journal
MENU ▼
Read by QxMD icon Read
search

World Journal of Gastroenterology: WJG

journal
https://www.readbyqxmd.com/read/29760546/thiopurines-are-negatively-associated-with-anthropometric-parameters-in-pediatric-crohn-s-disease
#1
Neera Gupta, Robert H Lustig, Cewin Chao, Eric Vittinghoff, Howard Andrews, Cheng-Shiun Leu
AIM: To determine the distribution of anthropometric parameter (AP)- z -scores and characterize associations between medications/serum biomarkers and AP- z -scores in pediatric Crohn's disease (CD). METHODS: CD patients [< chronological age (CA) 21 years] were enrolled in a cross-sectional study. Descriptive statistics were generated for participants' demographic characteristics and key variables of interest. Paired t -tests were used to compare AP- z -scores calculated based on CA (CA z -scores) and bone age (BA) (BA z -scores) for interpretation of AP's...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29760545/quantitative-assessment-of-hepatic-fibrosis-in-chronic-hepatitis-b-and-c-t1-mapping-on-gd-eob-dtpa-enhanced-liver-magnetic-resonance-imaging
#2
Shen Pan, Xiao-Qi Wang, Qi-Yong Guo
AIM: To assess the accuracy of Look-Locker on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for staging liver fibrosis in chronic hepatitis B/C (CHB/C). METHODS: We prospectively included 109 patients with CHB or CHC who underwent a 3.0-Tesla MRI examination, including T1-weighted and Look-Locker sequences for T1 mapping. Hepatocyte fractions (HeF) and relaxation time reduction rate (RE) were measured for staging liver fibrosis...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29760544/ischemia-reperfusion-injury-in-porcine-intestine-viability-assessment
#3
Runar J Strand-Amundsen, Henrik M Reims, Finn P Reinholt, Tom E Ruud, Runkuan Yang, Jan O Høgetveit, Tor I Tønnessen
AIM: To investigate viability assessment of segmental small bowel ischemia/reperfusion in a porcine model. METHODS: In 15 pigs, five or six 30-cm segments of jejunum were simultaneously made ischemic by clamping the mesenteric arteries and veins for 1 to 16 h. Reperfusion was initiated after different intervals of ischemia (1-8 h) and subsequently monitored for 5-15 h. The intestinal segments were regularly photographed and assessed visually and by palpation. Intraluminal lactate and glycerol concentrations were measured by microdialysis, and samples were collected for light microscopy and transmission electron microscopy...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29760543/microbiota-modification-by-probiotic-supplementation-reduces-colitis-associated-colon-cancer-in-mice
#4
Maria Carolina S Mendes, Daiane Sm Paulino, Sandra R Brambilla, Juliana A Camargo, Gabriela F Persinoti, José Barreto C Carvalheira
AIM: To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer (CAC). METHODS: C57BL/6 mice received an intraperitoneal injection of azoxymethane (10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water (5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus , Lactobacillus rhamnosus and Bifidobacterium bifidum . Microbiota composition was assessed by 16S rRNA Illumina HiSeq sequencing...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29760542/mouse-models-for-investigating-the-underlying-mechanisms-of-nonalcoholic-steatohepatitis-derived-hepatocellular-carcinoma
#5
REVIEW
Kazuki Takakura, Tsunekazu Oikawa, Yoichi Tomita, Yusuke Mizuno, Masanori Nakano, Chisato Saeki, Yuichi Torisu, Masayuki Saruta
As the incidence of hepatocellular carcinoma (HCC) caused by infection with the hepatotropic viruses hepatitis B and hepatitis C decreases, greater attention has become focused on HCC caused by nonalcoholic steatohepatitis (NASH), an advanced form of nonalcoholic fatty liver disease which has shown increasing prevalence in correspondence with the overall increase in metabolic syndrome over the recent decades. Several clinical population studies have shown a positive relationship between NASH and HCC, while also providing initial insights into the underlying mechanisms of HCC development from NASH...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29760541/laparoscopic-gastrojejunostomy-for-gastric-outlet-obstruction-in-patients-with-unresectable-hepatopancreatobiliary-cancers-a-personal-series-and-systematic-review-of-the-literature
