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Minerva Gastroenterologica e Dietologica

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https://www.readbyqxmd.com/read/30417630/over-the-scope-clips-as-primary-and-rescue-therapy-for-non-variceal-gastrointestinal-bleeding-a-systematic-review-and-meta-analysis
#1
Andrew Ofosu, Daryl Ramai, Febin John, Mohammed Barakat, Tagore Sunkara, Santosh Sharma, Vinaya Gaduputi, Douglas Adler, Madhavi Reddy
INTRODUCTION: Endoscopic hemostasis in patients with non-variceal bleeding (NVGIB) with standard therapy has improved outcomes. However, persistent bleeding and re-bleeding continues to drive morbidity and mortality. Use of Over-the-scope clips (OTSC) is an emerging treatment modality for managing gastrointestinal bleeding. We performed a systematic review and meta-analysis to evaluate the ability of OTSC to achieve primary hemostasis and re-bleeding rates as primary therapy and rescue endoscopic interventions in patients with NVGIB...
November 7, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/30356037/liver-stiffness-based-model-for-portal-hypertension-and-hepatocellular-cancer-risk-in-hbv-responsive-to-antivirals
#2
Alfredo Marzano, Alessandra Tucci, Claudia Chialá, Giorgio M Saracco, Maurizio Fadda, Wilma Debernardi Venon
BACKGROUND: In hepatitis B virus (HBV)-related cirrhosis the antiviral therapy reduces portal hypertension (PH) and risk of hepatocellular carcinoma (HCC). AIM: This study assessed the prognostic role of LSPS score (liver stiffness value X spleen diameter/platelet count) in predicting these goals in cirrhotic patients responsive to antiviral therapy. METHODS: The correlation between LSPS, PH, esophageal varices (EVs) and HCC was evaluated in 121 cirrhotic patients treated with nucleos(t)ide analogues (NUCs)...
October 24, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/30303340/challenges-and-future-developments-in-liver-transplantation
#3
Pierluigi Toniutto, Davide Bitetto, Ezio Fornasiere, Elisa Fumolo
Liver transplantation (LT) has become the treatment of choice for a wide range of liver diseases in both adult and pediatric patients. Until recently, the largest proportion of LT in adults, were performed in patients with hepatitis C (HCV) related cirrhosis. The recent availability of safe and effective direct antiviral agents to cure HCV infection in almost all patients whatever the HCV genotype and severity of liver disease, will reduce the need for LT in this category of recipients. Thus, it is presumed that in the next 1 to 2 decades HCV related liver disease will diminish substantially, whereas non-alcoholic steato-hepatitis (NASH) will correspondingly escalate as an indication for LT...
October 5, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/30293417/prevalence-of-helicobacter-pylori-infection-among-dyspeptic-patients-with-and-without-type-2-diabetes-mellitus-in-south-west-and-south-south-regions-of-nigeria
#4
Stella I Smith, Tolulope Jolaiya, Charles Onyekwere, Muinah Fowora, Rose Ugiagbe, Ifeanyi Agbo, Cara Cookey, Olufunmilayo Lesi, Dennis Ndububa, Olusegun Adekanle, Pia Palamides, Isaac Adeleye, Henry Njom, Idowu Ayodeji, Anna Clarke, Rinaldo Pellicano
BACKGROUND: This multicenter study was undertaken to determine the prevalence of Helicobacter pylori (H. pylori) infection among dyspeptic patients with and without type 2 diabetes mellitus (T2DM). METHODS: Patients with dyspepsia were recruited from tertiary teaching hospitals, three in the South-West and one in the South-South regions of Nigeria, between November 2016 and August 2017. The participants had breath samples analyzed for H. pylori by the Urea Breath Test (UBT) following manufacturer's instructions...
October 2, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/30293416/diverticulosis-today
#5
Walter Elisei, Giovanni Brandimarte, Antonio Tursi
The incidence of diverticulosis and diverticular disease of the colon is increasing worldwide. Although the majority of patients remains asymptomatic long-life, the prevalence of diverticular disease of the colon, including acute diverticulitis, is substantial and is becoming a significant burden on National Health Systems in terms of direct and indirect costs. Fiber, non-absorbable antibiotics and probiotics seem to be effective in treating symptomatic and uncomplicated patients, and 5-aminosalicylic acid might help prevent acute diverticulitis...
October 2, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/30293415/symptoms-and-dietary-practices-of-irritable-bowel-syndrome-patients-compared-to-controls-results-of-a-united-states-national-survey
#6
Rachel N Pauls, Joshua B Max
BACKGROUND: Little is known regarding the dietary behaviors and epidemiology of irritable bowel syndrome (IBS) patients in the United States (US). METHODS: This was an IRB-approved cross-sectional survey conducted via a secured online server (SurveyMonkey®). A representative sample of the US population were queried regarding demographics, gastrointestinal (GI) symptoms, treatments and dietary practices. Of 1,718 respondents, 161 reported IBS. These were compared to 1,116 subjects reporting no GI diagnosis (controls)...
