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International Urology and Nephrology

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https://www.readbyqxmd.com/read/28726035/evaluation-of-physical-activity-in-sarcopenic-conditions-of-kidney-transplantation-recipients
#1
Masaaki Yanishi, Hiroyasu Tsukaguchi, Yutaka Kimura, Yuya Koito, Kenji Yoshida, Maiko Seo, Eri Jino, Motohiko Sugi, Hidefumi Kinoshita, Tadashi Matsuda
INTRODUCTION: Sarcopenia is an involuntary decline in skeletal muscle mass, strength, and function that normally proceed with aging but may develop faster under some chronic disease conditions. In this study, we compared the physical activity between sarcopenia and non-sarcopenia subgroups in kidney transplant recipients. METHODS: Fifty-eight recipients (42 males and 16 females) were enrolled in this study. Mean age of the recipients was 46.6 ± 12.7 years. Mean duration of dialysis was 2...
July 19, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28711962/the-relation-between-hemoglobin-variability-and-carotid-intima-media-thickness-in-chronic-hemodialysis-patients
#2
Safa Ersen Ganidagli, Orcun Altunoren, Ertuğrul Erken, Ismet Onder Isık, Berivan Ganidagli, Necmi Eren, Yasemin Coskun Yavuz, Ozkan Gungor
PURPOSE: Hemoglobin variability is a common problem among hemodialysis patients. We have previously demonstrated an association between Hb variability and left ventricular mass index. In this study, we investigated a possible relation between Hb variability and carotid intima-media thickness (CIMT). METHODS: Twelve-month hemoglobin (Hb) values of 135 patients on maintenance hemodialysis were examined retrospectively. The range of 11-12 gr/dl was accepted as normal according to the KDOQI guidelines...
July 15, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28711961/heat-shock-protein-70-nitric-oxide-effect-on-stretched-tubular-epithelial-cells-linked-to-wt-1-cytoprotection-during-neonatal-obstructive-nephropathy
#3
Luciana Mazzei, Fernando Darío Cuello-Carrión, Neil Docherty, Walter Manucha
BACKGROUND: Mechanical stress is a key pathogenic driver of apoptosis in the tubular epithelium in obstructive nephropathy. Heat shock protein 70 (Hsp70) and Wilms' tumor (WT-1) have been proposed to represent linked downstream effectors of the cytoprotective properties of NO. In the present study, we sought to evaluate whether the cytoprotective effects of L-arginine in neonatal obstructive nephropathy may be associated with NO-dependent increases in WT-1 and Hsp70 expression. METHODS: Neonatal Wistar-Kyoto rats were submitted to complete unilateral ureteral obstruction (UUO) and treated thereafter with vehicle, L-NAME or L-arginine by daily gavage for 14 days to block or augment NO levels, respectively...
July 15, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28710616/are-we-underestimating-the-rates-of-incontinence-after-prostate-cancer-treatment-results-from-nhanes
#4
Michael Daugherty, Raju Chelluri, Gennady Bratslavsky, Timothy Byler
PURPOSE: Local therapy for prostate cancer (PCa) includes radical prostatectomy (RP) and radiotherapy (XRT), both of which share a complication of urinary incontinence. Post-treatment incontinence has been reported to occur 6-69%, yet no truly patient-centered report has been compiled. We evaluated patient-reported incontinence rates and bother scores after treatment for prostate cancer. METHODS: The NHANES database was queried for all men who reported a diagnosis and treatment of PCa from 2001 to 2010...
July 14, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28710615/aldosterone-antagonist-therapy-and-its-relationship-with-inflammation-fibrosis-thrombosis-mineral-bone-disorder-and-cardiovascular-complications-in-peritoneal-dialysis-pd-patients
#5
Rafał Donderski, Paweł Stróżecki, Beata Sulikowska, Magdalena Grajewska, Ilona Miśkowiec, Anna Stefańska, Joanna Siódmiak, Grażyna Odrowąż-Sypniewska, Jacek Manitius
BACKGROUND: High aldosterone level may contribute to pathogenesis of hypertension, vessels damage and cardiovascular system deterioration in chronic kidney disease patients. Besides its classical action via mineralocorticoid receptor, aldosterone is also involved in cell growth, inflammation, oxidative stress, endothelial dysfunction and exerts fibroproliferative effects. The aim of the study was to assess whether aldosterone antagonist treatment may influence serum level of inflammatory, fibrosis, thrombosis and mineral-bone metabolism markers in peritoneal dialysis (PD) patients and blood pressure, aortic stiffness, echocardiographic indices after 12 months of treatment...
