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https://www.readbyqxmd.com/read/28901247/effect-on-morphology-osmotic-fragility-and-electro-kinetic-potential-of-erythrocytes-in-hypertension
#1
Swati Sanjay Gaikwad, J G Avari
BACKGROUND: Hypertension is a common health problem concerning a large proportion of population and a leading global risk factor for the burden of cardiovascular disease (CVD). The purpose of this study was to assess the efficacy of the erythrocyte zeta potential as a potential additional indicator for cardiovascular disorder risk so that patients with this can be more rapidly identified and treated. METHODS: In the present study, blood samples were collected in 5% dextrose solution from patients suffering from hypertension and healthy volunteers (Not taken any medication)...
September 11, 2017: Current Hypertension Reviews
https://www.readbyqxmd.com/read/28899375/erratum-to-development-and-testing-of-a-mobile-application-to-support-diabetes-self-management-for-people-with-newly-diagnosed-type-2-diabetes-a-design-thinking-case-study
#2
Mira Petersen, Nana F Hempler
No abstract text is available yet for this article.
September 12, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28883718/contributions-of-copd-asthma-and-ten-comorbid-conditions-to-health-care-utilization-and-patient-centered-outcomes-among-us-adults-with-obstructive-airway-disease
#3
Terrence E Murphy, Gail J McAvay, Heather G Allore, Jason A Stamm, Paul F Simonelli
BACKGROUND: Among persons with obstructive airway disease, the relative contributions of chronic obstructive pulmonary disease (COPD), asthma, and common comorbid conditions to health care utilization and patient-centered outcomes (PCOs) have not been previously reported. METHODS: We followed a total of 3,486 persons aged ≥40 years with COPD, asthma, or both at baseline, from the Medical Expenditure Panel Survey (MEPS) cohorts enrolled annually from 2008 through 2012 for 1 year...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28877875/metabolic-syndrome-risks-following-the-great-recession-in-rural-black-young-adults
#4
Gregory E Miller, Edith Chen, Tianyi Yu, Gene H Brody
BACKGROUND: Some of the country's highest rates of morbidity and mortality from cardiovascular disease are found in lower-income black communities in the rural Southeast. Research suggests these disparities originate in the early decades of life, and partly reflect the influence of broader socioeconomic forces acting on behavioral and biological processes that accelerate cardiovascular disease progression. However, this hypothesis has not been tested explicitly. Here, we examine metabolic syndrome (MetS) in rural black young adults as a function of their family's economic conditions before and after the Great Recession...
September 6, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28877108/prevention-of-heel-pressure-injuries-and-plantar-flexion-contractures-with-use-of-a-heel-protector-in-high-risk-neurotrauma-medical-and-surgical-intensive-care-units-a-randomized-controlled-trial
#5
Tina Meyers
PURPOSE: The purpose of this study was to compare the use of a heel protector to standard of care (pillows) in the prevention of hospital-acquired pressure injuries (HAPI) of the heels and prevention of plantar flexion contractures. DESIGN: Randomized controlled trial. SUBJECTS AND SETTING: The study took place on a surgical intensive care unit, medical intensive care unit, and neurotrauma intensive care unit. Inclusion criteria were a minimum of 5 days of sedation related to care for a critical illness, immobility for 6 to 8 hours before study initiation, a Braden Scale for Pressure Sore Risk score 18 or less, and a mobility subscale score 2 or less...
September 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28869873/hplc-ms-ms-method-for-bioavailability-study-of-bruceines-d-e-in-rat-plasma
#6
Farahdina Man, Chee-Yan Choo
Bruceines D and E are quassinoids from seeds of Brucea javanica (L.) Merr. exhibiting hypoglycemia effect. The crude drug is used as a traditional medicine by diabetes patients. The aim of this study is to understand the bioavailability and pharmacokinetics of both the bruceines D & E. A rapid and sensitive HPLC-MS/MS method was developed and validated for the quantification of both quassinoids, bruceines D & E in rat plasma. Both the bruceines D & E were separated with the Zorbax SBC-18 column with gradient elution and mobile phase system of acetonitrile and deionized water with 0...
