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Minerva Gastroenterologica e Dietologica

Roberto de Sire, Gianenrico Rizzatti, Fabio Ingravalle, Marco Pizzoferrato, Valentina Petito, Loris Lopetuso, Cristina Graziani, Alessandro de Sire, Maria C Mentella, Maria C Mele, Antonio Gasbarrini, Franco Scaldaferri
In recent years, there has been an increasing interest on muscle wasting, considering the reduction of quality of life and the increase of morbidity and mortality associated. Sarcopenia and cachexia represent two conditions of reduction of muscle mass, sharing several elements involved in their pathogenesis, such as systemic inflammation, impaired muscle protein synthesis, increased muscle apoptosis, mitochondrial dysfunction in skeletal muscle tissue and insulin resistance. These features often characterize cancer, inactivity or denervation, but also inflammatory diseases, such as chronic obstructive pulmonary disease, renal failure, cardiac failure, rheumatoid arthritis, inflammatory bowel disease and aging in general...
July 18, 2018: Minerva Gastroenterologica e Dietologica
Fuchsia D Gold-Smith, Shayal K Chand, Maxim S Petrov
Post-pancreatitis diabetes mellitus (PPDM) is a sub-type of diabetes of the exocrine pancreas that develops after acute or chronic inflammation of the pancreas. While pro-inflammatory mileu, glucose metabolism, and lipid metabolism in PPDM have been investigated, little is known about gastrointestinal function in post-pancreatitis setting. This article overviews studies on epidemiology and impact of gastroparesis in the setting of type 1 and type 2 diabetes, with a view to estimating the possible burden of gastrointestinal dysfunction in PPDM...
June 14, 2018: Minerva Gastroenterologica e Dietologica
Benedetto Mangiavillano, Mouen A Khashab, Leonardo H Eusebi, Ilaria Tarantino, Mario Bianchetti, Rossella Semeraro, Rinaldo Pellicano, Mario Traina, Alessandro Repici
The two most relevant endoscopic treatable benign biliary diseases (BBD) are benign biliary strictures (BBSs) and biliary leaks (BLs), often associated with high morbidity. The most common endoscopic treatment for biliary strictures involves placement of multiple plastic stents (PSs), with or without balloon dilation, followed by planned exchange of the stents. Thus, there continues to be high interest in pursuing alternative endoscopic approaches that may achieve better results with fewer interventions. In this setting, the use of a fully-covered, self-expandable metal stent (FCSEMS) is an attractive alternative to single or multiple PSs for the treatment of BBDs...
May 31, 2018: Minerva Gastroenterologica e Dietologica
Claudia Chialà, Alessandra Tucci, Alfredo Marzano
No abstract text is available yet for this article.
May 31, 2018: Minerva Gastroenterologica e Dietologica
Davide G Ribaldone
No abstract text is available yet for this article.
May 31, 2018: Minerva Gastroenterologica e Dietologica
Jürgen Feisthammel, Kien Vu Trung, Marcus Hollenbach, Joachim Mössner, Albrecht Hoffmeister
BACKGROUND: The insufflation of gas during colonoscopy leads to distention of the colon with abdominal discomfort and pain for the patients. Use of CO2 during endoscopy is reported to minimize abdominal discomfort during and after endoscopy. Aim of this study was to find out whether this improvement leads to decreased dosage of sedation drugs in order to improve patient's safety and satisfaction. METHODS: In this double-blind, randomized and controlled study 150 Patients referred to colonoscopy were assigned to either CO2 or air insufflation...
September 2018: Minerva Gastroenterologica e Dietologica
Patrizia Burra, Giacomo Germani
No abstract text is available yet for this article.
June 2018: Minerva Gastroenterologica e Dietologica
Carmelo Luigiano, Giuseppe Iabichino, Maria A Palamara, Leonardo H Eusebi
No abstract text is available yet for this article.
June 2018: Minerva Gastroenterologica e Dietologica
Giacomo Germani, Chiara Becchetti
Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome, and it is defined by the presence of steatosis in >5% of hepatocytes, according to histological analysis or detected by specific proton density fat fraction obtained magnetic resonance imaging. The term NAFLD covers two pathologically distinct conditions: non-alcoholic fatty liver and non-alcoholic steatohepatitis (NASH), which can have similar clinical presentation, but with different prognosis. Both conditions can lastly lead to the development of cirrhosis...
June 2018: Minerva Gastroenterologica e Dietologica
Paulina K Phillips, Matthew W Caldis, Alexander D Hristov, Alexander S Lee, Michael R Lucey
The manufacture and consumption of alcohol are ubiquitous and as old as time. Alcohol use disorder (AUD) is defined as a problematic pattern of alcohol use leading to clinically significant impairment. The physical injuries that result from excessive alcohol consumption are varied including end-organ damage to liver (alcohol-associated liver disease [ALD]), pancreas, brain and heart, and systemic consequences including several forms of cancer. Liver transplantation (LT) remains the treatment of last resort for life-threatening liver disease...
June 2018: Minerva Gastroenterologica e Dietologica
Patrizia Burra, Alberto Ferrarese, Giuseppe Feltrin
The assessment of quality of life (QoL) after transplantation represents an ancillary tool to evaluate the efficacy of solid organ transplantation, in addition to graft and patient survival rates and complication. The global assessment of QoL after transplantation usually confirms the improvement when compared to pre-transplant setting. However, whereas significant improvement in physical activity has been widely reported, several studies have demonstrated that social domain and cognitive function do not reach the level of general population after surgery...
