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Cytopathology: Official Journal of the British Society for Clinical Cytology

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https://www.readbyqxmd.com/read/30007099/cytomorphologic-clues-for-correct-diagnosis-of-anaplastic-lymphoma-kinase-alk-large-b-cell-lymphoma
#1
Prerna Guleria, Saumya Ranjan Mallick, Prashant Ramteke, Deepali Jain
Anaplastic Lymphoma Kinase positive Large B-cell Lymphoma (ALK+LBCL), is a rare entity, of which case reports exist in literature. It is a B-cell neoplasm with plasma-cell differentiation and displays plasmablasts/immunoblast like cells along with a peculiar immuno-histochemical profile. The cytomorphological characteristics of this entity have been described earlier, however, with the help of this case which had misleading clinical presentation, we wish to highlight certain cytological features which will act as diagnostic clues in identification of cases of ALK+LBCL in aspiration cytology...
July 14, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/30007094/criterion-learning-a-neglected-aspect-of-training-in-cytopathology
#2
Andrew Evered
Cytologists search for rare signals (neoplastic cells) in visually noisy samples. The difficult nature of the task means that cytologists can never be completely certain about the diagnostic decisions they make. For most visual encounters a cytologist will adopt a probabilistic internal response (e.g. "I am 75% certain that this is an abnormal cell") but to be effective they must adopt a threshold, or decision criterion, that generates an explicit binary response. In other words, they must learn to decide whether each encountered cell is normal or abnormal...
July 14, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/30007090/all-tendon-swellings-are-not-giant-cell-tumor
#3
Prasath Sathiah, Priyadarshini Dehuri, Debasis Gochhait
A 32 year old male patient presented at the fine needle aspiration (FNA) clinic with slow progressive swellings on bilateral Achilles tendon (Figure: 1 Left larger than right) for more than 3 years. The clinical diagnosis was bilateral giant cell tumor of tendon sheath. The patient also carried an MRI report (performed elsewhere- T2 weighted image) which highlighted the soft tissue lesions in the bilateral tendon with speckled hyperintensity and focal thickening (Figure II). This article is protected by copyright...
July 14, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/30007089/expression-of-pten-in-imprint-smears-of-endometrial-carcinoma
#4
Konstantinos Kosmas, Georgia Mitropoulou, Ioannis Provatas, Marios Stamoulas, Anna Marouga
OBJECTIVE: The aims of this study were to determine the expression of PTEN in endometrial adenocarcinomas (as a potential prognostic indicator before treatment) in imprint smears and to correlate the results with clinicopathologic parameters of primary untreated endometrial cancer patients. METHODS: One hundred twenty-six patients with endometrial carcinoma were evaluated with samples freshly resected after a total abdominal hysterectomy during a 29-month period...
July 14, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29989244/management-of-cytological-material-pre-analytical-procedures-and-bio-banking-in-lymph-node-cytopathology
#5
REVIEW
Helena Barroca, Beata Bode-Lesniewska, Immacolata Cozzolino, Pio Zeppa
The range of pathologies that Lymph Node (LN) Fine-Needle Cytology (FNC) may deal with is extremely wide and ancillary techniques, in addition to traditional smears, are generally required to reach reliable cytological diagnoses. For this purpose, in the pre-analytical phase of LN-FNC, using the most effective vials, fixatives and supports is essential, since they may perform differently with different ancillary techniques, and even in different pathologies. Moreover, storing part of the cytological material may be useful or necessary for molecular testing...
July 10, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29969159/do-anticoagulation-medications-increase-the-risk-of-hematoma-in-ultrasound-guided-fine-needle-aspiration-of-thyroid-lesions
#6
Helmi Khadra, Roostam Kholmatov, Dominique Monlezun, Emad Kandil
BACKGROUND: A feared complication of thyroid fine needle aspiration (FNA) is bleeding diathesis and hematoma at the biopsy site. Patients are often advised to discontinue antithrombotic/anticoagulant (AT/AC) medications prior to the procedure. The aim of this study is to examine the risk of bleeding in patients on AT/AC medications undergoing cervical ultrasound (US) guided FNA. METHODS: A retrospective chart review of 803 patients who underwent US-guided FNA of thyroid nodules over 8 years by a single endocrine surgeon was undertaken...
July 3, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29956857/-raspberry-bodies-and-hyaline-globules-with-positive-napsin-a-immunoexpression-are-useful-features-in-diagnosing-clear-cell-carcinoma-of-the-female-genital-tract-in-cytology-samples
#7
LETTER
Bharat Rekhi, Kedar Deodhar, Seema Gulia, Jyoti Bajpai
Clear cell carcinoma(CCC) of the female genital tract, including ovary, is an uncommon malignant epithelial tumour, with a relatively aggressive clinical course, including poor response to chemotherapy This article is protected by copyright. All rights reserved.
