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International Urology and Nephrology

Rosa Park, Justin Gyorfi, Kalyan Dewan, Girish Kirimanjeswara, Joseph Y Clark, Matthew G Kaag, Kathleen Lehman, Jay D Raman
PURPOSE: To report outcomes 5 years after a resident quality initiative incorporated topical rectal antiseptic into our ultrasound-guided prostate needle biopsy (TRUS PNB) protocol. METHODS: A chart review was conducted on 1007 men who underwent TRUS PNB between 2010 and 2017. Comparison groups include those who received a topical rectal antiseptic (N = 437) compared to those who did not (N = 570). Povidone-iodine (N = 303) or 4% chlorhexidine solution without alcohol (N = 134) were topical agents...
July 17, 2018: International Urology and Nephrology
Paweł Porzycki, Ewa Ciszkowicz, Małgorzata Semik, Mirosław Tyrka
PURPOSE: Prostate cancer (PCa) is a common tumor disease in western countries and a leading cause of cancer-driven mortality in men. Current methods for prostate cancer detection, like prostate-specific antigen screening, lead to significant overtreatment. The purpose of the study was to analyze circulating microRNAs in serum as non-invasive biomarkers in patients with diagnosis of prostate cancer and healthy individuals. METHODS: This preliminary study included a population of 20 patients with mean age of 68...
July 16, 2018: International Urology and Nephrology
Yi Sun, Guo-Lin Lei, Cai Tang, Lu Yang, Hong Shen, Qiang Wei
AIMS: To compare the efficiency and complications of normal weight and overweight women with stress urinary incontinence (SUI) after surgery. METHODS: We searched the PubMed, Embase, and Cochrane Library Databases to identify all compared results, including those involving the terms normal weight, overweight, body mass index (BMI), and SUI. After treatment with surgery, the efficiency (subjective cure rate, objective cure rate, UDI-6, and IIQ-7) and complications were compared between the normal weight and overweight groups...
July 14, 2018: International Urology and Nephrology
Lunshan Wang, Yuhuai Sun, Xinan Cai, Guifeng Fu
PURPOSE: In this study, we investigated the diagnostic value of human epididymis protein 4 (HE4) in acute and chronic renal dysfunction and analyzed the correlation between HE4 levels and the results of routine renal function tests. We aimed to provide evidence to establish HE4 as a novel biomarker of renal injury and its appropriate application as a marker of ovarian cancer. METHODS: We collected 259 serum samples from hospitalized patients with different causes of renal damage...
July 13, 2018: International Urology and Nephrology
Crina Claudia Rusu, Simona Racasan, Diana Moldovan, Alina Potra, Dacian Tirinescu, Cristian Budurea, Remus Orasan, Ioan Mihai Patiu, Cosmina Bondor, Dan Vladutiu, Dan Delean, Alexandra Danu, Ina Maria Kacso
PURPOSE: Exogenous ghrelin is associated with cardiovascular protection in experimental and human studies. Nevertheless ESRD patients have increased ghrelin levels and severe cardiovascular comorbidities. This study aims to elucidate the metabolic factors influencing endogenous ghrelin/acyl ghrelin levels and to analyze the relation between endogenous ghrelin/acyl ghrelin levels and cardiac and vascular function markers in hemodialysis patients. METHODS: The cross-sectional study was conducted in hemodialysis patients (n = 88); 50 of them were men, mean age 61...
July 13, 2018: International Urology and Nephrology
Wei Sheng, Hongwei Zhang, Yong Lu
PURPOSE: To assess survival outcomes of locally advanced prostate cancer (LAPC) in patients aged < 50 years after local therapy (LT), as compared to that in the older patients (≥ 50 years). Moreover, effectiveness of postoperative radiation therapy (PRT) after radical prostatectomy (RP) was also assessed in patients aged < 50 years. METHODS: Within the Surveillance, Epidemiology, and End results database (2004-2014), non-metastatic cT3-4 LAPC patients treated with LT (RP, RT or RP+RT) were identified...
