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International Journal of Cardiology

Jun-Won Lee, Eunhee Choi, Sayma Sabrina Khanam, Jung-Woo Son, Young-Jin Youn, Min-Soo Ahn, Sung Gyun Ahn, Jang-Young Kim, Seung-Hwan Lee, Junghan Yoon, Byung-Su Yoo
BACKGROUND: Elevated B-type natriuretic peptide (BNP) levels in patients hospitalized for acute myocardial infarction (AMI) are associated with heart failure and mortality. However, the role of BNP after hospital discharge is not clear. Therefore, we assessed the relationship between short-term follow-up BNP levels and clinical outcomes including all-cause mortality and major adverse cardiovascular events (MACE) in patients with AMI after hospital discharge. METHODS: From a prospective single-center percutaneous coronary intervention (PCI) registry, a total of 442 out of 2157 patients with AMI who had measurements for both initial and follow-up BNP levels within 2 months after discharge were retrospectively enrolled...
January 8, 2019: International Journal of Cardiology
Margarita Brida, Gary Webb
No abstract text is available yet for this article.
January 6, 2019: International Journal of Cardiology
Atsuko Imai-Okazaki, Yoshihito Kishita, Masakazu Kohda, Yosuke Mizuno, Takuya Fushimi, Ayako Matsunaga, Yukiko Yatsuka, Tomoko Hirata, Hiroko Harashima, Atsuhito Takeda, Akihiro Nakaya, Yasushi Sakata, Shigetoyo Kogaki, Akira Ohtake, Kei Murayama, Yasushi Okazaki
BACKGROUND: Cardiomyopathy is a reported indicator of poor prognosis in children with mitochondrial disease. However, the association between prognosis and the genetic background of cardiomyopathy in children with mitochondrial disease has yet to be fully elucidated. METHODS AND RESULTS: Of 137 children with mitochondrial disease whose genetic diagnosis was made between 2004 and 2018, 29 had mitochondrial cardiomyopathy (21%). After a median follow-up of 35 months, the overall survival rate was significantly lower in patients with cardiomyopathy than in those without (p < 0...
January 5, 2019: International Journal of Cardiology
Jielin Deng, Xiaoya Zhou, Menglong Wang, Meng Wang, Liping Zhou, Guannan Meng, Yuhong Wang, Zhenya Wang, Yifeng Zhang, Zhen Zhou, Lilei Yu, Hong Jiang
BACKGROUND: It is reported interleukin (IL)-17A, a classical proinflammatory cytokine, is implicated in neuroimmune-associated remodeling in neural plasticity and pathological conditions. However, the effect of IL-17A on left stellate ganglion (LSG) remodeling remains unclear. OBJECTIVE: This study was performed to determine whether exogenous IL-17A promotes LSG remodeling and destabilize ventricular electrophysiological properties (EPs) in normal canines. METHODS: 24 beagles were randomly allocated into three groups...
January 4, 2019: International Journal of Cardiology
Anish N Bhuva, Peter Kellman, Adam Graham, Manish Ramlall, Redha Boubertakh, Patricia Feuchter, Angela Hawkins, Martin Lowe, Pier D Lambiase, Neha Sekhri, Richard J Schilling, James C Moon, Charlotte H Manisty
BACKGROUND: Myocardial scar assessment using late gadolinium enhancement Cardiovascular Magnetic Resonance (LGE CMR) is commonly indicated for patients with cardiac implantable electronic devices (CIEDs), however metal artifact can degrade images. We evaluated the clinical impact of LGE CMR incorporating a device-dependent metal artifact reduction strategy in patients with CIEDs. METHODS: 136 CMR studies were performed in 133 consecutive patients (age 56 ± 19 years, 69% male) with CIEDs (22% implantable loop recorders [ILRs], 40% permanent pacemakers [PPMs], 38% implantable cardioverter defibrillators [ICDs]; 42% non-MRI conditional) over 2 years, without complication...
January 4, 2019: International Journal of Cardiology
Maurizio Roberto, Rita Sicuso, Sabrina Manganiello, Valentina Catto, Luca Salvi, Matteo Nafi, Michela Casella, Fabiana Rossi, Francesco Grillo, Matteo Saccocci, Alessio Gasperetti, Rosario Cervellione, Davide Carcione, Francesco Alamanni, Claudio Tondo, Antonio Dello Russo
BACKGROUND: Nowadays, transvenous lead extraction (TLE) is considered an essential technique in lead management strategy. Since 2011, a multidisciplinary approach was undertaken in our centre involving electrophysiologists, cardiac surgeons and anaesthesiologists to improve cross- unit cooperation and minimize complications and mortality. The present paper reports procedural outcomes and complications of our lead extraction experience. METHODS: We retrospectively collected and analysed data from all consecutive patients undergoing cardiac implantable electronic device leads TLE at the IRCCS Centro Cardiologico Monzino between January 2011 and November 2017...
