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International Urology and Nephrology

Larisa Kovacevic, Hong Lu, Joseph A Caruso, Natalija Kovacevic, Yegappan Lakshmanan
PURPOSE: To study (1) the differences in the relative abundance of urinary proteins between children with kidney stones (RS) and hypercalciuria, hypocitraturia, normal metabolic work-up, and healthy controls (HC); (2) the association of these proteins with various diseases. METHODS: Quantitative proteomic comparison of pooled urine from RS (N = 30, 24 females, mean age 12.95 ± 4.03 years) versus age- and gender-matched HC, using mass spectrometry. Relative protein abundance was estimated using spectral counting...
September 12, 2018: International Urology and Nephrology
Aixia Ma, Fuqiang Liu, Chuan Wang, Kai Liang, Fei Yan, Xinguo Hou, Jinbo Liu, Li Chen
BACKGROUND: Metabolic syndrome (MetS) has been found to be associated with an increased risk for chronic kidney disease (CKD). However, the relationship between insulin resistance (IR), which is believed to play a central role in the pathogenesis of MetS, and CKD is still unclear in Chinese adults and needs further investigation. METHODS: This 3-year follow-up study included 3237 middle-aged and elderly Chinese without CKD at baseline. Estimated glomerular filtration rate (eGFR) 60-90 mL/min/1...
September 4, 2018: International Urology and Nephrology
Yosuke Saka, Tomohiko Naruse, Akihisa Kato, Naoto Tawada, Yuhei Noda, Tetsushi Mimura, Yuzo Watanabe
BACKGROUND: Reportedly, thiamine deficiency, resulting from malnutrition and long-term diuretic therapy, is observed in patients with chronic kidney disease (CKD). The risk of thiamine deficiency might be enhanced, especially in end-stage CKD patients. Here, we assessed thiamine status in incident dialysis patients. METHODS: This study was a single-center cross-sectional study which included 288 consecutive patients initiated into dialysis between April 2013 and March 2017 at our hospital...
September 4, 2018: International Urology and Nephrology
Marijan Bosevski
No abstract text is available yet for this article.
September 4, 2018: International Urology and Nephrology
Alaa Mohamed Abd El Aal, Sameh Fayek GamalEl Din, Laila Ahmed Rashed, Abd El Rahman Bakry Tawfik, Mohammed Said ElSheemy
PURPOSE: To compare serum level of vitamin D [25(OH)D] in patients with life-long premature ejaculation (LPE) versus healthy controls. METHODS: Healthy married potent males were recruited from February 2017 to January 2018. Group A included 40 patients suffering from LPE who were compared versus 40 healthy controls (Group B). Participants suffering from hormonal disorders, obesity, neurological, psychological, or chronic diseases or taking medications that may affect ejaculatory function, serum level of vitamin D, or the accuracy of intra-vaginal ejaculation latency time (IELT) were excluded...
August 28, 2018: International Urology and Nephrology
Samuel J Ivan, Puneet Sindhwani
PURPOSE: This review assesses guideline discrepancies for urologic surgery antimicrobial prophylaxis and identifies opportunities for improvement of antimicrobial prophylaxis and stewardship. METHODS: Literature search using PubMed, Embase, Cochrane, and association websites identified guidelines for review from the American Urological Association, Canadian Urological Association, European Association of Urology, Japanese Urological Association, and Association of Health-System Pharmacists/Infectious Disease Society of America/Surgical Infection Society/Society for Healthcare Epidemiology of America...
August 25, 2018: International Urology and Nephrology
Jing Zhu, Yu-Ling Jia, Yong-Wei Luo, Dong-Yan Huang, Cong-Cong Shao, Lei Li, Li Zhou, Zu-Yue Sun
PURPOSE: Folic acid (FA) intake has increased to high levels in many countries for the prevention of neural tube defects. However, the impact of excess FA intake, particularly before and during pregnancy, requires further investigation. Our aim was to investigate the effect of maternal folic acid supplementation on prostatitis risk in the rat offspring. METHODS: Female SD rats were administrated with different doses of FA by oral gavage from 2 weeks prior to mating to GD14: 0 mg/kg (distilled water), 0...
