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World Journal of Gastroenterology: WJG

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https://www.readbyqxmd.com/read/29991881/liposarcoma-of-the-stomach-report-of-two-cases-and-review-of-the-literature
#1
Wen-Zhe Kang, Li-Yan Xue, Gui-Qi Wang, Fu-Hai Ma, Xiao-Long Feng, Lei Guo, Yang Li, Wei-Kun Li, Yan-Tao Tian
Liposarcoma of the stomach is extremely rare, and only 37 cases have been reported worldwide. We herein report two cases of liposarcoma of the stomach. The first patient was referred to our hospital with upper abdominal discomfort. The endoscopic examination revealed a tumor mass about 3 cm in diameter. The patient underwent a partial gastrectomy and had an uneventful recovery. The histopathological examination revealed a well-differentiated liposarcoma. The second patient had symptoms of upper abdominal discomfort combined with nausea and anorexia...
July 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29991880/systematic-review-and-meta-analysis-on-the-association-of-tuberculosis-in-crohn-s-disease-patients-treated-with-tumor-necrosis-factor-%C3%AE-inhibitors-anti-tnf%C3%AE
#2
Brent L Cao, Ahmad Qasem, Robert C Sharp, Latifa S Abdelli, Saleh A Naser
AIM: To perform a meta-analysis on the risk of developing Mycobacterium tuberculosis (TB) infection in Crohn's disease (CD) patients treated with tumor necrosis factor-alpha (TNFα) inhibitors. METHODS: A meta-analysis of randomized, double-blind, placebo-controlled trials of TNFα inhibitors for treatment of CD in adults was conducted. Arcsine transformation of TB incidence was performed to estimate risk difference. A novel epidemiologically-based correction (EBC) enabling inclusions of studies reporting no TB infection cases in placebo and treatment groups was developed to estimate relative odds...
July 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29991879/current-global-trends-in-the-incidence-of-pediatric-onset-inflammatory-bowel-disease
#3
Josef Sýkora, Renáta Pomahačová, Marcela Kreslová, Dominika Cvalínová, Přemysl Štych, Jan Schwarz
AIM: To perform a comprehensive review and provide an up-to-date synopsis of the incidence and trends of inflammatory bowel disease (IBD). METHODS: We systematically searched the MEDLINE (source PubMed), EMBASE and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (period: 1985-2018) to identify studies reporting population-based data on the incidence of pediatric-onset (< 19 years at diagnosis) IBD in full manuscripts...
July 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29991878/transforming-growth-factor-%C3%AE-and-peripheral-regulatory-cells-are-negatively-correlated-with-the-overall-survival-of-hepatocellular-carcinoma
#4
Yang An, Song Gao, Wen-Chao Zhao, Bao-An Qiu, Nian-Xin Xia, Peng-Jun Zhang, Zhen-Ping Fan
AIM: To understand the cellular and molecular changes in peripheral blood that can lead to the development of hepatocellular carcinoma (HCC) and provide new methods for its diagnosis and treatment. METHODS: Peripheral blood mononuclear cells were isolated from the peripheral blood of HCC patients and normal controls and then analyzed by flow cytometry. The percentage of transforming growth factor-β (TGF-β)+ regulatory cells (Tregs) in the peripheral blood was measured, and the expression of TGF-β was also determined...
July 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29991877/gastric-cancer-in-alaska-native-people-a-cancer-health-disparity
#5
Holly A Martinson, Nancy J Shelby, Steven R Alberts, Matthew J Olnes
AIM: To evaluate recent trends in gastric cancer incidence, response to treatment, and overall survival among Alaska Native (AN) people. METHODS: A retrospective analysis of the Alaska Native Medical Center patient database was performed. Patient history, clinical, pathological, response to treatment and patient outcomes were collected from one-hundred and thirty-two AN gastric cancer patients. The Surveillance, Epidemiology and End Result database 18 was used to collect comparison United States non-Hispanic White (NHW) and AN gastric cancer patient data between 2006-2014...
