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Minerva Gastroenterologica e Dietologica

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https://www.readbyqxmd.com/read/28497936/grading-health-claims-by-weight-of-evidence-would-make-for-a-better-informed-public
#1
François A Allaert, Jacques Vandermander, Florent Herpin, Gabrielle Ventura
In the European Regulation 1924/2006 (1) and especially its first recital; the evaluation of health claims (HC) by European Food Safety Agency (EFSA) was introduced so as "to ensure a high level of consumer protection, [and] give the consumer the necessary information to make choices in full knowledge of the facts…" Now, with 10 years of hindsight since the Regulation was adopted, it can be asked whether EFSA HC process of evaluation that led to a marginal number of accepted claims is consistent with this objective, not just for protecting consumers but for allowing them to decide freely and make informed choices...
May 10, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28398025/hepatocarcinoma-genetic-and-epigenetic-features
#2
Angela Lombardi, Anna Grimaldi, Silvia Zappavigna, Gabriella Misso, Michele Caraglia
HCC is the third leading cause of cancer-related deaths worldwide, accounting for about 1 million deaths annually. The incidence of HCC is highest in Asia and Africa, where the endemic high prevalence of hepatitis B and hepatitis C strongly predisposes to the development of chronic liver disease and subsequent development of HCC. Patients with HCC generally present at an advanced stage due to compensated cirrhosis defined by the absence of pathognomonic symptoms, resulting in death within 6 to 20 months, suggesting an urgent need in treatment modalities that will dramatically decrease the mortality rate of HCC...
April 11, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28397484/gut-microbiota-and-gastrointestinal-tract-liver-and-pancreas-from-physiology-to-pathology
#3
Carmela Loguercio
No abstract text is available yet for this article.
April 7, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28381083/the-gut-microbiota-its-anatomy-and-physiology-during-all-life
#4
Giulia Gibiino, Gianluca Ianiro, Giovanni Cammarota, Antonio Gasbarrini
The wide assemblage of microorganisms inhabiting our gastrointestinal tract is an attractive field for overwhelming contemporary research in several aspects of the human health. Most recent molecular techniques, as the use of rRNAs or whole genome sequencing, definitely overcame traditional culture techniques in giving outline of the intestinal bacterial richness. Moreover, the crosstalk between host and intestinal microbes is considered a cornerstone affecting the host's metabolism, immunity, autoimmunity and autoinflammation and elaborate networks linked to several organs...
April 4, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28293938/effectiveness-and-safety-of-infliximab-biosimilar-ct-p13-in-treating-ulcerative-colitis-a-real-life-experience-in-ibd-primary-centers
#5
Antonio Tursi, Leonardo Allegretta, Stefania Chiri, Nicola Della Valle, Walter Elisei, Giacomo Forti, Roberto Lorenzetti, Giammarco Mocci, Antonio Penna, Giuseppe Pranzo, Cristina Ricciardelli, Marcello Picchio
BACKGROUND: To assess the efficacy and safety of biosimilar infliximab (IFX) IFX CT-P13 in inducing and maintain remission in Ulcerative Colitis (UC) outpatients in Italian primary gastroenterology centers. METHODS: Patients were prospectively assessed at entry, after 8, 12, 24, 36, and therefore 52 weeks. Clinical activity was scored according to the Mayo score. The primary endpoint was reaching of clinical remission (Mayo score ≤2). Several secondary endpoints were clinical response to treatment, reaching of mucosal healing (MH), safety of the drug...
March 14, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28293937/gut-microbiota-and-inflammatory-bowel-disease-an-update
#6
Grainne Holleran, Loris R Lopetuso, Gianluca Ianiro, Silvia Pecere, Marco Pizzoferrato, Valentina Petito, Cristina Graziani, Deirdre Mc Namara, Antonio Gasbarrini, Franco Scaldaferri
Major advances have occurred in the knowledge of the pathogenesis of Inflammatory Bowel Disease (IBD) over the last decade, and perhaps the most major, and clinically advantageous of these advances has been the discovery of the microbiome as a key multifaceted component of inflammation. The Gut microbiome is the largest known group of cells in the body, and is now recognised as an organ in its own right. Initial studies looking at a possible role of bacterial manipulation of the immune system in IBD, looked at identifying a specific bacterial species, and were not representative of a feasible model of inflammation in IBD overall...
