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Journal of International Medical Research

Jian Zhang, Ling Lin, Konghan Pan, Jiancang Zhou, Xiaoyin Huang
High-flow nasal cannula (HFNC) oxygen therapy has several physiological advantages over traditional oxygen therapy devices, including decreased nasopharyngeal resistance, washing out of the nasopharyngeal dead space, generation of positive pressure in the pharynx, increasing alveolar recruitment in the lungs, humidification of the airways, increased fraction of inspired oxygen and improved mucociliary clearance. Recently, the use of HFNC in treating adult critical illness patients has significantly increased, and it is now being used in many patients with a range of different disease conditions...
October 2, 2016: Journal of International Medical Research
Bei-Bei Zhang, Yu Liang, Bo Yang, Ying-Jun Tan
OBJECTIVE: To perform a meta-analysis to evaluate studies investigating the association between ATG16L1 gene polymorphism and Crohn's disease. METHODS: PubMed, Embase and Web of Science databases were searched for all studies focusing on the association of ATG16L1 and Crohn's disease. Combined odds ratios with 95% confidence intervals were calculated for four genetic models (allelic model: G allele versus A allele; additive model: GG versus AA; dominant model: GA + GG versus AA; recessive model: GG versus GA + AA) using either a random effects or fixed effects model...
October 2, 2016: Journal of International Medical Research
Ping Zhao, Qin Yu, Liang Chen, Man Zhang
OBJECTIVE: A retrospective study comparing the diagnostic performance of the BACTEC™ MGIT™ 960 system (M960 system; BD Worldwide, Franklin Lakes, NJ, USA) with Löwenstein-Jensen (L-J) culture to detect mycobacteria in sputum specimens from patients with suspected pulmonary tuberculosis (TB). METHODS: Sputum samples were analysed for the presence of acid-fast bacilli (AFB). Samples were inoculated into the M960 system and L-J culture. Positive cultures were examined for the presence of AFB...
September 29, 2016: Journal of International Medical Research
Ying Li, Gao Yang, Jinwei Qiang, Songqi Cai, Hao Zhou
OBJECTIVE: To investigate the incidence of insulin resistance (IR) and diabetes in patients with chronic hepatic schistosomiasis japonica (HSJ) and portosystemic shunts (PSS). METHODS: Pre- and post-contrasted computed tomography images obtained from patients with HSJ and control subjects were reviewed by two radiologists who identified and graded any shunting vessels. Anthropometric measurements, hepatic enzymes, lipid profile, blood levels of albumin, glucose, insulin and homeostasis model assessment (HOMA-2) index of all participants were also assessed...
September 29, 2016: Journal of International Medical Research
Gamal Hasan, Asaad Assiri, Naglaa Marzuuk, Enas Daef, Sayed Abdelwahab, Ahmed Ahmed, Ismail Mohamad, Ayman Al-Eyadhy, Ali Alhaboob, Mohamad-Hani Temsah
OBJECTIVE: To describe the characteristics of hepatitis E virus (HEV) infection in a cohort of children from Upper Egypt using data from a large multicentre prospective study of acute viral hepatitis (AVH). METHODS: Data from subjects aged 2-18 years with AVH or close contacts of those with AVH found to have asymptomatic AVH were included in the analysis. Information concerning medical history, clinical examination, liver function tests and screening for hepatotropic viruses was recorded and analysed...
September 29, 2016: Journal of International Medical Research
Mingchao Li, Zhengyun Wang, Hao Li
OBJECTIVE: To perform a meta-analysis of data from available published studies comparing laparoendoscopic single-site surgery varicocelectomy (LESSV) with conventional transperitoneal laparoscopic varicocele ligation. METHODS: A comprehensive data search was performed in PubMed and Embase to identify randomized controlled trials and comparative studies that compared the two surgical approaches for the treatment of varicoceles. RESULTS: Six studies were included in the meta-analysis...
September 29, 2016: Journal of International Medical Research
Yoon-Jung Shon, Jin Huh, Sung-Sik Kang, Seung-Kil Bae, Ryeong-Ah Kang, Duk-Kyung Kim
OBJECTIVE: To compare the effects of saddle, lumbar epidural and caudal blocks on anal sphincter tone using anorectal manometry. METHODS: Patients undergoing elective anorectal surgery with regional anaesthesia were divided randomly into three groups and received a saddle (SD), lumbar epidural (LE), or caudal (CD) block. Anorectal manometry was performed before and 30 min after each regional block. The degree of motor blockade of the anal sphincter was compared using the maximal resting pressure (MRP) and the maximal squeezing pressure (MSP)...