#6
REVIEW
Alba Manuel-Vázquez, Raquel Latorre-Fragua, Carmen Ramiro-Pérez, Aylhin López-Marcano, Roberto De la Plaza-Llamas, José Manuel Ramia
The major symptoms of advanced hepatopancreatic-biliary cancer are biliary obstruction, pain and gastric outlet obstruction (GOO). For obstructive jaundice, surgical treatment should de consider in recurrent stent complications. The role of surgery for pain relief is marginal nowadays. On the last, there is no consensus for treatment of malignant GOO. Endoscopic duodenal stents are associated with shorter length of stay and faster relief to oral intake with more recurrent symptoms. Surgical gastrojejunostomy shows better long-term results and lower re-intervention rates, but there are limited data about laparoscopic approach...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29760540/ambiguous-roles-of-innate-lymphoid-cells-in-chronic-development-of-liver-diseases
#7
REVIEW
Yue Shen, Jing Li, Si-Qi Wang, Wei Jiang
Innate lymphoid cells (ILCs) are defined as a distinct arm of innate immunity. According to their profile of secreted cytokines and lineage-specific transcriptional factors, ILCs can be categorized into the following three groups: group 1 ILCs (including natural killer (NK) cells and ILC1s) are dependent on T-bet and can produce interferon-γ; group 2 ILCs (ILC2s) are dependent on GATA3 and can produce type 2 cytokines, including interleukin (IL)-5 and IL-13; and, group 3 ILCs (including lymphoid tissue-like cells and ILC3s) are dependent on RORγt and can produce IL-22 and IL-17...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29760539/new-therapeutic-options-opened-by-the-molecular-classification-of-gastric-cancer
#8
REVIEW
Mihaela Chivu-Economescu, Lilia Matei, Laura G Necula, Denisa L Dragu, Coralia Bleotu, Carmen C Diaconu
Gastric cancer (GC) is one of the most lethal and aggressive cancers, being the third cause of cancer related death worldwide. Even with radical gastrectomy and the latest generation of molecular chemotherapeutics, the numbers of recurrence and mortality remains high. This is due to its biological heterogeneity based on the interaction between multiple factors, from genomic to environmental factors, diet or infections with various pathogens. Therefore, understanding the molecular characteristics at a genomic level is critical to develop new treatment strategies...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29760538/gastrointestinal-stromal-tumors-a-multidisciplinary-challenge
#9
REVIEW
Juan Manuel Sanchez-Hidalgo, Manuel Duran-Martinez, Rafael Molero-Payan, Sebastian Rufian-Peña, Alvaro Arjona-Sanchez, Angela Casado-Adam, Antonio Cosano-Alvarez, Javier Briceño-Delgado
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors located in the alimentary tract. Its usual manifestation is gastrointestinal bleeding. However, small asymptomatic lesions are frequently detected as incidental finding. Characteristically, most GISTs (> 95%) are positive for the KIT protein (CD117) by IHC staining and approximately 80%-90% of GISTs carry a mutation in the c-KIT or PDGFRA genes. Mutational analysis should be performed when planning adjuvant and neoadjuvant therapy, due to its possible resistance to conventional treatment...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29740207/development-of-tenofovir-disoproxil-fumarate-resistance-after-complete-viral-suppression-in-a-patient-with-treatment-na%C3%A3-ve-chronic-hepatitis-b-a-case-report-and-review-of-the-literature
#10
Woo Hee Cho, Hyun Jae Lee, Ki Bae Bang, Seok Bae Kim, Il Han Song
Tenofovir disoproxil fumarate (TDF) is a potent nucleotide analogue that is recommended as first-line therapy for patients with chronic hepatitis B. The results of a longitudinal study of TDF treatment demonstrated no development of resistance. We observed one treatment-naïve chronic hepatitis B (CHB) patient who developed TDF resistance after complete viral suppression during long-term TDF treatment. A 37-year-old HBeAg-positive man received TDF 300 mg/d for 43 mo. The hepatitis B virus (HBV) DNA titer was 8 log10 copies/mL at baseline and became undetectable at 16 mo after treatment...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29740206/usefulness-of-three-dimensional-visualization-technology-in-minimally-invasive-treatment-for-infected-necrotizing-pancreatitis
