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International Journal of Cardiology

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https://www.readbyqxmd.com/read/28823501/quality-of-life-metrics-in-arrhythmogenic-right-ventricular-cardiomyopathy-patients-the-impact-of-age-shock-and-sex
#1
Ashley C Rhodes, Brittney Murray, Crystal Tichnell, Cynthia A James, Hugh Calkins, Samuel F Sears
BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) patients face many medical and psychosocial challenges. However, the quality of life (QOL) outcomes of these patients remains largely unexplored. METHODS: 159 ARVC patients completed a psychosocial survey including the Short Form Health Survey, Florida Shock Anxiety Scale, and Florida Patient Acceptance Survey. These cross-sectional data were used to examine the general and device-specific QOL of these patients compared to normative samples, and to determine the impact of age, shock and sex on these outcome measures...
August 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28818353/does-calcium-burden-impact-culprit-lesion-morphology-and-clinical-results-an-adapt-des-ivus-substudy
#2
Peiren Shan, Gary S Mintz, Bernhard Witzenbichler, D Christopher Metzger, Michael J Rinaldi, Peter L Duffy, Giora Weisz, Thomas D Stuckey, Bruce R Brodie, Philippe Généreux, Aaron Crowley, Ajay J Kirtane, Gregg W Stone, Akiko Maehara
BACKGROUND: Increasing coronary lesion calcification is thought to be associated with adverse percutaneous coronary intervention (PCI) and clinical outcomes. We investigated the effects of calcium burden on culprit lesion morphology and clinical events after intravascular ultrasound (IVUS)-guided PCI in the ADAPT-DES study. METHODS: ADAPT-DES was a prospective, multicenter registry of 8582 consecutive patients undergoing successful PCI using DES. A pre-specified virtual histology (VH)-IVUS substudy of 638 culprit lesions (638 patients) had both pre- and post-PCI VH-IVUS...
August 12, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28811093/risk-factors-for-infective-endocarditis-in-children-with-congenital-heart-diseases-a-nationwide-population-based-case-control-study
#3
Li-Chuan Sun, Chih-Cheng Lai, Cheng-Yi Wang, Ya-Hui Wang, Jen-Yu Wang, Yo-Ling Hsu, Yin-Lan Hu, En-Ting Wu, Ming-Tai Lin, Leticia B Sy, Likwang Chen
BACKGROUND: Infective endocarditis (IE) is uncommon in childhood. Its associated epidemiological characteristics in patients with congenital heart disease (CHD) remain unclear. METHODS: The study population included children born in Taiwan during the years 1997 to 2005 who were diagnosed as having CHD before 3years of age. All children were followed up until the end year of 2010, the diagnosis of infective endocarditis, or death. The demographic characteristics of patients with and without IE, the invasive procedures performed during 6months before the index date, the prophylactic antibiotics related to dental procedures, and in-hospital mortality were collected...
August 12, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28807510/angina-after-percutaneous-coronary-intervention-the-need-for-precision-medicine
#4
Giampaolo Niccoli, Rocco Antonio Montone, Gaetano Antonio Lanza, Filippo Crea
Persistence or recurrence of angina after successful percutaneous coronary intervention (PCI) represent an important clinical issue involving from one fifth to one third of patients undergoing myocardial revascularization at one-year follow-up. A systematic approach to this syndrome is strongly needed. Precision medicine is particularly important in addressing angina after successful PCI because of the multiple underlying causes. Restenosis or coronary atherosclerosis progression explain symptom recurrence after successful PCI in some patients, while functional causes, including vasomotor abnormalities of epicardial coronary arteries and/or coronary microvascular dysfunction, explain symptoms in the remaining patients...
August 11, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28818354/retrospective-study-of-the-impact-of-unrecognised-kawasaki-disease-coronary-aneurysm-and-ectasia
#5
Benjamin R Waterhouse, Robert M R Tulloh, Yongcheol Kim, Will Creasy, David Adlam, Thomas W Johnson
BACKGROUND: Coronary artery aneurysms resulting from unrecognised or untreated Kawasaki Disease (KD) have thrombotic and stenotic potential leading to myocardial infarction. We aimed to characterise the prevalence and outcomes of patients presenting to a UK-based adult tertiary cardiology service with angiographic evidence of aneurysm or ectasia. METHODS: Retrospective review was undertaken of reports and original coronary angiograms in all patients under 50years old undergoing coronary angiography between 2011 and 2015...
