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JOURNAL ARTICLE
Lilin Chen, Shimei Cheng, Shouyi Liang, Yonghao Song, Jinshou Chen, Tingting Lei, Zhenhong Liang, Haiqing Zheng
OBJECTIVE: Poststroke spasticity (PSS) reduces arm function and leads to low levels of independence. This study suggested applying machine learning (ML) from routinely available data to support the clinical management of PSS. DESIGN: 172 patients with acute first-ever stroke were included in this prospective cohort study. Twenty clinical information and rehabilitation assessments were obtained to train various ML algorithms for predicting 6-month PSS defined by a modified Ashworth scale (MAS) score ≥ 1...
May 7, 2024: American Journal of Physical Medicine & Rehabilitation
#2
JOURNAL ARTICLE
I G Samoilova, D V Podchinenova, M V Matveeva, O A Oleynik, A E Stankova, D A Kudlay, A А Mazurina, I D Pak, M I Kharakhulah
BACKGROUND: Type 2 diabetes mellitus (DM) remains the most common type of DM and is associat-ed with disabling complications, reduced quality of life and reduced life expectancy. Satisfactory control of carbohydrate metabolism remains the key way to manage them. AIM: To perform a retrospective analysis of carbohydrate metabolism (in terms of glycated hemoglobin - HbA1c ), the prevalence of complications, and features of hypoglycemic and concomitant therapy in patients with type 2 DM...
April 16, 2024: Terapevticheskiĭ Arkhiv
#3
Janet I Ma, Ndidi Owunna, Nona M Jiang, Xiaodan Huo, Emily Zern, Jenna N McNeill, Emily S Lau, Eugene Pomerantsev, Michael H Picard, Dongyu Wang, Jennifer E Ho
BACKGROUND: Prior studies have established the impact of sex differences on pulmonary arterial hypertension (PAH). However, it remains unclear whether these sex differences extend to other hemodynamic subtypes of pulmonary hypertension (PH). METHODS: We examined sex differences in PH and hemodynamic PH subtypes in a hospital-based cohort of individuals who underwent right heart catheterization between 2005-2016. We utilized multivariable linear regression to assess the association of sex with hemodynamic indices of RV function [PA pulsatility index (PAPi), RV stroke work index (RVSWI), and right atrial: pulmonary capillary wedge pressure ratio (RA:PCWP)]...
April 27, 2024: medRxiv
#4
JOURNAL ARTICLE
Abel Tezera Abebe, Yabets Tesfaye Kebede, Bekri Delil Mohammed
BACKGROUND: Over 1 billion people worldwide suffer from the common chronic medical condition of hypertension. A hypertensive crisis occurs when blood pressure exceeds 180/110 mmHg. Depending on whether the target organ is harmed, the situation may be presented as a hypertensive emergency or urgency. OBJECTIVE: To assess the prevalence and risk factors of patients with hypertensive crises who visited the Emergency Outpatient Department (EOPD) at Adama Hospital Medical College in Adama, Oromia, Ethiopia, between January 01 and August 31, 2021, G...
2024: International Journal of Hypertension
#5
JOURNAL ARTICLE
Gassan Moady, Igor Yakubovich, Shaul Atar
INTRODUCTION: Sodium-glucose cotransporter- 2 (SGLT2) inhibitors have become a cornerstone in heart failure (HF), Type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD) management. In the current retrospective study, we aimed to assess efficacy and safety of SGLT2 inhibitors early following acute myocardial infarction (AMI). METHODS: Patients with T2DM hospitalized for AMI in 2017-2020 were divided according to SGLT2 inhibitors therapy status on discharge (with vs without therapy)...
2024: Journal of Cardiovascular Pharmacology and Therapeutics
#6
JOURNAL ARTICLE
Romain Schneckenburger, Marion Boulanger, Ahmad Nehme, Marguerite Watrin, Gwendoline Le Du, Sophie Guettier, Lydia Guittet, Emmanuel Touzé
INTRODUCTION: Transient ischemic attack (TIA) is a frequent neurological emergency which management and definition have changed radically over the last 15 years. However, recent epidemiological studies of TIA are scarce. We report here on the impact of the shift from a time-based to a tissue-based definition of TIA on its incidence and risk of recurrence in a new population-based cohort with a high rate of patients investigated by MRI. MATERIALS AND METHODS: We prospectively included all TIAs that occurred between May 2017 and May 2021 from the Normandy Stroke Study, a population-based registry using multiple overlapping sources for exhaustive case identification in Caen la Mer area...
