journal
MENU ▼
Read by QxMD icon Read
search

Developmental Cell

journal
https://www.readbyqxmd.com/read/28325473/foxh1-occupies-cis-regulatory-modules-prior-to-dynamic-transcription-factor-interactions-controlling-the-mesendoderm-gene-program
#1
Rebekah M Charney, Elmira Forouzmand, Jin Sun Cho, Jessica Cheung, Kitt D Paraiso, Yuuri Yasuoka, Shuji Takahashi, Masanori Taira, Ira L Blitz, Xiaohui Xie, Ken W Y Cho
The interplay between transcription factors and chromatin dictates gene regulatory network activity. Germ layer specification is tightly coupled with zygotic gene activation and, in most metazoans, is dependent upon maternal factors. We explore the dynamic genome-wide interactions of Foxh1, a maternal transcription factor that mediates Nodal/TGF-β signaling, with cis-regulatory modules (CRMs) during mesendodermal specification. Foxh1 marks CRMs during cleavage stages and recruits the co-repressor Tle/Groucho in the early blastula...
March 17, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28216382/the-physical-basis-of-coordinated-tissue-spreading-in-zebrafish-gastrulation
#2
Hitoshi Morita, Silvia Grigolon, Martin Bock, S F Gabriel Krens, Guillaume Salbreux, Carl-Philipp Heisenberg
Embryo morphogenesis relies on highly coordinated movements of different tissues. However, remarkably little is known about how tissues coordinate their movements to shape the embryo. In zebrafish embryogenesis, coordinated tissue movements first become apparent during "doming," when the blastoderm begins to spread over the yolk sac, a process involving coordinated epithelial surface cell layer expansion and mesenchymal deep cell intercalations. Here, we find that active surface cell expansion represents the key process coordinating tissue movements during doming...
February 12, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28292428/cell-cell-contact-area-affects-notch-signaling-and-notch-dependent-patterning
#3
Oren Shaya, Udi Binshtok, Micha Hersch, Dmitri Rivkin, Sheila Weinreb, Liat Amir-Zilberstein, Bassma Khamaisi, Olya Oppenheim, Ravi A Desai, Richard J Goodyear, Guy P Richardson, Christopher S Chen, David Sprinzak
During development, cells undergo dramatic changes in their morphology. By affecting contact geometry, these morphological changes could influence cellular communication. However, it has remained unclear whether and how signaling depends on contact geometry. This question is particularly relevant for Notch signaling, which coordinates neighboring cell fates through direct cell-cell signaling. Using micropatterning with a receptor trans-endocytosis assay, we show that signaling between pairs of cells correlates with their contact area...
March 13, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28292427/planarian-epidermal-stem-cells-respond-to-positional-cues-to-promote-cell-type-diversity
#4
Omri Wurtzel, Isaac M Oderberg, Peter W Reddien
Successful regeneration requires that progenitors of different lineages form the appropriate missing cell types. However, simply generating lineages is not enough. Cells produced by a particular lineage often have distinct functions depending on their position within the organism. How this occurs in regeneration is largely unexplored. In planarian regeneration, new cells arise from a proliferative cell population (neoblasts). We used the planarian epidermal lineage to study how the location of adult progenitor cells results in their acquisition of distinct functional identities...
March 13, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28292426/kibra-and-merlin-activate-the-hippo-pathway-spatially-distinct-from-and-independent-of-expanded
#5
Ting Su, Michael Z Ludwig, Jiajie Xu, Richard G Fehon
The Hippo pathway is emerging as a key evolutionarily conserved signaling mechanism that controls organ size. Three membrane-associated proteins, Kibra, Merlin, and Expanded, regulate pathway activity, but the precise molecular mechanism by which they function is still poorly understood. Here we provide evidence that Merlin and Kibra activate Hippo signaling in parallel to Expanded at a spatially distinct cellular domain, the medial apical cortex. Merlin and Kibra together recruit the adapter protein Salvador, which in turn recruits the core kinase Hippo...
March 13, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28292425/fat2-and-lar-define-a-basally-localized-planar-signaling-system-controlling-collective-cell-migration
#6
Kari Barlan, Maureen Cetera, Sally Horne-Badovinac
Collective migration of epithelial cells underlies diverse tissue-remodeling events, but the mechanisms that coordinate individual cell migratory behaviors for collective movement are largely unknown. Studying the Drosophila follicular epithelium, we show that the cadherin Fat2 and the receptor tyrosine phosphatase Lar function in a planar signaling system that coordinates leading and trailing edge dynamics between neighboring cells. Fat2 signals from each cell's trailing edge to induce leading edge protrusions in the cell behind, in part by stabilizing Lar's localization in these cells...