March 14, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28272380/complexity-and-diversity-of-gerd-phenotypes
#7
Patrizia Zentilin, Elisa Marabotto, Gaia Pellegatta, Claudia Coppo, Manuele Furnari, Edoardo Savarino, Vincenzo Savarino
Gastroesophageal reflux disease (GERD) is defined as a condition which develops when the reflux of gastric contents causes troublesome symptoms, impairs quality of life, or leads to mucosal damage or complications. There are two main phenotypic presentations of GERD, the erosive (ERD) and non-erosive reflux disease (NERD), with the latter one representing up to 70% of GERD spectrum. Moreover, patients with GERD can be clinically subdivided into two distinct syndromes: patinets with esophageal and extraesophageal symptoms...
March 7, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28260354/overlap-of-gerd-and-gastrointestinal-functional-disorders
#8
Nicola De Bortoli, Veronica Natali, Sara Melissari, Natalia Simonetti, Gherardo Tapete, Santino Marchi
The functional gastrointestinal disorders (FGIDs) are common conditions with an overall prevalence burden estimated at approximately one-third of the population. These represent a heterogeneous group of conditions which may include both abnormal symptom perception and functional causes and seems to share similar trigger factors as food, lifestyle and psychological factor. GERD develops when the reflux of gastric contents into the esophagus leads to troublesome symptoms, with or without mucosal involvement. Functional heartburn represents a subcategory of patients who refers with heartburn but without abnormal esophageal acid exposure, abnormal number of reflux events or any temporal correlation between symptoms and reflux events, on the same hands these patients do not report any symptom relief during antisecretory treatment with proton pump inhibitors...
March 3, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28260353/is-there-a-role-for-high-resolution-manometry-in-gerd-diagnosis
#9
Salvatore Tolone, Edoardo Savarino, Ludovico Docimo
Gastroesophageal reflux disease (GERD) is a condition, which develops when the reflux of stomach contents causes troublesome symptoms and/or complications. In patients with alarm symptoms or signs or in those refractory to antiacid therapy, it is indicated to perform instrumental tests to correctly diagnose GERD presence. Esophageal manometry is currently considered the gold standard test for the diagnosis of esophageal dysmotility. However, it has shown limited capability in diagnosing GERD. With the advent of high resolution manometry (HRM), more accurate evaluations of esophageal motility are now possible...
March 3, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28260352/extra-esophageal-presentation-of-gerd-new-understanding-in-a-new-era
#10
Irene Martinucci, Eleonora Albano, Santino Marchi, Corrado Blandizzi
Associations of gastroesophageal reflux disease (GERD) with extraesophageal manifestations, such as chronic cough, asthma, and laryngitis, are reported frequently, and there is a strong evidence of biological plausibility in support of this relationship. On the other hand, extraesophageal reflux disease (EERD) is usually multifactorial in nature with reflux being just one of the several potential contributing cofactors. Moreover, the accuracy of currently available diagnostic tests for EERD is suboptimal, and therefore the causal relationship between GERD and EERD remains far from being conclusively proven...
March 3, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28260351/trifecta-of-complications-post-ercp-it-can-happen
#11
Thanh-Truc LE, Mohammad Bilal, Sreeram Parupudi
No abstract text is available yet for this article.
March 3, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28251845/ppi-refractory-gerd-current-diagnosis-and-management
#12
Leonardo Frazzoni, Lorenzo Fuccio, Marzio Frazzoni
Proton pump inhibitor (PPI) therapy is the mainstay of treatment for gastroesophageal reflux disease (GERD). However, up to 30% of patients with reflux symptoms report inadequate symptom control with PPI therapy. PPI-refractory GERD should be suspected when troublesome reflux symptoms persist after 4-week standard dosage and 8-week high-dosage PPI therapy. Impedance-pH monitoring represents the gold standard for investigating the mechanism(s) of PPI refractoriness and for distinguishing patients with reflux-related from those with reflux- unrelated PPI-refractory syndromes...