May 6, 2024: European Stroke Journal
#7
JOURNAL ARTICLE
Tsutomu Murakami, Yusuke Watanabe, Norihito Nakamura, Makoto Natsumeda, Yohei Ohno, Gaku Nakazawa, Yuji Ikari, Akihisa Kataoka, Yosuke Nishihata, Kentaro Hayashida, Masanori Yamamoto, Jun Tanaka, Kentaro Jujo, Masaki Izumo, Kazuki Mizutani, Ken Kozuma
BACKGROUND: Severe aortic valve stenosis (AS) and atrial fibrillation (AF) are risk factors of hemodynamic instability in heart failure (HF) management due to low cardiac output, respectively. Therefore, the treatment of HF due to severe AS complicated with AF is anticipated to be difficult. Tolvaptan, a vasopressin V2 receptor inhibitor, is effective in controlling acute decompensated heart failure (ADHF) with hemodynamic stability. However, its clinical efficacy against ADHF caused by AS with AF remains to be determined...
May 7, 2024: Heart and Vessels
#8
JOURNAL ARTICLE
Robert J M Klautz, Vivek Rao, Michael J Reardon, G Michael Deeb, Francois Dagenais, Michael G Moront, Stephen H Little, Louis Labrousse, Himanshu J Patel, Saki Ito, Shuzhen Li, Joseph F Sabik, Jae K Oh
OBJECTIVES: The objective of this analysis was to assess the normal haemodynamic performance of contemporary surgical aortic valves at 1 year postimplant in patients undergoing surgical aortic valve replacement (SAVR) for significant valvular dysfunction. By pooling data from four multicentre studies, this study will contribute to a better understanding of the effectiveness of SAVR procedures, aiding clinicians and researchers in making informed decisions regarding valve selection and patient management...
May 6, 2024: European Journal of Cardio-thoracic Surgery
#9
JOURNAL ARTICLE
Samuel Berchi Kankam, Adrina Habibzadeh, Mike Tuffour Amirikah, Peter Kofi Neefjes Mensah, Catherine Opuku Fordjour, Manfred Nathan Mate-Kole, Samuel E Danso, Mohamed Jalloh, Oluwafeyisola Osifala, Fredrick Larbi Kwapong, Abigail Amofah Afriyie, Ruth Zeto, Olayinka Fokorede
OBJECTIVE: In Ghana, the shifting demographics of stroke incidence towards young adults have prompted the expansion of stroke care and rehabilitation efforts. Nevertheless, the precise impact of stroke rehabilitation remains unclear. We conducted a systematic review to explore the landscape and effects of stroke rehabilitation in Ghana. METHOD: We identified articles on stroke rehabilitation services in Ghana through searches of PubMed, Scopus, Embase, and Web of Science from inception until February 2024...
May 4, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#10
MULTICENTER STUDY
Thanh N Nguyen, Raul G Nogueira, Muhammad M Qureshi, Simon Nagel, Jean Raymond, Mohamad Abdalkader, Jelle Demeestere, João Pedro Marto, Sunil A Sheth, Volker Puetz, Anne Dusart, Patrik Michel, Marc Ribo, Osama O Zaidat, James E Siegler, Diogo C Haussen, Daniel Strbian, Hilde Henon, Mahmoud H Mohammaden, Markus A Möhlenbruch, Marta Olive-Gadea, Ajit S Puri, Simon Winzer, Johannes Kaesmacher, Piers Klein, Liisa Tomppo, Francois Caparros, João Nuno Ramos, Mouhammad A Jumaa, Syed F Zaidi, Nicolas Martinez-Majander, Stefania Nannoni, Lieselotte Vandewalle, Flavio Bellante, Mudassir Farooqui, Sergio Salazar-Marioni, Pekka Virtanen, Daniel P O Kaiser, Anke Wouters, Rita Ventura, Jessica Jesser, Adnan Mujanovic, Liqi Shu, Alicia C Castonguay, Zain Mansoor, Zhongming Qiu, Hesham E Masoud, Manuel Requena, Erno Peltola, Wei Hu, Eugene Lin, Kanta Tanaka, Charlotte Cordonnier, Daniel Roy, Shadi Yaghi, Davide Strambo, Hiroshi Yamagami, Urs Fischer, Tudor G Jovin, Robin Lemmens, Peter A Ringleb, Santiago Ortega-Gutierrez
BACKGROUND AND OBJECTIVES: There is uncertainty whether patients with large vessel occlusion (LVO) presenting in the late 6-hour to 24-hour time window can be selected for endovascular therapy (EVT) by noncontrast CT (NCCT) and CT angiography (CTA) for LVO detection. We evaluated the clinical outcomes of patients selected for EVT by NCCT compared with those medically managed in the extended time window. METHODS: This multinational cohort study was conducted at 66 sites across 10 countries...
