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World Journal of Gastroenterology: WJG

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https://www.readbyqxmd.com/read/30197486/neurofibromatosis-type-1-associated-multiple-rectal-neuroendocrine-tumors-a-case-report-and-review-of-the-literature
#1
Rui Xie, Kuang-I Fu, Shao-Min Chen, Bi-Guang Tuo, Hui-Chao Wu
Neurofibromatosis type 1 (NF-1) is commonly associated with benign or malignant tumors in both the central and peripheral nervous systems. However, rare cases of NF-1-associated multiple rectal neuroendocrine tumors have been reported. This report describes a case of a 39 year old female with NF-1 and intermittent hematochezia as a primary symptom. Physical examination showed multiple subcutaneous nodules and café au lait spots with obvious scoliosis of the back. Imaging examinations and colonoscopy found malformation of the left external iliac vein and multiple gray-yellow nodules with varying sizes and shapes in the rectal submucosal layer...
September 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30197485/percutaneous-transhepatic-extraction-and-balloon-dilation-for-simultaneous-gallbladder-stones-and-common-bile-duct-stones-a-novel-technique
#2
Bin Liu, De-Shun Wu, Pi-Kun Cao, Yong-Zheng Wang, Wu-Jie Wang, Wei Wang, Hai-Yang Chang, Dong Li, Xiao Li, Yancu Hertzanu, Yu-Liang Li
AIM: To evaluate the clinical efficacy and safety of an innovative percutaneous transhepatic extraction and balloon dilation (PTEBD) technique for clearance of gallbladder stones in patients with concomitant stones in the common bile duct (CBD). METHODS: The data from 17 consecutive patients who underwent PTEBD for clearance of gallbladder stones were retrospectively analyzed. After removal of the CBD stones by percutaneous transhepatic balloon dilation (PTBD), the gallbladder stones were extracted to the CBD and pushed into the duodenum with a balloon after dilation of the sphincter of Oddi...
September 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30197484/differentiation-of-intrahepatic-cholangiocarcinoma-from-hepatocellular-carcinoma-in-high-risk-patients-a-predictive-model-using-contrast-enhanced-ultrasound
#3
Li-Da Chen, Si-Min Ruan, Jin-Yu Liang, Zheng Yang, Shun-Li Shen, Yang Huang, Wei Li, Zhu Wang, Xiao-Yan Xie, Ming-De Lu, Ming Kuang, Wei Wang
AIM: To develop a contrast-enhanced ultrasound (CEUS) predictive model for distinguishing intrahepatic cholangiocarcinoma (ICC) from hepatocellular carcinoma (HCC) in high-risk patients. METHODS: This retrospective study consisted of 88 consecutive high-risk patients with ICC and 88 high-risk patients with HCC selected by propensity score matching between May 2004 and July 2016. Patients were assigned to two groups, namely, a training set and validation set, at a 1:1 ratio...
September 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30197483/secondary-endoscopic-submucosal-dissection-for-locally-recurrent-or-incompletely-resected-gastric-neoplasms
#4
Da Hyun Jung, Young Hoon Youn, Jie-Hyun Kim, Jae Jun Park, Hyojin Park
AIM: To investigate the feasibility and safety of secondary endoscopic submucosal dissection (ESD) for residual or locally recurrent gastric tumors. METHODS: Between 2010 and 2017, 1623 consecutive patients underwent ESD for gastric neoplasms at a single tertiary referral center. Among these, 28 patients underwent secondary ESD for a residual or locally recurrent tumor. Our analysis compared clinicopathologic factors between primary ESD and secondary ESD groups...
September 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30197482/beta-blockers-and-physical-frailty-in-patients-with-end-stage-liver-disease
#5
Selena Z Kuo, Blanca Lizaola, Hilary Hayssen, Jennifer C Lai
AIM: To investigate beta-blocker (BB) use in patients with cirrhosis and determine their effects on physical frailty and overall survival. METHODS: Adult outpatients with cirrhosis listed for liver transplantation underwent testing of physical frailty using the performance-based Liver Frailty Index, comprised of chair stands, grip strength, and balance testing, as well as self-reported assessments of exhaustion and physical activity. BB use was assessed from medical chart review...
