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https://www.readbyqxmd.com/read/28641285/role-of-glycyrrhizin-in-the-reduction-of-inflammation-in-diabetic-kidney-disease
#1
Vikram Thakur, Syeda Nargis, Mayra Gonzalez, Swetak Pradhan, Daniel Terreros, Munmun Chattopadhyay
BACKGROUND: Diabetic kidney disease (DKD) is one of the most debilitating complications of type 2 diabetes. Recent evidence suggests chronic inflammation to be one of the causal factors of DKD. The mechanisms entailed are not completely elucidated except that a variety of cytokines play a major role in this process. High mobility group box 1 (HMGB1) is a pro-inflammatory toll-like receptor-4 (TLR4)-binding cytokine that is involved in inflammation-associated gene expression. This investigation was designed to assess the involvement of HMGB1, TLR-4, and nuclear factor (NF)-κB in the development of DKD and to evaluate that whether blocking HMGB1 by its natural inhibitor Glycyrrhizin (GLC) can reduce the progression of the disease...
June 23, 2017: Nephron
https://www.readbyqxmd.com/read/28639375/challenges-in-regenerating-the-diabetic-heart-a-comprehensive-review
#2
REVIEW
Venkata R Satthenapalli, Regis R Lamberts, Rajesh Katare
Stem cell therapy is one of the promising regenerative strategies developed to improve cardiac function in patients with ischemic heart diseases (IHD). However, this approach is limited in IHD patients with diabetes due to a progressive decline in the regenerative capacity of stem cells. This decline is mainly attributed to the metabolic memory incurred by diabetes on stem cell niche and their systemic cues. Understanding the molecular pathways involved in the diabetes-induced deterioration of stem cell function will be critical for developing new cardiac regeneration therapies...
June 22, 2017: Stem Cells
https://www.readbyqxmd.com/read/28637356/-footsnap-a-new-mobile-application-for-standardizing-diabetic-foot-images
#3
Moi Hoon Yap, Katie E Chatwin, Choon-Ching Ng, Caroline A Abbott, Frank L Bowling, Satyan Rajbhandari, Andrew J M Boulton, Neil D Reeves
BACKGROUND: We describe the development of a new mobile app called "FootSnap," to standardize photographs of diabetic feet and test its reliability on different occasions and between different operators. METHODS: FootSnap was developed by a multidisciplinary team for use with the iPad. The plantar surface of 30 diabetic feet and 30 nondiabetic control feet were imaged using FootSnap on two separate occasions by two different operators. Reproducibility of foot images was determined using the Jaccard similarity index (JSI)...
June 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28633615/experts-opinion-on-manual-wheelchair-adjustments-for-adults-with-diabetes
#4
Sophie-Anne Scherrer, Joelle Chu Yu Chee, Nhi Vu, Patrice Lu, Michelle Ishack, Philippe S Archambault
Diabetes is a global health concern that can lead to mobility limitations necessitating a wheelchair. However, there are currently no guidelines for wheelchair adjustments tailored to the diabetic population. PURPOSE: To describe relevant manual wheelchair adjustments for adults with diabetes, and to explore how these adjustments apply to populations living in less-resourced countries. METHODS: Semi-structured interviews were conducted with 13 wheelchair experts from five different countries working with adult with diabetes...
March 2, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28630037/a-mobile-app-for-the-self-management-of-type-1-diabetes-among-adolescents-a-randomized-controlled-trial
#5
Shivani Goyal, Caitlin A Nunn, Michael Rotondi, Amy B Couperthwaite, Sally Reiser, Angelo Simone, Debra K Katzman, Joseph A Cafazzo, Mark R Palmert
BACKGROUND: While optimal blood glucose control is known to reduce the long-term complications associated with type 1 diabetes mellitus, adolescents often struggle to achieve their blood glucose targets. However, their strong propensity toward technology presents a unique opportunity for the delivery of novel self-management interventions. To support type 1 diabetes self-management in this population, we developed the diabetes self-management app bant, which included wireless blood glucose reading transfer, out-of-range blood glucose trend alerts, coaching around out-of-range trend causes and fixes, and a point-based incentive system...