January 3, 2019: International Journal of Cardiology
Fabian Belau, Katharina Metzner, Torsten Christ, Ursula Ravens, Michael Schaefer, Stephan Künzel, Wener Li, Erich Wettwer, Dobromir Dobrev, Ali El-Armouche, Susanne Kämmerer
BACKGROUND: Cardiac accessory β-subunits are part of macromolecular Nav1.5 channel complexes modulating biophysical properties and contributing to arrhythmias. Recent studies demonstrated the structural interaction between β-subunits of Na+ (Nav1.5) and K+ (Kv4.3) channels. Here, we identified the dipeptidyl peptidase-like protein-10 (DPP10), which is known to modulate Kv4.3-current kinetics, as a new regulator of Nav1.5 channels. METHODS: We assessed DPP10 expression in the healthy and diseased human heart and we studied the functional effects of DPP10 on the Na+ current in isolated rat cardiomyocytes expressing DPP10 after adenoviral gene-transfer (DPP10ad)...
January 3, 2019: International Journal of Cardiology
Ayman Jubran, Moshe Y Flugelman, Barak Zafrir, Avinoam Shiran, Nader Khader, Ronen Rubinshtein, Ronen Jaffe
BACKGROUND: Aortic regurgitation (AR) following transcatheter aortic valve replacement (TAVR) is usually due to paravalvular leak, is more common with self-expanding valves and is associated with adverse outcomes. Treatment of AR with a second valve (valve-in-valve) has been reported, however the mechanism of benefit is unclear. We hypothesized that location of the initial valve in relation to the aortic annulus should guide positioning of the second valve. METHODS: We assessed the outcomes of valve-in-valve deployment for treatment of AR following implantation of self-expanding valves in a single-center TAVR registry...
January 2, 2019: International Journal of Cardiology
Jordan Loader, Yih-Kai Chan, John A Hawley, Trine Moholdt, Christine F McDonald, Pardeep Jhund, Mark C Petrie, John J McMurray, Paul A Scuffham, Jay Ramchand, Louise M Burrell, Simon Stewart
BACKGROUND: Peaks and troughs in cardiovascular events correlated with seasonal change is well established from an epidemiological perspective but not a clinical one. METHODS: Retrospective analysis of the recruitment, baseline characteristics and outcomes during minimum 12-month exposure to all four seasons in 1598 disease-management trial patients hospitalised with chronic heart disease. Seasonality was prospectively defined as ≥4 hospitalisations (all-cause) AND >45% of related bed-days occurring in any one season during median 988 (IQR 653, 1394) days follow-up...
January 2, 2019: International Journal of Cardiology
Roberto Rordorf, Stefano Cornara, Catherine Klersy, Simone Savastano, Alessandro Vicentini, Antonio Sanzo, Barbara Petracci, Stefano Ghio, Luigi Oltrona Visconti, Gaetano M De Ferrari
BACKGROUND: Implantable cardioverter-defibrillator (ICD) is an effective therapy to reduce mortality in heart failure. When the ICD generator approaches the end of life, most of the patients undergo an elective generator replacement (GR) even if they no longer meet implantation criteria. Whether arrhythmic risk should be re-assessed at the time of GR is still an open question. The aim of our study was to assess, via a meta-analysis, the occurrence of appropriate ICD therapies after GR in patients stratified based on the presence/absence of ICD indication at the time of GR...
January 2, 2019: International Journal of Cardiology
Basmah Safdar, Xiaojia Guo, Caitlin Johnson, Gail D'Onofrio, James Dziura, Albert J Sinusas, Jeffrey Testani, Veena Rao, Gary Desir
AIMS: We explored the relationship between inflammation, renalase an anti-inflammatory protein, and acute chest pain with coronary microvascular dysfunction (CMD). METHODS AND RESULTS: We used cardiac Rb-82 PET/CT imaging to diagnose coronary artery disease (CAD/CALC) (defect or coronary calcification) and CMD (depressed coronary flow reserve without CAD) in patients with chest pain in an emergency department (ED). Blood samples were collected pre-imaging within 24 h of ED presentation and were analyzed for renalase and inflammatory markers including C-reactive protein, interleukins, interferon gamma, tumor necrosis factor, vascular endothelial growth factor, and metalloproteinases...
January 2, 2019: International Journal of Cardiology
B L Nørgaard, B Ko
No abstract text is available yet for this article.
December 29, 2018: International Journal of Cardiology
Christoph B Wiedenroth
No abstract text is available yet for this article.
December 29, 2018: International Journal of Cardiology
Mona Lichtblau, Michael Furian, Sayaka S Aeschbacher, Maya Bisang, Stefanie Ulrich, Stéphanie Saxer, Ulan Sheraliev, Nuriddin H Marazhapov, Batyr Osmonov, Bermet Estebesova, Talant Sooronbaev, Konrad E Bloch, Silvia Ulrich
BACKGROUND: Chronic obstructive pulmonary disease (COPD) may predispose to symptomatic pulmonary hypertension at high altitude. We investigated hemodynamic changes in lowlanders with COPD ascending rapidly to 3100 m and evaluated whether preventive dexamethasone treatment would mitigate the altitude-induced increase in pulmonary artery pressure. METHODS: In this placebo-controlled, double-blind trial, non-hypercapnic COPD patients living <800 m, were randomized to receive either dexamethasone (8 mg/day) or placebo tablets one day before ascent from 760 m and during a 3-day-stay at 3100 m...