#11
Peng-Fei Wang, Zhi-Wei Liu, Shou-Wang Cai, Jun-Jun Su, Lei He, Jian Feng, Xian-Lei Xin, Shi-Chun Lu
AIM: To explore the value of three-dimensional (3D) visualization technology in the minimally invasive treatment for infected necrotizing pancreatitis (INP). METHODS: Clinical data of 18 patients with INP, who were admitted to the PLA General Hospital in 2017, were retrospectively analyzed. Two-dimensional images of computed tomography were converted into 3D images based on 3D visualization technology. The size, number, shape and position of lesions and their relationship with major abdominal vasculature were well displayed...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29740205/mitochondrial-pathway-mediated-by-reactive-oxygen-species-involvement-in-%C3%AE-hederin-induced-apoptosis-in-hepatocellular-carcinoma-cells
#12
Jiao Li, Dan-Dan Wu, Ji-Xiang Zhang, Jing Wang, Jing-Jing Ma, Xue Hu, Wei-Guo Dong
AIM: To investigate the antitumor activity of α-hederin in hepatocellular carcinoma (HCC) cells and its underlying mechanisms in vitro and in vivo . METHODS: SMMC-7721, HepG-2 and Huh-7 HCC cells were cultured in vitro and treated with α-hederin (0, 5 μmol/L, 10 μmol/L, 15 μmol/L, 20 μmol/L, 25 μmol/L, 30 μmol/L, 35 μmol/L, 40 μmol/L, 45 μmol/L, 50 μmol/L, 55 μmol/L, or 60 μmol/L) for 12 h, 24 h, or 36 h, and cell viability was then detected by the Cell Counting Kit-8...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29740204/oral-treatment-with-plecanatide-or-dolcanatide-attenuates-visceral-hypersensitivity-via-activation-of-guanylate-cyclase-c-in-rat-models
#13
Illona-Marie Boulete, Anusha Thadi, Catherine Beaufrand, Viren Patwa, Apoorva Joshi, John A Foss, E Priya Eddy, Helene Eutamene, Vaseem A Palejwala, Vassilia Theodorou, Kunwar Shailubhai
AIM: To investigate the effects of plecanatide and dolcanatide on maintenance of paracellular permeability, integrity of tight junctions and on suppression of visceral hypersensitivity. METHODS: Transport of fluorescein isothiocyanate (FITC)-dextran was measured to assess permeability across cell monolayers and rat colon tissues. Effects of plecanatide and dolcanatide on the integrity of tight junctions in Caco-2 and T84 monolayers and on the expression and localization of occludin and zonula occludens-1 (ZO-1) were examined by immunofluorescence microscopy...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29740203/olfactomedin-4-in-digestive-diseases-a-mini-review
#14
REVIEW
Xin-Yu Wang, Sheng-Hui Chen, Ya-Nan Zhang, Cheng-Fu Xu
Olfactomedin-4 (OLFM4, GW112, hGC-1) is a glycoprotein belonging to the olfactomedin family. The expression of OLFM4 is strong in the small intestine, colon and prostate, and moderate in the stomach and bone marrow. Previous studies have revealed that OLFM4 is closely associated with many digestive diseases. Up-regulation of OLFM4 has been detected in the Helicobacter pylori ( H. pylori )-infected gastric mucosa, inflammatory bowel disease tissue and gastrointestinal malignancies, including gastric cancer, colorectal cancer, pancreatic cancer and gallbladder cancer...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29740202/anti-integrin-therapy-for-inflammatory-bowel-disease
#15
REVIEW
Sung Chul Park, Yoon Tae Jeen
In inflammatory bowel disease (IBD), tumor necrosis factor plays an important role in mediating inflammation, but several other pathways are also involved in eliciting an inflammatory response. One such pathway is the invasion of the intestinal mucosa by leukocytes. Leukocytes within the systemic circulation move to sites of inflammation, and blocking this pathway could be an important treatment strategy for IBD. Anti-integrin therapy blocks the action of integrin on the surface of circulating immune cells and endothelial cell adhesion molecules, thereby inhibiting the interactions between leukocytes and intestinal blood vessels...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29740201/endoscopic-management-of-crohn-s-strictures