July 7, 2018: International Urology and Nephrology
Serdar Celik, Ertugrul Sefik, Ismail Basmacı, Ibrahim Halil Bozkurt, Mehmet Erhan Aydın, Tarık Yonguc, Tansu Degirmenci
PURPOSE: The purpose of the study was to investigate the predictive value of stone measurements by including a novel method on non-contrast computed tomography (NCCT) images for stone composition. METHODS: We retrospectively evaluated patients who had stone analysis, NCCT images, and underwent percutaneous nephrolithotomy between 2013 and 2016. Patient characteristics, stone measurements on NCCT images, and stone analysis results were evaluated. Hounsfield unit (HU) values (maximum (HUmax ), minimum (HUmin ), and average (HUave ) of HU values) were investigated on NCCT images...
July 6, 2018: International Urology and Nephrology
Fu-Jun Lin, Xi Zhang, Lu-Sheng Huang, Gang Ji, Hai-Dong Huang, Yun Xie, Geng-Ru Jiang, Xin Zhou, Wei Lu
PURPOSE: Although the association between anemia and cardiovascular mortality in hemodialysis patients is well established, whether hemoglobin variability (Hgb-Var) affects the prognosis remains unclear. We aimed to evaluate the association between Hgb-Var and cardiovascular mortality in Chinese hemodialysis patients. METHODS: This retrospective study included 252 patients starting hemodialysis in Xin Hua Hospital between January 2009 and December 2015. Patients were divided into three tertiles based on Hgb-Var, as reflected by SD Hgbmean , SD Hgbrange , and Hgbdeflection during a 12-month evaluation period after hemodialysis initiation...
July 4, 2018: International Urology and Nephrology
Lijuan Gu, Yu Tao, Cheng Chen, Yingze Ye, Xiaoxing Xiong, Yao Sun
Ischemia/reperfusion injury (IRI) occurs commonly during renal transplantation. It has been well demonstrated that the inflammatory response has an important role in the pathogenesis and pathological processes of IRI. However, the signaling events that trigger the activation of the inflammatory response are less clear. Accumulated evidence has identified the role of various injury factors released from or exposed in ischemic, damaged, or dying cells, which serve as initiators of the inflammatory response and exacerbate kidney injury after renal IRI...
July 4, 2018: International Urology and Nephrology
Dragos Viorel Scripcariu, Dimitrie Siriopol, Mihaela Moscalu, Viorel Scripcariu
PURPOSE: The objective of this study is to investigate the impact of the temporary loop ileostomy on renal function and also to assess the factors associated with the change in renal function observed between the index surgery (the moment of the radical surgical procedure) and the closure of the ileostomy (the moment of the secondary surgical act of suppression of the ileostomy). METHODS: A total of 69 rectal cancer patients from a single referral surgical unit who had a loop ileostomy during low anterior resection of the rectum were included in this study...
July 4, 2018: International Urology and Nephrology
Murat Uçar, Ahsen Karagözlü Akgül, Ayşe Parlak, Cem Yücel, Nizamettin Kılıç, Emin Balkan
OBJECTIVE: We aimed to evaluate the efficacy and safety of intravesical onabotulinum toxin A (onaBoNTA) injections for the treatment of children diagnosed with refractory overactive bladder (OAB) by using non-invasive methods. METHODS: A total of 31 pediatric patients with a mean age of 10.2 years received intravesical onaBoNTA injection at the dose of 10 U/kg (max: 200 U). Twenty-one patients who failed to respond to the first injection, received second injection 6 months after the first one...
July 2, 2018: International Urology and Nephrology
Golnar Sabetian Fard, Farid Zand, Elham Asadpour, Mohammad Ghorbani, Pourya Adibi, Mohammad Mehdi Hosseini, Shahryar Zeyghami, Farzaneh Masihi
No abstract text is available yet for this article.
June 30, 2018: International Urology and Nephrology
Abdel Shakour Abdel Hafez Abdel Wahed, Mohamed Abdel Mawgood Amer, Nagah Mohamed Abou Mohamed, Mohamed Ismael Mobasher, Hassan Mamdouh, Sameh Fayek GamalEl Din, Mohammed Said ElSheemy
PURPOSE: The purpose of the study was to compare serum level of Arginase II in patients with vasculogenic erectile dysfunction (ED) versus healthy controls and to assess if its level is affected by severity of ED. METHODS: This is a prospective study that compared Arginase II in 40 patients with ED versus 40 healthy controls. Patients were excluded if they had any pelvic trauma or pelvic surgery, hormonal disorders, Peyronie's disease, smoking, drug addiction or systemic illnesses...
