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Journal of Obstetrics and Gynaecology Research

Nozomi Takahashi, Miyuki Harada, Ryosuke Tanabe, Akane Takayanagi, Gentaro Izumi, Nagisa Oi, Tetsuya Hirata, Osamu Wada-Hiraike, Tomoyuki Fujii, Yutaka Osuga
AIM: The objective of this study is to determine the factors associated with successful pregnancy in women of late reproductive age with uterine fibroids who undergo embryo cryopreservation before surgery (ECBS). METHODS: Patients who underwent in vitro fertilization treatment with controlled ovarian stimulation from November 2010 to January 2017 in our university hospital were included. Twenty-two patients older than 35 years of age at the first visit with cavity-distorting uterine fibroids underwent ECBS, a three-step therapeutic approach consisting of oocyte pick-up, myomectomy and embryo transfer (ET), which are performed in this order...
July 13, 2018: Journal of Obstetrics and Gynaecology Research
Kuniaki Ota, Toshifumi Takahashi, Satoru Shiraishi, Hideki Mizunuma
AIM: Menorrhagia and dysmenorrhea are common symptoms. Uterine adenomyosis is one of the causes of menorrhagia and dysmenorrhea. These symptoms often decrease the quality of life in women. Microwave endometrial ablation (MEA) is a recently developed procedure that enables endometrial ablation. Dienogest has long been used to suppress endometrium development and reduce adenomyosis-related dysmenorrhea. However, some cases could be resistant to dienogest. In this study, we evaluated the efficacy of a combination of MEA and postoperative dienogest in reducing adenomyosis-related dysmenorrhea and menorrhagia...
July 12, 2018: Journal of Obstetrics and Gynaecology Research
Kazuko Sugiura, Toshiyuki Ojima, Tetsumei Urano, Takao Kobayashi
AIM: We analyzed the incidence and prognosis of thromboembolism associated with combined oral contraceptives (COCs) by age groups in Japan. METHODS: A total of 581 events of venous thromboembolism (VTE) and arterial thromboembolism (ATE) associated with COCs were analyzed from the Pharmaceuticals and Medical Devices Agency database from 2004 to 2013. In a statistical analysis, a good-prognosis group included recovery cases and a poor-prognosis group involved unrecovered cases with some sequela and fatal cases...
July 12, 2018: Journal of Obstetrics and Gynaecology Research
Ayaka Tanaka, Hitomi Nakamura, Yasuhiko Tabata, Yuka Fujimori, Keiichi Kumasawa, Tadashi Kimura
AIM: Ovarian tissue cryopreservation before cancer treatment is the only option to preserve fertility under some circumstances. However, tissue ischemia after transplantation while awaiting angiogenesis induces dysfunctional folliculogenesis and reduces ovarian reserve and is one of the disadvantages of frozen-thawed ovarian tissue transplantation. Basic fibroblast growth factor (bFGF) is a major regulator of angiogenesis. However, bFGF rapidly loses biological activity when its free form is injected in vivo...
July 12, 2018: Journal of Obstetrics and Gynaecology Research
Osamu Yoshino, Takashi Minamisaka, Yosuke Ono, Sayaka Tsuda, Azusa Samejima, Tomoko Shima, Akitoshi Nakashima, Kaori Koga, Yutaka Osuga, Shigeru Saito
Endometrioma is known to be an occurrence site of ovarian cancer, but there is no evidence on how to reduce the risk of canceration. Here, we report three cases of ovarian cancer arising from endometrioma during hormone therapies of GnRH analogue and tamoxifen, low-dose estrogen-progestin (LEP) and dienogest. In all cases, each hormonal treatment was effective in shrinking the size of the endometrioma. During hormonal treatments, solid parts inside endometrioma were observed, which was followed by surgery. The histology of the solid parts was clear-cell adenocarcinoma in all cases...
July 12, 2018: Journal of Obstetrics and Gynaecology Research
Kenichiro Hiraoka, Seiji Kitamura, Yoshihito Otsuka, Kiyotaka Kawai, Tatsuya Harada, Tomonori Ishikawa
AIMS: The objective of this study was to investigate the effect of the head-first or tail-first injection of sperm into the cytoplasm by Piezo-ICSI (PICSI) on oocyte survival, fertilization, embryo development and implantation ability in humans. METHODS: We retrospectively investigated 632 mature oocytes retrieved from 152 infertile patients who attended our PICSI-ET program at the Niji Clinic between October 2010 and January 2014. Of these, 342 mature oocytes retrieved from 75 patients were injected with sperm head first, and 290 mature oocytes retrieved from 77 patients were injected with sperm tail first into the cytoplasm...