August 24, 2018: International Urology and Nephrology
Michele Marchioni, Luigi Schips, Francesco Greco, Antonio Frattini, Fabio Neri, Lorenzo Ruggera, Giuseppe Fasolis, Francesco Varvello, Paolo Destefanis, Gaetano De Rienzo, Pasquale Ditonno, Giovanni Ferrari, Luca Cindolo
BACKGROUND: Major acute cardiovascular events (MACE) prevalence after 180-W GreenLight (180-W GL) laser photoselective vaporization (PVP) have never been explored. Aim of our study is to evaluate perioperative MACE that occurred concomitantly with 180-W GL PVP. MATERIALS AND METHODS: We relied on a multi-institutional database that included 14 centers. Data from 923 patients who underwent 180-W GL PVP were reviewed. We abstracted pre- and perioperative data of patients who experienced perioperative MACE, such as angina pectoris, acute myocardial infarction, other chronic ischemic heart disease, transient ischemic attack, or cerebrovascular accident as well as deep venous thrombosis with or without pulmonary embolism...
August 23, 2018: International Urology and Nephrology
Melani R Custodio, Rosilene M Elias, Wagner D Velasquez, Luciene M Dos Reis, Ivone B Oliveira, Rosa M A Moysés, Aluizio B Carvalho, Vanda Jorgetti
PURPOSE: Bone biopsy defines classical diseases that constitute the renal osteodystrophy. There is a recent concern regarding other histological findings that are not appreciated by using the turnover, mineralization, and volume (TMV) classification. Iron (Fe) overload has been considered a new challenge and the real significance of the presence of this metal in bones is not completely elucidated. Therefore, the main goal of the current study was to not only to identify bone Fe, but also correlate its presence with demographic, and biochemical characteristics...
August 22, 2018: International Urology and Nephrology
Il Young Kim, June Hyun Kim, Min Jeong Kim, Dong Won Lee, Cheol Gu Hwang, Miyeun Han, Harin Rhee, Sang Heon Song, Eun Young Seong, Soo Bong Lee
PURPOSE: Erythropoietin (EPO) deficiency and resistance to endogenous EPO is an important pathophysiological feature in anemia of chronic kidney disease (CKD). Low 1,25 dihydroxyvitamin D [1,25(OH)2 D] level is known to contribute to anemia of CKD. We aimed to investigate the associations between serum 1,25(OH)2 D and anemia, EPO deficiency, and endogenous EPO resistance in patients with CKD. METHODS: This study included 409 patients with CKD [glomerular filtration rate (GFR) < 60 ml/min/1...
August 22, 2018: International Urology and Nephrology
Sanaz Tavasoli, Maryam Taheri
Urolithiasis is a common, highly recurrent disease with increasing prevalence worldwide. The association between vitamin D and calcium stones has often been investigated on the basis of the role of vitamin D in calcium homeostasis. Currently, there is no consensus on the management of vitamin D deficiency in patients with renal calculi, because of controversies about the relationship between vitamin D and calcium stones. However, the vitamin D deficiency is shown to be highly prevalent among kidney stone formers, and some studies found a higher prevalence in stone formers compared with non-stone formers...
August 22, 2018: International Urology and Nephrology
Bernadette M M Zwaans, Laura E Lamb, Sarah Bartolone, Heinz E Nicolai, Michael B Chancellor, Stangel-Wójcikiewicz Klaudia
PURPOSE: Given that more cancers are being diagnosed earlier and that treatment of cancer is improving, health issues of cancer survivors are becoming more common and apparent. Pelvic radiation therapy for the treatment of gynecological cancers can lead to long-term collateral damage to the bladder, a condition termed radiation cystitis (RC). Late sequelae may take many years to develop and include incontinence and pain as well as hematuria. RC is a rare but potentially life-threatening condition for which there are few management and treatment options...
August 21, 2018: International Urology and Nephrology
Hayato Yamamoto, Takuya Koie, Teppei Ookubo, Koji Mitsuzuka, Shintaro Narita, Takamitsu Inoue, Sadafumi Kawamura, Tomoyuki Kato, Tatsuo Tochigi, Norihiko Tsuchiya, Tomonori Habuchi, Yoichi Arai, Chikara Ohyama
PURPOSE: Prostate cancer (PCa) may be a multifocal or bilateral disease. A single positive biopsy core is usually associated with indolent PCa, and doctors may choose to perform active surveillance or focal therapy. We investigated the correlation between finding a single positive biopsy core and the pathological outcome after radical prostatectomy (RP). METHODS: Data from the Michinoku Japan Urological Cancer Study Group database including pre- and post-operative information, on 1928 consecutive patients with PCa treated with RP alone at four institutions was used...
August 20, 2018: International Urology and Nephrology
Zhonglin Cai, Weijie Chen, Jianzhong Zhang, Hongjun Li
Androgen deprivation therapy is an important therapy for prostate cancer (PCa) in aging men. Under the background of castration, it is inevitable that prostate cancer will develop into castration-resistant prostate cancer (CRPC), which has a high mortality rate, after 2-3 years. Androgen receptor (AR) plays a key role in PCa development and is essential to CRPC. More recent research studies have reported that the development of CRPC is largely due to altered mechanisms related to AR, so it is important for us to understand the roles of AR and detailed AR-related mechanisms in CRPC...
