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Bulletin of Experimental Biology and Medicine

A E Mamedov, N A Ponomarenko, A A Belogurov, A G Gabibov
No abstract text is available yet for this article.
August 13, 2016: Bulletin of Experimental Biology and Medicine
E Yu Sherstoboev, O G Shitikova, N V Masnaya, M G Danilets, E S Trofimova, A A Ligacheva, P G Madonov, D N Kinsht, K I Ershov, M A Shilova
Course treatment with IFN-α2b immobilized on polyethylene glycol stimulates phagocytic activity of peritoneal macrophages and neutrophils, enhances humoral immune response in CBA/CaLac mice, stimulates IL-4 synthesis, and suppresses IFN-γ production by mitogenstimulated splenocytes from experimental animals.
September 2016: Bulletin of Experimental Biology and Medicine
M L Mamalyga, L M Mamalyga
Circadian peculiarities of HR regulation and functional capacities of the heart in WAG/Rij rats with genetically determined absence epilepsy are related to spike-wave activity of the brain. The number of spike-wave discharges (SWD) is maximum at night, early morning, and evening time and decreases to minimum at 08.00-16.00. At night, functional capacities of the heart are reduced and stress test at night induces ischemic changes in the myocardium at a lower functional load than in the daytime (low level of SWD activity)...
September 2016: Bulletin of Experimental Biology and Medicine
L I Kozlova, M B Shtark, M E Mel'nikov, E G Verevkin, A A Savelov, E D Petrovskii
fMRI-EEG dynamics of brain activity in volunteers was studied during the course of EEG alpha-stimulation training (20 sessions). Twenty-three healthy men (20-35 years) were subjected to 3-fold mapping in a feedback loop (EEG alpha-rhythm biofeedback with acoustic reinforcement). This procedure was performed at the beginning, middle, and end of the course. During the first neurofeedback training session, deactivation (p<0.001) was found in the right angular gyrus, supramarginal, and superior temporal gyri, Brodmann area 39, and cerebellum...
September 2016: Bulletin of Experimental Biology and Medicine
M S Golovin, M S Golovin, R I Aizman
We studied the effect of audiovisual stimulation training course on physical development, functional state of the cardiovascular system, blood biochemical parameters, and hormonal status of athletes. The training course led to improvement of physical performance and adaptive capacities of the circulatory system, increase in plasma levels of total protein, albumin, and glucose and total antioxidant activity, and decrease in triglyceride, lipase, total bilirubin, calcium, and phosphorus. The concentration of hormones (cortisol, thyrotropin, triiodothyronine, and thyroxine) also decreased under these conditions...
September 2016: Bulletin of Experimental Biology and Medicine
A K Martusevich, S P Peretyagin, A A Martusevich, P V Peretyagin
The effects of inhalation of singlet oxygen mixture, dry and humidified ozone-oxygen mixture, and ozonated oils on heart rate variability as well as on the rate and control mechanisms of microcirculation were examined in rats. The most optimal were the responses of systemic and regional hemodynamics to inhalation of the gas produced by a generator of singlet oxygen and humidified ozone-oxygen mixtures. Singlet oxygen stabilized the cardiac rhythm and augmented microcirculation via activation of "internal" (endothelial and neurogenic) regulatory mechanisms...
September 2016: Bulletin of Experimental Biology and Medicine
S A Cherepanov, K I Cherepanova, N F Grinenko, O M Antonova, V P Chekhonin
We studied the effect of an activator (ShTh) and an inhibitor (cyclopamine) of the Hedgehog signaling pathway on proliferation of human glioma cell lines U87-MG and U251-MG and cultured human astrocytes. The Hedgehog signaling pathway is activated in glioma cells, but not in cultured human astrocytes. Experiments with Shh and cyclopamine can serve as an additional criterion for assessing activity of Hedgehog signaling in known cell lines and primary cultured cells.
