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Long-term safety of etanercept in psoriasis: Retrospective study focused on infections.
Journal of International Medical Research 2016 September
OBJECTIVE: Retrospective study to evaluate the incidence of infectious adverse events in patients with psoriasis treated with etanercept.
METHODS: Patients with psoriasis or psoriatic arthritis who were treated with etanercept (50 mg, administered weekly via subcutaneous injection) for ≥48 weeks were retrospectively enrolled. Patients were screened for occult infections before treatment commenced, and then every 12 months thereafter. Minor (not requiring hospitalization and/or discontinuation of treatment) and major (requiring hospitalization and/or discontinuation of treatment) infectious events were recorded.
RESULTS: The study included 50 patients. Minor infectious events included self-limiting upper respiratory tract infections (six patients), lower urinary tract infections (one patient) and recurrent herpes simplex labialis (two patients). Major infections occurred in only two cases.
CONCLUSION: These data support the good safety profile of etanercept in patients with psoriasis or psoriatic arthritis.
METHODS: Patients with psoriasis or psoriatic arthritis who were treated with etanercept (50 mg, administered weekly via subcutaneous injection) for ≥48 weeks were retrospectively enrolled. Patients were screened for occult infections before treatment commenced, and then every 12 months thereafter. Minor (not requiring hospitalization and/or discontinuation of treatment) and major (requiring hospitalization and/or discontinuation of treatment) infectious events were recorded.
RESULTS: The study included 50 patients. Minor infectious events included self-limiting upper respiratory tract infections (six patients), lower urinary tract infections (one patient) and recurrent herpes simplex labialis (two patients). Major infections occurred in only two cases.
CONCLUSION: These data support the good safety profile of etanercept in patients with psoriasis or psoriatic arthritis.
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