June 29, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29938861/the-enigma-of-a-pulmonary-papillary-lesion
#8
Rajesh Kumar, Nalini Gupta, Navneet Singh, Rakesh Kumar Vasishta, Arvind Rajwanshi
A 42-year non-smoker male with no occupational or environmental toxin exposure had an uneventful road traffic accident. A coin-shaped solitary nodule in the right lung was noted on chest X-ray. On computed tomography (CT) scan, it was a heterogeneously enhancing lesion (Figure 1A). This article is protected by copyright. All rights reserved.
June 25, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29938855/pd-l1-immunoexpression-in-matched-biopsy-and-liquid-based-cytology-samples-of-advanced-stage-non-small-cell-lung-carcinomas
#9
Deepali Jain, K S Supraja, Anant Mohan, V K Iyer
OBJECTIVE: PD-L1 immunohistochemistry (IHC) is essential in patients of advanced non-small-cell-lung cancer (NSCLC) to determine eligibility for immunotherapy. PD-L1 IHC assays have been clinically validated only on FFPE tissue; however, lung cancer is frequently diagnosed on cytology. PD-L1 immunocytochemistry (ICC) has shown high concordance of immunoexpression between cytology samples and paired small biopsies. Feasibility of liquid-based cytology (LBC) smears for PD-L1 ICC has not been analyzed previously...
June 25, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29923360/morphology-quiz-cytology-of-a-palmar-swelling-with-axillary-lymphadenopathy
#10
Parikshaa Gupta, Arvind Rajwanshi
Clear cell sarcoma of soft tissue (CCS-ST), also known as malignant melanoma of soft tissue and clear cell sarcoma of tendons and aponeuroses, is a rare high-grade, soft tissue sarcoma, currently included in the WHO category of soft tissue tumors with uncertain differentiation. Establishing a cytodiagnosis is challenging as there are many morphological mimics. Knowledge about the characteristic cytomorphological and immunocytochemical features of this entity is important to establish an accurate cytodiagnosis...
June 19, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29920811/cyto-histological-correlation-of-urine-cytology-in-a-tertiary-centre-with-application-of-the-paris-system
#11
Manish Rohilla, Priya Singh, Arvind Rajwanshi, Nalini Gupta, Radhika Srinivasan, Pranab Dey, Nandita Kakkar
OBJECTIVES: Urine cytology has a high sensitivity in morphological recognition of high grade urothelial carcinoma (HGUC) as compared to low grade urothelial neoplasms. The Paris system (TPS) was designed to standardise the reporting of HGUC on urine cytology. We evaluated the diagnostic efficacy of urine cytology in routine practice with the cytohistological correlation and application of TPS. METHODS: A retrospective review of urine cytology reported from the year 2014 to 2015 was carried out with cytohistological correlation, wherever available...
June 19, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29908089/morphology-quiz-identification-of-metastatic-cells-in-pleural-effusion
#12
Diane Frankel, Andrée Robaglia-Schlupp, Donatienne Bourlard, Elise Kaspi, Patrice Roll
Quiz related to cytological examination of pleural effusion in a patient with history of latero-thoracic malignant melanoma. This article is protected by copyright. All rights reserved.
June 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29904969/mucormycotic-parotitis-and-otitis-causing-facial-nerve-palsy-in-a-diabetic-patient
#13
Debasis Gochhait, Arun Alexender, Priyadarshini Dehuri, Vidhyalakshmi Rangarajan, Sajini Elizabeth Jacob, Neelaiah Siddaraju
Isolated invasive Mucormycosis of the parotid gland is rarely reported in the literature (1). Mucormycosis most commonly manifests as rhino-oculocerebral and pulmonary infections in the patients with altered immunity (uncontrolled Diabetes mellitus, recipients of immunosupressive therapy and underlying hematological malignancies) (2). Rarely, it causes infection in the immunocompetent individuals (3) with the involvement of unusual sites like gastrointestinal tract, ear, soft tissue and skin (4, 5). This article is protected by copyright...
