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Journal of International Medical Research

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https://www.readbyqxmd.com/read/30232917/giant-left-atrium-with-left-lung-damage-a-case-report
#1
Mingfeng Yang, Lan Zhang
Giant left atrium is most commonly associated with rheumatic mitral valve disease, causing a series of cardiac and extracardiac complications. Cardiac complications are often reported, such as atrial fibrillation, decreased cardiac output, and atrial thrombus formation. Extracardiac complications are rarely described in the literature. We report an unusual case of a 55-year-old woman who was diagnosed with rheumatic heart disease 20 years earlier. Her chief complaints were episodes of chest tightness and difficulty breathing, which she had for more than 30 years...
September 20, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30226089/targeting-the-cd47-sirp%C3%AE-signaling-axis-current-studies-on-b-cell-lymphoma-immunotherapy
#2
Jin Zhang, Shenhe Jin, Xiaojun Guo, Wenbin Qian
The function of the immune system in cancer initiation and progression has been widely examined. Notably, immunotherapy has become a promising approach for cancer treatment. CD47, a member of the immunoglobulin superfamily, plays an important role in the immune regulation of cancer by binding to SIRPα. Multiple studies have detected high CD47 expression on the surface of tumor cells, which indicates poor prognosis. Treatments that block the interaction of CD47 and SIRPα significantly suppress tumor growth and metastasis through diverse mechanisms, such as phagocytosis, antibody-dependent cellular cytotoxicity, and apoptosis...
September 18, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30223689/heart-rate-reduction-after-ivabradine-might-be-associated-with-reverse-electrical-remodeling-in-patients-with-cardiomyopathy-and-left-bundle-branch-block
#3
Andrea Kučerová, Petr Doškář, Libor Dujka, Veronika Lekešová, Petr Volf, Katarina Koščová, Petr Neužil, Filip Málek
Left bundle branch block increases the risk of death in patients with chronic heart failure. We herein report four clinical cases of patients with chronic heart failure caused by nonischemic cardiomyopathy with left bundle branch block that occurred when adding ivabradine to optimal medical therapy, resulting in reverse electrical and mechanical remodeling. This phenomenon might be explained by the effect of ivabradine on reverse remodeling of the left ventricle with improvement of intraventricular conduction...
September 18, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30223685/compression-screws-and-buttress-plate-versus-compression-screws-only-for-hoffa-fracture-in-chinese-patients-a-comparative-study
#4
Bangbao Lu, Shushan Zhao, Zhongwei Luo, Zhangyuan Lin, Yong Zhu
Objective To compare compression screws and buttress plate (CS plus BP) with compression screws only (CS) in treating patients with Hoffa fracture. Methods This retrospective study included Chinese patients with Hoffa fracture treated by open reduction and internal fixation. Radiographs and clinical outcomes (range of movement [ROM], bone union and Knee Society Score [KSS]) were compared between patients treated using CS plus BP versus CS only. Results At 4 months following surgery, significantly better outcomes were shown in the CS plus BP group ( n = 24) versus CS only group ( n = 21) regarding ROM (120...
September 18, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30222020/interdigitating-dendritic-cell-sarcoma-located-in-the-groin-a-case-report-and-literature-review
#5
Hong-Tao Wang, Hong-Yang Xu, Rong Zhang, Zhuo-Gang Liu, Guo-Jun Zhang
Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare subtype of dendritic cell neoplasms, and current knowledge on this tumor is limited. We herein report a case of an IDCS in a 64-year-old man who presented with a right inguinal mass combined with extensive retroperitoneal, pulmonary, hepatic, renal, and bone marrow infiltration. Because of the advanced stage of the disease, we performed five cycles of chemotherapy, including cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP); doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD); and ABVD combined with cisplatin, and one cycle of radiotherapy...
