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Modification of the 2012 CKD-EPI equations for the elderly Chinese.
International Urology and Nephrology 2017 March
BACKGROUND: Our previous studies demonstrated that 2012 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were inaccurate enough for estimating glomerular filtration rate in elderly Chinese. Thus, this study was constructed to modify these equations.
METHODS: A total of 839 subjects (aged ≥60 years) from four hospitals in China between October 2009 and December 2014 were included. A random sample of 674 (80.3 %) subjects was used as a training sample set, and the remaining 165 (19.7 %) subjects as the verification set. The equations were modified using the hill-climbing algorithm.
RESULTS: Compared with the original CKD-EPI equations, the accuracy assessment indexes (bias, precision, accuracy and misclassification) were obviously improved after modification. Bland-Altman analysis also demonstrated that this modification attempt gained success to some extent.
CONCLUSIONS: The modified 2012 CKD-EPI equations could be more accurate than the original equations for elderly Chinese individuals.
METHODS: A total of 839 subjects (aged ≥60 years) from four hospitals in China between October 2009 and December 2014 were included. A random sample of 674 (80.3 %) subjects was used as a training sample set, and the remaining 165 (19.7 %) subjects as the verification set. The equations were modified using the hill-climbing algorithm.
RESULTS: Compared with the original CKD-EPI equations, the accuracy assessment indexes (bias, precision, accuracy and misclassification) were obviously improved after modification. Bland-Altman analysis also demonstrated that this modification attempt gained success to some extent.
CONCLUSIONS: The modified 2012 CKD-EPI equations could be more accurate than the original equations for elderly Chinese individuals.
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