September 29, 2016: Journal of International Medical Research
Mi Li, Shengfu Lu, Gang Wang, Lei Feng, Bingbing Fu, Ning Zhong
OBJECTIVE: To investigate attentional bias toward happy and sad faces in remitted depressed (RD) patients compared with healthy control (HC) subjects. METHODS: This cross-sectional study enrolled RD patients and sex- and age-matched HC subjects. Eye movement data were acquired for all study participants while free viewing a 2 × 2 matrix of emotional faces. The attentional bias toward different emotional faces and whether the attention maintenance components generated attentional bias in the RD patients were analysed by comparing the attentional modes of the RD group with the HC group...
September 29, 2016: Journal of International Medical Research
Ruijie Sun, Xiaojie Ma, Xiaolan Cai, Xinliang Pan, Dayu Liu
OBJECTIVE: To investigate the effect and mechanism of action of metformin on proliferation of a human hypopharyngeal carcinoma cell line (FaDu). METHODS: FaDu cells were treated with metformin (25-125 mmol/l). Cell proliferation was evaluated via CCK-8 assay. Real-time quantitative reverse transcription-polymerase chain reaction was used to evaluate microRNA (miR)-21-5p and PDCD4 (programmed cell death 4) expression. PDCD4 protein was quantified by Western blot...
September 29, 2016: Journal of International Medical Research
Marta Gandolla, Simona Ferrante, Giancarlo Ferrigno, Davide Baldassini, Franco Molteni, Eleonora Guanziroli, Michele Cotti Cottini, Carlo Seneci, Alessandra Pedrocchi
OBJECTIVE: To design and implement an electromyography (EMG)-based controller for a hand robotic assistive device, which is able to classify the user's motion intention before the effective kinematic movement execution. METHODS: Multiple degrees-of-freedom hand grasp movements (i.e. pinching, grasp an object, grasping) were predicted by means of surface EMG signals, recorded from 10 bipolar EMG electrodes arranged in a circular configuration around the forearm 2-3 cm from the elbow...
September 27, 2016: Journal of International Medical Research
Da Eun Kim, Soo Hyun Cho, Hyoung Moo Park, Yu Kyung Chang
OBJECTIVE: To examine the relationship between nutritional intake and bone mineral density (BMD) in postmenopausal Korean women. METHODS: Dietary intake was recorded in postmenopausal Korean women using a semiquantitative questionnaire. The frequency of consumption of various food groups and nutrient intake were calculated. BMD T-scores were measured at the lumbar spine, femoral neck and total hip using dual-energy X-ray absorptiometry. Associations between T-scores and dietary intake were analysed using partial correlation coefficients and multiple linear regression analysis...
September 23, 2016: Journal of International Medical Research
Yue Chen, Ping Li, Chunli Cui, Aihong Yuan, Kun Zhang, Chen Yu
OBJECTIVE: To explore the clinical characteristics, renal histopathological spectrum and prognostic factors of biopsy-proven kidney diseases in the elderly. METHODS: A retrospective observational study was conducted in elderly patients who had received renal biopsies. Demographic, clinical and pathological data at the time of the biopsy were collected from the medical records. Follow-up records and prognostic factors were studied. RESULTS: The elderly (≥60 years) accounted for 74 of 434 (17...
September 5, 2016: Journal of International Medical Research
Yirong Zeng, Wenjun Feng, Xinyu Qi, Jie Li, Jinlun Chen, Lu Lu, Peng Deng, Jianchun Zeng, Feilong Li
OBJECTIVES: To monitor knee skin temperature changes for 12 months following total knee arthroplasty (TKA) and identify potential reasons for any differences in skin temperature and to investigate if there is a relationship between the differential temperature and clinical outcome. METHODS: Patients who attended for a unilateral TKA due to primary osteoarthritis between August 2012 and August 2014 were eligible for this prospective study. The skin temperature of both knees was monitored preoperatively and postoperatively using an infrared thermometer...
September 5, 2016: Journal of International Medical Research
Sarah Rae Easter, Greta B Raglan, Sarah E Little, Jay Schulkin, Julian N Robinson
OBJECTIVE: To characterize contemporary attitudes toward global health amongst board-certified obstetricians-gynecologists (Ob-Gyns) in the US. METHODS: A questionnaire was mailed to members of the American College of Obstetricians and Gynecologists. Respondents were stratified by interest and experience in global health and group differences were reported. RESULTS: A total of 202 of 400 (50.5%) surveys were completed; and 67.3% (n = 136) of respondents expressed an interest in global health while 25...