July 11, 2018: Journal of Obstetrics and Gynaecology Research
Akemi Koshiba, Taisuke Mori, Hiroyuki Okimura, Kanoko Akiyama, Hisashi Kataoka, Osamu Takaoka, Fumitake Ito, Hiroshi Matsushima, Izumi Kusuki, Jo Kitawaki
AIM: We aimed to evaluate whether hormonal therapy immediately after postsurgical recurrence of ovarian endometrioma controls disease progression and can be an alternative therapeutic option to avoid multiple repeat surgeries. METHODS: We enrolled 146 patients treated for endometrioma at the University Hospital of Kyoto Prefectural University of Medicine between 2009 and 2015. After laparoscopic cystectomy using the stripping technique, opening of cul-de-sac obliterations and complete resection of the deep infiltrating endometriosis lesions, the patients either received no treatment (n = 83), oral contraceptives (OC; n = 32) or dienogest (DNG; n = 27), depending on their medical history...
July 10, 2018: Journal of Obstetrics and Gynaecology Research
Takahiro Nakano, Haruka Muto, Keisuke Ishii, Shusaku Hayashi, Yoko Okamoto, Nobuaki Mitsuda
AIM: To examine the intrapartum cesarean delivery rate following failure of induction of labor (IOL) as well as risk factors associated with failed IOL among nulliparous women of advanced maternal age (AMA). METHODS: This was a retrospective cohort study conducted at a single perinatal care center. We retrospectively reviewed the medical records of nulliparous AMA women (aged 35 years or older) with singleton vertex pregnancy who underwent IOL at term. Data regarding maternal baseline characteristics and pregnancy course, including complications during pregnancy and maternal status at time of IOL, were collected...
July 10, 2018: Journal of Obstetrics and Gynaecology Research
Yair Daykan, Tal Biron-Shental, Daniella Navve, Netanella Miller, Mor Bustan, Rivka Sukenik-Halevy
AIM: To evaluate factors predictive of the success of dinoprostone slow release vaginal insert for cervical ripening. METHODS: A total of 169 women who underwent cervical ripening with dinoprostone slow release vaginal insert were included in the study cohort. The correlation between parameters present before cervical ripening with dinoprostone slow release and its success, as well as complications and adverse outcomes were analyzed. RESULTS: Dinoprostone slow release vaginal insert was successful in achieving vaginal delivery in 148 of 169 (87...
July 6, 2018: Journal of Obstetrics and Gynaecology Research
Adalgisa Cordisco, Bruno Murzi, Enrico Chiappa
We describe a rare case of right aortic arch with bilateral arterial duct and disconnected left pulmonary artery. Prenatal diagnosis allowed to plan delivery at the referral center and to maintain perfusion of the disconnected pulmonary artery through prostaglandin E1 infusion until surgical reconnection was performed. Early postnatal treatment avoided functional loss of the left lung that would have happened if malformation had not been identified before birth.
July 6, 2018: Journal of Obstetrics and Gynaecology Research
Nicolò Bizzarri, Franco De Cian, Stefano Di Domenico, Maria Grazia Centurioni, Serafina Mammoliti, Valentina Ghirardi, Valerio Gaetano Vellone
Paraganglioma is one of the rarest neoplasms involving the ovary, with only 10 previous reports. We present a case of peritoneal carcinomatosis from primary ovarian paraganglioma and a systematic review of the literature. Clinical information was retrieved from medical records, and a systematic review of the literature was performed according to meta-analysis of observational studies in epidemiology guidelines. A 33-year-old woman presented with a 12-month history of hypertension and weight loss. She was diagnosed with ovarian paraganglioma and was treated with extensive debulking surgery to no residual disease after three cycles of neoadjuvant chemotherapy...
July 6, 2018: Journal of Obstetrics and Gynaecology Research
Gulenay Gençosmanoğlu Türkmen, Zehra Vural Yilmaz, Korkut Dağlar, Özgür Kara, Cem Yaşar Sanhal, Aykan Yücel, Dilek Uygur
AIM: Intrahepatic cholestasis of pregnancy (ICP) is a unique hepatic disorder of pregnancy and is related to adverse maternal and perinatal outcomes. The pathogenesis of the disease is not clear and appears to be multifactorial. There is increasing evidence that vitamin D (Vit D) plays a role in hepatobiliary homeostasis and in various liver diseases. We aimed to investigate the association between serum Vit D level and ICP. METHODS: A total of 40 pregnant women with ICP and 40 healthy pregnant women were included in this controlled cross-sectional study...
