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Journal of International Medical Research

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https://www.readbyqxmd.com/read/29896983/elevated-kr%C3%A3-ppel-like-factor-5-expression-in-spatiotemporal-mouse-lungs-is-similar-to-human-congenital-cystic-adenomatoid-malformation-of-the-lungs
#1
Xueyan Wang, Huajing Wan, Shuo Yang, Rong Zhou, Yong Liao, Fan Wang, Ximin Chen, Zhiling Wu
Objective The study aimed to investigate the role of high Krüppel-like factor 5 (KLF5) expression on the pathogenesis of congenital cystic adenomatoid malformation of the lungs (CCAML) in mice. Methods A mouse model of high KLF5 expression in the lungs was established. KLF5 expression and the pulmonary lumen diameter were examined by immunohistochemistry to determine a successful model. Basement membrane damage and activity of matrix metalloproteinase-9 (MMP-9) were examined. After an adenovirus carrying KLF5 gene transfection in lung adenocarcinoma (H441) was created, changes in expression and activity of MMP-9 were determined...
July 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29896981/astragaloside-iv-ameliorates-early-diabetic-nephropathy-by-inhibition-of-mek1-2-erk1-2-rsk2-signaling-in-streptozotocin-induced-diabetic-mice
#2
Gaofeng Song, Pengxun Han, Huili Sun, Mumin Shao, Xuewen Yu, Wenjing Wang, Dongtao Wang, Wuyong Yi, Na Ge, Shunmin Li, Tiegang Yi
Objective The aim of this study was to investigate the renoprotective effects and molecular mechanisms of astragaloside IV (AS-IV) in streptozotocin (STZ)-induced diabetic mice. Methods Male C57BL/6 mice were injected intraperitoneally with STZ at 200 mg/kg body weight. AS-IV was administered for 8 consecutive weeks, beginning 1 week after STZ injection. Body weight, 24-hour urinary albumin excretion, and fasting blood glucose were measured. Kidney tissues were examined by histopathological analyses. Total levels and phosphorylation of mitogen-activated protein kinase 1/2 (MEK1/2), extracellular signal-regulated kinases 1 and 2 (ERK1/2), and ribosomal S6 kinase 2 (RSK2) were determined by Western blotting analysis...
July 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29923776/expression-of-%C3%AE-smooth-muscle-actin-in-the-periodontal-ligament-during-post-emergent-tooth-eruption
#3
Domna Dorotheou, Marie-Luce Bochaton-Piallat, Catherine Giannopoulou, Stavros Kiliaridis
Objective This study was performed to explore the expression of α-smooth muscle actin (α-SMA) in the periodontal ligament (PDL) of young and adult rats during post-emergent tooth eruption in opposed and unopposed teeth at two time points: 3 and 15 days after antagonist loss. Methods Four-week-old (n = 20) and 22-week-old (n = 20) male Wistar rats were used. The right maxillary molar crowns were cut down. PDL samples were isolated from the first mandibular molars at two time points: 3 and 15 days after cut-down of the right maxillary molars...
June 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29848122/impact-of-tip-apex-distance-and-femoral-head-lag-screw-position-on-treatment-outcomes-of-unstable-intertrochanteric-fractures-using-cephalomedullary-nails
#4
Cheng-Hung Lee, Kuo-Chih Su, Kun-Hui Chen, Chien-Chou Pan, Yun-Che Wu
Background Cephalomedullary nails are frequently used in unstable intertrochanteric fractures. The implant position is an important factor for surgical success. Thus, in the present study, finite element analysis methods were used to investigate the biomechanical behavior of five different cephalomedullary nail positions in unstable intertrochanteric fractures. Methods Five different cephalomedullary nail implant positions were investigated. The observed indicators were the maximum displacement of the lag screw, the stress on the intertrochanteric fracture with involvement of the posteromedial cortex, and the tip-apex distance...