August 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28818351/recent-trends-in-management-and-outcome-of-patients-with-acute-coronary-syndromes-and-atrial-fibrillation
#6
Leonardo De Luca, Gianni Casella, Andrea Rubboli, Lucio Gonzini, Donata Lucci, Alessandro Boccanelli, Francesco Chiarella, Antonio Di Chiara, Stefano De Servi, Andrea Di Lenarda, Giuseppe Di Pasquale, Stefano Savonitto
AIMS: To describe the clinical characteristics, contemporary trends of in-hospital management and outcome of patients admitted for an acute coronary syndrome (ACS) with associated atrial fibrillation (AF). METHODS: We analyzed data from four Italian nationwide prospective registries, conducted between 2001 and 2014, including consecutive ACS patients. RESULTS: Out of 16,803 ACS patients, 1019 (6.1%) presented with concomitant AF: 668 with non-ST elevation (NSTE)-ACS and 351 with ST-elevation myocardial infarction (STEMI)...
August 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28811091/pregravid-hypertension-may-have-different-secondary-sex-ratio-effects-in-different-races-in-the-united-states
#7
Victor Grech
BACKGROUND: Males are born in excess of females and the ratio is expressed as M/F (male/female births=secondary sex ratio, also known as secondary sex ratio). This is expected to approximate 1.048. Racial M/F disparities are known. A recent study in China showed that pregravid systolic hypertension is higher in women who delivered a boy than in those who had a girl. This study was carried out in order to identify the effect of pregravid hypertension in the United States on M/F by race...
August 9, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28807509/-18-f-fdg-pet-ct-angiography-in-the-diagnosis-of-infective-endocarditis-and-cardiac-device-infection-in-adult-patients-with-congenital-heart-disease-and-prosthetic-material
#8
María N Pizzi, L Dos-Subirà, Albert Roque, Nuria Fernández-Hidalgo, Hug Cuéllar-Calabria, Antonia Pijuan Domènech, María T Gonzàlez-Alujas, M T Subirana-Domènech, B Miranda-Barrio, Ignacio Ferreira-González, Juan J González-López, Albert Igual, Olga Maisterra-Santos, David García-Dorado, Joan Castell-Conesa, Benito Almirante, Manuel Escobar Amores, Pilar Tornos, Santiago Aguadé-Bruix
OBJECTIVES: Infective endocarditis (IE) and cardiac device infection (CDI) are a major complication in the growing number of patients with congenital heart disease (CHD) reaching adulthood. We aimed to evaluate the added value of (18)F-FDG-PET/CT angiography (PET/CTA) in the diagnosis of IE-CDI in adults with CHD and intravascular or intracardiac prosthetic material, in whom echocardiography (ECHO) and modified Duke Criteria (DC) have limitations because of the patients' complex anatomy...
August 9, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28801152/reply-to-increased-risk-of-thromboembolic-events-in-adult-congenital-heart-disease-patients-with-atrial-tachyarrhythmias-bias-due-to-the-data-sparsity
#9
LETTER
Keita Masuda, Tomoko Ishizu, Masahiko Gosho, Kazutaka Aonuma
No abstract text is available yet for this article.
August 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28811092/direct-oral-anticoagulants-in-patients-with-hypertrophic-cardiomyopathy-and-atrial-fibrillation
#10
Fernando Dominguez, Vicente Climent, Esther Zorio, Tomás Ripoll-Vera, Joel Salazar-Mendiguchía, Jose Manuel García-Pinilla, Jose Angel Urbano-Moral, Xusto Fernández-Fernández, David Lopez-Cuenca, Raquel Ajo-Ferrer, Jorge Sanz-Sanchez, Yolanda Gomez-Perez, Miguel A López-Garrido, Roberto Barriales-Villa, Juan Ramón Gimeno, Pablo Garcia-Pavia
BACKGROUND: Chronic anticoagulation with vitamin K antagonists (VKAs) is recommended in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF). Direct oral anticoagulants (NOACs) are an alternative to VKAs but there are limited data to support their use in HCM. We sought to describe the pattern of use, thromboembolic events, bleeding and quality of life in patients with HCM and AF treated with NOACs. METHODS: Data from patients treated with NOACs (n=99) and VKA (n=433) at 9 inherited cardiac diseases units were retrospectively collected...
