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Meniscal regeneration

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https://www.readbyqxmd.com/read/28203596/intra-articular-implantation-of-mesenchymal-stem-cells-part-2-a-review-of-the-literature-for-meniscal-regeneration
#1
Matthew J Kraeutler, Justin J Mitchell, Jorge Chahla, Eric C McCarty, Cecilia Pascual-Garrido
Knee osteoarthritis (OA) after partial or total meniscectomy is a prevalent issue that patients must face. Various methods of replacing meniscal tissue have been studied to avoid this progression, including meniscal allograft transplantation, meniscal scaffolds, and synthetic meniscus replacement. Studies have shown that meniscal scaffolds may improve symptoms but have not been shown to prevent progression of OA. Recently, mesenchymal stem cells (MSCs) have been proposed as a possible biological therapy for meniscal regeneration...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28169595/tissue-derived-extracellular-matrix-bioscaffolds-emerging-applications-in-cartilage-and-meniscus-repair
#2
Farrah A Monibi, James Lee Cook
Musculoskeletal injuries are a common and significant problem in orthopaedic practice. Given the long-term consequences of unaddressed cartilage and meniscal pathology, a number of treatments have been attempted to stimulate repair or to replace the injured tissue. Despite advances in orthopaedic surgery, effective treatments for cartilage and meniscus injuries remain a common and significant clinical challenge. Tissue engineering is a developing field that aims to regenerate injured tissues with a combination of cells, scaffolds, and signals...
February 7, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28165810/the-origin-and-distribution-of-cd68-cd163-and-%C3%AE-sma-positive-cells-in-the-early-phase-after-meniscal-resection-in-a-parabiotic-rat-model
#3
Shozaburo Terai, Yusuke Hashimoto, Kumi Orita, Shinya Yamasaki, Junsei Takigami, Takafumi Shinkuma, Takanori Teraoka, Yohei Nishida, Masafumi Takahashi, Hiroaki Nakamura
We previously reported that circulating peripheral blood-borne cells (PBCs) contribute to early-phase meniscal reparative change. Because macrophages and myofibroblasts are important contributors of tissue regeneration, we examined their origin and distribution in the reparative meniscus. Reparative menisci were evaluated at 1, 2, and 4 weeks post-meniscectomy by immunohistochemistry to locate monocytes and macrophages (stained positive for CD68 and CD163), and myofibroblasts (stained positive for αSMA). Of the total number of cells, 13% were CD68(+) at 1 week post-meniscectomy, which decreased to 1% by 4 weeks post-meniscectomy; of these, almost half of CD68(+) cells (49...
February 6, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28161573/chondrogenically-primed-tonsil-derived-mesenchymal-stem-cells-encapsulated-in-riboflavin-induced-photocrosslinking-collagen-hyaluronic-acid-hydrogel-for-meniscus-tissue-repairs
#4
Rachel H Koh, Yinji Jin, Byung-Jae Kang, Nathaniel S Hwang
: Current meniscus tissue repairing strategies involve partial or total meniscectomy, followed by allograft transplantation or synthetic material implantation. However, allografts and synthetic implants have major drawbacks such as the limited supply of grafts and lack of integration into host tissue, respectively. In this study, we investigated the effects of conditioned medium (CM) from meniscal fibrochondrocytes and TGF-β3 on tonsil-derived mesenchymal stem cells (T-MSCs) for meniscus tissue engineering...
February 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28051883/hydrogels-for-precision-meniscus-tissue-engineering-a-comprehensive-review
#5
Ana Rey-Rico, Magali Cucchiarini, Henning Madry
The meniscus plays a pivotal role to preserve the knee joint homeostasis. Lesions to the meniscus are frequent, have a reduced ability to heal, and may induce tibiofemoral osteoarthritis. Current reconstructive therapeutic options mainly focus on the treatment of lesions in the peripheral vascularized region. In contrast, few approaches are capable of stimulating repair of damaged meniscal tissue in the central, avascular portion. Tissue engineering approaches are of high interest to repair or replace damaged meniscus tissue in this area...