September 2016: Bulletin of Experimental Biology and Medicine
G A Slashcheva, V A Rykov, A V Lobanov, A N Murashev, Yu A Kim, T V Arutyunyan, A F Korystova, L N Kublik, M Kh Levitman, V V Shaposhnikona, Yu N Korystov
We analyzed changes in angiotensin-converting enzyme activity in the aorta of hypertensive SHR rats against the background of age-related BP increase (from week 7 to 14) and the effect of dihydroquercetin on BP rise and angiotensin-converting enzyme activity. Normotensive WKY rats of the same age were used as the control. BP and activity of angiotensin-converting enzyme in the aorta of SHR rats increased with age. Dihydroquercetin in doses of 100 and 300 μg/kg per day had no effect on the increase of these parameters; dihydroquercetin administered to 14-week-old WKY rats in a dose of 300 μg/kg reduced activity of the angiotensin-converting enzyme...
September 2016: Bulletin of Experimental Biology and Medicine
P P Tregub, N A Malinovskaya, V P Kulikov, A B Salmina, M E Nagibaeva, A S Zabrodina, G E Gertsog, S K Antonova
We compared the intensity of apoptosis in the peri-infarction area of the brain after isolated and combined exposure to hypoxia and hypercapnia prior to focal ischemic stroke modeling. Hypoxia and hypercapnia reduced the number of TUNEL-positive cells in the peri-infarction area, and their combination was most effective in comparison with effects of isolated exposures. The maximum neuroprotective effect of combined exposure to hypoxia and hypercapnia in comparison with isolated exposures was determined by inhibition of apoptosis in the peri-infarction zone...
September 2016: Bulletin of Experimental Biology and Medicine
V N Perfilova, G A Zhakupova, L I Lashchenova, S A Lebedeva, I N Tyurenkov
Spatial memory was studied in 2-month-old offspring of rats subjected to different types of experimental preeclampsia (replacement of drinking water with 1.8% NaCl from day 1 to 21 of gestation or intraperitoneal administration of non-selective NO-synthase inhibitor L-NAME to pregnant rats in a daily dose of 25 mg/kg for 7 days on gestation days 14-20). Spatial memory was evaluated in an elevated 8-arm radial maze. Both types of experimental preeclampsia impaired spatial (long-term and short-term) memory and can be used in the development of drugs correcting negative effects of this pregnancy complication on memory...
September 2016: Bulletin of Experimental Biology and Medicine
E S Trofimova, M V Zykova, A A Ligacheva, E Yu Sherstoboev, V V Zhdanov, M V Belousov, M S Yusubov, S V Krivoshchekov, M G Danilets, A M Dygai
A screening study of biological activity of native humic acids isolated from peat was performed; several physical and chemical parameters of their structures were studied by UV- and infrared spectroscopy. Spectroscopy yielded similar shape of light absorption curves of humic acids of different origin, which can reflect similarity of general structural principles of these substances. Alkaline humic acids have more developed system of polyconjugation, while molecular structures of pyrophosphate humic acids were characterized by higher aromaticity and condensation indexes...
September 2016: Bulletin of Experimental Biology and Medicine
T G Borovskaya, A M Dygai, Yu A Shchemerova, S I Kamalova, V A Mashanova, A V Vychuzhanina, M E Poluektova, P G Madonov, D N Kinsht, V E Goldberg
Effectiveness of the granulocyte colony-stimulating factor immobilized by using electronbeam synthesis nanotechnology was investigated on the model of experimental testicular failure caused by the toxic effect on stem spermatogonia. Administration of the drug to experimental paclitaxel-treated animals increased the number of sources of the proliferative pool of spermatogenesis and its productivity. The effectiveness of immobilized granulocyte colony-stimulating factor was based on its ability to stimulate reparative regeneration of the spermatogenic tissue, which manifested in a decrease in spermatogenic layer maturity and increase in the number of microenvironment cells...
September 2016: Bulletin of Experimental Biology and Medicine
V I Kirpatovskii, I S Mudraya, S V Revenko, A Yu Bablumyan, N K Adamyan, V P Ivanov
The therapeutic effect of doxazosin (40 μg/kg/day over one month) on urinary bladder was examined in female rats with modeled chronic infravesical obstruction (IVO) produced by graduated mechanical constriction of the proximal urethral segment. In one month, IVO induced a pronounced vesical hypertrophy both in treated and untreated rats that manifested in increased bladder weight and capacity, the latter increment being pronouncedly greater in treated rats. In untreated IVO rats, infusion cystometry revealed elevated basal intravesical pressure of void bladder P0, markedly increased maximal (premicturitional) pressure Pmax, and increased amplitude of spontaneous oscillations of intravesical pressure ΔPdet in filled bladder...