August 7, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28811090/guanosine-exerts-antiplatelet-and-antithrombotic-properties-through-an-adenosine-related-camp-pka-signaling
#11
Francisco Fuentes, Marcelo Alarcón, Lina Badimon, Manuel Fuentes, Karl-Norbert Klotz, Gemma Vilahur, Sonja Kachler, Teresa Padró, Iván Palomo, Eduardo Fuentes
BACKGROUND: Guanosine is a natural product and an endogenous nucleoside that has shown to increase during myocardial ischemia. Platelets are critically involved in ischemic coronary events. It remains unknown, however, whether guanosine may affect platelet activation and function. We sought to investigate the potential antiplatelet and antithrombotic properties of guanosine and decipher the mechanisms behind. METHODS: We firstly assessed the effects of guanosine on platelet activation/aggregation upon stimulation with several platelet agonists including adenosine diphosphate (ADP), collagen, arachidonic acid (AA), and TRAP-6...
August 7, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28823409/prasugrel-vs-clopidogrel-in-contemporary-western-european-patients-with-acute-coronary-syndromes-receiving-drug-eluting-stents-comparative-cost-effectiveness-analysis-from-the-basket-prove-cohorts
#12
Bastian Wein, Michael Coslovsky, Reza Jabbari, Søren Galatius, Matthias Pfisterer, Christoph Kaiser
BACKGROUND: Clinical and cost-effectiveness of prasugrel vs. clopidogrel in acute coronary syndrome (ACS) was only evaluated using TRITON-TIMI 38 event rates. A comparative analysis of both drugs in contemporary European ACS patients is lacking. METHODS: To address this issue, cardiac and bleeding events of 2 "sister" multicenter stent trials, BASKET-PROVE (BP) I with clopidogrel and BPII with prasugrel (for 12months each) were used in a hybrid analysis. Medication costs were 2015 sales prices, event costs modelled for Denmark (DNK), Germany (GER) and Switzerland (SUI) and quality adjusted life years (QALY) by EQ-5D-3L questionnaire...
August 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28821416/short-and-long-term-prognostic-value-of-hyponatremia-in-heart-failure-with-preserved-ejection-fraction-versus-reduced-ejection-fraction-an-analysis-of-the-korean-acute-heart-failure-registry
#13
Jin Joo Park, Young-Jin Cho, Il-Young Oh, Hyun-Ah Park, Hae-Young Lee, Kye Hun Kim, Byung-Su Yoo, Seok-Min Kang, Sang Hong Baek, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Byung-Hee Oh, Dong-Ju Choi
BACKGROUND: Hyponatremia is a well-known risk factor for worse outcomes in heart failure (HF) patients. The impact of hyponatremia according to the ejection fraction (EF) is unclear. We evaluated the prognostic value of hyponatremia according to HF type. METHODS AND RESULTS: The Korea Acute Heart Failure (KorAHF) registry consecutively enrolled 5625 patients. Hyponatremia was defined as serum sodium level<135mmol/L at hospital admission. HF with preserved and reduced ejection fraction were defined as an LVEF ≥50% and LVEF ≤40%, respectively...
August 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28818352/longitudinal-sequential-biventricular-assessment-in-adults-with-transposition-of-the-great-arteries-and-relationship-with-adverse-outcomes
#14
M Riahi, A Claman, M Kiess, M Orgad, D Human, S Chakrabarti, J Leipsic, J Grewal
BACKGROUND: In a cohort of congenitally corrected transposition of the great arteries (cc-TGA) and transposition of the great arteries after atrial switch procedure (d-TGA) the study objectives were: 1) to assess the change of quantitative systemic right ventricle (sRV) parameters over time and; 2) to examine the relationship of quantitative sRV parameters with adverse clinical outcomes. METHODS AND RESULTS: Single-center cohort study that included 49 (39%) cc-TGA and 76 (61%) d-TGA patients >18years who had at least one MUGA sRV assessment, 18/39 had more than one respectively...
August 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28801153/trends-causes-and-timing-of-30-day-readmissions-after-hospitalization-for-heart-failure-11-year-population-based-analysis-with-linked-data
#15
Lucía Fernandez-Gasso, Lauro Hernando-Arizaleta, Joaquín A Palomar-Rodríguez, M Victoria Abellán-Pérez, Domingo A Pascual-Figal
BACKGROUND: Reliable data are necessary if the burden of early readmissions following hospitalization for heart failure (HF) is to be addressed. We studied unplanned 30-day readmissions, their causes and timing over an 11-year period, using population-based linked data. METHODS: All hospitalizations from 2003 to 2013 were analyzed by using administrative linked data based on the Minimum Basic Set discharge registry of the Department of Health (Region of Murcia, Spain)...