January 4, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28002904/the-meniscus-vascularization-the-direct-correlation-with-tissue-composition-for-tissue-engineering-purposes
#6
A Di Giancamillo, L Mangiavini, I Tessaro, A Marmotti, R Scurati, G M Peretti
Meniscal lesions still represent an unsolved problem in clinical practice. Like the articular cartilage, meniscus has a scarce healing potential. Thus, when this tissue is damaged, the joint biomechanics is completely altered, leading to the development and progression of premature osteoarthritis. Therefore, in the last years, several tissue-engineering strategies have been developed to regenerate the meniscus with debated results. The comprehension of complex processes underlying meniscus maturation and structure is essential for a correct approach for the generation of a biomimetic meniscal substitute...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27824291/development-of-a-micronized-meniscus-extracellular-matrix-scaffold-for-potential-augmentation-of-meniscal-repair-and-regeneration
#7
Farrah A Monibi, Chantelle C Bozynski, Keiichi Kuroki, Aaron M Stoker, Ferris M Pfeiffer, Seth L Sherman, James L Cook
Decellularized scaffolds composed of extracellular matrix (ECM) hold promise for repair and regeneration of the meniscus, given the potential for ECM-based biomaterials to aid in stem cell recruitment, infiltration, and differentiation. The objectives of this study were to decellularize canine menisci to fabricate a micronized, ECM-derived scaffold and to determine the cytocompatibility and repair potential of the scaffold ex vivo. Menisci were decellularized with a combination of physical agitation and chemical treatments...
December 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/27805288/meniscal-regeneration-after-resection-of-the-anterior-half-of-the-medial-meniscus-in-mice
#8
Kanehiro Hiyama, Takeshi Muneta, Hideyuki Koga, Ichiro Sekiya, Kunikazu Tsuji
Various animal studies have indicated that reduced meniscal function significantly exacerbates articular-cartilage degeneration. Despite the importance of meniscal function for joint homeostasis and prevention of osteoarthritis, the healing process after meniscal injury and the regenerative process after meniscus removal have not been studied in detail. In this study, we examined the process of meniscal regeneration and cartilage degeneration after meniscectomy in mice. The left anterior halves of the medial menisci in male C57Bl/6J mice were resected, and histological assessment of the process of meniscal regeneration was conducted on day 3 and 2, 4, and 6 weeks after the surgical procedure...
November 2, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27664939/formation-and-maturation-of-the-murine-meniscus
#9
Laura W Gamer, Lin Xiang, Vicki Rosen
Meniscal injuries are commonplace, but current surgical repair procedures do not prevent degenerative joint changes that occur after meniscal injury and often lead to osteoarthritis. Successful tissue regeneration in adults often recapitulates events that occur during embryogenesis, suggesting that understanding the regulatory pathways controlling these early processes may provide clues for developing strategies for tissue repair. While the mouse is now widely used to study joint diseases, detailed knowledge of the basic biology of murine meniscus is not readily available...
September 24, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27347833/assessment-of-regeneration-in-meniscal-lesions-by-use-of-mesenchymal-stem-cells-derived-from-equine-bone-marrow-and-adipose-tissue
#10
Maria L González-Fernández, Saúl Pérez-Castrillo, Jaime A Sánchez-Lázaro, Julio G Prieto-Fernández, Maria E López-González, Sandra Lobato-Pérez, Bruno J Colaço, Elías R Olivera, Vega Villar-Suárez
OBJECTIVE To assess the ability to regenerate an equine meniscus by use of a collagen repair patch (scaffold) seeded with mesenchymal stem cells (MSCs) derived from bone marrow (BM) or adipose tissue (AT). SAMPLE 6 female Hispano-Breton horses between 4 and 7 years of age; MSCs from BM and AT were obtained for the in vitro experiment, and the horses were subsequently used for the in vivo experiment. PROCEDURES Similarities and differences between MSCs derived from BM or AT were investigated in vitro by use of cell culture...
