Drug-induced cholestasis. Clinical contribution.

We described two cases of drug-induced hepatitis: in both cases we recognised a pathogenesis based on hypersensivity mechanism. The first case, determined by naproxen, presented a serious cholestatic jaundice and histologic pattern due to ductular cholestasis without any inflammatory reaction. The second case, by a-metildopa, was characterized by spread necrosis of liver cells and peri-portal flogistic infiltrated. This chapter of modern epatology is becoming more and more important, because of both the opportunity of studyng physiopathologica mechanism and the increasing morbidity. The peculiarity of these cases was due not only to the morbidity, but also to the seriousnes of clinical symptoms which involved problems of early differential diagnosis and of attentive follow-up.