Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer.

Kelly Cristina da Silva Oliveira, Taíssa Maíra Thomaz Araújo, Camila Inagaki Albuquerque, Gabriela Alcantara Barata, Carolina Oliveira Gigek, Mariana Ferreira Leal, Fernanda Wisnieski, Fernando Augusto Rodrigues Mello Junior, André Salim Khayat, Paulo Pimentel de Assumpção, Rommel Mário Rodriguez Burbano, Marília Cardoso Smith, Danielle Queiroz Calcagno

World Journal of Gastroenterology : WJG 2016 September 22

Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the role of miRNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on miRNA activity.

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