July 14, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28710614/thymoma-associated-renal-pathology-is-renal-biopsy-always-necessary-a-clinical-problem-solving-exercise-and-teaching-example-for-physicians
#6
LETTER
Ugo Vertolli, Giacomo Malipiero, Marianna Alessi, Luciana Bonfante, Lorenzo A Calò
No abstract text is available yet for this article.
July 14, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28707190/novel-porcine-model-for-calcium-oxalate-stone-formation
#7
Brandon P Trojan, Sara J Trojan, Andrew Navetta, Bryce Staches, Bryan Sutton, Stephanie Filleur, Thomas Nelius
BACKGROUND: Mechanisms for calcium-based stone formation are not clearly delineated. Porcine are the most anatomically and physiologically congruent mammal to humans. Our objectives were to develop a cost-effective and easily reproducible porcine model for the study of calcium-based nephrolithiasis. METHODS: Crossbred male pigs (n = 16) were assigned randomly to one of the following treatments: (1) control; (2) ethylene glycol (EG) + vitamin D (VD); (3) EG + ammonium chloride (AC); (4) EG + gentamicin (G); (5) EG + Lasix; (6) EG + VD + AC; (7) EG + VD + G...
July 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28699016/position-related-renal-perfusion-disturbances-as-a-possible-underestimated-mechanism-in-patients-with-resistant-hypertension-a-case-vignette
#8
Jan Schiefer, Holger Amthauer, Philipp Genseke, Peter R Mertens, Christos Chatzikyrkou
PURPOSE: In patients with resistant hypertension and large blood pressure fluctuations, the role of orthostatic hypertension, associated with position-dependent renal perfusion disturbances, has not been investigated in detail yet. METHODS: In this regard, four patients from our outpatient clinic were investigated by the use of 24-h ambulatory blood pressure monitoring (ABPM), active standing test, renal duplex sonography and Tc99m-mercaptoacetyltriglycine [MAG3] renal scintigraphy in supine and upright position...
July 11, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28695313/elderly-patients-with-chronic-kidney-disease-have-higher-risk-of-hyperparathyroidism
#9
Rosilene M Elias, Rosa M A Moysés
PURPOSE: As the world's population ages, the incidence of chronic kidney disease (CKD) is growing. There is ongoing debate regarding whether high levels of parathyroid hormone (PTH) would be more common in elderly than young patients, and which factors are driven the risk of secondary hyperparathyroidism (SHPT), independent of renal function. METHODS: Elderly patients (age ≥ 65 years, N = 518) were compared to a 1:1 sex- and estimated glomerular filtration rate (eGFR)-matched sample of young patients (age < 65 years), in a cross-sectional analysis...
July 10, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28695312/use-of-biological-mesh-in-trans-anal-treatment-for-recurrent-recto-urethral-fistula
#10
G Moretto, A Casaril, M Inama
PURPOSE: To report the author's experience on a mini-invasive technique using bioprosthetic plug and a rectal wall flap advancement in the treatment of recurrent recto-urethral fistula. MATERIALS AND METHODS: Between 2013 and 2015, seven patients with recurrent recto-urethral fistula were referred to the Pederzoli Hospital, Peschiera del Garda, Verona, Italy. Intraoperatively all patients were found to have a rectal wall lesion and were treated with urinary and fecal diversion...