August 20, 2018: International Urology and Nephrology
Nick Vordos, Stilianos Giannakopoulos, Etienne F Vansant, Christos Kalaitzis, John W Nolan, Dimitrios V Bandekas, Ioannis Karavasilis, Athanasios Ch Mitropoulos, Stavros Touloupidis
PURPOSE: To evaluate urinary stones using small-angle X-ray scattering (SAXS) and nitrogen porosimetry (NP). Traditionally, stones are categorized as hard or soft based on their chemical composition. We hypothesized that stone hardness is associated not only with its chemical composition but also with its internal architecture. SAXS and NP are well-known techniques in material sciences. We tested whether SAXS and NP are applicable for evaluating human urinary stones and whether they provide information at the nanoscale level that could be useful in clinical practice...
August 20, 2018: International Urology and Nephrology
Min Wu, Fang Chen, Hua Xie, Yiqing Lv, Yichen Huang, Yidong Liu, Weijing Ye
OBJECTIVE: Because of the complexity of the abnormalities and limited options for reconstruction of failed hypospadias, creating a neourethra presents a challenge to surgeons. We reviewed our experiences with staged urethroplasty strategies to repair the penis of failed hypospadias. MATERIALS AND METHODS: We retrospectively reviewed 56 consecutives patients following multiple unsuccessful hypospadias repairs from 2010 to 2016. Patients were divided into the following two groups based on their penile conditions and urethroplasty procedures: staged buccal mucosa graft Bracka urethroplasty (group1) and two-stage urethroplasty with additional buccal mucosa graft augmentation of the dorsal urethral plate (group2)...
August 18, 2018: International Urology and Nephrology
Menglin Bai, Benkui Zou, Zhendan Wang, Pang Li, Huansheng Wang, Yang Ou, Kai Cui, Jiasheng Bian, Sheng Li, Xiaobin Xu
BACKGROUND/AIMS: Detection of circulating tumor cells (CTCs) in cancer patients has diagnostic and prognostic importance. However, the clinical implications of CTC detection in patients with renal cell carcinoma (RCC) are still unclear. In this study, we investigated the clinical significance of CTCs using two detection systems, the CellSearch system (CSS) and isolation by size of epithelial tumor cells (ISET), among RCC patients. METHODS: We recruited 36 RCC patients and 22 healthy volunteers as controls...
August 18, 2018: International Urology and Nephrology
Y Chowaniec, F Luyckx, G Karam, P Glemain, J Dantal, J Rigaud, J Branchereau
PURPOSE: To determine the impact of transplant nephrectomy on morbidity and mortality and HLA immunization. METHODS: All patients who underwent transplant nephrectomy in our centre between 2000 and 2016 were included in this study. A total of 2822 renal transplantations and 180 transplant nephrectomies were performed during this period. RESULTS: The indications for transplant nephrectomy were graft intolerance syndrome: 47.2%, sepsis: 22.2%, vascular thrombosis: 15...
August 17, 2018: International Urology and Nephrology
Christian Thomas, Maximilian P Brandt, Stephanie Baldauf, Igor Tsaur, Sebastian Frees, Hendrik Borgmann, Wolfgang Jäger, Georg Bartsch, Meike Schneider, Robert Dotzauer, Andreas Neisius, Axel Haferkamp
PURPOSE: The purpose of the study was to define clinical factors for successful treatment response and re-exposure to docetaxel in metastatic castration-resistant prostate cancer (mCRPC). METHODS: An mCRPC database of patients receiving first-line docetaxel and rechallenge courses was established. Several clinical factors were evaluated for prediction of treatment response. Multivariate cox-regression analysis was used to define pre-treatment and treatment factors for survival...
August 17, 2018: International Urology and Nephrology
Jingyi Cao, Qichao Wang, Gang Wu, Shasha Li, Qian Wang
OBJECTIVES: Gemcitabine resistance is a major obstacle for effective treatment of bladder cancer. This study was aimed to investigate the potential role of miR-129-5p in the development of gemcitabine resistance in bladder cancer cells and its underlying mechanism. METHODS: The IC50 for gemcitabine in 20 bladder cancer cells was first profiled from Genomics of Drug Sensitivity in Cancer. miR-129-5p level and gene mRNA expression were detected using quantitative real-time PCR (qRT-PCR)...
August 16, 2018: International Urology and Nephrology
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