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Bulletin of Experimental Biology and Medicine

N A Kraskovskaya, E O Kukanova, N S Lin'kova, E A Popugaeva, V Kh Khavinson
On the page 553 Acknowledgements should be as follows: The study was supported by the Russian Science Foundation (grant 14-25-00024-P).
October 3, 2017: Bulletin of Experimental Biology and Medicine
I V Maiborodin, V V Morozov, A A Anikeev, N F Figurenko, R V Maslov, V A Matveeva, G A Chastikin, V I Maiborodina
The author name G. A. Chastikina should read G. A. Chastikin.
October 3, 2017: Bulletin of Experimental Biology and Medicine
A L Rusanov, K V Nakhod, V I Nakhod, E V Poverennaya, N A Petushkova, N G Luzgina
Changes in the proteome of keratinocytes of immortalized HaCaT line exposed to cytotoxic substance Triton X-100 in concentrations of 12.5 and 25 μg/ml were studied by liquid chromatography combined with mass spectrometry. The appearance of proteins involved in the regulation of mitosis, RNA stability, and catabolic processes were detected; the number of apoptosis-associated proteins increased, while the number of proteins involved in differentiation and energy metabolism of keratinocytes decreased.
September 27, 2017: Bulletin of Experimental Biology and Medicine
V G Zilov, A A Khadartsev, I V Terekhov, S S Bondar'
The contents of cyclins A1, B1, E1, and D1, cyclin-dependent kinases 2 and 4 (CDK2 and CDK4), cyclin-dependent kinase 2C inhibitor (p18), and cyclin-dependent kinase 1C inhibitor (p57) in whole blood mononuclear cells of practically healthy donors and convalescents from community-acquired pneumonia were measured after cell exposure to low-intensity electromagnetic radiation of 1 GHz. The level of cyclins A1, D1, and B1, p57, and p18 proteins, and CDK2 was reduced in convalescents, while the content of cyclin B1 was elevated in both groups...
September 26, 2017: Bulletin of Experimental Biology and Medicine
K A Fomicheva, E N Knyazev, D V Mal'tseva
The gene expression profiles of MDA-MB-231 cell line of breast cancer and xenografts derived from this tumor in murine model were analyzed using GeneChip Human Transcriptome array 2.0 platform (Affymetrix). A more than 1000-fold increase in the MIR1973 gene expression was observed in the xenografts compared to the original cell line. Real-time reverse transcription PCR showed that the content of mature hsa-miR-1973 microRNA encoded by this gene was elevated in the xenografts by more than 300 times. According to microarray analysis, none of hsa-miR-1973 target genes available in the databases changed the expression in the cell line and xenografts...
September 26, 2017: Bulletin of Experimental Biology and Medicine
E G Skurikhin, O V Stronin, A A Epanchintsev, O V Pershina, N N Ermakova, V A Krupin, A V Pakhomova, O E Vaizova, A M Dygai
Biological activity of a new pegylated form of an of glucagon-like peptide-1 (GLP-1) analogue pegGLP-1 was studied in C57Bl/6 mice under normal conditions and during modeling of streptozotocin-induced type I diabetes mellitus. pegGLP-1 differs from GLP-1 (7-37) by polyethylene glycol residue covalently bound to His7, Lys26, and Lys34 of the GLP-1 molecule. It was shown that single intragastrical administration of pegGLP-1 induced an increase in GLP-1 level in blood serum of healthy mice. The maximum level of this parameter was observed in 4-8 h...
September 26, 2017: Bulletin of Experimental Biology and Medicine
E V Kochurova, V N Nikolenko
Dental and immunological features of the influence of various prosthetic structures of orthopedic prostheses on tissues and organs of the maxillofacial region were evaluated by the parameters of expression of oral fluid biomarkers. Healthy people without tumor and somatic diseases and patients with neoplasms of maxillofacial area in need of dental rehabilitation were examined before and in 2 weeks and 3 months after treatment. Certain regularities in the reaction of biomarkers to orthopedic prostheses were observed: a decrease in activity of MMP-2 and MMP-8 and their inhibitors or an increase in MMP-9; an increase in activity of biomarkers at early terms and a decrease in delayed terms after prosthetics...
