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Application of The Paris System to atypical urine cytology samples: correlation with histology and UroVysion(®) FISH.
OBJECTIVES: To evaluate whether atypical urine cytology cases may be stratified more objectively using The Paris System (TPS) and whether reclassified cases correlate with histology and UroVysion(®) results.
METHODS: Atypical urine cytology cases subjected to UroVysion(®) testing over a period of 6 years were reviewed. Each case was reclassified according to TPS and correlated with histology and UroVysion(®) results.
RESULTS: A total of 91 cases were identified; 70.3% were reclassified as 'negative for high-grade urothelial carcinoma (HGUC)' and 14.3% as 'atypical urothelial cells (AUC)'. The histological correlation was available in 45 cases. In the 'negative for HGUC' category, 67.9% had no histological evidence of malignancy, but 17.9% were diagnosed as HGUC. In the 'AUC' category, histology revealed urothelial carcinoma in 70% of the cases (of these, 71.4% were high grade). There was no histological evidence of malignancy in 30% of cases; notably, all of which were from patients under surveillance. The sensitivity and specificity of UroVysion(®) were 85.7% and 33.3% in the 'AUC' group and 62.5% and 100% in the 'negative for HGUC' group.
CONCLUSIONS: The Paris System is an objective template for reporting urine cytology specimens, and is particularly useful in identifying HGUC cases and refining the category of 'AUC'.
METHODS: Atypical urine cytology cases subjected to UroVysion(®) testing over a period of 6 years were reviewed. Each case was reclassified according to TPS and correlated with histology and UroVysion(®) results.
RESULTS: A total of 91 cases were identified; 70.3% were reclassified as 'negative for high-grade urothelial carcinoma (HGUC)' and 14.3% as 'atypical urothelial cells (AUC)'. The histological correlation was available in 45 cases. In the 'negative for HGUC' category, 67.9% had no histological evidence of malignancy, but 17.9% were diagnosed as HGUC. In the 'AUC' category, histology revealed urothelial carcinoma in 70% of the cases (of these, 71.4% were high grade). There was no histological evidence of malignancy in 30% of cases; notably, all of which were from patients under surveillance. The sensitivity and specificity of UroVysion(®) were 85.7% and 33.3% in the 'AUC' group and 62.5% and 100% in the 'negative for HGUC' group.
CONCLUSIONS: The Paris System is an objective template for reporting urine cytology specimens, and is particularly useful in identifying HGUC cases and refining the category of 'AUC'.
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