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Research Support, Non-U.S. Gov't
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Toxic Effects of Lithium Chloride during Early Neonatal Period of Rat Development.

P N Menshanov, A V Bannova, N N Dygalo
Bulletin of Experimental Biology and Medicine 2016 Februrary
Lithium chloride (85, 255, or 255+127 μg/kg) or dexamethasone (0.2 or 2 mg/kg) were subcutaneously injected to 3-day-old rat pups, whose excretory system did not yet attain functional maturity. Both agents retarded the growth of rat pups and delayed the appearance of negative geotaxis. LD50 and therapeutic index of lithium chloride were 255 μg/kg and TI≤3, respectively. Thus, lithium salts even in low doses can be highly toxic for the developing organism.

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