May 28, 2024: Neurology
#11
JOURNAL ARTICLE
William O Roberts
A 23-year-old woman completing her first marathon collapsed near the finish line at 4 hours 6 min with a rectal temperature of 41.8°C. She was in good health before the race with no recent illness, had completed a full training program, and was taking no medications or supplements. On the initial exam, she was unconscious with a response to painful stimulus, spontaneous breathing, rapid pulse, eyes closed, fully dilated pupils, poor muscle tone, and pale skin that was warm to touch. The medical team initiated whole-body cooling using rapidly rotating ice water towels and ice packs placed in the neck, axilla, and groin...
May 1, 2024: Current Sports Medicine Reports
#12
JOURNAL ARTICLE
Dung Tien Nguyen, Ton Duy Mai, Phuong Viet Dao, Hung Tran Ha, Anh Tuan Le, Tuyet Trinh Thi Nguyen, Trung Xuan Vuong, Minh Cong Tran
Early neurological deterioration (END) is progressive neurological deterioration with an increase in NIHSS score of 2 points or more in the first 72 hours from the onset of acute ischemic stroke. END increases the risk of poor clinical outcomes at day 90 of ischemic stroke. We will study the frequency, predictors, and outcomes of patients with END in a case-control study at a comprehensive stroke centre in Vietnam. of the design is a descriptive observational study, longitudinal follow-up of patients with minor stroke hospitalized at the Stroke Center of Bach Mai Hospital from December 1, 2023, to December 1, 2024...
2024: PloS One
#13
JOURNAL ARTICLE
Charles de Mestral, Husam M Abdel-Qadir, Peter C Austin, Alice S Chong, Finlay A McAlister, Thomas F Lindsay, Heather J Ross, George Oreopoulos, Duminda N Wijeysundera, Douglas S Lee
OBJECTIVE: To characterize the association between ambulatory cardiology or general internal medicine (GIM) assessment prior to surgery and outcomes following scheduled major vascular surgery. BACKGROUND: Cardiovascular risk assessment and management prior to high-risk surgery remains an evolving area of care. METHODS: This is population-based retrospective cohort study of all adults who underwent scheduled major vascular surgery in Ontario, Canada, April 1, 2004-March 31, 2019...
May 6, 2024: Annals of Surgery
#14
JOURNAL ARTICLE
Yu Yao, Yuefei Wu, Xiaoqin Zhang, Chang Liu, Lingling Cai, Yisha Ying, Jianhong Yang
BACKGROUND: This retrospective observational cohort study aimed to evaluate whether tenecteplase's use for acute ischemic stroke (AIS) has time management advantages and clinical benefits. METHODS: 144 AIS patients treated with alteplase and 120 with tenecteplase were included. We compared baseline clinical characteristics, key reperfusion therapy time indices [onset-to-treatment time (OTT), door-to-needle time (DNT), and door-to-puncture time (DPT)] and clinical outcomes (24-h post-thrombolysis NIHSS improvement, and intracranial hemorrhage incidence) between the groups using univariate analysis...