September 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30197481/metabolomic-alterations-and-chromosomal-instability-status-in-gastric-cancer
#6
Cheng-Kun Tsai, Ta-Sen Yeh, Ren-Chin Wu, Ying-Chieh Lai, Meng-Han Chiang, Kuan-Ying Lu, Cheng-Yu Hung, Hung-Yao Ho, Mei-Ling Cheng, Gigin Lin
AIM: To explore the correlation of metabolomics profiles of gastric cancer (GC) with its chromosomal instability (CIN) status. METHODS: Nineteen GC patients were classified as CIN and non-CIN type by The Cancer Genome Atlas Research Group system, based on 409 oncogenes and tumor suppressor genes sequenced. The aqueous metabolites of the GC tumor and its surrounding adjacent healthy tissues were identified through liquid chromatography-mass spectrometry. Groups were compared by defining variable importance in projection score of > 1...
September 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30197480/establishment-functional-and-genetic-characterization-of-a-colon-derived-large-cell-neuroendocrine-carcinoma-cell-line
#7
Michael Gock, Christina S Mullins, Christine Harnack, Friedrich Prall, Robert Ramer, Anja Göder, Oliver H Krämer, Ernst Klar, Michael Linnebacher
AIM: To establish cell line and patient-derived xenograft (PDX) models for neuroendocrine carcinomas (NEC) which is highly desirable for gaining insight into tumor development as well as preclinical research including biomarker testing and drug response prediction. METHODS: Cell line establishment was conducted from direct in vitro culturing of colonic NEC tissue (HROC57). A PDX could also successfully be established from vitally frozen tumor samples. Morphological features, invasive and migratory behavior of the HROC57 cells as well as expression of neuroendocrine markers were vastly analyzed...
September 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30197479/antiangiogenic-therapy-for-portal-hypertension-in-liver-cirrhosis-current-progress-and-perspectives
#8
REVIEW
Dmitry Victorovich Garbuzenko, Nikolay Olegovich Arefyev, Evgeniy Leonidovich Kazachkov
Developing medicines for hemodynamic disorders that are characteristic of cirrhosis of the liver is a relevant problem in modern hepatology. The increase in hepatic vascular resistance to portal blood flow and subsequent hyperdynamic circulation underlie portal hypertension (PH) and promote its progression, despite the formation of portosystemic collaterals. Angiogenesis and vascular bed restructurization play an important role in PH pathogenesis as well. In this regard, strategic directions in the therapy for PH in cirrhosis include selectively decreasing hepatic vascular resistance while preserving or increasing portal blood flow, and correcting hyperdynamic circulation and pathological angiogenesis...
September 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30197478/long-non-coding-rnas-involved-in-metastasis-of-gastric-cancer
#9
REVIEW
Meng-Ting Lin, Hao-Jun Song, Xiao-Yun Ding
Gastric cancer (GC) is one of the most frequently diagnosed malignant diseases. The molecular mechanisms of metastasis remain unclear. Recently, studies have shown that long non-coding RNAs (lncRNAs) play critical roles in metastasis. Therefore, deeper understanding of this mechanism could provide potential diagnostic tools and therapeutic targets for metastatic GC. This review focuses on dysregulated lncRNAs in GC metastases. Due to the identification of multiple diverse mechanisms involved in GC metastasis, we classified them into seven categories, including lncRNAs related to epithelial-mesenchymal transition, regulation of degradation of extracellular matrix, angiopoiesis, vasculogenic mimicry, and immunologic escape...
September 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30197477/p21-activated-kinase-signalling-in-pancreatic-cancer-new-insights-into-tumour-biology-and-immune-modulation
#10
REVIEW
Kai Wang, Graham S Baldwin, Mehrdad Nikfarjam, Hong He
Pancreatic cancer is one of the most aggressive and lethal malignancies worldwide, with a very poor prognosis and a five-year survival rate less than 8%. This dismal outcome is largely due to delayed diagnosis, early distant dissemination and resistance to conventional chemo-therapies. Kras mutation is a well-defined hallmark of pancreatic cancer, with over 95% of cases harbouring Kras mutations that give rise to constitutively active forms of Kras. As important down-stream effectors of Kras, p21-activated kinases (PAKs) are involved in regulating cell proliferation, apoptosis, invasion/migration and chemo-resistance...
