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Journal Article
Research Support, Non-U.S. Gov't
Effect of S100A6 over-expression on β-catenin in endometriosis.
Journal of Obstetrics and Gynaecology Research 2015 September
AIM: S100A6 is over-expressed in several human tumors, including pancreatic carcinoma, malignant fibrous histiocytoma, breast, colon, and gastric carcinoma, but little is known about the role of S100A6 in endometriosis. The aim of the present study was to investigate the effect of S100A6 over-expression on β-catenin in endometrial stromal cells.
METHODS: Endometrial stromal cells were transfected with an hS100A6-expressing recombinant lentivirus construct. The expression of β-catenin was assessed using western blot and reverse transcription-polymerase chain reaction.
RESULTS: S100A6 over-expression promoted β-catenin expression at the RNA and protein levels, in endometrial stromal cells.
CONCLUSIONS: S100A6 induces expression of β-catenin in endometrial stromal cells.
METHODS: Endometrial stromal cells were transfected with an hS100A6-expressing recombinant lentivirus construct. The expression of β-catenin was assessed using western blot and reverse transcription-polymerase chain reaction.
RESULTS: S100A6 over-expression promoted β-catenin expression at the RNA and protein levels, in endometrial stromal cells.
CONCLUSIONS: S100A6 induces expression of β-catenin in endometrial stromal cells.
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