September 2016: Bulletin of Experimental Biology and Medicine
S I Zaichkina, A R Dyukina, O M Rozanova, S P Romanchenko, N P Sirota, E A Kuznetsova, N B Simonova, S S Sorokina, D T Zakrzhevskaya, V I Yusupov, V N Bagratishvili
We studied the effect of exposure to helium-neon laser (dose range 0.16-50 mJ/cm(2)) on activation of natural protection reserve in mice using the adaptive response test. DNA comets method revealed a protective response manifested in DNA damage level in whole blood leukocytes of mice and in lymphoid organs by the thymus and spleen weight index; preexposure to laser did not induce the adaptive response. ROS level in the whole blood was assessed by the level of zymosan-induced luminol chemiluminescence. In mice subjected to adaptive laser irradiation in doses of 0...
September 2016: Bulletin of Experimental Biology and Medicine
N V Kirbaeva, N E Sharanova, V A Baturina, V M Zhminchenko, S S Pertsov, A V Vasil'ev
The dynamics of coenzyme Q10 concentration in the blood plasma, liver, and brain of passive and active rats was studied on the model of metabolic stress. This parameter was shown to differ in rats with various patterns of behavior. Dietary consumption of coenzyme Q10 in doses of 10 and 100 mg/kg body weight was followed by changes in its content in experimental animals.
September 2016: Bulletin of Experimental Biology and Medicine
L M Birioukova, E Yu Sitnikova, M A Kulikov, V V Raevsky
Involvement of the brain dopaminergic system in the age-related dynamics of absence epilepsy in WAG/Rij rats was examined by histological, immunohistochemical, and electrophysiological (EEG) methods. We revealed reduced expression of dopamine receptors in various brain structures prior to first manifestations of the disease (at the age of 1-3 months), reduced density of neurons in the center of nigrostriatal system (substantia nigra pars compacta) in 10-month-old rats in comparison with 1-month-old rats, and positive correlation between neural density in the substantia nigra and intensity of epileptic activity in EEG...
September 2016: Bulletin of Experimental Biology and Medicine
V A Yurkiv, V I Melikhov, V S Shubin
We studied substrate specificity of Na(+),Cl(-)(HCO3(-))-ATPase. In most cases, replacement of ATP for other phosphate-containing substances resulted in not only pronounced suppression of phosphohydrolase reactions, but also dramatic changes of their responsiveness to the stimulating effect of monovalent ions. The data showed that Na(+),Cl(-)(HCO3(-))-ATPase is a highly specific enzyme for ATP.
September 2016: Bulletin of Experimental Biology and Medicine
M I Guryanov
No abstract text is available yet for this article.
September 2016: Bulletin of Experimental Biology and Medicine
S P Syatkin, V A Frolov, N Ya Gridina, N G Draguntseva, A S Skorik
For the development of methods of additional differential diagnostics of gliomas of various grades of malignancy and gliomas and local inflammatory processes in the CNS we studied the intensity of aggregation of peripheral blood cells under the influence of channel blockers ketamine and verapamil. In in vitro experiments, verapamil and ketamine in various dilutions (from 10 to 100,000 times) were added to blood samples and the effects of these dilutions on the intensity of blood aggregation in patients with gliomas of different degree of malignancy, traumatic brain injuries, and other types of neurosurgical pathologies were studied...
September 2016: Bulletin of Experimental Biology and Medicine
L V Shurygina, E I Zlishcheva, T V Androsova, E A Nemchinova, A N Kravtsova
The effects of potassium comenate on functional state of CNS in mice and rats were studied in the open-field and hole-board tests under control conditions and after acute exposure to hypoxia-hypercapnia. The effects of potassium comenate on CNS were also studied in rodents subjected to propofol-induced sleep. Preliminary administration of 4 mg/kg potassium comenate for 3 days attenuated the posthypoxic changes in behavioral reactions (emotional anxiety/reactivity). The pronounced stress-protective effect of potassium comenate was observed both on days 1 and 14 after exposure to hypoxia-hypercapnia...
September 2016: Bulletin of Experimental Biology and Medicine
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