We have located links that may give you full text access.
Journal Article
Observational Study
Impact of epicardial adipose tissue volume quantified by non-contrast electrocardiogram-gated computed tomography on ergonovine-induced epicardial coronary artery spasm.
International Journal of Cardiology 2016 October 16
OBJECTIVE: Endothelial dysfunction of the coronary artery is thought to lead to the development of coronary spasms. Epicardial adipose tissue may be a marker of coronary atherosclerosis. This study investigated the diagnostic impact of epicardial fat volume (EFV), quantified with non-contrast electrocardiogram (ECG)-gated computed tomography (CT), on ergonovine-induced coronary spasms.
METHODS: We included 97 patients with suspected coronary spastic angina who underwent ECG-gated CT and an ergonovine provocation test. The EFV was measured with CT data sets using dedicated software. Coronary spasm was defined as total or subtotal occlusion (compared with the relaxed state after nitroglycerin) that was associated with ischemic ECG changes and concurrent chest pain.
RESULTS: Coronary spasms were observed in 27 patients (28%). The EFV was significantly higher in patients with spasms compared with those without spasms (175.0±57.8cm(3) vs. 129.7±57.8cm(3), p<0.01). Univariate logistic regression analyses indicated significant relationships between coronary spasms and EFV (per 10cm(3), odds ratio (OR): 1.13; p<0.01), male gender (OR: 3.34; p<0.01), and smoking (OR: 3.42; p<0.01). In the multivariate model, EFV (per 10cm(3), OR: 1.10; p=0.03) and male gender (OR: 5.94; p=0.02) remained significant predictors of coronary spasm. The optimal EFV threshold for predicting coronary spasm was 149.4cm(3), identified with a receiver operating characteristic curve.
CONCLUSIONS: Increased EFV was associated with ergonovine-induced epicardial coronary artery spasms.
METHODS: We included 97 patients with suspected coronary spastic angina who underwent ECG-gated CT and an ergonovine provocation test. The EFV was measured with CT data sets using dedicated software. Coronary spasm was defined as total or subtotal occlusion (compared with the relaxed state after nitroglycerin) that was associated with ischemic ECG changes and concurrent chest pain.
RESULTS: Coronary spasms were observed in 27 patients (28%). The EFV was significantly higher in patients with spasms compared with those without spasms (175.0±57.8cm(3) vs. 129.7±57.8cm(3), p<0.01). Univariate logistic regression analyses indicated significant relationships between coronary spasms and EFV (per 10cm(3), odds ratio (OR): 1.13; p<0.01), male gender (OR: 3.34; p<0.01), and smoking (OR: 3.42; p<0.01). In the multivariate model, EFV (per 10cm(3), OR: 1.10; p=0.03) and male gender (OR: 5.94; p=0.02) remained significant predictors of coronary spasm. The optimal EFV threshold for predicting coronary spasm was 149.4cm(3), identified with a receiver operating characteristic curve.
CONCLUSIONS: Increased EFV was associated with ergonovine-induced epicardial coronary artery spasms.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app