June 19, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28630035/the-effects-of-preoperative-volume-replacement-in-diabetic-patients-undergoing-coronary-artery-bypass-grafting-surgery-protocol-for-a-randomized-controlled-trial-verdict-trial
#6
Madeleine Clout, Tracy Harris, Chris Rogers, Lucy Culliford, Jodi Taylor, Gianni Angelini, Pradeep Narayan, Barnaby Reeves, James Hillier, Kate Ashton, Kunal Sarkar, Raimondo Ascione
BACKGROUND: Diabetes mellitus is a major risk factor for prolonged hospital stays, renal failure, and mortality in patients having coronary artery bypass grafting (CABG). Complications pose a serious threat to patients and prolong intensive care and hospital stays. Low glomerular filtration rate (GFR) due to existing renal impairment or volume depletion may exacerbate acute renal impairment/failure in these patients. Preoperative volume replacement therapy (VRT) is reported to increase the GFR and we hypothesize that VRT will reduce renal impairment and related complications in diabetic patients...
June 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28622617/determination-and-pharmacokinetics-of-engeletin-in-rat-plasma-by-ultra-high-performance-liquid-chromatography-with-tandem-mass-spectrometry
#7
Weijian Ye, Ruijie Chen, Wei Sun, Chengke Huang, Xixi Lin, Yaoyao Dong, Congcong Wen, Xianqin Wang
Engeletin, a bioactive flavonoid, has attracted much attention recently by virtue of its multiple biological (anti-diabetic and anti-inflammatory) activities. Despite signifying many therapeutic applications researches indicating quantification or pharmacokinetics of engeletin in biological matrix are still lacking. Here, a simple, sensitive, accurate and reliable ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) approach for the quantification of engeletin in rat plasma was developed and fully validated for the first time...
June 10, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28619996/farnesoid-x-receptor-and-liver-x-receptor-ligands-initiate-formation-of-coated-platelets
#8
Amanda J Unsworth, Alexander P Bye, Dionne S Tannetta, Michael J R Desborough, Neline Kriek, Tanya Sage, Harriet E Allan, Marilena Crescente, Parveen Yaqoob, Timothy D Warner, Chris I Jones, Jonathan M Gibbins
OBJECTIVES: The liver X receptors (LXRs) and farnesoid X receptor (FXR) have been identified in human platelets. Ligands of these receptors have been shown to have nongenomic inhibitory effects on platelet activation by platelet agonists. This, however, seems contradictory with the platelet hyper-reactivity that is associated with several pathological conditions that are associated with increased circulating levels of molecules that are LXR and FXR ligands, such as hyperlipidemia, type 2 diabetes mellitus, and obesity...
June 15, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28619625/hmgb1-an-innate-alarmin-plays-a-critical-role-in-chronic-inflammation-of-adipose-tissue-in-obesity
#9
REVIEW
Jing Zhang, Lei Zhang, Shu Zhang, Qilin Yu, Xiong Fei, Kun Huang, Cong-Yi Wang, Ping Yang
Obesity has emerged as an imminent global public health concern over the past several decades. It has now become evident that obesity is characterized by the persistent and low-grade inflammation in the adipose tissue, and serves as an independent risk factor for many metabolic disorders such as diabetes and cardiovascular disease. Particularly, adipocytes originated from obese mice and humans likely predominate necrosis upon stressful insults, leading to passive release of cellular contents including the high mobility group box 1 (HMGB1) into the extracellular milieu...
