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International Urology and Nephrology

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https://www.readbyqxmd.com/read/28528353/adrenomedullin-ameliorates-podocyte-injury-induced-by-puromycin-aminonucleoside-in-vitro-and-in-vivo-through-modulation-of-rho-gtpases
#1
Nan Dong, Lixia Meng, Ruqun Xue, Meng Yu, Zhonghua Zhao, Xueguang Liu
PURPOSE: Podocyte injury is a key event in proteinuric kidney disease and eventually glomerular scarring. While adrenomedullin (AM), a potent vasodilatory peptide, has been reported to confer renoprotection in several experimental models of kidney diseases, its effect on injured podocytes and the related mechanism is still largely unknown. METHODS: Employing Western blotting analysis, immunoprecipitation and immunofluorescence, we investigated the effects of AM on the expressions of podocyte cytoskeletal proteins and Rho-family small GTPases (Rho GTPases) in puromycin aminonucleoside (PAN)-induced podocyte injury, both in cultured podocytes and in PAN nephrosis rats...
May 20, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28526969/glycaemia-and-phosphatemia-after-oral-glucose-and-maltitol-ingestion-in-subjects-from-two-different-race-groups-preliminary-evidence-of-inter-race-differences-in-metabolism-and-possible-implications-for-urinary-stone-disease
#2
Takalani Theka, Allen Rodgers
PURPOSE: Glucose (Glu) and maltitol (Mal) ingestion affect calciuria and phosphaturia. Renal phosphate leak involving hypophosphatemia is thought to be a mechanism. Inter-race differences in carbohydrate metabolism are known. We investigated the effects of Glu and Mal ingestion on glycaemia and phosphatemia in subjects from two race groups to better understand potential implications for nephrolithiasis. METHODS: Healthy black (B) (n = 8) and white (W) (n = 8) males followed a self-selected standardized diet for 7 days and a strictly controlled standardized diet on Day 8...
May 19, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28523594/the-relationship-between-coronary-artery-calcium-scores-and-left-atrium-size-in-hemodialysis-patients
#3
Ismail Baloglu, Kultigin Turkmen, H Zeki Tonbul, N Yılmaz Selcuk
PURPOSE: Hemodialysis patients have extremely increased cardiovascular mortality. The coronary artery calcification score (CACS) in uremic patients receiving hemodialysis reflects the severity of atherosclerotic vascular disease and predicts the cardiovascular events. In cardiac conditions, left atrial (LA) size has a prognostic importance. In this study, relationship between coronary artery calcification and left atrial size was investigated. METHODS: This was a cross-sectional study involving 32 hemodialysis patients (16 females, 16 males; mean age, 52...
May 18, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28523593/emotion-oriented-coping-increases-the-risk-of-depression-among-caregivers-of-end-stage-renal-disease-patients-undergoing-hemodialysis
#4
Paulo Roberto Santos, Ítala Mônica de Sales Santos, João Laerte Alves de Freitas Filho, Carlos Wellington Macha, Priscila Garcia Câmara Cabral Tavares, Ana Cláudia de Oliveira Portela, Ana Mayara Barros Campos, Ana Raquel Ferreira de Azevedo, Catarine Cavalcante Ary, Felipe Peixoto Nobre, Jamille Fernandes Carneiro, Yandra Maria Gomes Pontes
PURPOSE: We investigated the possible association between coping style and depressive feelings among caregivers of end-stage renal disease patients undergoing hemodialysis. METHODS: We studied 107 main caregivers of hemodialysis patients. Main caregiver was defined as the person on whom the patient counts for daily care or the one the patient calls upon in case of difficulties. Demographic data of caregivers and clinical data of patients were collected. The Jalowiec Coping Scale was applied to score two styles of coping: problem-oriented coping (POC) and emotion-oriented coping (EOC)...
May 18, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28516385/conservative-surgical-treatment-predictors-of-maternal-hydronephrosis-results-of-a-single-center-retrospective-non-randomized-non-controlled-observational-study
#5
Hakan Ercil, Burak Arslan, Ferhat Ortoglu, Ergun Alma, Umut Unal, Mehmet Eflatun Deniz, Aykut Bugra Senturk, Zafer Gokhan Gurbuz
PURPOSE: To determine the parameters that may help the clinicians decide the best suitable treatment method for the pregnant women with symptomatic hydronephrosis which will be based on the easily accessible laboratory tests, monitoring methods and clinical symptoms. METHODS: Digital data and documents of 246 pregnant women with symptomatic hydronephrosis who were hospitalized in our clinic between the dates of January 2011 and January 2016 were retrospectively evaluated...