2024: Frontiers in Neurology
#15
Gonçalo Costa, Mafalda Griné, Mariana Simões, Manuel Oliveira-Santos, Luís Paiva, Marco Costa, Lino Gonçalves
BACKGROUND: Clinical practice guidelines recommend oral anticoagulation (OAC) for stroke prevention in selected patients with atrial fibrillation (AF). However, some patients still experience thrombo-embolic events despite adequate anticoagulation. The optimal management of these cases remains uncertain, leading to practice pattern variability. We present a series of three cases illustrating the use of left atrial appendage occlusion (LAAO) as an adjunctive stroke prevention strategy in AF patients with recurrent thrombo-embolic events despite adequate anticoagulation...
May 2024: European Heart Journal. Case Reports
#16
JOURNAL ARTICLE
Kenta Nakase, Fumihiko Nishimura, Shohei Yokoyama, Miho Kakutani, Taekyun Kim, Ryosuke Matsuda, Yasuhiro Takeshima, Shuichi Yamada, Young-Soo Park, Ichiro Nakagawa
Background Treatment of patients with a giant pituitary neuroendocrine tumor (GPitNET) is challenging. Here, we present the methods used for the clinical management of patients who underwent GPitNET resection mainly via endoscopic endonasal surgery along with multimodal support to avoid surgical complications, which can affect the outcomes. Methodology The medical records of 25 patients with a GPitNET who underwent endonasal endoscopic surgery were retrospectively reviewed. Complications were analyzed and factors affecting the extent of resection were evaluated...
April 2024: Curēus
#17
JOURNAL ARTICLE
Emmanuel Imeh-Nathaniel, Samuel Imeh-Nathaniel, Adebobola Imeh-Nathaniel, Oreoluwa Coker-Ayo, Nikhil Kulkarni, Thomas I Nathaniel
OBJECTIVE: This study aims to determine sex differences in poststroke hypertriglyceridemia (serum triglyceride levels ⩾ 200 mg/dl) and high stroke severity in ischemic stroke patients. METHOD: Our study analyzed data from 392 males and 373 females with hypertriglyceridemia. Stroke severity on admission was measured using the National Institute of Health Stroke Scale (NIHSS) with a value ⩽7 indicating a more favorable post-stroke prognosis while a score of >7 indicates poorer post-stroke outcomes...
2024: Neuroscience insights
#18
JOURNAL ARTICLE
Dharmendra Pradhan, Prafulla Kumar Sahu, Sukumar Purohit, Santosh Kumar Ranajit, Biswajeet Acharya, Shreya Sangam, Amit Kumar Shrivastava
BACKGROUND: Diabetes Mellitus (DM) is an alarming health concern, affecting approximately 537 million people worldwide. As a leading cause of morbidity and mortality, DM demands a comprehensive understanding of its diverse pathophysiological mechanisms and disease progression. METHODS: This traditional review has consolidated literature on the pathogenesis of hyperglycemia, its progression into complications, and advances in optimal treatment strategies. The literature in the last two decades has been reviewed using several keywords, including "diabetes," "diabetes-associated complications", "novel therapeutic interventions for diabetes-associated diseases", "phyto-extracts as antidiabetic drugs", etc...
May 3, 2024: Current Diabetes Reviews
#19
JOURNAL ARTICLE
Andrea Sterenstein, Rajeev Garg
OBJECTIVE: Data on sex differences in spontaneous intracerebral hemorrhages are limited. METHODS: An automated comprehensive scoping literature review was performed using PubMed and Scopus. Articles written in English about spontaneous intracerebral hemorrhage and sex were reviewed. RESULTS: Males experience spontaneous intracerebral hemorrhage more frequently than females, at younger ages, and have a higher prevalence of deep bleeds compared to females...
May 3, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#20
REVIEW
Zifang Zhou, Xiaoqun Fang, Youhong Huang, Jiangyu Hu, Kaibing Zhang, Shulei Jia
PURPOSE: To synthesize the available evidence on factors associated with self-management behavior in young stroke patients. METHODS: The methodological guidelines for scoping reviews developed by the Joanna Briggs Institute and the PRISMA-scR-checklist for scoping reviews were used. A total of 5586 studies were identified through bibliographic searches of the scientific databases Medline (OVID), Embase (OVID), CINAHL (EBSCO), and PsycINFO, limited to the period 2000-2023...
April 30, 2024: Patient Education and Counseling
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