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Research Support, Non-U.S. Gov't
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Second- and third-generation ALK inhibitors for non-small cell lung cancer.

Jingjing Wu, John Savooji, Delong Liu
Journal of Hematology & Oncology 2016 March 9
Crizotinib as the first-generation ALK inhibitor has shown significant activity in ALK-mutated non-small cell lung cancer (NSCLC). Second- and third-generation ALK inhibitors are entering clinical applications for ALK+ NSCLC. In addition, a third-generation ALK inhibitor, lorlatinib (PF-06463922), was reported to resensitize NSCLC to crizotinib. This review provided a summary of clinical development of alectinib, ceritinib, brigatinib (AP26113), and lorlatinib.

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