July 6, 2018: Journal of Obstetrics and Gynaecology Research
Ki H Lee, Ye W Jung, Soo Y Song, Byung H Kang, Jung B Yang, Young B Ko, Mina Lee, Hye Y Han, Heon J Yoo
AIM: To compare the efficacy between dienogest and levonorgestrel-releasing intrauterine system (LNG-IUS) after laparoscopic surgery for endometriosis. METHODS: A total of 285 women were diagnosed as endometriosis by laparoscopy between 2011 and 2015. Patients were grouped into no treatment (n = 83), treatment with dienogest (n =130) and treatment with LNG-IUS (n =72) after laparoscopic surgery. The changes of the pain scores were checked at 6, 12 and 24 months after the surgery, and the rates of disease recurrence and treatment discontinuation rate were determined...
July 5, 2018: Journal of Obstetrics and Gynaecology Research
Mohammad Moazeni, Mohammad Asadpour, Seyed Hossein Malekpour
AIM: Hydatid disease during pregnancy may lead to various complications in both mother and child. Accordingly, enough knowledge is required to manage these complications. This study was done to evaluate the interaction between hydatid disease and pregnancy in laboratory mice. METHODS: Twenty female BALB/c mice (Mus musculus) were divided into test and control groups, 10 animal in each. The mice of the test group were infected intraperitoneally by injection of 1000 protoescolices...
July 5, 2018: Journal of Obstetrics and Gynaecology Research
Lenan Liu, Qin Fang, Yan Xing
Female adnexal tumors of probable Wolffian origin (FATWO) are a rare neoplasm from the mesonephric duct remnants with less than 90 cases having been reported worldwide. A 34-year-old nulliparous woman was referred to our clinic for a recent discovery of a pelvic mass, the diagnosis of FATWO has been confirmed based on the pathological and immunohistochemical results.
July 5, 2018: Journal of Obstetrics and Gynaecology Research
Gabriel Levin, Amihai Rottenstreich
No abstract text is available yet for this article.
July 5, 2018: Journal of Obstetrics and Gynaecology Research
Shigeki Matsubara
No abstract text is available yet for this article.
July 5, 2018: Journal of Obstetrics and Gynaecology Research
Miki Akasaka, Kazuhiro Osato, Mito Sakamoto, Tomohisa Kihira, Tomoaki Ikeda, Takaharu Yamawaki
Amniotic fluid embolism (AFE) causes consumption coagulopathy, which requires a massive transfusion to save the mother's life. The preparation of such a massive transfusion is too time-consuming in extremely emergent clinical settings and occasionally leads to devastating side effects such as transfusion-associated acute lung injury. C1 esterase inhibitor (C1INH) is a protein with the ability to inhibit complement, coagulation and kinin pathways. The C1INH concentration in AFE patients is low, and it has been speculated that the administration of C1INH concentrate could have a striking and beneficial effect on AFE patients in critical condition by ameliorating their perturbed coagulation system...
July 5, 2018: Journal of Obstetrics and Gynaecology Research
Pablo Olmos, Gisella Borzone, Andrés Poblete
AIM: Prevalence of type 2 diabetes mellitus (T2DM) during childbearing age in Chile had a 47-fold rise in 7 years, reaching 120 844 women, half of which are unaware of their condition. We aimed to project pregnancies and births among Chilean women of childbearing age (WCBA) with T2DM and report the incidence of birth defects and the associated years of life lost and lifetime costs. METHODS: Markov model of cohort of WCBA with T2DM (WCBA-DM) with a 20-year time horizon (2018-2037), using data from previous studies...
July 5, 2018: Journal of Obstetrics and Gynaecology Research
Iori Kisu, Kouji Banno, Yusuke Matoba, Masataka Adachi, Daisuke Aoki
Uterus transplantation (UTx) is now a potential option for women with uterine factor infertility to have a child. However, UTx is still in an experimental stage and basic animal studies including in nonhuman primates are needed for accumulation of data that will provide important information for establishment of UTx in humans. Herein, we summarized our experiences using cynomolgus macaques, with the goal of promoting further development of UTx studies in nonhuman primates. Our basic studies using cynomolgus macaques were summarized, including the results of other teams in nonhuman primates...
July 5, 2018: Journal of Obstetrics and Gynaecology Research
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