August 30, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28867396/the-healthy-hearts-and-kidneys-hhk-study-design-of-a-2%C3%A3-2-rct-of-technology-supported-self-monitoring-and-social-cognitive-theory-based-counseling-to-engage-overweight-people-with-diabetes-and-chronic-kidney-disease-in-multiple-lifestyle-changes
#7
Mary Ann Sevick, Kathleen Woolf, Aditya Mattoo, Stuart D Katz, Huilin Li, David E St-Jules, Ram Jagannathan, Lu Hu, Mary Lou Pompeii, Lisa Ganguzza, Zhi Li, Alex Sierra, Stephen K Williams, David S Goldfarb
Patients with complex chronic diseases usually must make multiple lifestyle changes to limit and manage their conditions. Numerous studies have shown that education alone is insufficient for engaging people in lifestyle behavior change, and that theory-based behavioral approaches also are necessary. However, even the most motivated individual may have difficulty with making lifestyle changes because of the information complexity associated with multiple behavior changes. The goal of the current Healthy Hearts and Kidneys study was to evaluate, different mobile health (mHealth)-delivered intervention approaches for engaging individuals with type 2 diabetes (T2D) and concurrent chronic kidney disease (CKD) in behavior changes...
August 31, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28867311/distal-technologies-and-type-1-diabetes-management
#8
REVIEW
Danny C Duke, Samantha Barry, David V Wagner, Jane Speight, Pratik Choudhary, Michael A Harris
Type 1 diabetes requires intensive self-management to avoid acute and long-term health complications. In the past two decades, substantial advances in technology have enabled more effective and convenient self-management of type 1 diabetes. Although proximal technologies (eg, insulin pumps, continuous glucose monitors, closed-loop and artificial pancreas systems) have been the subject of frequent systematic and narrative reviews, distal technologies have received scant attention. Distal technologies refer to electronic systems designed to provide a service remotely and include heterogeneous systems such as telehealth, mobile health applications, game-based support, social platforms, and patient portals...
August 31, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28866479/type-1-diabetes-patient-decision-simulator-for-in-silico-testing-safety-and-effectiveness-of-insulin-treatments
#9
M Vettoretti, A Facchinetti, G Sparacino, C Cobelli
OBJECTIVE: Type 1 diabetes (T1D) treatment requires exogenous insulin administrations finely tuned based on glucose monitoring to avoid hyper/hypoglycemia. The safety and effectiveness of insulin treatments is commonly assessed in clinical trials, which are time demanding and expensive. These limitations can be overtaken by in silico clinical trials (ISCT) that require realistic patient and treatment models. The aim is to develop a T1D patient decision simulator usable to perform reliable ISCT...
August 29, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28865457/vision-related-quality-of-life-and-visual-outcomes-from-cataract-surgery-in-patients-with-vision-threatening-diabetic-retinopathy-a-prospective-observational-study
#10
Bijun Zhu, Yingyan Ma, Senlin Lin, Haidong Zou
BACKGROUND: To examine the benefit of cataract surgery on visual acuity and vision related quality of life in patients with stabilized vision-threatening diabetic retinopathy. METHODS: A total of 126 patients (153 eyes) who were diagnosed with cataract combined with stabilized vision-threatening diabetic retinopathy underwent phacoemulsification. Measurements included the best-corrected visual acuity (BCVA), which was converted into a weighted logarithm of the minimum angle of resolution (logMAR) and vision related quality of life (VRQoL) using the Chinese-version low vision quality of life questionnaire (CLVQOL)...