March 1, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28251844/overview-of-pathophysiological-features-of-gerd
#13
Paolo Usai Satta, Francesco Oppia, Francesco Cabras
Gastro-esophageal reflux disease (GERD) is a very prevalent condition and has a high impact on the quality of life. Nevertheless, pathophysiology is complex and multi-factorial. Several mechanisms have been proposed: decreased salivation, decreased lower esophageal sphincter pressure resting tone, presence of hiatal hernia, increased number of transient lower esophageal sphincter relaxations, increased acid, and pepsin secretion, duodeno-gastro-esophageal reflux of bile acids and trypsin. Other factors contributing to the pathophysiology of GERD include poor esophageal clearance, delayed gastric emptying and impaired mucosal defensive factors...
March 1, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28391677/moxifloxacin-but-not-metronidazole-can-be-used-in-therapeutic-regimens-against-helicobacter-pylori
#14
Amin Talebi Bezmin Abadi, Shakiba Shafahi Tilaki, Golzar Fattahi, Sakineh Safarnejad
No abstract text is available yet for this article.
June 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28391676/malignant-gastrocolic-fistula-diagnosed-by-esophagogastroduodenoscopy-and-colonoscopy
#15
Molly Orosey, Tusar Desai, Mitual Amin, Mitchell S Cappell
No abstract text is available yet for this article.
June 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28391675/effect-of-morning-vs-afternoon-scheduling-of-endoscopic-us-guided-fna-on-outcomes-of-solid-pancreatic-lesions
#16
Gustavo Gomez, Shailendra Singh, Vamsi Kantamaneni, Pavithra Indramohan, Mohammad Bilal, Suzanne Morrissey, Shyam Thakkar, Heitham Abdul-Baki, Manish Dhawan
No abstract text is available yet for this article.
June 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28391674/diverticular-disease-myths-and-facts
#17
Bruno Annibale
No abstract text is available yet for this article.
June 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28240005/surgery-for-diverticulitis-in-the-21st-century-recent-evidence
#18
Arden M Morris, Cindy Kin
Sigmoid diverticulitis is an increasingly common disease in Western countries. As technology has led to increased knowledge about the disease and options for treatment, management strategies have become less certain. In previous years, the rationale for early elective surgery was largely preventive, due to concern that diverticulitis recurrence would result in increased risk of sepsis or the need for a colostomy. New technology has enabled diagnosis, through computed tomography scans, predictive information through clinical and administrative databases, and less invasive treatment options, through laparoscopic techniques...
June 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28240003/natural-history-of-bleeding-risk-in-colonic-diverticulosis
#19
Lior Segev, Gokhan Ozuner
Colonic diverticulosis prevalence is gradually increasing worldwide. From 3% to 15% of the patients with diverticulosis will bleed at some point. The risk for rebleeding after the first episode is substantial but varies in the literature between 13-48%. We analyzed risk factors for diverticular bleed and management options for initial and recurrent diverticular bleeding. A review of the literature on this subject is presented.
June 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28150481/lifestyle-and-other-risk-factors-for-diverticulitis
#20
Stephan K Böhm, Wolfgang Kruis
Diverticulosis is a very common condition. Around 20% of the carriers of diverticula are believed to suffer from diverticular disease during their lifetime. This makes diverticular disease one of the clinically and economically most significant diseases in gastroenterology. The etiopathogenesis of diverticulosis and diverticular disease is not well understood. Epidemiological studies allow defining risk factors for the development of diverticulitis and its complications. A comprehensive literature search was performed and the current knowledge about risk factors for diverticulitis and associated conditions reviewed...
June 2017: Minerva Gastroenterologica e Dietologica
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