June 28, 2018: International Urology and Nephrology
Christophe Bontoux, Sarah Khaddour, Gaëlle Pérot, Christophe Vaessen, Haidé Boostandoost, Jérémy Augustin, Jean-François Côté
No abstract text is available yet for this article.
June 26, 2018: International Urology and Nephrology
Li Wan, Dongliang Zhang
TARGET: To observe the effect on hemoglobin (Hb) variability with different treatment frequencies of intravenous iron in maintenance hemodialysis (MHD) patients. METHODS: There were 41 MHD patients enrolled in the cohort. The patients were separated into two groups randomly. The baseline data were collected after oral iron agents for 1 month (wash out). There were two methods of intravenous iron administration, either continuous or intermittent. For continuous administration (CA), 100 mg sucrose iron agents were given during every HD session with total dose of 1000 mg...
June 26, 2018: International Urology and Nephrology
Koray Uludag, Nilufer Oguzhan, Tamer Arıkan, Gulsah Boz
PURPOSE: To examine whether an elevated serum total bilirubin level affects the decline in renal function or new-onset chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (DM2). METHODS: This was a longitudinal observational study in patients who presented at the University of Health Sciences Hospital in Kayseri. Five hundred twenty-nine patients with DM2 who had conserved renal function were enrolled (estimated glomerular filtration rate > 60 ml/min/1...
June 26, 2018: International Urology and Nephrology
Frank-Peter Tillmann, Lars Christian Rump, Ivo Quack
PURPOSE: Pre-diabetes, a risk factor for post-transplant diabetes mellitus (PTDM), represents an early therapeutic target for prevention of PTDM. We evaluated glucose metabolism post-transplantation and the ability to predict pre-diabetes and PTDM from haemoglobin A1c (HbA1c) levels at 90 days, at 1 year, and at 3 years in long-term post-transplantation follow-up. METHODS: HbA1c levels were measured in 71 non-diabetic deceased-donor transplant recipients at four time points (during transplantation, 90-days post-transplantation, 1-year post-transplantion, and at the final post-transplantation follow-up visit 2...
June 26, 2018: International Urology and Nephrology
Kerem Teke, Hasan Yilmaz, Ali Kemal Uslubas, Gurler Akpinar, Murat Kasap, Oguz Mutlu, Demir Kursat Yildiz, Nil Guzel, Ozdal Dillioglugil
PURPOSE: Recent studies have shown that Aurora-A expression is associated with bladder cancer initiation and progression. In this study, the effects of intravesical Aurora-A inhibitor Alisertib (ALS) and bacillus Calmette-Guérin (BCG) were compared on bladder carcinogenesis. METHODS: Two mg N-Methyl-N-nitrosourea was administered intravesically to forty of Wistar-albino rats every other week for 8 weeks. At week 10, rats were divided into four groups (10/group): No-treatment (vehicle), ALS-alone, BCG-alone, and ALS + BCG...
June 21, 2018: International Urology and Nephrology
Zekeriya Tasdemir, Funda Özsarı Tasdemir, Cem Gürgan, Eray Eroglu, Inayet Gunturk, Ismail Kocyigit
PURPOSE: Chronic inflammation is an obvious risk factor of atherosclerotic diseases, and the presence of periodontal disease is one of the important sources of chronic inflammation in patients with chronic kidney disease (CKD) and diabetes mellitus (DM). Thus, we aimed to investigate the effects of non-surgical periodontal therapy of the patients undergoing CAPD due to diabetic nephropathy, diabetic patients without CKD, and healthy controls on inflammation exponents. METHODS: Thirty-two CAPD patients due to diabetic nephropathy (group III), 31 diabetic patients without nephropathy (group II), and 38 healthy subjects (group I) were enrolled to the study...
June 20, 2018: International Urology and Nephrology
Eva Tvrdá, Francisca Arroyo, Jaime Gosálvez
AIM: The purpose of the study was to evaluate the impact of seminal plasma in human ejaculates on the sperm DNA quality and DNA longevity. METHODS: Semen samples for this study were obtained from 20 donors with a normal spermiogram. Following centrifugation, the sperm pellet was resuspended either in the seminal plasma proceeding from its respective donor, or in an equal amount of PBS, adjusting the concentration to 50 × 106 /ml. Each set of samples was incubated at 37 °C for 24 h and the sperm DNA damage was assessed using the chromatin-dispersion test following 0, 2, 6, and 24 h of incubation...
June 20, 2018: International Urology and Nephrology
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