September 26, 2017: Bulletin of Experimental Biology and Medicine
S A Kryzhanovskii, L G Kolik, I B Tsorin, V N Stolyaruk, M B Vititnova, E O Ionova, A V Sorokina, A D Durnev
We developed a translation model of alcoholic cardiomyopathy in rats. By the end of forced alcoholization (the rats received 10% ethanol solution as the only source of fluid for 24 weeks; mean daily ethanol consumption was 5.0-6.5 g/kg), the rats developed dilated heart failure. Echocardiography and morphometric study of the myocardium revealed a decrease in inotropic function of the heart and dilatation of the right and left ventricles. Fatty degeneration of the myocardium (pathognomonic sign of alcoholic cardiomyopathy) and decrease in electrical stability of cardiomyocytes reliably reproduce the clinical pattern of alcoholic cardiomyopathy...
September 26, 2017: Bulletin of Experimental Biology and Medicine
L K Khnychenko, E E Yakovleva, E R Bychkov, P D Shabanov
The effects of the new structural analogue of benactyzine, a derivative of fluorencarbonic acid, on monoamine levels in brain structures were studied in male Wistar rats with experimental depression. Depressive state in rats was modeled by single injection of reserpine (4 mg/kg). The concentrations of norepinephrine (NE), dopamine (DA), serotonin (5-HT), and their metabolites 3,4-dihydroxyphenylacetic acid (DOPAC), homovanilic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in the hypothalamus and striatum were measured by HPLC...
September 26, 2017: Bulletin of Experimental Biology and Medicine
S V Notova, E V Kiyaeva, I V Radysh, I E Laryushina, M L Blagonravov
The element status was studied in students with different levels of adaptation determined by the parameters of cardiointervalography. The content of chemical elements in the hair was measured by atomic emission and mass spectrometry. In students whose autonomic status was characterized by sympathicotonia, the level of cobalt in the hair was significantly higher, while the levels of manganese and magnesium were lower than normal. The content of selenium in the hair was 2.3 times lower in the study group in comparison with the median level in Russia...
September 25, 2017: Bulletin of Experimental Biology and Medicine
D V Abramochkin, K B Pustovit, V S Kuz'min
The modulatory influence of diadenosine tetraphosphate (Ap4A) and diadenosine pentaphosphate (Ap5A) on the effect of intramural autonomic nerve stimulation in isolated rabbit sinoatrial node were examined. Electrical activity of the sinoatrial node was recorded intracellularly. Against the background of blockade of adrenergic effects with propranolol (3×10(-6) M) or in preparations isolated 2 h after injection of reserpine (2 mg/kg), nerve stimulation induced short-term membrane hyperpolarization and diminished the sinus node firing rate...
September 25, 2017: Bulletin of Experimental Biology and Medicine
A L Shim, V M Mitrokhin, L R Gorbacheva, I G Savinkova, K B Pustovit, M I Mladenov, A G Kamkin
Discrete mechanical stretch of isolated spontaneously contracting cardiac myocytes was employed to examine the kinetics of NO production in these cells. NO oscillations were detected with fluorescent dye 4-amino-5-methylamino-2',7'-difluorofluorescein diacetate. The mechanisms underlying stretch-induced changes in NO concentration remain unclear and further studies are needed to evaluate the role of NO oscillation in the regulation of cardiomyocyte function.
September 25, 2017: Bulletin of Experimental Biology and Medicine
O V Gruzdeva, O E Akbasheva, Yu A Dyleva, L V Antonova, V G Matveeva, E G Uchasova, E V Fanaskova, V N Karetnikova, S V Ivanov, O L Barbarash
The content of adipokines, pro- and anti-inflammatory cytokines were studied in adipocytes isolated from epicardial and subcutaneous adipose tissue of 24 coronary heart disease patients. The content of leptin and soluble leptin receptor in adipocytes of epicardial adipose tissue was higher by 28.6 and 56.9% and the level of adiponectin was lower by 33% than in adipocytes of the subcutaneous fat. In culture of epicardial adipocytes, the levels of proinflammatory cytokines TNF-α and IL-1 were higher. Subcutaneous adipose tissue adipocytes were characterized by higher levels of anti-inflammatory cytokines IL-10 and FGF-β...
September 25, 2017: Bulletin of Experimental Biology and Medicine
E A Ivanova, I G Kapitsa, N N Zolotov, V F Pozdnev, T A Voronina
In 60-day-old Wistar rats with fetal valproate syndrome, the brain to body weight ratio was higher by 9.4% and activity of dipeptidyl peptidase IV in the serum and cerebrospinal fluid was higher by 18.4 and 40.6%, respectively, than in healthy controls. Activity of prolylendopeptidase in the serum and cerebrospinal fluid in rats with the fetal valproate syndrome did not differ from the control.