September 2, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28865394/clinical-measures-of-balance-in-people-with-type-two-diabetes-a-systematic-literature-review
#11
REVIEW
C J Dixon, T Knight, E Binns, B Ihaka, D O'Brien
Approximately 422 million people have diabetes mellitus worldwide, with the majority diagnosed with type 2 diabetes mellitus (T2DM). The complications of diabetes mellitus include diabetic peripheral neuropathy (DPN) and retinopathy, both of which can lead to balance impairments. Balance assessment is therefore an integral component of the clinical assessment of a person with T2DM. Although there are a variety of balance measures available, it is uncertain which measures are the most appropriate for this population...
August 24, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28864287/age-related-cataracts-role-of-unfolded-protein-response-ca-2-mobilization-epigenetic-dna-modifications-and-loss-of-nrf2-keap1-dependent-cytoprotection
#12
REVIEW
Palsamy Periyasamy, Toshimichi Shinohara
Age-related cataracts are closely associated with lens chronological aging, oxidation, calcium imbalance, hydration and crystallin modifications. Accumulating evidence indicates that misfolded proteins are generated in the endoplasmic reticulum (ER) by most cataractogenic stresses. To eliminate misfolded proteins from cells before they can induce senescence, the cells activate a clean-up machinery called the ER stress/unfolded protein response (UPR). The UPR also activates the nuclear factor-erythroid-2-related factor 2 (Nrf2), a central transcriptional factor for cytoprotection against stress...
September 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28862538/postoperative-continuous-catheter-infused-local-anesthetic-reduces-pain-scores-and-narcotic-use-after-lower-extremity-revascularization
#13
William Shutze, William P Shutze, Purvi Prajapati, Gerald Ogola, Jordan Schauer, Emily Biller, Nicholas Douville, Ryan A Shutze
Objective Postoperative pain following lower extremity revascularization procedures is traditionally controlled with narcotic administration. However, this may not adequately control the pain and puts the patient at risk for complications from opiate use. Here we report an alternative strategy for pain management using a continuous catheter-infused local anesthetic into the operative limb. Design Retrospective case-control study. Methods Patients undergoing lower extremity revascularization procedures using continuous catheter-infused local anesthetic were compared to similar patients undergoing similar procedures during the same time period who did not receive continuous catheter-infused local anesthetic...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28862361/accumulation-of-advanced-glycation-end-products-ages-accelerates-arthrogenic-joint-contracture-in-immobilized-rat-knee
#14
Junya Ozawa, Akinori Kaneguchi, Kengo Minamimoto, Ryo Tanaka, Nobuhiro Kito, Hideki Moriyama
Joint mobility decreases in the elderly and in diabetics, this process is thought to be caused by accumulation of advanced-glycation end products (AGEs). Here, we aimed to elucidate the role of AGEs in joint contracture formation in rat knees. Rats were injected with ribose or saline into the knees twice weekly for eight weeks. Pentosidine (AGE) levels were measured in the knee-joint tissues. After serial injections, rats were subjected to unilateral knee-joint immobilization in a flexion position for various periods...
September 1, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28859673/multiple-therapeutic-effect-of-endothelial-progenitor-cell-regulated-by-drugs-in-diabetes-and-diabetes-related-disorder
#15
REVIEW
Rashmi K Ambasta, Harleen Kohli, Pravir Kumar
BACKGROUND: Reduced levels of endothelial progenitor cells (EPCs) counts have been reported in diabetic mellitus (DM) patients and other diabetes-related disorder. EPCs are a circulating, bone marrow-derived cell population that appears to participate in vasculogenesis, angiogenesis and damage repair. These EPC may revert the damage caused in diabetic condition. We aim to identify several existing drugs and signaling molecule, which could alleviate or improve the diabetes condition via mobilizing and increasing EPC number as well as function...