September 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30197476/updates-on-the-hepatocyte-growth-factor-c-met-axis-in-hepatocellular-carcinoma-and-its-therapeutic-implications
#11
REVIEW
Javier A García-Vilas, Miguel Ángel Medina
Hepatocellular carcinoma (HCC) is the fifth most common cancer and is the second leading cause of cancer death. Since the diagnosis of HCC is difficult, in many cases patients with HCC are diagnosed advanced stage of development. Hepatocyte growth factor (HGF)/c-mesenchymal-epithelial transition receptor (c-Met) axis is a key signaling pathway in HCC, either via canonical or non-canonical pathways. Available treatments against HCC based upon HGF/c-Met inhibition can increase patient lifespan, but do not reach the expected therapeutic benefits...
September 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30197475/from-bench-to-bedside-fecal-calprotectin-in-inflammatory-bowel-diseases-clinical-setting
#12
REVIEW
Maria Gloria Mumolo, Lorenzo Bertani, Linda Ceccarelli, Gabriella Laino, Giorgia Di Fluri, Eleonora Albano, Gherardo Tapete, Francesco Costa
Fecal calprotectin (FC) has emerged as one of the most useful tools for clinical management of inflammatory bowel diseases (IBD). Many different methods of assessment have been developed and different cut-offs have been suggested for different clinical settings. We carried out a comprehensive literature review of the most relevant FC-related topics: the role of FC in discriminating between IBD and irritable bowel syndrome (IBS) and its use in managing IBD patients In patients with intestinal symptoms, due to the high negative predictive value a normal FC level reliably rules out active IBD...
September 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30197474/time-to-think-selecting-patients-who-may-benefit-from-synchronous-resection-of-primary-pancreatic-cancer-and-liver-metastases
#13
EDITORIAL
Si Shi, Xian-Jun Yu
Pancreatic cancer remains a lethal disease and is associated with poor prognosis, particularly for patients with distant metastasis at diagnosis. Recently, Oweira reported a retrospective study that included 13233 metastatic pancreatic cancer patients from the Surveillance, Epidemiology and End Results database. They demonstrated that pancreatic cancer patients with isolated liver metastases had worse outcomes than patients with isolated lung metastases or distant nodal metastases. At present, the standard treatment for metastatic pancreatic cancer is chemotherapy...
September 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30166862/vascular-anatomy-of-inferior-mesenteric-artery-in-laparoscopic-radical-resection-with-the-preservation-of-left-colic-artery-for-rectal-cancer
#14
Ke-Xin Wang, Zhi-Qiang Cheng, Zhi Liu, Xiao-Yang Wang, Dong-Song Bi
AIM: To investigate the vascular anatomy of inferior mesenteric artery (IMA) in laparoscopic radical resection with the preservation of left colic artery (LCA) for rectal cancer. METHODS: A total of 110 patients with rectal cancer who underwent laparoscopic surgical resection with preservation of the LCA were retrospectively reviewed. A 3D vascular reconstruction was performed before each surgical procedure to assess the branches of the IMA. During surgery, the relationship among the IMA, LCA, sigmoid artery (SA) and superior rectal artery (SRA) was evaluated, and the length from the origin of the IMA to the point of branching into the LCA or common trunk of LCA and SA was measured...
August 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30166861/c-peptide-as-a-key-risk-factor-for-non-alcoholic-fatty-liver-disease-in-the-united-states-population
#15
Amporn Atsawarungruangkit, Jirat Chenbhanich, George Dickstein
AIM: To determine whether fasting C-peptide is an independent predictor for non-alcoholic fatty liver disease (NAFLD) in United States population. METHODS: Using the National Health and Nutrition Examination Survey (NHANES) 1988-1994, NAFLD participants aged 20 or greater without any other liver diseases were included in this study. Excessive alcohol intake is defined as > 2 drinks per day for males and > 1 drink per day for females. C-peptide and 27 other factors known to be associated with NAFLD ( e...