September 17, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30222016/acute-cardiac-dyspnea-in-the-emergency-department-diagnostic-value-of-n-terminal-prohormone-of-brain-natriuretic-peptide-and-galectin-3
#6
Alexandra Stoica, Victoriţa Şorodoc, Cătălina Lionte, Irina M Jaba, Irina Costache, Ecaterina Anisie, Cristina Tuchiluș, Ovidiu Rusalim Petriș, Oana Sîrbu, Elisabeta Jaba, Alexandr Ceasovschih, Luminiţa Vâţă, Laurenţiu Şorodoc
Objective This study was performed to determine whether a dual-biomarker approach using N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and galectin-3 optimizes the diagnosis and risk stratification of acute cardiac dyspnea. Atypical clinical manifestations and overlapping pathologies require objective and effective diagnostic methods to avoid treatment delays. Methods This prospective observational study included 208 patients who presented to the emergency department for acute dyspnea. NT-proBNP and galectin-3 were measured upon admission...
September 17, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30222013/retained-surgical-needle-and-gauze-after-cesarean-section-and-adnexectomy-a-case-report-and-literature-review
#7
Vida Gavrić Lovrec, Andrej Cokan, Lara Lukman, Darja Arko, Iztok Takač
Although the incidence of retained surgical items (RSIs) is low, it is nevertheless an important preventable cause of patient injury that can ultimately lead to the patient's death and to subsequent high medical and legal costs. Unintentional RSI is the cause of 70% of re-interventions, with a morbidity of 80% and mortality of 35%. The most common RSIs are sponges or gauze (gossypiboma or textiloma), while retained surgical instruments and needles are rare. Perioperative counting of equipment and materials is the most common method of screening for RSIs, while a diagnosis can later be confirmed by the clinical appearance and by imaging studies...
September 17, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30213231/ectopic-transglutaminase-1-and-3-expression-accelerating-keratinization-in-oral-lichen-planus
#8
Katsumitsu Shimada, Takanaga Ochiai, Hiromasa Hasegawa
Objective Oral lichen planus (OLP) characterized by interface mucositis frequently shows hyper-keratinization. To clarify mechanisms of excess keratinization, we investigated key molecules for cornified cell envelope (CE). Methods Involucrin (IVL), loricrin (LOR), transglutaminase 1 (TGase 1) and transglutaminase 3 (TGase 3) were immunohistochemically examined in 20 specimens of OLP; five specimens of buccal mucosa served as controls. Subsequently, the data were statistically analyzed. Results IVL in OLP was localized in the cell membrane, in contrast to its localization in the cytoplasm in controls...
September 13, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30213226/spleen-thickness-can-predict-significant-liver-pathology-in-patients-with-chronic-hepatitis-b-with-persistently-normal-alanine-aminotransferase-or-minimally-raised-alanine-aminotransferase-a-retrospective-study
#9
Junli Zhang, Xiaoxing Du, Zhihui Zhou, Fangfang Lv, Yunsong Yu
Objective Liver biopsy is the gold standard test for assessment of liver pathology. This study was performed to assess the predictive value of spleen thickness for liver pathology and the role of routine follow-up procedures in significant liver pathology for patients with chronic hepatitis B (CHB) with persistently normal alanine aminotransferase (PNALT) or minimally raised alanine aminotransferase (ALT). Methods Patients with CHB who underwent percutaneous liver biopsy were retrospectively reviewed. The relationship of liver pathology with age, ALT, hepatitis B e-antigen, and spleen thickness was statistically analyzed, and the predictive accuracy of spleen thickness was evaluated...
September 13, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30213225/added-value-of-contrast-echocardiography-in-characterization-of-nonischemic-cardiomyopathy
#10
Shufang Pi, Yingwu Liu, Tong Li, Wenjin Peng, Dong Wang, Lei Huang, Ningdong Kang
Nonischemic cardiomyopathy (NICM) is a group of noncoronary heterogonous myocardial diseases. The heterogonous nature of NICM has impeded its diagnosis. In the present case series, we demonstrate the added value of using contrast echocardiography in the characterization of NICM. Two patients of advanced age were admitted for possible acute coronary syndrome, which was subsequently excluded by coronary angiography. Conventional and contrast echocardiography revealed characteristic structural and dynamic features of the left ventricle that were compatible with two distinct NICM diseases: stress-induced cardiomyopathy and noncompaction of the ventricular myocardium...
