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International Urology and Nephrology

Lixin Wang, Ying Cao, Ye Tian, Guangheng Luo, Xiushu Yang, Zhaolin Sun
OBJECTIVES: The present study aimed to investigate the influence of urine on re-epithelialization in canine prostatic urethra after prostatectomy and explore possible causes. METHOD: We established two groups of prostatic canine models. The first group contained urine that canines underwent the surgery by two-micron laser resection of the prostate-tangerine technique (TmLRP-TT), and no transurethral catheter was required. The second group was without urine that canines accepted the surgery by TmLRP-TT add ureter skin ostomy urine bypass...
November 7, 2018: International Urology and Nephrology
Jih-Chao Yeh, Rebecca Do, Hanul Choi, Ching-Ting Lin, Jia-Jin Chen, Xiaolin Zi, Huiyi H Chang, Gamal Ghoniem
PURPOSE: This study investigated the effect of gabapentin on lower urinary tract dysfunction focusing on urethral activities and cystitis-induced hyperalgesia in a mouse model of painful bladder syndrome/interstitial cystitis (PBS/IC). The electromyography (EMG) of external urethral sphincter (EUS) was difficult to obtain, but contained useful information to examine the drug effect in mice. METHODS: Female C57BL/6J mice were intraperitoneally (ip) administration with either saline or 200 mg/kg of cyclophosphamide (CYP) 48 h before experimental evaluation...
November 1, 2018: International Urology and Nephrology
Jonathan Bloom, Neel Patel, Jonathan Wagmaister, Muhammad Choudhury, Majid Eshghi, Sensuke Konno
PURPOSE: As oxidative stress (OXS) has been shown to play a primary role in renal ischemia/reperfusion injury (RIRI), we investigated whether antioxidant such as ethyl pyruvate (EPy) might effectively prevent RIRI. Possible prophylactic effects of EPy and mannitol (Mann), one of perioperative agents often used, were tested against harmful OXS in vitro. METHODS: Hydrogen peroxide (H2 O2 ) was used to exert OXS on the renal proximal tubular MDCK cells. Severity of OXS and protective effects of EPy and Mann were assessed by lipid peroxidation assay and cell viability test, respectively...
October 31, 2018: International Urology and Nephrology
Ning Li, Honglin Ding, Zizheng Li, Yili Liu, Ping Wang
PURPOSE: Obesity usually induces overactive bladder (OAB) associated with detrusor overactivity, which is related to increased contractility of the detrusor smooth muscle (DSM). Small-conductance Ca2+ -activated K+ (SK) channels play a constitutive role in the regulation of DSM contractility. However, the role of SK channels in the DSM changes in obesity-related OAB is still unknown. Here, we tested the hypothesis that obesity-related OAB is associated with reduced expression and activity of SK channels in DSM and that SK channels activation is a potential treatment for OAB...
October 25, 2018: International Urology and Nephrology
Huimin Chen, Ying Cui, Changying Xing, Yogendranath Purrunsing, Xiaoming Zha, Chong Shen, Ming Zeng, Guang Yang, Xiangbao Yu, Lina Zhang, Yao Jiang, Zhixiang Shen, Haoyang Ma, Caixia Yin, Yunfei Li, Ningning Wang
PURPOSE: Decreased heart rate variability (HRV) is closely related to abnormal cardiac autonomic nervous function, especially sympathetic hyperactivity, which intensifies the risk of cardiovascular events and sudden death. HRV parameters are lower in chronic kidney disease (CKD) and parathyroidectomy (PTX) can improve these abnormalities in severe secondary hyperparathyroidism (SHPT) patients. However, few studies have evaluated correlations between circulating bone markers and HRV in CKD patients...
October 25, 2018: International Urology and Nephrology
Masaaki Yanishi, Hidefumi Kinoshita, Hiroyasu Tsukaguchi, Yutaka Kimura, Yuya Koito, Motohiko Sugi, Tadashi Matsuda
INTRODUCTION: Measuring muscle mass is an important step in detecting sarcopenia. The evaluation of sarcopenia is also important for kidney transplant recipients. Methods for estimating muscle mass have been established using computed tomography or magnetic resonance imaging, which are considered the gold standards. But these methods are invasive and costly, and there is a need for a more practical and simple method using blood samples from kidney transplant recipients. METHODS: The study population was 62 patients who underwent kidney transplantation at Kansai Medical University Hospital, and were evaluated from August to October 2017...
