessment of cancers. MATERIALS AND METHODS: A novel cuproptosis-related (CR) risk signature was constructed using the Lasso regression analysis. Its prognostic value was assessed via a series of survival analyses and validated in four GEO cohorts...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497884/apoa-5-genetic-variant-and-a-hypocaloric-diet-enriched-in-%C3%AF-6-fatty-acids-with-mediterranean-pattern
#9
JOURNAL ARTICLE
D de Luis, O Izaola, D Primo
OBJECTIVE: The APOA5-1131C allele is related to a worse lipid profile and metabolic response to diet interventions. The present study was designed to investigate the effect of SNP rs662799 on the lipid profile of patients with obesity after a hypocaloric diet with a Mediterranean pattern enriched in ω-6 polyunsaturated fatty acids (PUFA). PATIENTS AND METHODS: A population of 362 Caucasian patients with obesity was evaluated. Anthropometric evaluation and serum parameters (lipid profile, insulin, homeostasis model assessment (HOMA-IR), glucose, C reactive protein, and adipokines) were measured at basal time and after 12 weeks...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497883/association-between-uncarboxylated-osteocalcin-blood-glucose-and-bmi-among-saudi-diabetic-patients-an-evaluation-study
#10
JOURNAL ARTICLE
T Alamri, F Alhumaydhi, A Z Wasti
OBJECTIVE: Uncarboxylated osteocalcin is an important osteocalcin enzyme found in the bloodstream and is a crucial protein for maintaining calcium binding in bones, controlling blood sugar levels, and balancing body minerals. PATIENTS AND METHODS: Due to the lack of data, the current study intends to investigate the relationship between uncarboxylated osteocalcin levels and DM-II in Saudi patients. For 138 patients, case-control research was conducted in 2021-2023, with 69 type II diabetes mellitus patients and 69 matching healthy control participants...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497882/association-between-parvovirus-b19-and-thyroid-celiac-autoantibodies-among-t1dm-pediatric-patients
#11
JOURNAL ARTICLE
H C Chandramoorthy, A A Shati, A A Aseeri, A Subramanian, A Alhanshani, E A H Almohseny, R Ram Mani, A Kumar, R A Ali Moosa, A Al-Hakami, K Chidambaram
OBJECTIVE: In recent years, an overwhelming association between Pediatric Type 1 Diabetes Mellitus (T1DM) and autoimmune diseases has been largely reported. The current study was designed to determine a possible association between autoimmune thyroiditis (AIT), celiac disease (CD) - associated autoantibodies, and Parvovirus B19 infection among pediatric T1DM cases in the southwestern region of Saudi Arabia. PATIENTS AND METHODS: Blood samples from age groups 1-18 years attending the Diabetic Clinic were collected over a period of 12 months...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497881/metabolic-control-level-and-glucose-variability-in-adolescents-with-type-1-diabetes-during-low-and-high-intensity-exercise
#12
JOURNAL ARTICLE
M Skalska, A Myśliwiec, A Michalak, J Chrzanowski, A Lejk, J Jastrzębska, Ł Radzimiński, G F Lopez-Sanchez, K Myśliwiec, Z Jastrzębski, K Weiss, B Knechtle
OBJECTIVE: The main purpose of this study was to characterize the determinants of metabolic changes in young type 1 diabetes (T1DM) and to determine glycemic variability during low and high-intensity exercise. PATIENTS AND METHODS: 20 young male T1DM patients were divided into two subgroups characterized by levels of glycated hemoglobin (HbA1c): HbA1c<7.3% (better HbA1c subgroup, n=10) and with levels HbA1c>7.3% (worse HbA1c subgroup, n=10). All participants performed a maximal oxygen uptake test and two efforts of various intensities (45 minutes of aerobic exercise and 30 minutes of mixed aerobic-anaerobic intensity exercise)...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497880/negative-outcomes-pertaining-to-patients-that-leave-against-medical-advice-a-systematic-review-and-meta-analysis
#13
JOURNAL ARTICLE
F Abuguyan
OBJECTIVE: Leaving Against Medical Advice (LAMA) is a prevalent issue in healthcare settings that may lead to negative patient outcomes. We conducted a systematic review and meta-analysis to assess the impact of LAMA on patient outcomes. MATERIALS AND METHODS: A comprehensive literature search was performed across PubMed, MEDLINE, Embase, Cochrane Library, CINAHL, PsycINFO, Web of Science, and Scopus. Studies reporting adverse outcomes, including mortality and hospital readmission rates, in patients who underwent LAMA were included...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497879/inflammatory-factors-mediated-the-effect-of-air-pollution-on-ischemic-stroke-a-two-step-mediation-mendelian-randomization-study
#14
JOURNAL ARTICLE
Z-L Huang, Z-H Huang, Y Xie, Y-D Li, Z-D Pi, C Jiang, A-M Chen, X-Y Gao, J Wen, J-M Zhu
OBJECTIVE: Numerous investigations have indicated a correlation between air pollution (AP) and an elevated ischemic stroke (IS) likelihood. The existing literature does not provide a consensus about the possible link between AP and IS. A two-sample Mendelian randomization (MR) analysis was utilized to systematically measure the causal link between AP and ischemic stroke. Furthermore, the mediating impact of inflammatory factors was also performed by a two-step MR. MATERIALS AND METHODS: A two-sample MR analysis was utilized to examine the AP impact on the incidence of IS...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497878/causal-role-of-gut-microbiota-in-intracranial-aneurysm-evidence-from-a-mendelian-randomization-study