July 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27347022/osteoarthritis-prevention-and-meniscus-regeneration-induced-by-transplantation-of-mesenchymal-stem-cell-sheet-in-a-rat-meniscal-defect-model
#11
Yiying Qi, Guangnan Chen, Gang Feng
Transplantation of mesenchymal stem cells (MSCs) is a potential therapy for meniscus regeneration. However, when using single cell suspension injection, there is frequently a significant loss of cells, with only a small percentage of cells remaining at the target site. This issue may be solved with the use of MSC sheets. In the present study, we investigated whether the use of MSC sheets were able to regenerate the meniscus effectively in a rat meniscectomized model. The anterior half of the medial meniscus in 10 rats was excised and an MSC sheet was transplanted in the MSC sheet treatment group, while untreated rats served as the control...
July 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27274735/cell-based-strategies-for-meniscus-tissue-engineering
#12
REVIEW
Wei Niu, Weimin Guo, Shufeng Han, Yun Zhu, Shuyun Liu, Quanyi Guo
Meniscus injuries remain a significant challenge due to the poor healing potential of the inner avascular zone. Following a series of studies and clinical trials, tissue engineering is considered a promising prospect for meniscus repair and regeneration. As one of the key factors in tissue engineering, cells are believed to be highly beneficial in generating bionic meniscus structures to replace injured ones in patients. Therefore, cell-based strategies for meniscus tissue engineering play a fundamental role in meniscal regeneration...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27159292/local-administration-of-simvastatin-stimulates-healing-of-an-avascular-meniscus-in-a-rabbit-model-of-a-meniscal-defect
#13
Shurong Zhang, Takehiko Matsushita, Ryosuke Kuroda, Kyohei Nishida, Tokio Matsuzaki, Tomoyuki Matsumoto, Koji Takayama, Kanto Nagai, Shinya Oka, Yasuhiko Tabata, Kouki Nagamune, Masahiro Kurosaka
BACKGROUND: Repair of an avascular meniscus is challenging because of its low capacity for healing. Several reports have shown that simvastatin stimulates the anabolic activity of intervertebral fibrochondrocytes, suggesting that simvastatin may be used for the treatment of meniscal defects. PURPOSE: To test whether the local administration of simvastatin stimulates healing of an avascular meniscus in rabbits. STUDY DESIGN: Controlled laboratory study...
July 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27151837/autologous-bone-marrow-concentrate-in-a-sheep-model-of-osteoarthritis-new-perspectives-for-cartilage-and-meniscus-repair
#14
Giovanna Desando, Gianluca Giavaresi, Carola Cavallo, Isabella Bartolotti, Federica Sartoni, Nicolò Nicoli Aldini, Lucia Martini, Annapaola Parrilli, Erminia Mariani, Milena Fini, Brunella Grigolo
INTRODUCTION: Cell-based therapies are becoming a valuable tool to treat osteoarthritis (OA). This study investigated and compared the regenerative potential of bone marrow concentrate (BMC) and mesenchymal stem cells (MSC), both engineered with Hyaff(®)-11 (HA) for OA treatment in a sheep model. METHODS: OA was induced via unilateral medial meniscectomy. Bone marrow was aspirated from the iliac crest, followed by concentration processes or cell isolation and expansion to obtain BMC and MSC, respectively...
June 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/27107410/characterization-of-synovial-fluid-cytokine-profiles-in-chronic-meniscal-tear-of-the-knee
#15
Marco Bigoni, Marco Turati, Paola Sacerdote, Diego Gaddi, Massimiliano Piatti, Alberto Castelnuovo, Silvia Franchi, Marta Gandolla, Alessandra Pedrocchi, Robert J Omeljaniuk, Elena Bresciani, Vittorio Locatelli, Antonio Torsello
Concentrations of pro- and anti-inflammatory cytokines in synovial fluid samples collected from patients with chronic meniscal tears were investigated. An acute inflammatory response is generally reported 24-48 h after knee injury, but the largest body of data available in literature concerns anterior cruciate ligament injury and very little information is available about the balance of soluble factors in the synovial fluid of knees with chronic meniscal tears. Sixty-nine patients (46 males and 23 females) with meniscal tear that occurred more than 3 months earlier were enrolled...
