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Journal of International Medical Research

Runjia Wang, Gongming Wang, Yang Liu, Mengyuan Zhang
OBJECTIVE: Prevention of postoperative cognitive dysfunction (POCD) in patients of advanced age remains unclear. Studies have shown that the cholinergic anti-inflammatory pathway contributes to a decreased risk of POCD and that nicotine stimulates the cholinergic anti-inflammatory pathway. We investigated whether patients of advanced age with a preoperative smoking history have a decreased risk of POCD. METHODS: In total, 382 patients (190 smokers, 192 nonsmokers) aged ≥60 years who underwent major noncardiac surgery were enrolled...
November 12, 2018: Journal of International Medical Research
Tong Gao, Mingming Sun, Liangqing Yao, Wei Jiang
OBJECTIVE: This study aimed to determine the diagnostic value of magnetic resonance imaging (MRI), hysteroscopy, and laparoscopy to avoid unnecessary treatment when patients present with clinical manifestations that are close to those of gestational trophoblastic neoplasia (GTN). METHODS: Three patients who were falsely diagnosed with presumed GTN and received needless chemotherapy in our hospital from July 2011 to March 2012 were studied. We also reviewed data of patients with similar clinical features who were diagnosed as having residual pregnancy in recent years...
November 9, 2018: Journal of International Medical Research
Li-Jun Bo, Pei-Xia Yu, Xiang Qi, Rong-Tian Kang
OBJECTIVE: This study was performed to investigate the management of general anesthesia in an unusual case involving a patient with a broken tracheostomy tube presenting as an airway foreign body. METHODS: We herein describe the anesthetic management of a patient with a broken tracheostomy tube. A 77-year-old Chinese man who had been involved in a car accident underwent a tracheostomy. One year later, he presented with cough and bleeding at the tracheostomy site...
November 9, 2018: Journal of International Medical Research
Yu Zhu, Chengmao Zhou, Qixiong He
OBJECTIVE: To observe the expression and clinical significance of micro RNA (miR)-139-3p in liver cancer tissues, and to explore its relationship with miR-139-3p target genes related to the prognosis of hepatocellular carcinoma (HCC). METHODS: A total of 362 patients with HCC were included in the study. Liver hepatocellular carcinoma data were obtained directly from The Cancer Genome Atlas data portal .The bioinformatics analysis tool TargetScan was applied to predict miR-139-3p target genes...
November 5, 2018: Journal of International Medical Research
Marie Edvinsson, Nicole Welvaart, Lars Ryttberg, Per Wretenberg, Tomas Vikerfors, Christina Nyström-Rosander
OBJECTIVE: Osteoarthritis (OA) is a common cause of disability affecting millions of people of all ages worldwide. The pathogenesis involves an inflammatory component, but the cause of the inflammation remains incompletely understood. The intracellular bacteria Chlamydia trachomatis and C. pneumoniae have been demonstrated in patients with reactive arthritis. Both of these microorganisms can cause chronic and persistent infections, with C. trachomatis being the most common cause of reactive arthritis...
November 5, 2018: Journal of International Medical Research
Maria Cristina Maggio, Silvio Maringhini, Saveria Sabrina Ragusa, Giovanni Corsello
A 9-year-old boy with petechiae on the legs and abdominal pain was unsuccessfully treated with steroids. He was admitted to our hospital for the onset of fever, ecchymosis, and arthralgia. Skin lesions suggested vasculitis, but they were not typical of Henoch-Schönlein purpura. He showed ecchymosis of the scrotal bursa, diffusion of petechiae to the trunk and arms, vomiting, severe abdominal pain, oliguria with hyponatremia, hypoalbuminemia, low C3 levels, high levels of creatinine, blood urea nitrogen, and tubular enzymes, proteinuria, and glycosuria...
November 5, 2018: Journal of International Medical Research
Ruirong Pan, Haiming Zhang, Shuping Yu, Jialiang Deng, Suxian Ma, Yanyan Li, Guoyue Yuan, Jifang Wang
OBJECTIVES: Betatrophin is a widely used diagnostic marker for type 2 diabetes mellitus (DM), but its clinical utility in diagnosing gestational DM (GDM) is unclear. We evaluated the relationship between betatrophin and the risk of GDM as well as the ability of betatrophin to predict postpartum type 2 DM (PDM). METHODS: In total, 386 patients were categorized into those with and without PDM. All underwent the oral glucose tolerance test while pregnant. Betatrophin was assessed to examine the diagnostic characteristics of GDM...
