Efficacy and Safety of Sofosbuvir/Velpatasvir in Patients With Chronic Hepatitis C Virus Infection Receiving Opioid Substitution Therapy: Analysis of Phase 3 ASTRAL Trials.

Jason Grebely, Gregory J Dore, Stefan Zeuzem, Richard J Aspinall, Raymond Fox, Lingling Han, John McNally, Anu Osinusi, Diana M Brainard, G Mani Subramanian, Macky Natha, Graham R Foster, Alessandra Mangia, Mark Sulkowski, Jordan J Feld

Clinical Infectious Diseases 2016 December 2

In this analysis of the ASTRAL trials (non-opioid substitution therapy [OST], n = 984; OST, n = 51) evaluating the once-daily, pan-genotypic regimen of sofosbuvir/velpatasvir for hepatitis C virus infection, OST did not impact completion, adherence, sustained virologic response (SVR12), or safety. SVR12 was 96% (95% confidence interval, 87%, >99%) in those receiving OST.

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