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Journal Article
Proteins and renal fibrosis: low-protein diets induce Kruppel-like factor-15, limiting renal fibrosis.
Kidney International 2011 May
The mechanisms underlying beneficial influences of low-protein diets on the progressive nature of chronic kidney disease are incompletely understood. Gao et al. identify a downregulation of Kruppel-like factor-15 (KLF15) associated with increased renal fibrosis. The KLF15 downregulation and renal fibrosis are reversed with dietary protein restriction, especially when ketoacids are added. The results suggest that KLF15 may play a role in suppressing renal fibrosis and could contribute to the benefits of dietary protein restriction.
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