October 25, 2018: International Urology and Nephrology
Zhenzhu Yong, Fen Li, Xiaohua Pei, Xun Liu, Dan Song, Xiaoxuan Zhang, Weihong Zhao
BACKGROUND: The recent guidelines recommend using the estimated glomerular filtration rate (eGFR) to evaluate renal function. There are two reported full-age-spectrum (FAS) equations in 2017, which are based on serum cystatin C concentrations with or without accompanying serum creatinine level (FASCr-Cys or FASCys ). We compared the performance and assessed the applicability of the new FAS equation with the 2012 CKD-EPI (CKD-EPICys and CKD-EPICr-Cys ) equation in Chinese subjects. METHODS: A total of 1184 patients, mean aged 55...
October 24, 2018: International Urology and Nephrology
Dmitry Enikeev, Petr Glybochko, Leonid Rapoport, Olesya Snurnitsyna, Natalia Potoldykova, Tamara Novoselova, Ekaterina Laukhtina, Mark Taratkin, Vitaly Margulis
INTRODUCTION: Benign prostatic hyperplasia (BPH) can be associated with marked intravesical protrusion, placing ureteral orifices at risk for injury during bladder outlet procedures. AIM: To determine whether ureteral stenting is necessary in cases of ureteral orifice injury during laser enucleation. MATERIALS AND METHODS: Retrospective study included 465 patients with bladder outlet obstruction (IPSS > 20, Qmax < 10) secondary to BPH who were managed with thulium fiber laser (ThuFLEP) or holmium laser enucleation of the prostate (HoLEP)...
October 22, 2018: International Urology and Nephrology
S Mohammad Jafri, Laura N Nguyen, Larry T Sirls
INTRODUCTION: Robotic-assisted laparoscopic prostatectomy (RALP) has largely replaced open radical prostatectomy in many centers. Radical perineal prostatectomy (RPP) is another less invasive approach that has not been widely adopted. RPP offers excellent exposure of the urinary sphincter and bladder neck that may provide good urinary function outcomes. We evaluate urinary function after RALP and RPP. METHODS: Retrospective review of a prospective radical prostatectomy database was performed...
October 16, 2018: International Urology and Nephrology
Te-Jung Lu, Chee-Hong Chan, Pin Ling, Yung-Mei Chao, Bo-Ying Bao, Chun-Yen Chiang, Te-Hsiu Lee, Yui-Ping Weng, Wei-Chih Kan, Te-Ling Lu
Defective renal salt and water excretion, together with increased salt intake, frequently contributes to hypertension. Recent studies indicate that Ste20 family kinases, such as proline-alanine-rich Ste20-related kinase (SPAK) and oxidative stress-response protein 1 (OSR1), are regulators of cell volume, ion transport, and hypertension. The aim of this study was to investigate whether mammalian sterile 20-like protein kinase 3 (MST3), which is also a stress-regulated kinase, is involved in the development of hypertension...
October 16, 2018: International Urology and Nephrology
Xiaogang Guo, Tao Han, Pingping Hu, Xiaojun Guo, Changming Zhu, Youbao Wang, Shaoyan Chang
BACKGROUND: Prostate cancer (PCa) is a common malignant human tumor and one of the main causes of cancer-related deaths in men. At present, prostate-specific antigen levels are widely used to diagnose PCa in the clinic, but they are not sufficient for an accurate early diagnosis or prognosis. METHODS: To identify potential molecular markers for PCa, we used real-time PCR to measure the expression levels of various microRNAs, including miR-1825, miR-484, miR-205, miR-141, and let-7b, in the serum of 72 PCa patients and 34 healthy controls...
October 15, 2018: International Urology and Nephrology
Namiko A Goto, Marije E Hamaker, Hanna C Willems, Marianne C Verhaar, Mariëlle H Emmelot-Vonk
PURPOSE: The aim of the current study was to evaluate the association between a decreased estimated glomerular filtration rate (eGFR) and accidental falling in elderly patients who visited the day clinic of the department of geriatric medicine of the University of Medical Center Utrecht (UMCU). STUDY DESIGN: A cross-sectional analysis with people aged ≥ 65 years of the Utrecht Cardiovascular Cohort was performed. Patients were stratified into different stages of kidney disease (< 45, 45-59, and ≥ 60 ml/min per 1...
October 15, 2018: International Urology and Nephrology
Ron J Jankowski, Le Mai Tu, Christopher Carlson, Magali Robert, Kevin Carlson, David Quinlan, Andreas Eisenhardt, Min Chen, Scott Snyder, Ryan Pruchnic, Michael Chancellor, Roger Dmochowski, Melissa R Kaufman, Lesley Carr
PURPOSE: The purpose of the study was to assess safety and efficacy of autologous muscle derived cells for urinary sphincter repair (AMDC-USR) in female subjects with predominant stress urinary incontinence. METHODS: A randomized, double-blind, multicenter trial examined intra-sphincteric injection of 150 × 106 AMDC-USR versus placebo in female subjects with stress or stress predominant, mixed urinary incontinence. AMDC-USR products were generated from vastus lateralis needle biopsies...