December 28, 2018: International Journal of Cardiology
Pedro Freitas, Ana Rita Santos, António Miguel Ferreira, Afonso Oliveira, Mariana Gonçalves, Ana Corte-Real, Catarina Lameiras, Joana Maurício, Énia Ornelas, Clara Matos, Daniel Faria, João Augusto, Joana Simões, Inês Ferreira, Ana Pedroso, Ana Coutinho Santos, Miguel Gago, João Diogo Oliveira, Ricardo Mamede Antunes, David Correia, Ana Lynce, João Brito, Carlos Aguiar, Jorge Ferreira, Carlos Morais, Luís Campos, Luís Raposo, Miguel Mendes
BACKGROUND: Identifying patients with normotensive pulmonary embolism (PE) who may benefit from thrombolysis remains challenging. We sought to develop and validate a score to predict 30-days PE-related mortality and/or rescue thrombolysis. METHODS: We retrospectively assessed 554 patients with normotensive PE. Independent predictors of the studied endpoint were identified from variables available at admission in the emergency department and were used to create a score...
December 28, 2018: International Journal of Cardiology
Zongzhe Li, Peng Chen, Jinchao Xu, Bo Yu, Xianqing Li, Dao Wu Wang, Dao Wen Wang
BACKGROUND: Pathogenic variants in human phospholamban coding gene (PLN) are known to cause hereditary dilated cardiomyopathy with heart failure in an autosomal dominant mode. METHODS: We performed high-depth targeted next-generation sequencing using a cardiomyopathy-panel containing 80 disease-related genes in 650 unrelated patients with non-ischemic cardiomyopathy to identify potential pathogenic PLN variants. To comprehensively evaluate the genetic cause of the proband and his pedigree, whole-exome sequencing and Sanger sequencing were performed...
December 28, 2018: International Journal of Cardiology
Lena Bosch, Judith de Haan, Tom Seijkens, Claudia van Tiel, Maike Brans, Gerard Pasterkamp, Esther Lutgens, Saskia de Jager
BACKGROUND: CD40 signalling is involved in chronic inflammation, a condition that plays an important role in non-ischemic heart failure (HF). Small molecule inhibitors of CD40-TRAF6 have shown to be effective in multiple animal-models of chronic inflammatory disease, such as obesity and atherosclerosis. METHODS & RESULTS: Mice were subjected to transverse aortic constriction (TAC) and randomized to small molecule inhibition of CD40-TRAF6 or placebo. CD40-TRAF6 inhibition resulted in less cardiac remodelling 10 weeks after TAC with a reduced end systolic volume (TAC-placebo group: 71...
December 28, 2018: International Journal of Cardiology
González Ricardo Izquierdo, García Ramón María Dorrego, Ledo Pilar Rodríguez, Heras José Vicente Segura
BACKGROUND: The risk factors for abdominal aortic aneurysm (AAA) are present in many of the patients that attend our cardiology service. The aim of this study was the evaluation of the prospects of examining the abdominal aorta during our consultations and the relationship of AAA with risk factors and ischemic cardiopathy. METHODS: A descriptive transversal observational study was designed including 274 male patients aged ≥60 years, attended consecutively in the cardiology service, in which we studied the abdominal aorta and adjusted a logistic regression model to determine the risk factors associated with AAA...
December 27, 2018: International Journal of Cardiology
Tomohiko Imamura, Naokata Sumitomo, Shota Muraji, Hitoshi Mori, Yousuke Osada, Takayuki Oyanagi, Takuro Kojima, Shigeki Yoshiba, Toshiki Kobayashi, Katsushige Ono
The most common cardiac feature of Kearns-Sayre syndrome (KSS) is atrioventricular block (AVB), and pacemaker implantations (PMIs) are recommended for KSS patients with advanced AVB. However, some KSS patients develop fatal arrhythmias such as polymorphic ventricular tachycardia (PMVT) and ventricular fibrillation (VF) and die suddenly even after PMIs. We report a patient with KSS who developed PMVT, VF, and QT prolongation, and was treated with mexiletine and successfully managed with an implantable cardioverter defibrillator (ICD)...
December 27, 2018: International Journal of Cardiology
Christine Rootwelt-Norberg, Øyvind H Lie, Lars A Dejgaard, Monica Chivulescu, Ida S Leren, Thor Edvardsen, Kristina H Haugaa
BACKGROUND: Arrhythmogenic cardiomyopathy (AC) is an inheritable progressive heart disease with high risk of life-threatening ventricular arrhythmia (VA). We aimed to explore the prevalence of VA as presenting event in patients with AC over two decades, symptoms preceding VA and compare the clinical presentations and rate of AC-diagnosis over time. METHODS: We included consecutive AC-patients from our tertiary referral center. We recorded clinical history, VA (aborted cardiac arrest, sustained ventricular tachycardia or appropriate implantable cardioverter-defibrillator therapy), cardiac symptoms preceding VA in AC, and compared the history of patients diagnosed before and after implementation of genetic testing...
December 27, 2018: International Journal of Cardiology
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