July 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29991876/intra-individual-comparison-of-therapeutic-responses-to-vascular-disrupting-agent-ca4p-between-rodent-primary-and-secondary-liver-cancers
#6
Ye-Wei Liu, Frederik De Keyzer, Yuan-Bo Feng, Feng Chen, Shao-Li Song, Johan Swinnen, Guy Bormans, Raymond Oyen, Gang Huang, Yi-Cheng Ni
AIM: To compare therapeutic responses of a vascular-disrupting-agent, combretastatin-A4-phosphate (CA4P), among hepatocellular carcinomas (HCCs) and implanted rhabdomyosarcoma (R1) in the same rats by magnetic-resonance-imaging (MRI), microangiography and histopathology. METHODS: Thirty-six HCCs were created by diethylnitrosamine gavage in 14 rats that were also intrahepatically implanted with one R1 per rat as monitored by T2-/T1-weighted images (T2WI/T1WI) on a 3...
July 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29991875/minimally-invasive-donor-hepatectomy-are-we-ready-for-prime-time
#7
REVIEW
Kin Pan Au, Kenneth Siu Ho Chok
Minimally invasive surgery potentially reduces operative morbidities. However, pure laparoscopic approaches to donor hepatectomy have been limited by technical complexity and concerns over donor safety. Reduced-wound donor hepatectomy, either in the form of a laparoscopic-assisted technique or by utilizing a mini-laparotomy wound, i.e ., hybrid approach, has been developed to bridge the transition to pure laparoscopic donor hepatectomy, offering some advantages of minimally invasive surgery. To date, pure laparoscopic donor left lateral sectionectomy has been validated for its safety and advantages and has become the standard in experienced centres...
July 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29991874/advances-in-immuno-oncology-biomarkers-for-gastroesophageal-cancer-programmed-death-ligand-1-microsatellite-instability-and-beyond
#8
REVIEW
Emily M Lin, Jun Gong, Samuel J Klempner, Joseph Chao
Blockade of the programmed death ligand 1 (PD-L1) and programmed cell death 1 (PD-1) receptor axis represents an effective form of cancer immunotherapy. Preclinical evidence initially suggested that gastric and gastroesophageal junction (GEJ) cancers are potentially immunotherapy-sensitive tumors. Early phase clinical trials have demonstrated promising antitumor activity with PD-1/PD-L1 blockade in advanced or metastatic gastric/GEJ cancer. Microsatellite instability (MSI) and PD-L1 expression have been shown to predict higher response to PD-1 inhibitors as highlighted by the recent approvals of pembrolizumab in treatment-refractory solid tumors with MSI status and the third-line or greater treatment of PD-L1 positive advanced gastric/GEJ cancers...
July 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29991873/diets-functional-foods-and-nutraceuticals-as-alternative-therapies-for-inflammatory-bowel-disease-present-status-and-future-trends
#9
REVIEW
Mohammad Al Mijan, Beong Ou Lim
Inflammatory bowel disease (IBD) is a serious health concern among western societies. The disease is also on the rise in some East Asian countries and in Australia. Health professionals and dietitians around the world are facing an unprecedented challenge to prevent and control the increasing prevalence of IBD. The current therapeutic strategy that includes drugs and biological treatments is inefficient and are associated with adverse health consequences. In this context, the use of natural products is gaining worldwide attention...
July 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29991872/apoptosis-and-non-alcoholic-fatty-liver-diseases
#10
REVIEW
Tatsuo Kanda, Shunichi Matsuoka, Motomi Yamazaki, Toshikatsu Shibata, Kazushige Nirei, Hiroshi Takahashi, Tomohiro Kaneko, Mariko Fujisawa, Teruhisa Higuchi, Hitomi Nakamura, Naoki Matsumoto, Hiroaki Yamagami, Masahiro Ogawa, Hiroo Imazu, Kazumichi Kuroda, Mitsuhiko Moriyama
The number of patients with nonalcoholic fatty liver diseases (NAFLD) including nonalcoholic steatohepatitis (NASH), has been increasing. NASH causes cirrhosis and hepatocellular carcinoma (HCC) and is one of the most serious health problems in the world. The mechanism through which NASH progresses is still largely unknown. Activation of caspases, Bcl-2 family proteins, and c-Jun N-terminal kinase-induced hepatocyte apoptosis plays a role in the activation of NAFLD/NASH. Apoptotic hepatocytes stimulate immune cells and hepatic stellate cells toward the progression of fibrosis in the liver through the production of inflammasomes and cytokines...