November 5, 2018: Journal of International Medical Research
Zhaohua Meng, Yanling Dong, Hengbo Gao, Dongqi Yao, Yu Gong, Qingbing Meng, Tuokang Zheng, Xiaolei Cui, Xiaoyun Su, Yingping Tian
OBJECTIVE: To investigate the effects of parenteral nutrition (PN) including ω-3 fish-oil emulsion on nutritional state, inflammatory response, and prognosis in patients with acute paraquat poisoning. METHODS: Patients randomized to receive medium chain triglycerides (MCT)/long chain triglycerides (LCT)-based PN (control group) or MCT/LCT-based PN containing ω-3 fish-oil emulsion (intervention group) were compared for 90-day survival and short-term treatment efficacy...
November 5, 2018: Journal of International Medical Research
Caixia Jiang, Wei Gong, Rong Chen, Huihui Ke, Xiaoyan Qu, Weihong Yang, Zhongping Cheng
OBJECTIVE: This study aimed to investigate RhoA, RhoA-associated coiled-coil containing protein kinase (ROCK) 1, ROCK2, and Rho GTPase-activating protein 26 (ARHGAP26) expression in the eutopic endometrium (EU) and ectopic endometrium (EC), and examine their relationships with the clinical characteristics of adenomyosis. METHODS: Twenty patients with adenomyosis who underwent laparoscopy were recruited. Protein and mRNA expression of RhoA, ROCK1, ROCK2, and ARHGAP26 in EU and EC of patients with adenomyosis and in control endometrium without adenomyosis (CE) was detected...
November 2, 2018: Journal of International Medical Research
Songhe Shen, Xiongjing Jiang, Hui Dong, Meng Peng, Zhixue Wang, Wuqiang Che, Yubao Zou, Yuejin Yang
OBJECTIVE: This study was performed to explore the effect of the aortic arch type on technical indicators in patients undergoing carotid artery stenting (CAS). METHODS: The data of 224 consecutive patients who underwent unilateral CAS from January 2011 to December 2012 were retrospectively analyzed. The requirement for placement of the guiding catheter into the common carotid artery with assistance of an angiographic catheter, fluoroscopy time, contrast agent dose, and adverse events were recorded...
October 31, 2018: Journal of International Medical Research
Eva Maria Valesky, Manuela Denise Maier, Roland Kaufmann, Nadja Zöller, Markus Meissner
OBJECTIVE: Frontal fibrosing alopecia (FFA) is an underestimated scarring alopecia. This study aimed to examine epidemiological information, as well as predilection sites, associated diseases, and responses to therapy of patients with FFA. We also aimed to determine whether the extent or duration of disease correlated with the quality of life (QoL). METHODS: Twelve outpatients with FFA for > 2 years were analyzed. The Erlanger atopic score and the Functional Assessment of Non-life-threatening Conditions (FANLTC) for QoL-assessment were used as scoring systems...
October 31, 2018: Journal of International Medical Research
Asli Nuriye Melekoglu, Osman Baspinar
OBJECTIVE: Percutaneous cardiac catheterization has been used as a diagnostic tool and as a therapeutic option in neonates with congenital heart disease (CHD). This study aimed to evaluate the procedural and short-term follow-up data of newborns who underwent cardiac catheterization procedures. METHODS: This retrospective study reviewed demographic, diagnostic and clinical data from the medical records of newborns who underwent percutaneous transcatheter interventions to treat CHD...
October 30, 2018: Journal of International Medical Research
Yueying Xie, Junjie Wang, Xiaoya Zhao, Xuli Zhou, Xiaohui Nie, Chuncheng Li, Fulian Huang, Haibin Yuan
OBJECTIVE: This meta-analysis was conducted to examine the possible association between serum zinc concentration and cervical cancer risk. METHODS: PubMed, WanFang, China National Knowledge Infrastructure, and SinoMed databases were searched for relevant articles published between January 1980 and September 2017. Results were combined using a random-effects model, and pooled standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare serum zinc levels in patients with cervical cancer versus controls...
October 29, 2018: Journal of International Medical Research
Ling-Jie Zheng, Ning Liu, Kun Yang, Ai-Feng Wang, Zhi-Rong Tan, Xiang Li
BACKGROUND: To directly achieve cytochrome P450 2C19 gene ( CYP2C19) classification using one-step real-time fluorescent PCR detection and to verify the capabilities of this method with nucleic acid extracted from whole blood samples. METHODS: A human CYP2C19 genotyping kit based on one-step real-time fluorescent PCR detection was used to analyze whole blood or genomic DNA samples. This method was compared with pyrosequencing and another quantitative (q)PCR kit for its accuracy, repeatability, detection range analysis, sensitivity, specificity, and anti-interference analysis...