June 12, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28617628/pilot-study-of-a-novel-application-for-data-visualization-in-type-1-diabetes
#10
Jenise C Wong, Aaron B Neinstein, Howard Look, Brandon Arbiter, Nora Chokr, Cassie Ross, Saleh Adi
BACKGROUND: A novel software application, Blip, was created to combine and display diabetes data from multiple devices in a uniform, user-friendly manner. The objective of this study was to test the usability of this application by adults and caregivers of children with type 1 diabetes (T1D). METHODS: Patients (n = 35) and caregivers of children with T1D (n = 30) using an insulin pump for >1 year ± CGM were given access to the software for 3 months. Diabetes management practices and the use of diabetes data were assessed at baseline and at study end, and feedback was gathered in a concluding questionnaire...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28617617/accuracy-and-user-performance-evaluation-of-a-new-wireless-enabled-blood-glucose-monitoring-system-that-links-to-a-smart-mobile-device
#11
Timothy S Bailey, Jane F Wallace, Scott Pardo, Mary Ellen Warchal-Windham, Bern Harrison, Robert Morin, Mark Christiansen
BACKGROUND: The new Contour(®)Plus ONE blood glucose monitoring system (BGMS) features an easy-to-use, wireless-enabled blood glucose meter that links to a smart mobile device via Bluetooth(®) connectivity and can sync with the Contour(™) Diabetes app on a smartphone or tablet. METHODS: The accuracy of the new BGMS was assessed in 2 studies according to ISO 15197:2013 criteria. In Study 1 (laboratory study), fingertip capillary blood samples from 100 subjects were tested in duplicate using 3 test strip lots...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28616932/analysis-of-accuracy-and-user-performance-evaluation-of-a-new-wireless-enabled-blood-glucose-monitoring-system-that-links-to-a-smart-mobile-device
#12
Malte Rutschmann
In the study published in Journal of Diabetes, Science and Technology, Timothy S. Bailey and coauthors evaluated system accuracy and user performance of a new, wireless-enabled blood glucose monitoring system, the Contour Plus ONE blood glucose monitoring system. The authors declare that the study protocol was performed according to ISO 15197:2013 guidelines, in particular to clauses 6.3 and 8. Results show a high level of accuracy of the product in a laboratory setting as well as in the hands of lay users...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28615159/mobile-health-in-oncology-a-patient-survey-about-app-assisted-cancer-care
#13
Kerstin Anne Kessel, Marco Me Vogel, Carmen Kessel, Henning Bier, Tilo Biedermann, Helmut Friess, Peter Herschbach, Rüdiger von Eisenhart-Rothe, Bernhard Meyer, Marion Kiechle, Ulrich Keller, Christian Peschel, Roland M Schmid, Stephanie E Combs
BACKGROUND: In the last decade, the health care sector has been enriched by numerous innovations such as apps and connected devices that assist users in weight reduction and diabetes management. However, only a few native apps in the oncological context exist, which support patients during treatment and aftercare. OBJECTIVE: The objective of this study was to analyze patients' acceptance regarding app use and to investigate the functions of an oncological app that are most required, and the primary reasons for patients to refuse app-assisted cancer care...
June 14, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28614104/is-there-an-app-for-that-mobile-phones-and-secondary-prevention-of-cardiovascular-disease
#14
Lis Neubeck, Susie Cartledge, Susan Dawkes, Robyn Gallagher
PURPOSE OF REVIEW: Advances in technology coupled with increased penetration of mobile phones and smart devices are rapidly changing healthcare delivery. Mobile phone applications ('apps'), text messages, and Internet platforms used alone or in combination are now providing interventions targeting people with multiple cardiovascular risk factors. The present article will review the emerging evidence regarding apps and discuss their potential role in providing secondary prevention interventions via mobile phones...
June 13, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28605474/digital-innovations-and-emerging-technologies-for-enhanced-recovery-programmes
#15
F Michard, T J Gan, H Kehlet
Enhanced recovery programmes (ERPs) are increasingly used to improve post-surgical recovery. However, compliance to various components of ERPs-a key determinant of success-remains sub-optimal. Emerging technologies have the potential to help patients and caregivers to improve compliance with ERPs.Preoperative physical condition, a major determinant of postoperative outcome, could be optimized with the use of text messages (SMS) or digital applications (Apps) designed to facilitate smoking cessation, modify physical activity, and better manage hypertension and diabetes...