June 15, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29904955/performance-of-rapid-prescreening-and-100-rapid-review-as-internal-quality-control-methods-for-cervical-cytopathology
#14
Alessandra Hermógenes Gomes Tobias, Aline Costa Vitalino, Mariana Trevisan Rezende, Renata Rocha E Rezende Oliveira, Wendel Coura-Vital, Rita Goreti Amaral, Cláudia Martins Carneiro
BACKGROUND: An objective of quality control for cervical cytopathology is reducing high rates of false-negative results of laboratory tests. Therefore, methods to review smears such as rapid prescreening and 100% rapid review, which have shown better performance detecting false-negative results, have been widely used. The performance of rapid prescreening and of 100% rapid review as internal quality control methods for cervical cytology examinations were evaluated. METHODS: During 24 months, 9318 conventional cervical cytology smears underwent rapid prescreening and routine screening...
June 15, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29904975/the-eyes-don-t-see-what-the-mind-doesn-t-know-pleural-endometriosis-on-effusion-cytology
#15
Parikshaa Gupta, Nalini Gupta, Amanjit Bal, Inderpaul Singh Sehgal, Valliappan Muthu, Arvind Rajwanshi
Thoracic endometriosis is the presence of endometrial tissue in the pleura, lung parenchyma and/or airways. It is an extremely rare occurence and is challenging to diagnose clinically due to variable clinical presentations. A high index of clinical suspicion and recognition of the association of the clinical symptoms with menstruation is important to establish a clinical diagnosis of pleural endometriosis. The definitive diagnosis requires tissue diagnosis, demonstrating the presence of endometrial tissue in pleura, either by cytological or histopathological examination...
June 14, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29893443/neoplasms-with-cytoplasmic-vacuoles-many-differential-diagnoses-on-cytology
#16
D Gochhait, V Rangarajan, S Umamahesweran, H Subramanian, P Dehuri, N Siddaraju
No abstract text is available yet for this article.
June 12, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29893438/internal-quality-control-indicators-in-cervical-cytopathology-of-a-university-laboratory
#17
L I Cardoso Filho, S B N Tavares, M L B Siqueira, E N Dos Passos, N L A S Araújo, J M A Martins, A A Ribeiro, S H R Dos Santos
INTRODUCTION: To evaluate the internal quality control indicators and quality management programme in a university cytopathology laboratory. METHODS: All results of conventional cervical smears tests (taken from the SISCAN, the Brazilian cervical cancer screening system) of women aged ≥15 years at the time of Papanicolaou smear specimen collection during January 2007-December 2014 were included. The final results of the cytopathology were classified in accordance with the Bethesda System...
June 12, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29885011/management-of-thyroid-cytological-material-pre-analytical-procedures-and-bio-banking
#18
REVIEW
Beata Bode-Lesniewska, Beatrix Cochand-Priollet, Patrizia Straccia, Guido Fadda, Massimo Bongiovanni
Thyroid nodules are common and increasingly detected due to recent advances in imaging techniques. However, clinically relevant thyroid cancer is rare and the mortality from aggressive thyroid cancer remains constant. FNAC (Fine Needle Aspiration Cytology) is a standard method for diagnosing thyroid malignancy and the discrimination of malignant nodules from goiter. As the examined nodules on thyroid FNAC are often small incidental findings, it is important to maintain a low rate of undetermined diagnoses requiring further clinical work up or surgery...
June 9, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29873857/foamy-macrophages-on-cytosmear-the-approach-to-diagnosis
#19
Debasis Gochhait, Vidhyalakshmi Rangarajan, Hema Subramanian, Sajini Elizabeth Jacob, Neelaiah Siddaraju, Laxmisha Chandrasekhar
A 65 year old emaciated patient presented to the Fine needle aspiration cytology (FNAC) clinic with multiple subcutaneous nodules for 1 year. The painful nodules of variable size were scattered throughout the body with ulceration in some of them (Figure I). In addition to that, the patient had generalized lympadenopathy which raised a clinical differential diagnosis of hematolymphoid/metastatic malignancy or disseminated fungal infection. This article is protected by copyright. All rights reserved.
June 6, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29873855/aquaporin-1-aqp-1-expression-in-fluoro-edenite-induced-mesothelioma-effusions-an-approach-by-cell-block-procedure
#20
Giuseppe Angelico, Antonio Ieni, Rosario Caltabiano, Pio Zeppa, Giovanni Tuccari
OBJECTIVE: Aquaporin 1 (AQP-1) is a water channel protein found in cell membranes, whose expression has been considered an independent favourable prognostic factor in pleural Malignant Mesothelioma (MM). The aim of this study is to evaluate the expression of AQP-1 and its prognostic value in a series of pleural MM effusions, from a geographic area with high concentrations of Fluoro-Edenite (FE). METHODS: We selected twenty-five MM cases from Biancavilla (Italy), an area with high environmental concentrations of FE...
June 6, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
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