July 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29991871/role-of-micrornas-in-the-main-molecular-pathways-of-hepatocellular-carcinoma
#11
REVIEW
Francesco Vasuri, Michela Visani, Giorgia Acquaviva, Thomas Brand, Michelangelo Fiorentino, Annalisa Pession, Giovanni Tallini, Antonia D'Errico, Dario de Biase
Hepatocellular carcinoma (HCC) is the most common primary liver malignant neoplasia. HCC is characterized by a poor prognosis. The need to find new molecular markers for its diagnosis and prognosis has led to a progressive increase in the number of scientific studies on this topic. MicroRNAs (miRNAs) are small non-coding RNA that play a role in almost all main cellular pathways. miRNAs are involved in the regulation of expression of the major tumor-related genes in carcinogenesis, acting as oncogenes or tumor suppressor genes...
July 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29962820/primary-hepatic-neuroendocrine-tumor-case-with-a-preoperative-course-of-26-years-a-case-report-and-literature-review
#12
Xiang-Fei Meng, Ying-Wei Pan, Zhan-Bo Wang, Wei-Dong Duan
Primary hepatic neuroendocrine tumor (PHNET) is an extremely rare liver tumor. Patients often have no clinical symptoms or have only non-specific symptoms, such as abdominal pain and abdominal mass. The clinical manifestations, disease development, treatment methods, and treatment outcomes of PHNET vary greatly among cases. Here we report a case of PHNET with a confirmed 26-year survival before surgery. The patient was a 56-year-old female. A large right hepatic mass was detected when the patient was 30 years old...
June 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29962819/comparison-between-uncut-roux-en-y-and-roux-en-y-reconstruction-after-distal-gastrectomy-for-gastric-cancer-a-meta-analysis
#13
Ming-Ming Sun, Yi-Yi Fan, Sheng-Chun Dang
AIM: To compare uncut Roux-en-Y (U-RY) gastrojejunostomy with Roux-en-Y (RY) gastrojejunostomy after distal gastrectomy (DG) for gastric cancer. METHODS: A literature search was conducted in Pubmed, Embase, Web of Science, Cochrane Library, Science Direct, Chinese National Knowledge Infrastructure, Wanfang, and China Science and Technology Journal Database to identify studies comparing U-RY with RY after DG for gastric cancer until the end of December 2017. Pooled odds ratio or weighted mean difference with 95% confidence interval was calculated using either fixed- or random-effects models...
June 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29962818/mediterranean-dietary-components-are-inversely-associated-with-advanced-colorectal-polyps-a-case-control-study
#14
Naomi Fliss-Isakov, Revital Kariv, Muriel Webb, Dana Ivancovsky, Dana Margalit, Shira Zelber-Sagi
AIM: To evaluate the association between the Mediterranean diet (MD) pattern and its components, and advanced colorectal polyps (adenoma and serrated adenoma). METHODS: A case-control study among patients undergoing screening, diagnostic or surveillance colonoscopies during 2010-2015 at the Tel-Aviv Medical Center, Gastroenterology Department. Cases with advanced polyps were defined as: Advanced adenoma [> 10 mm, with features of high grade dysplasia (HGD) or villous histology], advanced serrated adenoma (> 10 mm or with dysplasia) or multiple (≥ 3) non-advanced adenomas or serrated adenomas...
June 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29962817/bioinformatics-analysis-of-aberrantly-methylated-differentially-expressed-genes-and-pathways-in-hepatocellular-carcinoma
#15
Liang Sang, Xue-Mei Wang, Dong-Yang Xu, Wen-Jing Zhao
AIM: To discover methylated-differentially expressed genes (MDEGs) in hepatocellular carcinoma (HCC) and to explore relevant hub genes and potential pathways. METHODS: The data of expression profiling GSE25097 and methylation profiling GSE57956 were gained from GEO Datasets. We analyzed the differentially methylated genes and differentially expressed genes online using GEO2R. Functional and enrichment analyses of MDEGs were conducted using the DAVID database. A protein-protein interaction (PPI) network was performed by STRING and then visualized in Cytoscape...