September 13, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30213220/increased-circulating-levels-of-tumor-necrosis-factor-like-cytokine-1a-and-decoy-receptor-3-correlate-with-syntax-score-in-patients-undergoing-coronary-surgery
#11
Xin-Ya Li, Hai-Tao Hou, Huan-Xin Chen, Zheng-Qing Wang, Guo-Wei He
Objective Chronic inflammation of the arteries is a critical mechanism responsible for coronary atherosclerosis. We aimed to determine if tumor necrosis factor (TNF)-like cytokine 1A (TL1A) and decoy receptor 3 (DcR3) were involved in promoting atherosclerosis. Methods We compared plasma levels of TL1A and DcR3 in patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting (n=40) and patients without CAD group (n=37, normal coronary artery angiogram) by enzyme-linked immunosorbent assay...
September 13, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30213219/association-of-low-socioeconomic-status-and-physician-assessment-of-disease-severity-with-oral-health-related-quality-of-life-in-patients-with-systemic-sclerosis-a-pilot-study-from-croatia-a-country-in-transition
#12
Katica Parat, Mislav Radić, Katarina Borić, Dijana Perković, Dolores Biočina Lukenda, Dušanka Martinović Kaliterna
Objective This study was performed to identify a possible association of the clinical parameters of systemic sclerosis (SSc) and the socioeconomic status (SES) with oral health-related quality of life (OHrQoL) as measured by the Oral Health Impact Profile 49 (OHIP 49), taking into account the effect of educational level (as a proxy of SES) on oral health. Methods Subjects were recruited from the Croatian SSc Center of Excellence cohort. Detailed dental and clinical examinations were performed according to standardized protocols...
September 13, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30213216/rescue-of-four-pediatric-patients-with-severe-influenza-a-h3n2-in-weifang-china
#13
Tianhua Li, Ningning Qi, Xiaona Gao, Haili Yu
In this report, we summarize our experience of rescuing four children with severe type A H3N2 influenza from January to February 2017 in Weifang People's Hospital, Shandong Province, China for reference in clinical treatment. Two boys and two girls, ranging in age from 3 months to 6 years, with fever, cough, and asthma, were admitted to the pediatric intensive care unit. All children had severe pulmonary infection with respiratory distress. Three children had myocardial damage, two had liver damage, and one had encephalitis...
September 13, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30213215/hand-strength-and-dexterity-in-patients-with-prader-willi-syndrome-a-pilot-intervention-study
#14
Wan-Ling Hsu, Valeria Jia-Yi Chiu, Wei-Hsiu Chang, Mei-Chun Lin, Jang-Ting Wei, I-Shiang Tzeng
Objective The study aim was to examine the hand function (hand strength and dexterity) and intervention effects of training in adults with Prader-Willi syndrome (PWS). Methods Six adults with PWS (two females; mean age 26.14 years) underwent hand muscle strength and dexterity training for 3 months (2 hours per week). The following hand function tests were performed pre- and post-intervention: (1) hand grip, lateral pinch, and tip pinch hand strength tests, (2) the Box and Block test (BBT) for gross manual dexterity and (3) the Purdue Pegboard test for finger dexterity...
September 13, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30209965/safety-and-tolerability-of-sauna-detoxification-for-the-protracted-withdrawal-symptoms-of-substance-abuse
#15
Richard D Lennox, Marie Cecchini-Sternquist
Objective Protracted drug withdrawal symptoms can last months or years after drug cessation, often precipitating a return to substance misuse. We evaluated the safety and preliminary health benefits of a unique chemical exposure regimen based on exercise, sauna and therapeutic nutrients. Methods This was a prospective evaluation of 109 individuals sequentially enrolled into a sauna detoxification component of a multi-modal, long-term residential substance abuse treatment centre. Results Data from medical charts, client self-reports and Short Form Health Survey (SF-36) responses indicated that the Hubbard sauna detoxification method was well tolerated, with a 99% completion rate, including one human immunodeficiency virus and nine hepatitis C positive clients...