#15
JOURNAL ARTICLE
J-W Sun, Y-B Yu
OBJECTIVE: An increasing number of studies suggest that the alteration of gut microbiota may affect the pathogenesis of intracranial aneurysm (IA). However, the exact causal relationship between gut microbiota and IA has not been confirmed. MATERIALS AND METHODS: The instrumental variables (IVs) for gut microbiota were obtained from a meta-analysis of a genome-wide association study (GWAS) conducted by the MiBioGen consortium (n = 13,266). The summary of GWAS data for IA was obtained from a large genome-wide meta-analysis involving 23 cohorts...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497877/asprosin-improved-neuronal-survival-by-suppressing-apoptosis-and-enhancing-the-activity-of-the-autophagy-pathway-in-the-mcao-model-in-rats
#16
JOURNAL ARTICLE
K Tanbek, F Yuksel, S Tekin, C Tekin, S Sandal
OBJECTIVE: Cerebral ischemia (CI) is a condition in which metabolic stress increases when blood flow is interrupted in a part of the brain, resulting in oxygen and glucose deprivation. It is known that asprosin (Asp), secreted from adipose tissue during fasting, has an effect on some metabolic processes such as apoptosis, autophagy, and glucose metabolism. This study aimed to explain which of the cell death/survival Asp induces in the CI/reperfusion model. MATERIALS AND METHODS: In the study, 48 male Wistar Albino rats were divided into 6 groups: Sham, CI, Asp+CI, CI+Asp, CI+Asp+3-MA, and Asp+CI+3-MA (n=48)...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497876/analysis-of-orthostatic-intolerance-symptoms-in-patients-with-premature-ejaculation
#17
JOURNAL ARTICLE
M O Ozilhan, E Bulbul, F Y Ilki, E Uzun
OBJECTIVE: The autonomic nervous system (ANS) plays an important role in maintaining physiological regulation. It regulates the body's response to many variable situations. Orthostatic intolerance (OI) is one of the most important signs of autonomic dysfunction. Autonomic dysfunction is known to cause premature ejaculation (PE) by disturbing the balance in erection and ejaculation cycles. Considering that OI may develop due to autonomic dysfunction in patients with PE, we hypothesized that OI symptoms would increase in these patients...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497875/effect-of-melatonin-on-reproductive-function-in-propylthiouracil-induced-hypothyroidism-in-adult-male-rats
#18
JOURNAL ARTICLE
W Ezzat, W K Abdelbasset, R S Hussien, A R Azab, A Sulieman, S Yousry
OBJECTIVE: Thyroid hormones are essential for regulating metabolism, reproduction, and growth. Hypothyroidism is connected with lower sperm count and motility, leading to male infertility. Oxidative stress is likely to be linked to this interaction. Melatonin, being known as an oxidative scavenger, may offer a feasible treatment method for reproductive dysfunction accompanying hypothyroidism in adult male rats. The purpose of this investigation was to determine the mechanism by which melatonin treatment affected spermatogenic and steroidogenic function in an experimental model-induced hypothyroidism in adult male rats...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497874/measures-of-health-related-quality-of-life-in-pcos-women-a-cross-sectional-study-from-saudi-arabia
#19
JOURNAL ARTICLE
L S M AlAhmari, H S Alzahrani, N Alzahrani, S O AlDhafyan, R H Al-Qahtani, J A Al-Zaid, M S AlShahrani, L A Al-Ghamdi
OBJECTIVE: Polycystic ovary syndrome (PCOS) is the most common endocrine-gynecologic disorder affecting women of childbearing age. It has a wide range of clinical manifestations, including menstrual irregularity, infertility, hirsutism, acne, and obesity. Studies have confirmed that PCOS can significantly reduce a patient's health-related quality of life (HRQoL). The pathophysiology of PCOS is poorly understood, but it is believed to be caused by the interaction of several factors. Moreover, there is a lack of information about HRQoL among PCOS women in Saudi Arabia...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497873/hepatitis-e-virus-infection-increases-the-risk-of-obstetric-complications-and-perinatal-adverse-outcomes-in-pregnant-women-with-chronic-hepatitis-b-virus-infection
#20
JOURNAL ARTICLE
C Chen, M-L Wang, W-X Li, X Qi, Q Li, L Chen
OBJECTIVE: Hepatitis E virus (HEV) infection may occur in pregnant women who had chronic hepatitis B virus (HBV) infection. This study aimed to evaluate whether HEV-HBV co-infection increases the risk of obstetric complications and perinatal adverse outcomes in pregnant women. PATIENTS AND METHODS: We investigated the clinical data of 3,251 pregnant women with chronic HBV infection. The obstetric complications and perinatal adverse outcomes were compared between patients with HEV-HBV co-infection and patients who had pure chronic HBV infection...
March 2024: European Review for Medical and Pharmacological Sciences
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