August 25, 2016: Journal of International Medical Research
Wei-Hong Guo, Qiang Li, Hong-Yan Wei, Hong-Yan Lu, Hui-Qi Qu, Mei Zhu
Polyuria and polydipsia are the characteristics of congenital nephrogenic diabetes insipidus (CNDI). Approximately 90% of all patients with CNDI have X-linked hereditary disease, which is due to a mutation of the arginine vasopressin receptor 2 (AVPR2) gene. This case report describes a 54-year-old male with polyuria and polydipsia and several male members of his pedigree who had the same symptoms. The proband was diagnosed with diabetes insipidus using a water-deprivation and arginine vasopressin stimulation test...
August 25, 2016: Journal of International Medical Research
Yongjian Yang, Yi Yang, Xiong Wang, Jin Du, Juanni Hou, Juan Feng, Yue Tian, Lei He, Xiuchuan Li, Haifeng Pei
The pathogenesis of myocardial ischaemia/reperfusion injury is multifactorial. Understanding the mechanisms of myocardial ischaemia/reperfusion will benefit patients with ischaemic heart disease. Growth differentiation factor 11 (GDF11), a member of the secreted transforming growth factor-β superfamily, has been found to reverse age-related hypertrophy, revealing the important role of GDF11 in cardiovascular disease. However, the functions of GDF11 in myocardial ischaemia/reperfusion have not been elucidated yet...
August 25, 2016: Journal of International Medical Research
Bi Song Zhu, Hui Chuan Jiang, Yuan Li
OBJECTIVE: To investigate the impact of urethral catheterization on uroflow by comparing urodynamic parameters of free uroflowmetry versus pressure-flow study in adult patients with benign prostatic hyperplasia, female stress incontinence, lumbosacral spinal injury or spina bifida. METHODS: Each patient was required to perform pressure-flow study immediately following free uroflowmetry. Maximum flow rate (Qmax), average flow rate (Qave), voided volume (VV), Tmax (time to Qmax) and post-voiding residual urine (PVR) were compared between the two tests...
August 25, 2016: Journal of International Medical Research
Shinya Suzuki, Kiwako Ikegawa, Kaori Yamamoto, Shinichiro Saito
OBJECTIVES: To evaluate the effects of the timing of warfarin (WF) administration in patients with gastric cancer who received S-1 oral chemotherapy. METHODS: This retrospective chart review collected patient data including the prothrombin time international normalized ratio (PT-INR). Patients were categorized into three groups based on the timing of WF administration in relation to S-1 oral chemotherapy: group A patients received WF before S-1 chemotherapy; group B patients started WF during S-1 chemotherapy; and group C patients started WF after completing S-1 chemotherapy...
August 23, 2016: Journal of International Medical Research
Juan A Peraza-Zaldívar, Juan A Suárez-Cuenca, Rocío Aceves-Millán, Carlos Ixcamparij-Rosales, Lilia Amezcua, Rebeca Pérez-Cabeza de Vaca, Nuria Guerrero-Celis, Alberto Melchor-López, Paul Mondragón-Terán, Sofía L Alcaráz-Estrada
OBJECTIVE: To evaluate the relationship between pro-atherogenic biomarkers and epicardial adipose tissue (EAT) thickness in patients with cardiovascular risk factors. METHODS: Plasma nitric oxide (NO), soluble intercellular adhesion molecule-1 and malondialdehyde (MDA) levels, EAT thickness, flow-mediated dilation (FMD) and carotid intima media thickness (CIMT) were determined in patients aged >18 years who were referred for echocardiography for heart ischemia or non-ischemic diseases...
August 7, 2016: Journal of International Medical Research
Jing Zhang, Guangpu Fan, Hui Zhao, Xu Wang, Zhiwei Wang, Peide Zhang, Wei Wang
OBJECTIVE: To compare the aortic diameter after isolated aortic valve replacement (AVR) in patients with a bicuspid (BAV) or tricuspid aortic valve (TAV) and an initially normal ascending aorta. METHODS: Patients with an ascending aortic diameter of < 45 mm who had undergone isolated AVR were studied. Ultrasonic cardiographic measurements of the ascending aortic diameter made pre- and postoperatively and follow-up data concerning adverse aortic events and death were analyzed...
August 2, 2016: Journal of International Medical Research
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