March 13, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28292424/btbd18-regulates-a-subset-of-pirna-generating-loci-through-transcription-elongation-in-mice
#7
Liquan Zhou, Bertram Canagarajah, Yangu Zhao, Boris Baibakov, Keizo Tokuhiro, Dragan Maric, Jurrien Dean
PIWI-interacting RNAs (piRNAs) are small non-coding RNAs essential for animal germ cell development. Despite intense investigation of post-transcriptional processing, chromatin regulators for piRNA biogenesis in mammals remain largely unexplored. Here we document that BTBD18 is a pachytene nuclear protein in mouse testes that occupies a subset of pachytene piRNA-producing loci. Ablation of Btbd18 in mice disrupts piRNA biogenesis, prevents spermiogenesis, and results in male sterility. Transcriptome profiling, chromatin accessibility, and RNA polymerase II occupancy demonstrate that BTBD18 facilitates expression of pachytene piRNA precursors by promoting transcription elongation...
March 13, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28292423/a-wnt5-activity-asymmetry-and-intercellular-signaling-via-pcp-proteins-polarize-node-cells-for-left-right-symmetry-breaking
#8
Katsura Minegishi, Masakazu Hashimoto, Rieko Ajima, Katsuyoshi Takaoka, Kyosuke Shinohara, Yayoi Ikawa, Hiromi Nishimura, Andrew P McMahon, Karl Willert, Yasushi Okada, Hiroshi Sasaki, Dongbo Shi, Toshihiko Fujimori, Toshihisa Ohtsuka, Yasunobu Igarashi, Terry P Yamaguchi, Akihiko Shimono, Hidetaka Shiratori, Hiroshi Hamada
Polarization of node cells along the anterior-posterior axis of mouse embryos is responsible for left-right symmetry breaking. How node cells become polarized has remained unknown, however. Wnt5a and Wnt5b are expressed posteriorly relative to the node, whereas genes for Sfrp inhibitors of Wnt signaling are expressed anteriorly. Here we show that polarization of node cells is impaired in Wnt5a(-/-)Wnt5b(-/-) and Sfrp mutant embryos, and also in the presence of a uniform distribution of Wnt5a or Sfrp1, suggesting that Wnt5 and Sfrp proteins act as instructive signals in this process...
March 13, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28292422/buffering-global-variability-of-morphogen-gradients
#9
REVIEW
Ben-Zion Shilo, Naama Barkai
Morphogen gradients determine tissue pattern by triggering differential cell responses to distinct morphogen concentrations. The strict quantitative dependence of the emerging patterns on morphogen distribution raises the challenge of buffering variability in morphogen profile to ensure a reproducible outcome. We describe the underlying principles of two modules for buffering morphogen distribution: buffering morphogen amplitude by storing excess morphogen in a limited spatial region, and buffering morphogen spread by pinning morphogen levels at a distal position through global feedback that adjusts morphogen diffusion or degradation across the tissue...
March 13, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28292421/rna-methylation-clears-the-way
#10
Cassandra Kontur, Antonio Giraldez
During the maternal-to-zygotic transition, maternal mRNAs are cleared by multiple distinct but interrelated pathways. A recent study in Nature by Zhao et al. (2017) finds that YTHDF2, a reader of N(6)- methylation, facilitates maternal mRNA decay, introducing an additional facet of control over transcript fate and developmental reprogramming.
March 13, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28292420/fat2-and-lar-dance-a-pas-de-deux-during-collective-cell-migration
#11
Qiyan Mao, Jules Lavalou, Thomas Lecuit
What coordinates the internal leading and trailing edges in collectively migrating cells is largely unknown. In this issue of Developmental Cell, Barlan et al. (2017) delineate a Fat2/Lar planar signaling pathway at the basal, motile cell-cell contacts of Drosophila egg chamber follicle cells.
March 13, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28292419/wnt-pcp-instructions-for-cilia-in-left-right-asymmetry
#12
Jun Wu, Marek Mlodzik
Wnt-Frizzled/planar cell polarity (PCP) signaling establishes cell orientation within the epithelial plane, but whether Wnts are instructive or permissive is debated. Reporting in Developmental Cell, Minegishi et al. (2017) uncover an instructive link from Wnt5a/b gradients to PCP-factor-regulated polarized cilia positioning that is essential to mouse embryo left-right asymmetry establishment.
March 13, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28245926/tmem2-regulates-embryonic-vegf-signaling-by-controlling-hyaluronic-acid-turnover
#13
Jessica E De Angelis, Anne K Lagendijk, Huijun Chen, Alisha Tromp, Neil I Bower, Kathryn A Tunny, Andrew J Brooks, Jeroen Bakkers, Mathias Francois, Alpha S Yap, Cas Simons, Carol Wicking, Benjamin M Hogan, Kelly A Smith
No abstract text is available yet for this article.