June 2018: Minerva Gastroenterologica e Dietologica
Carmelo Luigiano, Leonardo H Eusebi, Maria A Palamara, Giuseppe Iabichino
No abstract text is available yet for this article.
June 2018: Minerva Gastroenterologica e Dietologica
Carmela Colica, Antonino DE Lorenzo, Ludovico Abenavoli
No abstract text is available yet for this article.
June 2018: Minerva Gastroenterologica e Dietologica
Alberto Ferrarese, Alberto Zanetto, Francesco P Russo
Liver transplantation (LT) is the only effective treatment for hepatitis B-virus (HBV) related end stage liver disease, even if the outcome of these patients, has significantly improved after introduction of effective and well tolerated nucleoside/nucleotide analogues (NUC). Pre-transplant therapy has been initially based on lamivudine, but entecavir and tenofovir represent the currently recommended first-line therapeutic option in patients with HBV decompensated cirrhosis. After LT, the development of hepatitis B immunoglobulin (HBIG) in the early 1990's dramatically changes the prognosis of these patients by reducing the incidence of HBV recurrence and increasing survival rate...
June 2018: Minerva Gastroenterologica e Dietologica
James Neuberger
Liver allocation policies determine how those livers that are offered for transplantation are allocated to those who have met the criteria for liver transplantation and are fit enough to undergo the procedure. The goals of allocation policies are based on varying combinations of need (reducing mortality awaiting a graft), benefit (maximizing the outcomes of candidates on the list) or utility (maximizing the life-years gained). Improvement in quality of life is rarely included in the setting of allocation policies...
June 2018: Minerva Gastroenterologica e Dietologica
Dalbir S Sandhu, Ye J Lee, Henning Gerke
BACKGROUND: Large sessile/flat colonic polyps are traditionally removed by lift polypectomy. Underwater endoscopic mucosal resection (UEMR) is a novel technique where air is suctioned out and replaced by water to decompress the colon so that the flat lesions assumes a more polypoid shape facilitating its removal with the standard snare resection. We report the feasibility and safety in our series of patients utilizing this technique. METHODS: A retrospective, observational study of all patients who underwent removal of large colonic polyps (>10 mm) over a period of 3 years (January 2012 to January 2015) at a tertiary care center by UEMR were included in the study...
June 2018: Minerva Gastroenterologica e Dietologica
Birgit Klee, Oliver Barske, Andrea Mack, Christoph K Thoeringer, Bernhard Haller, Valentin Becker, Simon Nennstiel
BACKGROUND: The role of sorbitol malabsorption in patients with functional abdominal discomfort has not been finally clarified yet. Therefore, aim of this study was to evaluate the clinical significance of sorbitol malabsorption, diagnosed by sorbitol hydrogen breath testing in these patients. METHODS: Data of all patients referred to our hospital for hydrogen breath testing between May 1st, 2013 and December 31st, 2014 were retrospectively collected and analyzed...
June 2018: Minerva Gastroenterologica e Dietologica
Silvia Martini
Hepatitis C virus (HCV)-related liver disease represents the leading indication for liver transplantation (LT) in the USA and Europe and HCV recurrence is universal in recipients who are viremic at LT. Until a few years ago, pegylated-interferon in association with ribavirin was the only therapeutic strategy, usable only in compensated cirrhotic patients, in order to prevent post-LT viral recurrence. The recent advent of direct-acting antiviral agents (DAAs) has dramatically increased the chances of curative treatment for the transplant population and the debate about which should be the best time for treating the infection is still open: whether to pursue HCV eradication 1) before LT, in order to improve liver function, delist some patients and prevent graft infection; or 2) as early as possible after LT, rather than 3) waiting for hepatitis C recurrence before starting treatment...
June 2018: Minerva Gastroenterologica e Dietologica
Abdul Haseeb, Ali Siddiqui, Linda J Taylor, Alyssa Mills, Thomas E Kowalski, David E Loren, Jessica Dahmus, Silpa Yalamanchili, Christopher Cao, Andrew Canakis, Tayebah Mumtaz, Meet Parikh, Douglas G Adler
BACKGROUND: Fully-covered self-expandable metal stents (FCSEMS) have been used in benign biliary diseases although reported data is limited. These devices are most commonly used to treat biliary leaks, strictures, or both. The aim of this study was to evaluate effectiveness of FCSEMS in treating benign biliary disease and recognize the associated complications. METHODS: We performed a multicenter longitudinal retrospective cohort study of patients with benign biliary disease needing FCSEMS between 2011 and 2016...
June 2018: Minerva Gastroenterologica e Dietologica
Philippe Lehours
Helicobacter pylori colonizes the stomach of half of humanity. The prevalence of this infection is higher among people of low socioeconomic status and from developing countries. In the absence of effective antibiotic treatment, the infection persists decades or even lifetime. The diagnosis of H. pylori can be made by invasive methods when biopsies are obtained: culture, histological examination, polymerase chain reaction or rapid urease test. Non-invasive methods have been developed, including the urea breath test, a test of high reliability, particularly suitable for post treatment monitoring, but also the fecal antigen test, as well as the detection of antibodies in the serum...
April 12, 2018: Minerva Gastroenterologica e Dietologica
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