July 10, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28677091/does-topical-hemostatic-agent-floseal-%C3%A2-have-a-long-term-adverse-effect-on-erectile-function-recovery-after-nerve-sparing-robot-assisted-radical-prostatectomy
#11
Eugenio Martorana, Bernardo Rocco, Shaniko Kaleci, Giacomo Maria Pirola, Luigi Bevilacqua, Luca Reggiani Bonetti, Stefano Puliatti, Salvatore Micali, Giampaolo Bianchi
OBJECTIVES: To investigate the long-term effects of Floseal(®) on erectile function recovery (EFR) after nerve-sparing robot-assisted radical prostatectomy (RALP). METHODS: We prospectively collected results of the self-administered International Index Erectile Function Questionnaire 1-5 and 15 (IIEF 1-5 and 15) of 532 consecutive patients who underwent RALP for prostate cancer in our institution between October 2007 and December 2015. Patients were divided into two groups according to Floseal(®) application after prostatectomy...
July 4, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28677090/klotho-levels-association-with-insulin-resistance-and-albumin-to-creatinine-ratio-in-type-2-diabetic-patients
#12
Ana Paula Silva, Filipa Mendes, Luísa Pereira, André Fragoso, Rui Baptista Gonçalves, Nélio Santos, Fátima Rato, Pedro Leão Neves
PURPOSE: The present study aimed at evaluating the relationship between Klotho levels and insulin resistance and albumin-to-creatinine ratio (ACR) in type 2 diabetic patients with CKD. METHODS: We conducted an observational, cross-sectional study in our outpatient diabetic nephropathy clinic from 2014 to 2016, enrolling a total of 107 type 2 diabetic patients with stage 2-3 CKD, with a mean age of 59 years. Several clinical and laboratorial parameters were evaluated, including those related to mineral and carbohydrate metabolism...
July 4, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28674854/icodextrin-and-peritoneal-dialysis-advantages-and-new-applications
#13
REVIEW
Periklis Dousdampanis, Carlos Guido Musso, Konstantina Trigka
The impact of icodextrin (ico) on peritoneal dialysis (PD) extension and patient survival is well established. Predominantly, ico-based solutions were prescribed in high-transporter PD patients. Advantages of the ico-based solutions include increased biocompatibility, avoidance of glucotoxicity, enhanced ultrafiltration failure (UF), sodium removal rates, better metabolic and blood pressure control. Bimodal solutions and twice daily exchanges of ico-based solutions are two newly introduced strategies to avoid glucose exposure and/or enhance UF in PD patients with UF failure...
July 3, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28674853/fdg-pet-ct-for-response-evaluation-of-invasive-bladder-cancer-following-neoadjuvant-chemotherapy
#14
E E Fransen van de Putte, E Vegt, L S Mertens, A Bruining, K Hendricksen, M S van der Heijden, S Horenblas, B W G van Rhijn
PURPOSE: We investigated the accuracy of FDG-PET/CT response identification following neoadjuvant or induction chemotherapy (NAIC) for invasive bladder cancer (BC) as to better select patients for radical cystectomy (RC). METHODS: Between 2010 and 2014, 37 cT1-4N1-3 BC patients received a FDG-PET/CT before and after NAIC followed by RC. Metabolic lymph node (LN) response was evaluated according to EORTC recommendations. Additionally, primary tumor response was evaluated for 23 patients by means of delayed pelvic imaging after forced diuresis...
July 3, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28674852/effects-of-long-term-treatment-with-haloperidol-clozapine-and-aripiprazole-on-mice-isolated-vas-deferens
#15
Mehmet Hanifi Tanyeri, Mehmet Emin Buyukokuroglu, Pelin Tanyeri, Oguz Mutlu, Füruzan Yildiz Akar, Güner Ulak, Bekir Faruk Erden
PURPOSE: Sexual dysfunction is a common condition in patients taking antipsychotics and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. Pharmacology research into human ejeculatory disorders is limited to clinical studies with registered drugs affecting the ejaculation process; therefore, animal research has become the need. We aimed to investigate the effects of haloperidol, clozapine and aripiprazole on serotonin, noradrenaline, adenosine triphosphate (ATP) and potassium chloride (KCl)-induced contractions of the vas deferens in order to evaluate the effect of haloperidol, clozapine and aripiprazole on the contraction of the vas deferens...