June 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29756537/use-of-negative-pressure-wound-therapy-in-a-chronic-leg-wound-with-coexisting-rheumatoid-arthritis-a-case-study
#5
Dariusz Bazaliński, Paweł Więch, Beata Barańska, Monika Binkowska-Bury
We present a case of a 69-year-old woman with rheumatoid arthritis. The patient's condition was managed with steroid therapy for more than 12 years. She had a coexisting infected chronic ulceration in the left leg, which was treated with negative pressure wound therapy for 52 days. Use of this therapy within the wound reduced exudate and the bacterial count, which dramatically accelerated the process of wound healing.
June 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29756515/effects-of-polaprezinc-on-gastric-mucosal-damage-and-neurotransmitters-in-a-rat-model-of-chemotherapy-induced-vomiting
#6
Zhao Yang Liu, Wen Bo Xie, Ming Ru Li, Nan Teng, Xiao Liang, Zi Qiang Zhang
Objective To investigate the effects of polaprezinc (PZ) on cyclophosphamide (CTX)- or cisplatin (DDP)-induced gastric mucosal injury and on a rat model of neurotransmitter-mediated vomiting. Methods Sprague-Dawley rats were divided at random into Control, CTX, DDP, PZ+CTX, and PZ+DDP groups. After 20 days, brain tissues and sera were analyzed for the levels of dopamine (DA), 5-hydroxytryptamine (5-HT), and nuclear factor kappa B (NF-κB). Hematoxylin and eosin-stained sections of stomach, intestine, and brain tissues were examined using light microscopy...
June 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29734850/icariin-influences-cardiac-remodeling-following-myocardial-infarction-by-regulating-the-cd147-mmp-9-pathway
#7
Yu Shi, Weihong Yan, Qiaoyan Lin, Weimin Wang
Objective We investigated the protective effect of icariin on myocardial infarction-induced cardiac remodeling. Methods A cardiac remodeling model was constructed by ligating rats' coronary artery. Different icariin and CD147 concentrations were administered in the model group, and echocardiography was used to detect systolic function, screening out ideal experimental concentrations. The ventricular systolic function, myocardial apoptosis rate, and expression of collagen type I (Col I), Col III, CD147, matrix metalloproteinase 9 (MMP-9), and tissue inhibitor of metalloproteinase 1 (TIMP-1) were detected by hematoxylin-eosin staining, TUNEL assay, and western blot...
June 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29708004/traumatic-glioblastoma-commentary-and-suggested-mechanism
#8
Nissim Ohana, Daniel Benharroch, Dimitri Sheinis, Abraham Cohen
The role of head trauma in the development of glioblastoma is highly controversial and has been minimized since first put forward. This is not unexpected because skull injuries are overwhelmingly more common than glioblastoma. This paper presents a commentary based on the contributions of James Ewing, who established a major set of criteria for the recognition of an official relationship between trauma and cancer. Ewing's criteria were very stringent. The scholars who succeeded Ewing have facilitated the characterization of traumatic brain injuries since the introduction of computed tomography and magnetic resonance imaging...
June 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29614897/effect-of-oral-nutritional-supplementation-on-growth-and-recurrent-upper-respiratory-tract-infections-in-picky-eating-children-at-nutritional-risk-a-randomized-controlled-trial
#9
Apurba K Ghosh, Bala Kishore, Irfan Shaikh, Vinita Satyavrat, Anil Kumar, Tapan Shah, Prahlad Pote, Sandeep Shinde, Yatin Berde, Yen Ling Low, Verena M H Tan, Dieu T T Huynh
Objectives To evaluate the effect of oral nutritional supplementation (ONS) plus dietary counselling (DC) (intervention) versus DC alone (control) on growth and upper respiratory tract infection (URTI) in nutritionally at-risk, picky eating children in India. Methods We performed a 90-day, prospective, randomized, controlled trial. A total of 255 children aged 24-72 months with a weight-for-age z-score ≥-2 and <-1, picky eating behaviour, and acute URTI were randomized to the control (n = 128) or intervention group (n = 127)...