June 9, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28603808/relationship-between-hyperbaric-oxygen-therapy-and-quality-of-life-in-participants-with-chronic-diabetic-foot-ulcers-data-from-a-randomized-controlled-trial
#16
Guowei Li, Robert B Hopkins, Mitchell A H Levine, Xuejing Jin, James M Bowen, Lehana Thabane, Ron Goeree, Ludwik Fedorko, Daria J O'Reilly
AIMS: To investigate the effect of hyperbaric oxygen therapy on health-related quality of life (HRQoL) in participants with diabetes and chronic foot ulcers. METHODS: Using data from a randomized controlled trial, we included 103 participants (49 in hyperbaric oxygen therapy group and 54 in sham group) for analyses. The primary outcome was HRQoL as measured by the EQ-5D-3L instrument, while secondary outcomes included quality of life evaluated by the Short Form 36 (SF-36) and Diabetic Foot Ulcers Scale-Short Form (DFS-SF)...
June 12, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28599963/prevalence-of-type-2-diabetes-mellitus-complications-among-palestinians-with-t2dm
#17
Ahmad Abu Al-Halaweh, Nadav Davidovitch, Thomas Peter Almdal, Anna Cowan, Samah Khatib, Lana Nasser-Eddin, Ziad Baradia
AIMS: To assess the prevalence of microvascular and macrovascular complications of type 2 diabetes (T2DM) among Palestinians. METHODS: 1308 diagnosed T2DM attending four main Primary Health Care Clinics on the Southern West Bank of Palestine examined by a Mobile Diabetes Clinic team. All diabetes patients visiting the clinics during a one-month period for each clinic were included. Interviews, anthropometric measurements, physical examination, and laboratory tests: HbA1c, lipid profile, and kidney function tests analyzed in a central laboratory were obtained RESULTS: 1308 diabetes patients, including 839 females (64%), with a mean age of 57 years (SD=8...
June 3, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28585558/correlates-of-self-reported-physical-function-in-individuals-with-spinal-cord-injuries-and-disorders-does-self-efficacy-matter
#18
J N Hill, B Etingen, S Miskevics, S L LaVela
STUDY DESIGN: Data were collected via a cross-sectional mailed survey with Veterans with spinal cord injury and disorders (SCI/D). OBJECTIVES: To examine self-efficacy in Veterans with SCI/D reporting high versus low perceptions of physical function. SETTING: Department of Veterans Affairs (VA) Spinal Cord Injury System of Care-nation-wide, 24 Spinal Cord Injury (SCI) Centers. METHODS: The survey provided patient-reported data on demographic and injury characteristics, basic mobility and fine motor function, and perceived self-efficacy...
June 6, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28578165/antihypertensive-and-vasorelaxant-effects-of-aqueous-extract-of-artemisia-campestris-l-from-eastern-morocco
#19
Ikram Dib, Monique Tits, Luc Angenot, Jean Noel Wauters, Asmae Assaidi, Hassane Mekhfi, Mohammed Aziz, Mohammed Bnouham, Abdelkhaleq Legssyer, Michel Frederich, Abderrahim Ziyyat
ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia campestris L. (Asteraceae) has many traditional uses, among which treatment of diabetes and hypertension. AIM OF THE STUDY: This study was conducted in order to confirm the antihypertensive and hypotensive effects of A. campestris L. aqueous extract (AcAE) and to explore the underlying mechanism of action of its vasorelaxant effect, besides the acute toxicity. Also, the chemical composition of AcAE was investigated. MATERIAL AND METHODS: the chemical content of AcAE was determined by using HPLC and NMR techniques...
May 31, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28572917/mobilizing-for-a-war-on-the-home-front-against-sugar-related-morbidity-and-mortality
#20
Dean Schillinger, James G Kahn
In Israel today, there are 420,200 Israelis diagnosed with diabetes, and every year, Israelis sustain thousands of diabetes-related deaths and tens of thousands of diabetes-related amputations. As such, in Israel, as in much of the world, there is a silent and deadly public health war against obesity and diabetes taking place on the home front -- one in which clinicians, patients, and families fight thousands of life- and limb-threatening battles daily, involving preventable heart disease, diabetes, strokes and amputations...
2017: Israel Journal of Health Policy Research
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