August 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30166860/abnormal-expression-of-hmgb-3-is-significantly-associated-with-malignant-transformation-of-hepatocytes
#16
Wen-Jie Zheng, Min Yao, Miao Fang, Li Wang, Zhi-Zhen Dong, Deng-Fu Yao
AIM: To explore the relationship between dynamic expression of high mobility group box-3 (HMGB3) and malignant transformation of hepatocytes. METHODS: Expression of HMGB family proteins were observed in rat hepatocarcinogenesis models induced with 2-acetylaminofluorene. Alterations of HMGB3 were analyzed at the mRNA level by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and at the protein level by immunohistochemistry or Western blotting...
August 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30166859/diagnosis-and-management-of-fibromuscular-dysplasia-and-segmental-arterial-mediolysis-in-gastroenterology-field-a-mini-review
#17
REVIEW
Masayoshi Ko, Kenya Kamimura, Kohei Ogawa, Kentaro Tominaga, Akira Sakamaki, Hiroteru Kamimura, Satoshi Abe, Kenichi Mizuno, Shuji Terai
The vascular diseases including aneurysm, occlusion, and thromboses in the mesenteric lesions could cause severe symptoms and appropriate diagnosis and treatment are essential for managing patients. With the development and improvement of imaging modalities, diagnostic frequency of these vascular diseases in abdominal lesions is increasing even with the small changes in the vasculatures. Among various vascular diseases, fibromuscular dysplasia (FMD) and segmental arterial mediolysis (SAM) are noninflammatory, nonatherosclerotic arterial diseases which need to be diagnosed urgently because these diseases could affect various organs and be lethal if the appropriate management is not provided...
August 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30166858/expansion-of-the-hepatocellular-carcinoma-milan-criteria-in-liver-transplantation-future-directions
#18
REVIEW
Mihai-Calin Pavel, Josep Fuster
Milan criteria are currently the benchmark related to liver transplantation (LT) for hepatocellular carcinoma. However, several groups have proposed different expanded criteria with acceptable results. In this article, we review the current status of LT beyond the Milan criteria in three different scenarios-expanded criteria with cadaveric LT, downstaging to Milan criteria before LT, and expansion in the context of adult living donor LT. The review focuses on three main questions: what would the impact of the expansion beyond Milan criteria be on the patients on the waiting list; whether the dichotomous criteria (yes/no) currently used are appropriate for LT or continuous survival estimations, such as the one of "Metroticket" and whether it should enter into the clinical practice; and, whether the use of living donor LT in the context of expansion beyond Milan criteria is justified...
August 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30166857/-helicobacter-pylori-infection-and-liver-diseases-epidemiology-and-insights-into-pathogenesis
#19
REVIEW
Kazuya Okushin, Takeya Tsutsumi, Kazuhiko Ikeuchi, Akira Kado, Kenichiro Enooku, Hidetaka Fujinaga, Kyoji Moriya, Hiroshi Yotsuyanagi, Kazuhiko Koike
Both Helicobacter pylori ( H. pylori ) infection and liver diseases, including nonalcoholic fatty liver disease (NAFLD), viral hepatitis, and hepatocellular carcinoma (HCC), have high prevalences worldwide, and the relationship between H. pylori infection and liver disease has been discussed for many years. Although positive correlations between H. pylori and NAFLD have been identified in some clinical and experimental studies, negative correlations have also been obtained in high-quality clinical studies. Associations between H...
August 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30166856/prognostic-significance-of-tumor-immune-microenvironment-and-immunotherapy-novel-insights-and-future-perspectives-in-gastric-cancer
#20
REVIEW
Daniela Cornelia Lazăr, Mihaela Flavia Avram, Ioan Romoșan, Mărioara Cornianu, Sorina Tăban, Adrian Goldiș
Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients...
August 28, 2018: World Journal of Gastroenterology: WJG
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