September 13, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30209964/comparison-between-a-novel-knotless-technique-and-the-conventional-single-knot-technique-of-laparoscopic-radical-prostatectomy-by-novice-laparoscopists
#16
Jianfei Ye, Jian Lu, Guoliang Wang, Lulin Ma
Objectives This study aimed to investigate a novel knotless technique for novice laparoscopists in traditional laparoscopic radical prostatectomy. Methods We studied 68 patients who had a novel technique performed in laparoscopic radical prostatectomy (knotless group) and 89 who had the conventional single knot technique (single knot group). The operations were all performed by novice laparoscopists with experience of fewer than 100 cases of laparoscopic radical prostatectomy. Knotless suture of the dorsal vein complex was conducted using a barbed self-retaining suture with three bites at the same location...
September 13, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30209962/influence-of-dexmedetomidine-and-lidocaine-on-perioperative-opioid-consumption-in-laparoscopic-intestine-resection-a-randomized-controlled-clinical-trial
#17
Lea Andjelković, Vesna Novak-Jankovič, Neva Požar-Lukanovič, Zoran Bosnić, Alenka Spindler-Vesel
Objective The consumption of opioid analgesics could be reduced by the use of analgesics with different mechanisms of action. We investigated whether additional treatment with dexmedetomidine or lidocaine could reduce opioid consumption. Methods We randomized 59 study participants into three groups and examined: (i) fentanyl consumption, (ii) consumption of piritramide, and (iii) cognitive function and neuropathic pain. The control group received continuous propofol infusion and fentanyl boluses. Continuous intravenous infusion of dexmedetomidine (0...
September 13, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30209960/association-between-serum-level-of-advanced-glycation-end-products-and-obstructive-sleep-apnea-hypopnea-syndrome-a-meta-analysis
#18
Xingyu Wu, Wensheng She, Xun Niu, Xiong Chen
Objective This meta-analysis was performed to assess the difference in the serum level of advanced glycation end products (AGEs) between patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and controls. Methods A systematic literature search was performed using PubMed, Elsevier, SCI, Wanfang, Weipu, and China National Knowledge Internet. Eligible studies that reported the serum AGE level in patients with OSAHS were identified by two reviewers. Review Manager version 5.2 (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark) and R version 3...
September 13, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30208769/addition-of-cyclosporine-tacrolimus-for-pediatric-relapsed-lupus-nephritis-during-mycophenolate-mofetil-maintenance-therapy
#19
Youying Mao, Lei Yin, Hua Huang, Zhengyu Zhou, Tongxin Chen, Wei Zhou
Objective We aimed to evaluate the efficacy of low-dose cyclosporine (CsA) or tacrolimus (Tac) in children with proliferative lupus nephritis (PLN) during maintenance therapy. Methods A low dose of CsA or Tac was added to 11 children who relapsed during mycophenolate mofetil (MMF) maintenance therapy. Renal remission was analyzed at 3 and 6 months, and at 1, 2, and 3 years after CsA/Tac addition. Adverse effects were recorded. Results The clinical response rates were 81.9%, 100%, 90.0%, 100%, and 100% at 3 months, 6 months, 1 year, 2 years, and 3 years after CsA/Tac addition, respectively...
September 12, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30208754/predictive-value-of-fasting-blood-glucose-for-serious-coronary-atherosclerosis-in-non-diabetic-patients
#20
Tong Zhao, Hui-Ping Gong, Zhao-Qiang Dong, Yi-Meng Du, Qing-Hua Lu, Hui-Qiang Chen
Objective To determine if high fasting blood glucose (FBG) level is an independent predictor of serious coronary lesions in patients with coronary artery disease (CAD). Methods We enrolled 64 patients who had symptoms of chest discomfort and who underwent coronary angiography. FBG was determined from blood samples and the extent of coronary artery lesions was analyzed according to Gensini score. We examined the relationships among diabetes, FBG, and coronary artery severity. Results Diabetes and FBG were significantly and positively related to Gensini score...
September 12, 2018: Journal of International Medical Research
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