June 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29962816/novel-serum-micrornas-panel-on-the-diagnostic-and-prognostic-implications-of-hepatocellular-carcinoma
#16
Yang An, Song Gao, Wen-Chao Zhao, Bao-An Qiu, Nian-Xin Xia, Peng-Jun Zhang, Zhen-Ping Fan
AIM: To determine a panel of serum microRNAs (miRNAs) that could be used as novel biomarkers for diagnosis of hepatocellular carcinoma (HCC). METHODS: We initially screened 9 out of 754 serum miRNAs by TaqMan Low Density Array in two pooled samples respectively from 35 HCC and 35 normal controls, and then validated individually by RT-qPCR in another 114 patients and 114 controls arranged in two phases. The changes of the selected miRNAs after operation and their prognostic value were examined...
June 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29962815/direct-acting-antivirals-and-hepatocellular-carcinoma-in-chronic-hepatitis-c-a-few-lights-and-many-shadows
#17
REVIEW
Maria Guarino, Anna Sessa, Valentina Cossiga, Federica Morando, Nicola Caporaso, Filomena Morisco
With the introduction of direct-acting antiviral agents (DAA), the rate of sustained virological response (SVR) in the treatment of hepatitis C virus (HCV) has radically improved to over 95%. Robust scientific evidence supports a beneficial role of SVR after interferon therapy in the progression of cirrhosis, resulting in a decreased incidence of hepatocellular carcinoma (HCC). However, a debate on the impact of DAAs on the development of HCC is ongoing. This review aimed to analyse the scientific literature regarding the risk of HCC in terms of its recurrence and occurrence after the use of DAAs to eradicate HCV infection...
June 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29962814/tumor-heterogeneity-of-gastric-cancer-from-the-perspective-of-tumor-initiating-cell
#18
REVIEW
Jian-Peng Gao, Wei Xu, Wen-Tao Liu, Min Yan, Zheng-Gang Zhu
Gastric cancer (GC) remains one of the most common and malignant types of cancer due to its rapid progression, distant metastasis, and resistance to conventional chemotherapy, although efforts have been made to understand the underlying mechanism of this resistance and to improve clinical outcome. It is well recognized that tumor heterogeneity, a fundamental feature of malignancy, plays an essential role in the cancer development and chemoresistance. The model of tumor-initiating cell (TIC) has been proposed to explain the genetic, histological, and phenotypical heterogeneity of GC...
June 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29962813/hepatitis-c-virus-infection-in-children-in-the-era-of-direct-acting-antiviral
#19
REVIEW
Malgorzata Pawlowska, Malgorzata Sobolewska-Pilarczyk, Krzysztof Domagalski
Hepatitis C virus (HCV) infection remains an important global health problem with chronic infection affecting approximately 11 million children worldwide. The emergence of direct-acting antiviral (DAA) therapies and the development of non-invasive methods for the determination of liver fibrosis will significantly improve the management of paediatric patients with chronic HCV infection in subsequent years. For paediatric patients, a new era of highly effective DAA agents is beginning, and the first results of available clinical trials are very promising...
June 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29962812/glycoprotein-biomarkers-for-the-detection-of-pancreatic-ductal-adenocarcinoma
#20
REVIEW
Esther Llop, Pedro E Guerrero, Adrià Duran, Sílvia Barrabés, Anna Massaguer, María José Ferri, Maite Albiol-Quer, Rafael de Llorens, Rosa Peracaula
Pancreatic cancer (PaC) shows a clear tendency to increase in the next years and therefore represents an important health and social challenge. Currently, there is an important need to find biomarkers for PaC early detection because the existing ones are not useful for that purpose. Recent studies have indicated that there is a large window of time for PaC early detection, which opens the possibility to find early biomarkers that could greatly improve the dismal prognosis of this tumor. The present manuscript reviews the state of the art of the existing PaC biomarkers...
June 28, 2018: World Journal of Gastroenterology: WJG
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