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DAPK1 Keeps the Peace in Antifungal Inflammation.

Tonia Akoumianaki, Georgios Chamilos
Cell Host & Microbe 2016 December 15
Unabated inflammation and impaired antifungal immunity underlie genetic defects in NOX-2-dependent activation of LC3-associated phagocytosis (LAP). In this issue of Cell Host & Microbe, Oikonomou et al. (2016) identify a molecular link between IFN-γ/DAPK1 signaling, the proteosomal degradation pathway, and LAP that is critical for dampening Aspergillus-triggered immunopathology.

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