May 17, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28508247/in-human-cell-cultures-everolimus-is-inferior-to-tacrolimus-in-inhibiting-cellular-alloimmunity-but-equally-effective-as-regards-humoral-alloimmunity
#6
Theodoros Eleftheriadis, Georgios Pissas, Maria Sounidaki, Georgia Antoniadi, Nikolaos Antoniadis, Vassilios Liakopoulos, Ioannis Stefanidis
PURPOSE: Acute cellular rejection is the major cause of immune-mediated graft failure early in the course of kidney transplantation, whereas chronic antibody-mediated rejection is a major contributor to graft loss in the late post-transplant phase. Based mainly on the results of short-term studies, the calcineurin inhibitor tacrolimus prevails over the mammalian target of rapamycin (mTOR) inhibitors. However, the toxicity profile of the two drug categories differs, making the interchange between them appealing...
May 15, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28508246/the-significance-of-histological-analysis-following-laser-transurethral-resection-of-the-prostate
#7
Shady Nafie, John Dormer, Masood A Khan
PURPOSE: Monopolar transurethral resection of the prostate is the gold standard for the treatment of benign prostatic hyperplasia. However, due to the associated risks of bleeding and TUR syndrome, laser prostate surgery is gaining popularity. We perform thulium-laser vaporesection of the prostate (TmLRP), where histological samples are generated in every case. We determined postoperative incidence and significance of prostate cancer detection, by retrospective histological examination of our cases...
May 15, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28501912/idiopathic-retroperitoneal-fibrosis-clinical-features-and-long-term-renal-function-outcome
#8
Mohamed H Zahran, Yasser Osman, Mohamed A Soltan, Ahmed Elhussein Abolazm, Mostafa K Ghazy, Ahmed M Harraz, Ahmed A Shokeir, Hassan Abol-Enein, Bedeir Ali-El-Dein
PURPOSE: To evaluate the long-term renal function outcome of management of retroperitoneal fibrosis (RPF)-induced ureteral obstruction. METHODS: Thirty-six patients with idiopathic RPF-induced ureteral obstruction were classified according to the management type into two groups, group A; managed by indwelling JJ stent and group B managed by ureterolysis and omental wrapping (UOR). The primary outcome was to define the long-term outcome of management on RF. It was evaluated by changes in serum creatinine and estimated GFR (eGFR) using Modification of Diet in Renal Disease equation where 20% changes in eGFR is considered significant...
May 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28484945/the-de-ritis-aspartate-transaminase-alanine-transaminase-ratio-as-a-predictor-of-oncological-outcomes-in-patients-after-surgery-for-upper-urinary-tract-urothelial-carcinoma
#9
Yang Hyun Cho, Jun Eul Hwang, Ho Seok Chung, Myung Soo Kim, Eu Chang Hwang, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Seock Hwan Choi, Hyun Tae Kim, Tae-Hwan Kim, Tae Gyun Kwon, Joon Hwa Noh, Myung Ki Kim, Chul-Sung Kim, Sung Gu Kang, Seok Ho Kang, Jun Cheon, Chan Ho Lee, Ja Yoon Ku, Hong Koo Ha, Bum Sik Tae, Chang Wook Jeong, Ja Hyeon Ku, Cheol Kwak, Hyeon Hoe Kim
PURPOSE: Recently, several studies have shown that the De Ritis ratio (aspartate transaminase/alanine transaminase) can be a useful prognostic biomarker for certain types of malignant tumors. However, the prognostic value of the De Ritis ratio in patients with upper tract urothelial carcinoma remains largely unknown. The aim of the present study was to evaluate the prognostic significance of the De Ritis ratio in patients who had undergone radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma...