August 31, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28853753/a-multiscale-study-of-the-role-of-dynamin-in-the-regulation-of-glucose-uptake
#16
Raphaël Trouillon, M Cristina Letizia, Keir J Menzies, Laurent Mouchiroud, Johan Auwerx, Kristina Schoonjans, Martin A M Gijs
Glucose uptake in muscle cells in response to insulin is a fundamental mechanism for metabolism. The inability of cells to mobilize the specific glucose transporter GLUT4 is believed to be at least partially accountable for diseases, like diabetes, where cells do not respond to an insulin stimulus. In this work, a microchip is used to detect electrochemically glucose uptake from C2C12 myoblasts cultured on a patch of paper upon exposure to insulin. More importantly, the data suggest a new role for dynamin, a molecular motor which would be involved in GLUT4 translocation by facilitating exocytosis...
August 30, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28845486/the-effects-of-chronic-medical-conditions-and-obesity-on-self-reported-disability-in-older-mexican-americans
#17
Sanggon Nam, Soham Al Snih, Kyriakos Markides
We investigated the effect of chronic medical conditions including obesity on self-reported disability and mobility in Mexican Americans aged 75 or over using data from the Hispanic Established Population for the Epidemiological Study of the Elderly (Hispanic EPESE) Wave 5 (2004-2005). Disability was assessed with a modified version of the Katz activities of daily living (ADL) scale and mobility was assessed with the Rosow Breslau scale of gross mobility function. The percentage of participants needing assistance with ADLs were as follows: 26...
2017: Texas Public Health Journal
https://www.readbyqxmd.com/read/28844679/syzygium-cumini-leaf-extract-inhibits-ldl-oxidation-but-does-not-protect-the-liproprotein-from-glycation
#18
Matheus M Dos Santos, Alessandro S Prestes, Gabriel T de Macedo, Assis Ecker, Rômulo P Barcelos, Aline A Boligon, Diego Souza, Andreza F de Bem, João B T da Rocha, Nilda V Barbosa
ETNOPHARMACOLOGICAL RELEVANCE: Syzygium cumini (L.) Skeels is a plant widely used in folk medicine to treat diabetes mellitus (DM). The tea from its leaves is frequently used by diabetics for lowering hyperglycemia. There is a close relationship between DM and atherosclerosis, a chronic immuno-inflammatory disease, were the early stages encompass oxidative and glycative modifications in the structure of low density lipoprotein (LDL). AIM OF THIS STUDY: To investigate the potential protective effects of aqueous-leaf extract from Syzygium cumini (S...
August 26, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28842686/the-validity-and-reliability-of-remote-diabetic-foot-ulcer-assessment-using-mobile-phone-images
#19
Jaap J van Netten, Damien Clark, Peter A Lazzarini, Monika Janda, Lloyd F Reed
Despite their potential for telemedicine in diabetic foot ulcer treatment, diagnostic accuracy of assessment of diabetic foot ulcers using mobile phone images is unknown. Our aim was to determine the validity and reliability of remote diabetic foot ulcer assessment using mobile phone images. Fifty diabetic foot ulcers were assessed live and photographed. Five independent observers remotely assessed the mobile phone images twice for presence of nine clinical characteristics and three treatment decisions. Positive likelihood (LLR+) and negative likelihood (LLR-) ratios were calculated for validity...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28839093/imaging-the-emergence-and-natural-progression-of-spontaneous-autoimmune-diabetes
#20
James F Mohan, Rainer H Kohler, Jonathan A Hill, Ralph Weissleder, Diane Mathis, Christophe Benoist
Type 1 diabetes in the nonobese diabetic mouse stems from an infiltration of the pancreatic islets by a mixed population of immunocytes, which results in the impairment and eventual destruction of insulin-producing β-cells. Little is known about the dynamics of lymphocyte movement in the pancreas during disease progression. Using advanced intravital imaging approaches and newly created reporter mice (Flt3-BFP2, Mertk-GFP-DTR, Cd4-tdTomato, Cd8a-tdTomato), we show that the autoimmune process initiates first with a T cell infiltration into the islets, where they have restricted mobility but reside and are activated in apposition to CX3CR1(+) macrophages...
September 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
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