June 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29584526/corrected-qt-interval-prolongation-during-anesthetic-induction-for-laryngeal-mask-airway-insertion-with-or-without-cisatracurium
#10
Chengluan Xuan, Nan Wu, Yanhui Li, Xiaoting Sun, Qunshu Zhang, Haichun Ma
Objective This study was performed to observe the occurrence of corrected QT (QTc) interval prolongation during anesthetic induction for laryngeal mask airway insertion and the effects of cisatracurium administration on the QTc interval. Methods Eighty-eight patients were assigned to two groups: the cisatracurium administration group (n = 45) and non-cisatracurium administration group (n = 43). The QTc interval was continuously recorded by a 12-lead Holter electrocardiogram beginning in the hospital ward and continuing until after anesthetic induction...
May 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29569987/inhibitory-effects-of-cp-on-the-growth-of-human-gastric-adenocarcinoma-bgc-823-tumours-in-nude-mice
#11
Hai-Jun Wang, Yu Liu, Bao-Jun Zhou, Zhan-Xue Zhang, Ai-Ying Li, Ran An, Bin Yue, Li-Qiao Fan, Yong Li
Objective To investigate the potential antitumour effects of [2-(6-amino-purine-9-yl)-1-hydroxy-phosphine acyl ethyl] phosphonic acid (CP) against gastric adenocarcinoma. Methods Human BGC-823 xenotransplants were established in nude mice. Animals were randomly divided into control and CP groups, which were administered NaHCO3 vehicle alone or CP dissolved in NaHCO3 (200 µg/kg body weight) daily, respectively. Tumour volume was measured weekly for 6 weeks. Resected tumours were assayed for proliferative activity with anti-Ki-67 or anti-proliferating cell nuclear antigen (PCNA) antibodies...
May 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29569985/predictive-risk-factors-of-failed-laryngeal-mask-airway-insertion-at-first-attempt
#12
Jia Wang, Xiaoping Shi, Tao Xu, Geng Wang
Objectives A failed first attempt at laryngeal mask airway (LMA) insertion could increase the risk of laryngospasm, hypoxemia, and postoperative sore throat. This study was performed to investigate the risk factors for failed first-attempt LMA placement. Methods In total, 461 patients who underwent general anesthesia with a Supreme LMA (Teleflex Medical, Shanghai, China) and who had an American Society of Anesthesiologists (ASA) physical status of I to III were prospectively enrolled. The LMA was inserted after anesthetic induction...
May 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29569965/analysis-of-risk-factors-for-cervical-lymph-node-metastases-in-patients-with-sporadic-medullary-thyroid-carcinoma
#13
Weina Fan, Cheng Xiao, Fusheng Wu
Objective Medullary thyroid carcinoma (MTC) is classified as either sporadic or inherited. This study was performed to analyze the risk factors for cervical lymph node metastases and predict the indication for prophylactic lateral neck dissection in patients with sporadic MTC. Methods Sixty-five patients with sporadic MTC were retrospectively reviewed. Univariate analysis with the chi-square test and multiple logistic regression analysis were applied to identify the clinicopathological features (sex, age, tumor size, number of tumor foci, capsule or vascular invasion, and others) associated with cervical lymph node metastases...
May 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29569963/analysis-of-alterations-in-white-matter-integrity-of-adult-patients-with-comitant-exotropia
#14
Dan Li, Shenghong Li, Xianjun Zeng
Objective This study was performed to investigate structural abnormalities of the white matter in patients with comitant exotropia using the tract-based spatial statistics (TBSS) method. Methods Diffusion tensor imaging data from magnetic resonance images of the brain were collected from 20 patients with comitant exotropia and 20 age- and sex-matched healthy controls. The FMRIB Software Library was used to compute the diffusion measures, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD)...
May 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29562812/balanced-scorecard-based-performance-evaluation-of-chinese-county-hospitals-in-underdeveloped-areas
#15
Hongda Gao, He Chen, Jun Feng, Xianjing Qin, Xuan Wang, Shenglin Liang, Jinmin Zhao, Qiming Feng
Objective Since the Guangxi government implemented public county hospital reform in 2009, there have been no studies of county hospitals in this underdeveloped area of China. This study aimed to establish an evaluation indicator system for Guangxi county hospitals and to generate recommendations for hospital development and policymaking. Methods A performance evaluation indicator system was developed based on balanced scorecard theory. Opinions were elicited from 25 experts from administrative units, universities and hospitals and the Delphi method was used to modify the performance indicators...