May 8, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28477302/association-between-multiple-chronic-conditions-and-urolithiasis
#10
Michael E Rezaee, Charlotte E Ward, Martha Pollock, Sugandh D Shetty
PURPOSE: Given the risk factors for stone disease, it is possible that multiple chronic condition (MCC) patients are at increased risk of developing new, recurrent, or worsening urolithiasis. The purpose of our investigation was to evaluate the relationship between MCCs and urolithiasis. METHODS: Retrospective cohort using outpatient claims data for all adult members (≥18 years) of the Beaumont Employee Health Plan who received outpatient care between 2008 and 2013...
May 5, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28477301/diagnostic-value-of-mri-based-psa-density-in-predicting-transperineal-sector-guided-prostate-biopsy-outcomes
#11
Findlay MacAskill, Su-Min Lee, David Eldred-Evans, Wahyu Wulaningsih, Rick Popert, Konrad Wolfe, Mieke Van Hemelrijck, Giles Rottenberg, Sidath H Liyanage, Peter Acher
PURPOSE: Prostate-specific antigen (PSA) density (PSAD) has potential to increase the diagnostic utility of PSA, yet has had poor uptake in clinical practice. We aimed to determine the diagnostic value of magnetic resonance imaging-derived PSAD (MR-PSAD) in predicting transperineal sector-guided prostate biopsy (TPSB) outcomes. MATERIALS AND METHODS: Men presenting for primary TPSB from 2007 to 2014 were considered. Histological outcomes were assessed and defined as: presence of any cancer or significant cancer defined as presence of Gleason 4 and/or maximum tumour core length (MCCL) ≥ 4 mm (G4); or Gleason 4 and/or MCCL ≥ 6 mm (G6)...
May 5, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28474311/the-effect-of-ultrasound-guided-compression-immediately-after-transrectal-ultrasound-guided-prostate-biopsy-on-postbiopsy-bleeding-a-randomized-controlled-pilot-study
#12
Bong Hee Park, Jung Im Kim, Sang Rak Bae, Yong Seok Lee, Sung Hak Kang, Chang Hee Han
PURPOSE: To evaluate whether ultrasound-guided compression performed immediately after transrectal ultrasound (TRUS)-guided prostate biopsy decreases bleeding complications. METHODS: We prospectively evaluated a total of 148 consecutive patients who underwent TRUS-guided prostate biopsy between March 2015 and July 2016. Systematic 12-core prostate biopsy was performed in all patients. Of these, 100 patients were randomly assigned to one of two groups: the compression group (n = 50) underwent TRUS-guided compression on bleeding biopsy tracts immediately after prostate biopsy, while the non-compression group (n = 50) underwent TRUS-guided prostate biopsy alone...
May 4, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28466251/establishment-of-the-u-l-t-r-a-measurement-rating-system-for-anterior-urethral-stricture
#13
Lei Chen, Rui Hou, Chao Feng, Xinru Zhang, Diancheng Li, Jie Chen, Bing Hu
PURPOSE: Anterior urethral stricture treatments are various, and comprehensive consideration should be given in selecting individualized treatment programs, which must be combined with the patient's stricture, length, complexity, and other factors. At present, there is no standard for the clinical description of the anterior urethral stricture for the selection of the characteristic index, and most of the indicators are qualitative information. In order to achieve consistent decisions and effective comparisons, it is imperative to establish a standardized description system...
May 2, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28456923/penile-fracture-with-bilateral-corpus-cavernosa-tears-and-complete-urethral-disruption
#14
LETTER
Deepak Batura, Asif Raza, Michael Mikhail, Tumaj Hashemzehi, Malwina Julia Figaszewska
No abstract text is available yet for this article.
April 29, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28456922/nutritional-status-after-conversion-from-conventional-to-in-centre-nocturnal-hemodialysis
#15
Nazanin Noori, Andrew T Yan, Mercedeh Kiaii, Andrea Rathe, Marc B Goldstein, Olugbenga Bello, Ron Wald
INTRODUCTION: Recipients of conventional hemodialysis (CHD; 3-4 h/session, 3 times/week) experience volume expansion and nutritional impairment which may contribute to high mortality. Prolongation of sessions with in-centre nocturnal hemodialysis (INHD; 7-8 h/session, 3 times/week) may improve clinical outcomes by enhancement of ultrafiltration and uremic toxin removal. MATERIALS AND METHODS: In this prospective cohort study, 56 adult patients who were receiving maintenance CHD for at least 90 days were assigned to CHD (patients who remained in CHD) and INHD (patients who switched to INHD) groups...