July 3, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28669104/the-prognostic-significance-of-preoperatively-assessed-ast-alt-de-ritis-ratio-on-survival-in-patients-underwent-radical-cystectomy
#16
Sacit Nuri Gorgel, Osman Kose, Esra Meltem Koc, Erhan Ates, Yigit Akin, Yuksel Yilmaz
PURPOSES: We aimed to evaluate prognostic significance of preoperatively assessed aspartate aminotransaminase (AST)/alanine aminotransferase (ALT) (De Ritis) ratio on survival in bladder cancer (BC) patients underwent radical cystectomy (RC). METHODS: We, respectively, analysed clinical and pathological data of 153 patients who underwent RC for BC between February 2006 and December 2016 at a tertiary level hospital. The potential prognostic value of De Ritis ratio was assessed by using ROC curve analysis...
July 1, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28667579/the-impact-of-fish-oil-and-wheat-germ-oil-combination-on-mineral-bone-and-inflammatory-markers-in-maintenance-hemodialysis-patients-a-randomized-double-blind-placebo-controlled-clinical-trial
#17
Hadeer Zakaria, Tarek M Mostafa, Gamal A El-Azab, Ahmed M Abd El Wahab, Heba Elshahawy, Nagy Ah Sayed-Ahmed
PURPOSE: This study aimed to examine the impact of combined supplementation of fish oil (FO) with antioxidants like wheat germ oil (WGO) on mineral-bone and inflammatory markers in maintenance HD patients. METHODS: This randomized, double-blind, placebo-controlled trial involved 46 HD patients who were randomly assigned into two groups to receive daily 3000 mg of FO [1053 mg omega-3 fatty acids (ω-3 FAs)] plus 300 mg of WGO [0.765 mg vitamin E] or placebo for 4 months...
June 30, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28656510/alprostadil-protects-type-2-diabetes-mellitus-patients-treated-with-metformin-from-contrast-induced-nephropathy
#18
Jing Wang, Xiaobo Ai, Li Li, Yanyan Gao, Nina Sun, Changgui Li, Weihong Sun
PURPOSE: Type 2 diabetes mellitus (T2DM) patients treated with metformin are predisposed to develop contrast-induced nephropathy (CIN) after received emergency contrast-enhanced computed tomography (CT) examination. We evaluated the protective effects of alprostadil on CIN in T2DM patients treated with metformin after contrast media (CM) administration. METHODS: In this single-institution, single-blind, superiority trial, we randomly assigned 451 T2DM patients taking metformin and underwent emergency contrast-enhanced CT examination to either the alprostadil group (227 patients) receiving alprostadil or the control group (224 patients) without alprostadil...
June 27, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28646483/from-novice-to-expert-analyzing-the-learning-curve-for-mri-transrectal-ultrasonography-fusion-guided-transrectal-prostate-biopsy
#19
R Mager, M P Brandt, H Borgmann, K M Gust, A Haferkamp, M Kurosch
PURPOSE: To investigate the learning curve of a novice in MRI/TRUS software fusion biopsy and to compare his results with the expert standard at our institution. METHODS: Overall 126 MRI/TRUS fusion-guided transrectal biopsies were performed using an electromagnetic tracking ultrasonography platform. The learning progress of the novice was evaluated comparing his initial 42 procedures (group A) with his following 42 (group B). The institution's expert standard (group C), which was compared to the novice's groups, was defined by the expert's experience of 42 MRI/TRUS fusion biopsies...
June 23, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28646482/clinical-serological-and-histological-determinants-of-patient-and-renal-outcome-in-anca-associated-vasculitis-with-renal-involvement-an-analysis-from-a-referral-centre
#20
Matija Crnogorac, Ivica Horvatic, Luka Toric, Danica Galesic Ljubanovic, Miroslav Tisljar, Krešimir Galesic
PURPOSE: To evaluate significance of clinical and histopathological prognostic factors for renal and patient outcome in AAV patient cohort. METHODS: Retrospective study included consecutive patients diagnosed with pauci-immune crescentic glomerulonephritis from January 2003 to December 2013. Primary outcome was combined endpoint patient death or progression to end-stage renal disease (ESRD). Secondary outcomes were patient survival and progression to ESRD (renal survival) singularly and disease relapse...
June 23, 2017: International Urology and Nephrology
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