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IRGB10 Exposes Bacteria's Intimate Secrets.

Florian Hoss, Christina F Budden, Eicke Latz
Developmental Cell 2016 October 11
When bacteria infect a cell, the bacterial membrane partially shields microbial structures from the immune system, preventing detection and clearance. In a recent issue of Cell, Man et al. (2016) show that the interferon-inducible protein IRGB10 liberates bacterial ligands for sensing by both the AIM2 and the non-canonical NLRP3 inflammasomes.

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