October 2, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/30293414/negative-payoffs-of-upper-gastrointestinal-endoscopy-in-patients-admitted-under-observation-status
#7
Adil Mir, Rupinder Mann, Andrew Canakis, Steven Lichtenstein
BACKGROUND: More than 70 million americans (23% of the US population) have non-cardiac chest pain at least once in their lifetime with gastroesophageal reflux disease (GERD) being the leading cause (37-66%). Current guidelines support the use of a proton pump inhibitor (PPI) prior to invasive or noninvasive testing as a diagnostic, therapeutic and cost effective method as a part of High Value Care recommendations. METHODS: We performed a chart review of 126 patients admitted to the hospital under observation status who underwent upper GI endoscopies in the hospital at 3 different urban community hospitals...
October 2, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/30293413/radiofrequency-hemorrhoidectomy-less-is-less-results-of-a-comparative-study
#8
Giorgio Lisi, Michela Campanelli, Domenico Mascagni, Simona Grande, Michele Grande, Giovanni Milito
BACKGROUND: Radiofrequency has been introduced as an instrument conceived to upgrade the conventional treatment of hemorrhoidectomy. To reduce the economic aspect, recently has been introduced a new radiofrequency device: VojantTM. Aim was to compare clinical outcomes of hemorrhoidectomy with LigaSureTM and VojantTM, performed with the Milligan- Morgan technique, in medium-term perspective. METHODS: Between January 2016 and December 2016, 50 consecutive patients with symptomatic grade III and IV were scheduled for surgical treatment...
October 2, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/30008194/is-co2-insufflation-an-amelioration-of-routine-colonoscopy
#9
Jürgen Feisthammel, Kien Vu Trung, Marcus Hollenbach, Joachim Mössner, Albrecht Hoffmeister
BACKGROUND: The insufflation of gas during colonoscopy leads to distention of the colon with abdominal discomfort and pain for the patients. Use of CO2 during endoscopy is reported to minimize abdominal discomfort during and after endoscopy. Aim of this study was to find out whether this improvement leads to decreased dosage of sedation drugs in order to improve patient's safety and satisfaction. METHODS: In this double-blind, randomized and controlled study 150 Patients referred to colonoscopy were assigned to either CO2 or air insufflation...
September 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29652111/actual-diagnosis-of-helicobacter-pylori-infection
#10
Philippe Lehours
Helicobacter pylori colonizes the stomach of half of humanity. The prevalence of this infection is higher among people of low socioeconomic status and from developing countries. In the absence of effective antibiotic treatment, the infection persists decades or even lifetime. The diagnosis of H. pylori can be made by invasive methods when biopsies are obtained: culture, histological examination, polymerase chain reaction or rapid urease test. Non-invasive methods have been developed, including the urea breath test, a test of high reliability, particularly suitable for post-treatment monitoring, but also the fecal antigen test, as well as the detection of antibodies in the serum...
September 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29600697/pharmacological-considerations-and-step-by-step-proposal-for-the-treatment-of-helicobacter-pylori-infection-in-the-year-2018
#11
Rinaldo Pellicano, Rocco M Zagari, Songhua Zhang, Giorgio M Saracco, Steven F Moss
Over the past 30 years, multidrug regimens consisting of a proton pump inhibitor (PPI) and two or three antibiotics have been used in treating Helicobacter pylori (H. pylori) infection. In clinical practice, the optimal regimen to cure H. pylori infection should be decided regionally. Considering the first treatment, the Maastricht V/Florence Consensus Report and the American College of Gastroenterology Clinical Management Guideline highlight that in countries with low clarithromycin resistance rates (<15%), an empiric clarithromycin-based regimen can be used...
September 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29600696/helicobacter-pylori-in-metabolic-related-diseases
#12
Gianenrico Rizzatti, Maria V Matteo, Gianluca Ianiro, Giovanni Cammarota, Francesco Franceschi, Antonio Gasbarrini
Helicobacter pylori is one of the most common gastrointestinal infection affecting humans worldwide. Hp colonizes the stomach with preferential trophism for the antrum. Hp infection is associated with the development of a chronic gastritis and subsequently with several gastric diseases such as peptic disease, gastric carcinoma and MALT lymphoma. Moreover, Helicobacter pylori infection has also been reported in literature to be associated with many other extra-gastric conditions including sideropenic anemia, thrombocytopenia, neurological, liver and cardiovascular diseases...
September 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29521488/the-role-of-adenosyl-methionine-in-alcoholic-liver-disease-and-intrahepatic-cholestasis
#13
Gianni Testino, Silvia Leone, Sharmila Fagoonee, Rinaldo Pellicano
No abstract text is available yet for this article.