October 25, 2018: Journal of International Medical Research
Qurat Ulain, Lu Han, Qian Wu, Lanbo Zhao, Qi Wang, Xiaoqian Tuo, Yiran Wang, Qing Wang, Sijia Ma, Chao Sun, Qing Song, Qiling Li
OBJECTIVES: The effectiveness of indocyanine green (ICG) dye for detecting sentinel lymph nodes (SLNs) in cervical cancer compared with other tracers is unknown. This study aimed to assess the validity of ICG dye in detecting SLNs in cervical cancer preoperatively. METHODS: We performed a literature search for identifying eligible articles from PubMed database using the search terms "cervical cancer", "sentinel lymph node", "indocyanine green", "blue dyes", "human serum albumin", and "technetium-99 radiocolloid"...
October 25, 2018: Journal of International Medical Research
Chengliang Zhang, Xiuqin Zheng, Rulan Lu, Wenwei Yun, Huifang Yun, Xianju Zhou
OBJECTIVE: This study was performed to determine whether repetitive transcranial magnetic stimulation (rTMS) combined with neuromuscular electrical stimulation (NMES) effectively ameliorates dysphagia and how rTMS protocols (bilateral vs. unilateral) combined with NMES can be optimized. METHODS: Sixty-four patients were randomly divided into four groups using a random distribution table: the sham rTMS plus NMES (Sham-rTMS/NMES), ipsilesional 10-Hz rTMS plus NMES (Ipsi-rTMS/NMES), contralesional 1-Hz rTMS plus NMES (Contra-rTMS/NMES), and bilateral rTMS plus NMES (Bi-rTMS/NMES) groups...
October 25, 2018: Journal of International Medical Research
Shicong Tang, Qiong Zhang, Xianghui Tang, Dong Chen, Fan Zhang, Jianlun Liu, Wei Wei, Dequan Liu
OBJECTIVE: To compare the efficacy, safety, and pregnancy outcomes of tamoxifen plus ovarian function suppression (OFS) between Han and Zhuang women with hormone receptor-positive breast cancer. METHODS: A total of 236 Han and 101 Zhuang women with hormone receptor-positive breast cancer who received tamoxifen plus OFS were analyzed retrospectively. Long-term disease-free survival (DFS) and overall survival (OS) were evaluated by Kaplan-Meier analysis, and adverse events and pregnancy outcomes were assessed by χ2 and Fisher's exact-probability tests...
October 25, 2018: Journal of International Medical Research
Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichirou Ishigami, Masaru Kohori, Kunihiro Mae, Ryusho Sangen, Daisuke Usuda, Atsushi Saito, Masaharu Iguchi, Yuji Kasamaki, Akihiro Fukuda, Hitoshi Saito, Tsugiyasu Kanda, Masashi Okuro
OBJECTIVE: To assess the effect of 12 months of treatment with tofogliflozin on electrolytes and dehydration in Japanese patients with type 2 diabetes mellitus (T2DM). METHODS: This retrospective study involved mainly elderly patients with T2DM who had received tofogliflozin for 12 months. Data on glycated haemoglobin (HbA1c), serum electrolytes (sodium, potassium, chloride), haematocrit, estimated glomerular filtration rate (eGFR) and blood urea nitrogen (BUN)/creatinine ratio were retrieved and analysed...
October 25, 2018: Journal of International Medical Research
Hamdi H Almaramhy
Hepatopulmonary fusion is a rare malformation that is often discovered during operative repair of right-sided congenital diaphragmatic defects. Based on a search using medical search engines, we only found 22 cases of hepatopulmonary fusion in the English literature worldwide to date. We describe herein a case of hepatopulmonary fusion with right-sided congenital diaphragmatic hernia in a female neonate who presented with respiratory distress. We discuss management of this case and review the relevant literature...
October 23, 2018: Journal of International Medical Research
Huihao Chen, Gang Yin, Chunlin Hou, Liangyu Zhao, Haodong Lin
The patient was a 26-year-old man who fell while riding a motorcycle and friction led to defects in the lateral malleolus and soft tissue of the ankle. Although the wound surface healed with scarring and skin grafting, the patient had symptoms of ankle joint instability 4 months after the injury. Using a second metatarsal composite tissue flap with a dorsalis pedis artery pedicle, we repaired the soft tissue defect of the ankle and reconstructed the lateral malleolus. The head of the metatarsal bone was used to reconstruct the lateral malleolus and the flap was used to cover the wound surface...
October 23, 2018: Journal of International Medical Research
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