PDGFA Makes Thin Skin Thicker: Molecular Regulation of Adipose Progenitor Maintenance.

Adipocyte progenitor proliferation and self-renewal contribute to adipose tissue maintenance; however, the regulatory circuits of these processes are less understood. In this issue of Cell Stem Cell, Rivera-Gonzalez et al. (2016) show that PDGFA, which acts through PI3K-Akt pathways, plays a vital role in the proliferation and maintenance of adipocyte progenitors in dermal adipose tissues.