August 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28797953/varying-clinical-presentations-of-anomalous-origin-of-the-left-main-coronary-artery-from-the-right-coronary-sinus-with-an-interarterial-course-in-adults
#16
Ronen Rubinshtein, Moshe Y Flugelman, Ayman Jubran, Avinoam Shiran, Ronen Jaffe
The diagnosis of anomalous origin of the left main coronary artery from the right coronary sinus with an interarterial course in children and adolescents is considered life-threatening and clinical guidelines recommend surgical correction. The prognostic implications of this diagnosis in adults are not clear. This anomaly may present in adults as sudden cardiac death or may be diagnosed incidentally. Treatment of this anomaly in adults should be tailored individually taking into account the clinical presentation and patient characteristics...
August 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28789842/impact-of-target-vessel-on-long-term-cardiac-mortality-after-successful-chronic-total-occlusion-percutaneous-coronary-intervention-insights-from-a-japanese-multicenter-registry
#17
Satoru Mitomo, Toru Naganuma, Richard J Jabbour, Katsumasa Sato, Hideo Takebayashi, Tsuyoshi Kobayashi, Jun-Ei Obata, Kenji Sakamoto, Kenichi Tsujita, Kiyotaka Kugiyama, Hisao Ogawa, Sunao Nakamura
BACKGROUND: The impact of successful chronic total occlusion (S-CTO) percutaneous coronary intervention (PCI) on cardiac mortality may differ depending on target CTO vessel; however, to date this has not yet been adequately evaluated. The aim of this study was to investigate the impact of target vessel on cardiac mortality after S-CTO PCI. METHODS: From January 2004 to December 2011, 1517 CTO PCIs were performed in 4 Japanese centers and enrolled in a multicenter registry...
August 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28784436/value-of-the-sodium-channel-blocker-challenge-in-brugada-syndrome
#18
Dylan Therasse, Frederic Sacher, Dominique Babuty, Philippe Mabo, Jacques Mansourati, Florence Kyndt, Richard Redon, Jean Jacques Schott, Julien Barc, Vincent Probst, Jean-Baptiste Gourraud
AIMS: Intravenous drug challenge is frequently performed to unmask Brugada syndrome (BrS). However, its true sensitivity has never been assessed. We used the obligate BrS transmitters in families affected by BrS to evaluate the true accuracy of drug challenge. METHODS: All consecutive patients from 2000 to 2014 who underwent drug challenge during familial screening for BrS were included in the study. Obligate BrS transmitters were defined as the presence of a descendant and non-descendant first-degree relative affected by BrS...
August 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28789843/the-thirsty-dropsy-early-descriptions-in-medical-and-non-medical-authors-of-thirst-as-symptom-of-chronic-heart-failure
#19
M A Riva, F Cesana, F Achilli, F Scordo, G Cesana
BACKGROUND: Patients with chronic heart failure may suffer from severe thirst, even if mechanisms that cause thirst in subjects affected by this condition are not clear. Medical and non-medical authors may have already recognized this symptom during the classical age. METHODS: We analyzed association between thirst and dropsy (an ancient medical term used to indicate different conditions including chronic heart failure) in past medical and non-medical literature...
August 3, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28807511/prevalence-and-predictors-of-inappropriate-anticoagulation-in-patients-with-a-cha2ds2-vasc-score-of-0-and-atrial-fibrillation
#20
Sepehr Saberian, Auroa Badin, Vince Siebert, Ashish Roy, Sandeep Banga, Harshavardhan R Ghadiam, Rebecca R Wigant, Ashim Aggarwal, Timir S Baman
BACKGROUND: Previous studies have shown underutilization of anticoagulation therapy in patients with atrial fibrillation and a CHA2DS2-VASc score ≥2; however there exists little data regarding the inappropriate use of anticoagulation in patients with a CHA2DS2-VASc score of 0. We aimed to determine the true prevalence and predictors of inappropriate anticoagulation therapy in patients with atrial fibrillation and a CHA2DS2-VASc score of 0. METHODS: A retrospective chart review was performed on all patients with atrial fibrillation and a CHA2DS2-VASc score of 0 in our institution from January 2009 to January 2016...
August 2, 2017: International Journal of Cardiology
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