February 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28245925/a-mechanism-for-controlled-breakage-of-under-replicated-chromosomes-during-mitosis
#14
Heike Duda, Meret Arter, Jiradet Gloggnitzer, Federico Teloni, Philipp Wild, Miguel G Blanco, Matthias Altmeyer, Joao Matos
No abstract text is available yet for this article.
February 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28245924/resolving-heart-regeneration-by-replacement-histone-profiling
#15
Joseph Aaron Goldman, Guray Kuzu, Nutishia Lee, Jaclyn Karasik, Matthew Gemberling, Matthew J Foglia, Ravi Karra, Amy L Dickson, Fei Sun, Michael Y Tolstorukov, Kenneth D Poss
Chromatin regulation is a principal mechanism governing animal development, yet it is unclear to what extent structural changes in chromatin underlie tissue regeneration. Non-mammalian vertebrates such as zebrafish activate cardiomyocyte (CM) division after tissue damage to regenerate lost heart muscle. Here, we generated transgenic zebrafish expressing a biotinylatable H3.3 histone variant in CMs and derived cell-type-specific profiles of histone replacement. We identified an emerging program of putative enhancers that revise H3...
February 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28245923/eye-absence-does-not-regulate-planarian-stem-cells-during-eye-regeneration
#16
Samuel A LoCascio, Sylvain W Lapan, Peter W Reddien
Dividing cells called neoblasts contain pluripotent stem cells and drive planarian flatworm regeneration from diverse injuries. A long-standing question is whether neoblasts directly sense and respond to the identity of missing tissues during regeneration. We used the eye to investigate this question. Surprisingly, eye removal was neither sufficient nor necessary for neoblasts to increase eye progenitor production. Neoblasts normally increase eye progenitor production following decapitation, facilitating regeneration...
February 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28245922/an-hdac1-rpd3-poised-circuit-balances-continual-self-renewal-and-rapid-restriction-of-developmental-potential-during-asymmetric-stem-cell-division
#17
Derek H Janssens, Danielle C Hamm, Lucas Anhezini, Qi Xiao, Karsten H Siller, Sarah E Siegrist, Melissa M Harrison, Cheng-Yu Lee
How the developmental potential of differentiating stem cell progeny becomes rapidly and stably restricted following asymmetric stem cell division is unclear. In the fly larval brain, earmuff (erm) uniquely functions to restrict the developmental potential of intermediate neural progenitors (INPs) generated by asymmetrically dividing neural stem cells (neuroblasts). Here we demonstrate that the histone deacetylase Hdac1/Rpd3 functions together with self-renewal transcriptional repressors to maintain the erm immature INP enhancer in an inactive but poised state in neuroblasts...
February 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28245921/a-gradient-of-glycolytic-activity-coordinates-fgf-and-wnt-signaling-during-elongation-of-the-body-axis-in-amniote-embryos
#18
Masayuki Oginuma, Philippe Moncuquet, Fengzhu Xiong, Edward Karoly, Jérome Chal, Karine Guevorkian, Olivier Pourquié
Mammalian embryos transiently exhibit aerobic glycolysis (Warburg effect), a metabolic adaptation also observed in cancer cells. The role of this particular type of metabolism during vertebrate organogenesis is currently unknown. Here, we provide evidence for spatiotemporal regulation of glycolysis in the posterior region of mouse and chicken embryos. We show that a posterior glycolytic gradient is established in response to graded transcription of glycolytic enzymes downstream of fibroblast growth factor (FGF) signaling...
February 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28245920/spatiotemporal-analysis-of-a-glycolytic-activity-gradient-linked-to-mouse-embryo-mesoderm-development
#19
Vinay Bulusu, Nicole Prior, Marteinn T Snaebjornsson, Andreas Kuehne, Katharina F Sonnen, Jana Kress, Frank Stein, Carsten Schultz, Uwe Sauer, Alexander Aulehla
How metabolism is rewired during embryonic development is still largely unknown, as it remains a major technical challenge to resolve metabolic activities or metabolite levels with spatiotemporal resolution. Here, we investigated metabolic changes during development of organogenesis-stage mouse embryos, focusing on the presomitic mesoderm (PSM). We measured glycolytic labeling kinetics from (13)C-glucose tracing experiments and detected elevated glycolysis in the posterior, more undifferentiated PSM. We found evidence that the spatial metabolic differences are functionally relevant during PSM development...
February 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28245919/un-masc-ing-stem-cell-dynamics-in-mammary-branching-morphogenesis
#20
Erin Greenwood, Emma D Wrenn, Kevin J Cheung
The properties of stem cells that participate in mammary gland branching morphogenesis remain contested. Reporting in Nature, Scheele et al. (2017) establish a model for post-pubertal mammary branching morphogenesis in which position-dependent, lineage-restricted stem cells undergo cell mixing in order to contribute to long-term growth.
February 27, 2017: Developmental Cell
journal
journal
39717
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"