October 15, 2018: International Urology and Nephrology
Lucas De Lavallaz, Carlos G Musso
INTRODUCTION: Chronobiology studies the phenomenon of rhythmicity in living organisms. The circadian rhythms are genetically determined and regulated by external synchronizers (the daylight cycle). Several biological processes involved in the pharmacokinetics and pharmacodynamics of drugs are subjected to circadian variations. Chronopharmacology studies how biological rhythms influence pharmacokinetics, pharmacodynamics, and toxicity, and determines whether time-of-day administration modifies the pharmacological characteristics of the drug...
October 15, 2018: International Urology and Nephrology
Punnaka Pongpanich, Pasvich Pitakpaiboonkul, Kullaya Takkavatakarn, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong
BACKGROUND: The prevalence of hypertension and its associated complications are markedly growing. Most patients need more than one drug to achieve blood pressure (BP) target. However, most guidelines only focus on the first-line treatment. We conducted a meta-analysis to explore the benefits of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin II receptor blockers (ARBs) combined with calcium channel blockers (CCBs) on metabolic, renal, and cardiovascular outcomes in hypertensive patients...
October 15, 2018: International Urology and Nephrology
C Kaiser, F P Tillmann, J Löchter, S Landgraeber, M Jäger
PURPOSE: Elective hip or knee replacement is an optimal, standardised orthopaedic surgical procedure. The influence of chronic kidney disease, defined as an estimated glomerular filtration rate (eGFR) of 15-45 ml/min/1.73 m2 body surface area (BSA) (KDIGO stage G3a-G4), on the duration of hospitalisation, perioperative decrease in haemoglobin (Hb) levels, and transfusion rates after orthopaedic procedures has not been fully clarified. Our study, therefore, aimed to evaluate the impact of chronic kidney disease on the previously mentioned variables...
October 15, 2018: International Urology and Nephrology
Chi-Chu Liu, Li-Ping Chou, Tsang-Shan Chen, Chien-An Chen, Yueh-Feng Tsai
BACKGROUND: Hemodialysis patients have a high incidence of anti-platelet factor 4/heparin antibody (PF4-H Ab) and are at a high risk of cardiovascular disease. This study determines the association between PF4-H Ab and cardiovascular events including coronary artery disease (CAD), ischemic stroke (IS), and native arteriovenous fistula thrombosis (AVFT), in a longitudinal 7-year follow-up. PATIENTS AND METHODS: 84 hemodialysis patients were enrolled. Data collection included chart reviews and assessments of laboratory records...
October 15, 2018: International Urology and Nephrology
Burak Arslan, Okan Gürkan, Bugra Çetin, Öykü Aksoy Arslan, Taha Göv, Gökhan Yazıcı, Tolga Eroglu, Mustafa Asım Avcı, Enver Ozdemir
PURPOSE: The aim of our study was to investigate the impact of the ABO blood groups and blood-based biomarkers on the growth kinetics of renal angiomyolipoma (AML). METHODS: A total of 124 patients with AML who were followed-up between 2010 and 2018 were retrospectively reviewed. The patients' characteristics were recorded, including age, body mass index (BMI), blood pressure, smoking history, and ABO blood group. Baseline laboratory test results, including serum creatinine, AST, ALT, platelet, neutrophil and lymphocyte count, were used to calculate the estimated glomerular filtration rate (eGFR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and De Ritis ratio...
October 15, 2018: International Urology and Nephrology
Yusuke Yagihashi, Shuichi Shimabukuro, Tomotune Toyosato, Yoshitaka Arakaki
PURPOSE: Acute pyelonephritis (AP), a complication of urolithiasis, can be fatal if it progresses to septic shock. We aimed to evaluate the performance of excretory phase computed tomography (CT) in predicting bacteremia among AP patients with upper urinary tract calculi. METHODS: We reviewed medical records of 250 patients diagnosed with AP and upper urinary tract calculi and who were admitted to our institute. We analyzed 132 patients who underwent excretory phase CT...
October 13, 2018: International Urology and Nephrology
Ahmed Zaki Mohamed Anwar, Tarek Khalaf Fathelbab, Amr Mohamed Abdelhamid, Ehab Mohmed Galal, Mostafa Magdi Ali, Ehab Rifat Tawfiek
PURPOSE: We evaluated the role of initial laparoscopy and optimized approach in cases of unilateral nonpalpable testis. METHODS: Seventy-four patients with nonpalpable testes were presented. We excluded 9 patients, with palpable testes under anesthesia. Laparoscopy was offered to 65 patients. Contralateral testis hypertrophy with length ≥ 1.8 cm was confirmed in 47 patients. Ultrasound results were available for 35 patients. RESULTS: Age ranged from 1 to 10 years...
October 11, 2018: International Urology and Nephrology
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