April 29, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28455663/predictors-and-outcomes-of-non-adherence-in-patients-receiving-maintenance-hemodialysis
#16
Fadi Tohme, Maria K Mor, Julio Pena-Polanco, Jamie A Green, Michael J Fine, Paul M Palevsky, Steven D Weisbord
PURPOSE: Predictors of and outcomes associated with non-adherent behavior among patients on chronic hemodialysis (HD) have been incompletely elucidated. We conducted a post hoc analysis of data from the SMILE trial to identify patient factors associated with non-adherence to dialysis-related treatments and the associations of non-adherence with clinical outcomes. METHODS: We defined non-adherence as missed HD and abbreviated HD. We used negative binomial regression to model the associations of demographic and clinical factors with measures of non-adherence, and negative binomial and Cox regression to analyze the associations of non-adherence with hospitalizations and mortality, respectively...
April 28, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28455662/close-correlation-between-the-ankle-brachial-index-and-symptoms-of-depression-in-hemodialysis-patients
#17
Ing-Chin Jong, Hung-Bin Tsai, Chien-Hung Lin, Tsung-Liang Ma, How-Ran Guo, Peir-Haur Hung, Kuan-Yu Hung
BACKGROUND: As both of peripheral arterial disease (PAD) and depression carried a poor prognosis in patients on maintenance hemodialysis (MHD), we investigated the correlation between the ankle-brachial index (ABI), an indicator of subclinical PAD, and symptoms of depression in patients on MHD. METHODS: One hundred and twenty-nine patients on MHD (75 males and 54 females, mean age 64.8 ± 12 years) were enrolled in this cross-sectional study, which aimed at evaluating the relationship between symptoms of depression and ABI...
April 28, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28455661/modified-laparoscopic-placement-of-peritoneal-dialysis-catheter-with-intra-abdominal-fixation
#18
Quanquan Shen, Xinxin Jiang, Xiaogang Shen, Fangyan Yu, Qiudi Tu, Wangfang Chen, Qing Ye, Tapas Ranjan Behera, Qiang He
PURPOSE: Peritoneal dialysis (PD) is a commonly accepted method of treating end-stage renal disease (ESRD). Various laparoscopic techniques for the placement of PD catheter have been described. In this study, we developed a novel modified laparoscopic technique for PD catheter placement and evaluated the early results. METHODS: A straight Tenckhoff PD catheter was placed employing the modified technique in 39 consecutive patients with ESRD from May 2013 to April 2016...
April 28, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28455660/radial-artery-sclerostin-expression-in-chronic-kidney-disease-stage-5-predialysis-patients-a-cross-sectional-observational-study
#19
Hua Zhou, Min Yang, Min Li, Li Cui
PURPOSE: Bone metabolism disorder is often associated with cardiovascular calcification in patients with chronic kidney disease (CKD). Sclerostin, a novel candidate protein, has been identified to be involved in the bone-vascular axis. The aims of the current investigation were to assess vessel sclerostin expression and its relationship with circulating sclerostin levels. METHODS: A cross-sectional observational study was conducted from January 2012 to December 2014...
April 28, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28455659/differential-expression-of-circulating-mir-21-mir-142-3p-and-mir-155-in-renal-transplant-recipients-with-impaired-graft-function
#20
Sepideh Zununi Vahed, Ahmad Poursadegh Zonouzi, Hossein Ghanbarian, Morteza Ghojazadeh, Nasser Samadi, Yadollah Omidi, Mohammadreza Ardalan
BACKGROUND: The discovery of circulating microRNAs (miRNAs), as potential noninvasive diagnostic biomarkers, has opened new avenues of research for identifying patients with chronic failure in renal transplantation. The present study aimed to investigate the expression levels of four immune-related miRNAs (miR-21, miR-31, miR-142-3p and miR-155) in plasma samples of renal recipients. METHODS: The plasma expression levels of the miRNAs were evaluated by quantitative real-time PCR (qPCR) in 53 renal recipients with long-term stable allograft function, SGF (N = 27), and with biopsy-proven interstitial fibrosis and tubular atrophy (IFTA) (N = 26) and also healthy controls (N = 15)...
April 28, 2017: International Urology and Nephrology
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