April 23, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/26971202/characterization-of-mesenchymal-stem-cells-and-fibrochondrocytes-in-three-dimensional-co-culture-analysis-of-cell-shape-matrix-production-and-mechanical-performance
#16
Mary Clare McCorry, Jennifer L Puetzer, Lawrence J Bonassar
BACKGROUND: Bone marrow mesenchymal stem cells (MSCs) have shown positive therapeutic effects for meniscus regeneration and repair. Preliminary in vitro work has indicated positive results for MSC applications for meniscus tissue engineering; however, more information is needed on how to direct MSC behavior. The objective of this study was to examine the effect of MSC co-culture with primary meniscal fibrochondrocytes (FCCs) in a three-dimensional collagen scaffold in fibrochondrogenic media...
March 12, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/26916126/transplantation-of-autologous-synovial-mesenchymal-stem-cells-promotes-meniscus-regeneration-in-aged-primates
#17
Shimpei Kondo, Takeshi Muneta, Yusuke Nakagawa, Hideyuki Koga, Toshifumi Watanabe, Kunikazu Tsuji, Shinichi Sotome, Atsushi Okawa, Shinji Kiuchi, Hideo Ono, Mitsuru Mizuno, Ichiro Sekiya
Transplantation of aggregates of synovial mesenchymal stem cells (MSCs) enhanced meniscus regeneration in rats. Anatomy and biological properties of the meniscus depend on animal species. To apply this technique clinically, it is valuable to investigate the use of animals genetically close to humans. We investigated whether transplantation of aggregates of autologous synovial MSCs promoted meniscal regeneration in aged primates. Chynomolgus primates between 12-13 years old were used. After the anterior halves of the medial menisci in both knees were removed, an average of 14 aggregates consisting of 250,000 synovial MSCs were transplanted onto the meniscus defect...
February 24, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/26914757/role-of-mesenchymal-stem-cells-in-meniscal-repair
#18
Peter Angele, Richard Kujat, Matthias Koch, Johannes Zellner
Meniscus integrity is the key for joint health of the knee. Therefore, the main goal of every meniscus treatment should be the maintenance of as much meniscus tissue as possible.Repair of meniscus tears can be achieved by meniscus suture. However, in a recently published meta-analysis, the long-term outcome of meniscus repair showed a mean failure rate of 24%.In a preclinical trial, locally applied mesenchymal stem cells produced differentiated meniscus-like tissue in meniscus tears indicating that mesenchymal-based cells, harvested from the bone marrow, enhance meniscus healing in critical-size meniscus tears...
December 2014: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/26893631/targeted-transplantation-of-iron-oxide-labeled-adipose-derived-mesenchymal-stem-cells-in-promoting-meniscus-regeneration-following-a-rabbit-massive-meniscal-defect
#19
Yiying Qi, Zhigao Yang, Qianhai Ding, Tengfei Zhao, Zhongming Huang, Gang Feng
Repair of a massive meniscal defect remains a challenge in the clinic. However, targeted magnetic cell delivery, an emerging technique, may be useful in its treatment. The present study aimed to determine the effect of targeted intra-articular injection of superparamagnetic iron oxide (SPIO)-labeled adipose-derived mesenchymal stem cells (ASCs) in a rabbit model of a massive meniscal defect. ASCs may be directly labeled and almost 100% of the ASCs were labeled with SPIO after 24 h; these SPIO-labeled ASCs may be orientated by magnet...
February 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26842062/repair-of-avascular-meniscus-tears-with-electrospun-collagen-scaffolds-seeded-with-human-cells
#20
Jihye Baek, Sujata Sovani, Nicholas E Glembotski, Jiang Du, Sungho Jin, Shawn P Grogan, Darryl D D'Lima
The self-healing capacity of an injured meniscus is limited to the vascularized regions and is especially challenging in the inner avascular regions. As such, we investigated the use of human meniscus cell-seeded electrospun (ES) collagen type I scaffolds to produce meniscal tissue and explored whether these cell-seeded scaffolds can be implanted to repair defects created in meniscal avascular tissue explants. Human meniscal cells (derived from vascular and avascular meniscal tissue) were seeded on ES scaffolds and cultured...
March 2016: Tissue Engineering. Part A
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