September 25, 2017: Bulletin of Experimental Biology and Medicine
V M Ushakova, E A Zubkov, A Y Morozova, A V Gorlova, D A Pavlov, A N Inozemtsev, V P Chekhonin
We studied the effect of electroconvulsive therapy on cognitive functions in rats with depression-like disorder caused by exposure to ultrasound of varying frequency (20-45 kHz). Object recognition and Morris water-maze tests revealed no negative effects of the therapy on memory. Moreover, positive effect of therapy was demonstrated that manifested in amelioration of memory disturbances in depression-like disorders in these behavioral tests. The results of this study do not support the idea about side effects of electroconvulsive therapy, in particular, development of transient amnesia, and are a prerequisite for a more thorough study of internal mechanisms of the effect of the therapy on cognitive sphere...
September 25, 2017: Bulletin of Experimental Biology and Medicine
A A Simankova, E N Sazonova, O A Lebed'ko
In 60-day-old male rats after antenatal hypoxia, the body weight and the absolute weight of the cerebral hemispheres were significantly lower than in the progeny of intact animals. Analysis of brain sections stained with silver nitrate revealed reduced number of nucleoli in neocortical layer II and hippocampal CA1 neurons and smaller area of neuronal nuclei in neocortical layer V and total area of nucleoli in neurons of all studied zones. The animals demonstrated increased locomotor activity in the elevated plus-maze test...
September 25, 2017: Bulletin of Experimental Biology and Medicine
D S Kondratieva, S A Afanasiev, V Yu Usov, S V Popov
We studied the dependence of post-rest positive inotropic response of isolated rat papillary muscles subjected to rhythmic stimulation on severity of postinfarction cardiosclerosis developed during 6 weeks after occlusion of the left descending coronary artery. The isolated papillary muscles were perfused with oxygenated Krebs-Henseleit solution and electrically stimulated at a rate of 0.5 Hz. In all rats, coronary occlusion provoked postinfarction cardiosclerosis with the formation of a scar occupying 20-50% (min-max of the sample) of the left ventricular wall...
September 25, 2017: Bulletin of Experimental Biology and Medicine
V Kh Khavinson, D Yu Kormilets, A T Mar'yanovich
We have discovered motives of short-chain epigenetically active peptides in some proteins of long-lived African mole rat Heterocephalus glaber. These epigenetic regulators are located in the protein structure between lysine and arginine residues, thus facilitating their release in limited proteolysis. Some of these epigenetic regulators are not found in the proteins of short-lived species - Norway rat Rattus norvegicus and house mouse Mus musculus.
September 25, 2017: Bulletin of Experimental Biology and Medicine
L F Kalenova, V P Melnikov, I M Besedin, A S Bazhin, M A Gabdulin, S S Kolyvanova
An ointment containing metabolites of Bacillus sp. microorganisms isolated from permafrost samples was applied onto the skin wound of BALB/c mice. Metabolites isolated during culturing of Bacillus sp. at 37°C produced a potent therapeutic effect and promoted wound epithelialization by 30% in comparison with the control (ointment base) and by 20% in comparison with Solcoseryl. Treatment with Bacillus sp. metabolites stimulated predominantly humoral immunity, reduced the time of wound contraction and the volume of scar tissue, and promoted complete hair recovery...
September 25, 2017: Bulletin of Experimental Biology and Medicine
V P Nikolin, S S Bogachev, N A Popova, Yu V Tornuev, E V Vinogradova
We studied radioprotective effects of a preparation based on yeast RNA and its influence on therapeutic efficiency of ionizing radiation against transplanted tumors. Parenteral administration of yeast RNA preparation to mice in a dose of 10 mg 1 h prior to exposure to ionizing γ-radiation ((137)Cs) in a lethal dose (LD80/30) increased 30-day survival by 66%; by day 80, 80% of animals survived (vs. 2.5% in the control). Whole-body exposure to ionizing γ-radiation in a dose of 7 Gy significantly increased the mean lifespan of mice with experimental lung metastases or intraperitoneally transplanted leukemia L-1210 by 42 and 20...
September 25, 2017: Bulletin of Experimental Biology and Medicine
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