May 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29562793/wolff-parkinson-white-syndrome-and-noncompaction-in-leber-s-hereditary-optic-neuropathy-due-to-the-variant-m-3460g-a
#16
Josef Finsterer, Claudia Stollberger, Edmund Gatterer
This report describes a 66-year-old Caucasian male who acutely developed severe, bilateral impairment of visual acuity at 24 years of age. Leber's hereditary optic neuropathy (LHON) was suspected but the diagnosis was not genetically confirmed until the age of 49 years when the primary LHON mutation m.3460G>A was detected. Since onset, visual acuity had slightly improved. The family history was positive for LHON (brother, two sisters of mother, female cousin) and genetically confirmed in his brother and one aunt...
May 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29560772/rivaroxaban-versus-nadroparin-for-preventing-deep-venous-thrombosis-after-total-hip-arthroplasty-following-femoral-neck-fractures-a-retrospective-comparative-study
#17
Chi Zhang, Bo Xu, Guanzhao Liang, Xianshang Zeng, Chen Yang, Fan Zhang, Zi Wan, Weiguang Yu, Deng Chen, Zhe Ge, Xinchao Zhang
Objective This study was performed to evaluate the efficacy of rivaroxaban versus nadroparin for preventing deep venous thrombosis (DVT) in elderly patients with osteoporosis undergoing initial total hip arthroplasty (THA) for femoral neck fractures. Methods Prospectively maintained databases were reviewed to retrospectively compare elderly patients with osteoporosis who underwent initial THA for femoral neck fractures from 2007 to 2015. The patients received peroral rivaroxaban at 10 mg/day for 2 weeks or subcutaneous injections of nadroparin at 0...
May 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29557300/treatment-with-triple-combination-of-atorvastatin-perindopril-and-amlodipine-in-patients-with-stable-coronary-artery-disease-a-subgroup-analysis-from-the-papa-cad-study
#18
Csaba András Dézsi
Background In patients with stable coronary artery disease, aspirin, a statin, and an angiotensin-converting enzyme inhibitor are recommended as first-line agents for secondary prevention. Subgroup analyses of the previously published Hungarian Perindopril plus Amlodipine in PAtients with Coronary Artery Disease (PAPA-CAD) non-interventional trial demonstrated that the addition of the metabolically beneficial, fixed combination of perindopril + amlodipine to atorvastatin further improves the patient's lipid profile...
May 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29557270/integrated-approach-to-pain-management-for-a-patient-with-multiple-bone-metastases-of-uterine-cervical-cancer
#19
De-An Qin, Jie-Fu Song, Li-Ping Song, Gui-Sheng Feng
Background Pain management for multiple bone metastases is complex and often requires multidisciplinary treatment. We herein describe patient-centered multidisciplinary pain management for metastatic cancer. CASE PRESENTATION: A 61-year-old woman with multiple bone metastases of uterine cervical cancer developed intractable low back pain. After external beam radiotherapy failed, we performed lumbar spinal intralesional curettage, pedicle screw fixation, and nerve decompression. However, the neuralgia persisted...
May 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29557269/acute-diffuse-alveolar-haemorrhage-accompanied-by-gastrointestinal-bleeding-in-a-patient-with-serious-systemic-lupus-erythematosus-a-case-report
#20
Jing Du, Ying Wang, Yan-Chun Li, Tong-Tong Wang, Yong-Lie Zhou, Zhen-Hua Ying
Systemic lupus erythematosus (SLE) is an autoimmune disease that affects many organs, but multisystem dysfunction is rare. Here, we report a case of a 29-year-old woman who was initially diagnosed with SLE complications including lupus nephritis, lupus encephalopathy, renal hypertension, thrombocytopenia, anaemia and hyperkalaemia. She recovered following treatment with high dose methylprednisolone, intravenous immunoglobulin (IVIG) and continuous renal replacement therapy (CRRT). However, a few days after hospital discharge, she developed gastrointestinal bleeding...
May 2018: Journal of International Medical Research
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