#16
REVIEW
Talat Bessissow, Jason Reinglas, Achuthan Aruljothy, Peter L Lakatos, Gert Van Assche
Symptomatic intestinal strictures develop in more than one third of patients with Crohn's disease (CD) within 10 years of disease onset. Strictures can be inflammatory, fibrotic or mixed and result in a significant decline in quality of life, frequently requiring surgery for palliation of symptoms. Patients under the age of 40 with perianal disease are more likely to suffer from disabling ileocolonic disease thus may have a greater risk for fibrostenotic strictures. Treatment options for fibrostenotic strictures are limited to endoscopic and surgical therapy...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29740200/emergence-of-immunotherapy-as-a-novel-way-to-treat-hepatocellular-carcinoma
#17
REVIEW
Naofumi Mukaida, Yasunari Nakamoto
Tumor immunity proceeds through multiple processes, which consist of antigen presentation by antigen presenting cells (APCs) to educate effector cells and destruction by the effector cytotoxic cells. However, tumor immunity is frequently repressed at tumor sites. Malignantly transformed cells rarely survive the attack by the immune system, but cells that do survive change their phenotypes to reduce their immunogenicity. The resultant cells evade the attack by the immune system and form clinically discernible tumors...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29740199/is-it-possible-to-stop-nucleos-t-ide-analogue-treatment-in-chronic-hepatitis-b-patients
#18
REVIEW
Elia Moreno-Cubero, Robert T Sánchez Del Arco, Julia Peña-Asensio, Eduardo Sanz de Villalobos, Joaquín Míquel, Juan Ramón Larrubia
Chronic hepatitis B (CHB) remains a challenging global health problem, with nearly one million related deaths per year. Nucleos(t)ide analogue (NA) treatment suppresses viral replication but does not provide complete cure of the hepatitis B virus (HBV) infection. The accepted endpoint for therapy is the loss of hepatitis B surface antigen (HBsAg), but this is hardly ever achieved. Therefore, indefinite treatment is usually required. Many different studies have evaluated NA therapy discontinuation after several years of NA treatment and before HBsAg loss...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29713134/compared-efficacy-of-preservation-solutions-on-the-outcome-of-liver-transplantation-meta-analysis
#19
Ágnes Lilla Szilágyi, Péter Mátrai, Péter Hegyi, Eszter Tuboly, Daniella Pécz, András Garami, Margit Solymár, Erika Pétervári, Márta Balaskó, Gábor Veres, László Czopf, Bastian Wobbe, Dorottya Szabó, Juliane Wagner, Petra Hartmann
AIM: To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations. METHODS: A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31st , 2017. The inclusion criteria were comparative, randomized controlled trials (RCTs) for deceased donor liver (DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin (UW) solution or histidine-tryptophan-ketoglutarate (HTK), Celsior (CS) and Institut Georges Lopez (IGL-1) solutions...
April 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29713133/papillary-fistulotomy-vs-conventional-cannulation-for-endoscopic-biliary-access-a-prospective-randomized-trial
#20
Carlos Kiyoshi Furuya, Paulo Sakai, Fabio Ramalho Tavares Marinho, Jose Pinhata Otoch, Spencer Cheng, Lívia Lemes Prudencio, Eduardo Guimarães Hourneaux de Moura, Everson Luiz de Almeida Artifon
AIM: To compare the cannulation success, biochemical profile, and complications of the papillary fistulotomy technique vs catheter and guidewire standard access. METHODS: From July 2010 to May 2017, patients were prospectively randomized into two groups: Cannulation with a catheter and guidewire (Group I) and papillary fistulotomy (Group II). Amylase, lipase and C-reactive protein at T0, as well as 12 h and 24 h after endoscopic retrograde cholangiopancreatography, and complications (pancreatitis, bleeding, perforation) were recorded...
April 28, 2018: World Journal of Gastroenterology: WJG
journal
journal
34574
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"