September 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29458241/management-of-helicobacter-pylori-in-piedmont-italy
#14
Davide G Ribaldone, Dario Mazzucco, Sharmila Fagoonee, Lucia Crocellà, Alessandro Lavagna, Mario Fracchia, Gian P Caviglia, Daniele Simondi, Rodolfo Rocca, Marco Astegiano
Helicobacter pylori (H. pylori) is a Gram-negative bacterium, usually acquired during childhood, whose natural habitat is the gastric lumen. H. pylori is accepted as the most important cause of gastritis and peptic ulcer in humans. Nevertheless, its important role in the pathogenesis of gastric cancer as well as in several extra-gastroduodenal diseases has been confirmed. The aim of this work is to discuss, for the first time in a single article, all publications concerning H. pylori infection arising from Piedmont region, Italy, where in 1893 Giulio Bizzozero was the first who observed and described spiral organisms in the stomach of animal models...
September 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29458240/benign-and-malignant-gastroduodenal-diseases-associated-with-helicobacter-pylori-a-narrative-review-and-personal-remarks-in-2018
#15
György M Buzás
The subject of Helicobacter pylori continues to elicit worldwide interest in many research fields. Epidemiological data suggest that the prevalence of the infection is decreasing in Western/developed countries and even in some developing regions, but this is masked by the high prevalence in the most populous regions. Chronic gastritis, caused invariably by the bacterium, was again classified in Kyoto and Helicobacter pylori-associated gastritis was included as a distinct entity. The prevalence of peptic ulcers is decreasing, but bleeding ulcers are a challenging problem, with stable mortality levels even in the endoscopic era...
September 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29458239/transmission-of-helicobacter-pylori
#16
Irena Mladenova, Marilena Durazzo
The exact modes and routes of transmission of Helicobacter pylori (H. pylori) infection remain unproven. Studies showed that H. pylori bacteria can spread directly from one person to the other, or indirectly from an infected person to the environment. Presently, interpersonal pathways are more probable than environmental exposure routes. Person to person transmission can be mainly fecal-oral or oral-oral. In the last 30 years many authors have investigated the main potential sources of H. pylori infections, vectors and risk factors for both fecal-oral and oral-oral routes of transmission, eating of contaminated food, drinking of contaminated water, and exposure to animals...
September 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29442489/helicobacter-pylori-what-are-the-challenges-of-today-and-in-the-years-to-come
#17
Rinaldo Pellicano, Carlo A Fallone
No abstract text is available yet for this article.
September 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29442488/biological-properties-and-pathogenicity-factors-of-helicobacter-pylori
#18
Guzel S Isaeva, Sharmila Fagoonee
The unexpected discovery of Helicobacter pylori (H. pylori) has revolutionised the history of microbiology as well as of gastroenterology in the last 30 years, with an invaluable benefit for millions of persons worldwide. The confirmation that this Gram-negative spiral bacterium could live in the stomach has rendered out-of-date the concept of inhospitality of micro-organisms in the gastric environment, after a long history of unheard reports on the presence of spiral bacteria in the stomach. The pathogenicity of H...
September 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29431335/open-label-study-of-ademetionine-for-the-treatment-of-intrahepatic-cholestasis-associated-with-alcoholic-liver-disease
#19
Vladimir T Ivashkin, Marina V Maevskaya, Zhanna D Kobalava, Yuriy P Uspenskiy, Julia A Fominih, Alexander V Rozanov, Veronica V Tolkacheva, Tatiana I Sotnikova, Bagdadi A Alikhanov, Irina A Gorbacheva, Olga B Ershova, Antonina A Znakhyrenko, Kirill A Sokolov, Suntje Sander-Struckmeier
BACKGROUND: The effect of oral and/or parenteral ademetionine (500 mg intravenous [IV] and tablet formulation) on clinical symptoms and biochemical markers of intrahepatic cholestasis (IHC) was investigated in subjects with alcoholic liver disease (ALD) and compensated liver function. METHODS: Prospective, multicenter, open-label study consisting of a screening period and an 8-week treatment period and performed in subjects (18-75 years) with compensated ALD and confirmed IHC...
September 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29327822/efficacy-and-safety-of-long-term-entecavir-therapy-in-a-european-population
#20
Alessandro Collo, Paola Belci, Sharmila Fagoonee, Lucia Loreti, Valeria Gariglio, Ramona Parise, Paola Magistroni, Marilena Durazzo
BACKGROUND: Therapy in chronic hepatitis B (chronic hepatitis B) patients aims at improving their survival by preventing disease progression to cirrhosis and its complications. Entecavir (ETV) is currently a first line therapeutic agent recommended for the treatment of CHB. Our aim was to evaluate the long term outcome of a cohort of CHB patients treated with ETV. METHODS: Thirty-four patients treated with ETV for at least 6 months were included in this study. The virologic response was determined by the dosage of serum HBV-DNA, HBsAg, HBeAg, anti-HBs and anti-HBe antibodies...
September 2018: Minerva Gastroenterologica e Dietologica
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