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https://www.readbyqxmd.com/read/29770246/development-of-the-imb-model-and-an-evidence-based-diabetes-self-management-mobile-application
#1
Eunjoo Jeon, Hyeoun-Ae Park
Objectives: This study developed a diabetes self-management mobile application based on the information-motivation-behavioral skills (IMB) model, evidence extracted from clinical practice guidelines, and requirements identified through focus group interviews (FGIs) with diabetes patients. Methods: We developed a diabetes self-management (DSM) app in accordance with the following four stages of the system development life cycle. The functional and knowledge requirements of the users were extracted through FGIs with 19 diabetes patients...
April 2018: Healthcare Informatics Research
https://www.readbyqxmd.com/read/29768196/loss-of-abhd15-impairs-the-anti-lipolytic-action-of-insulin-by-altering-pde3b-stability-and-contributes-to-insulin-resistance
#2
Wenmin Xia, Ariane R Pessentheiner, Dina C Hofer, Melina Amor, Renate Schreiber, Gabriele Schoiswohl, Thomas O Eichmann, Evelyn Walenta, Bianca Itariu, Gerhard Prager, Hubert Hackl, Thomas Stulnig, Dagmar Kratky, Thomas Rülicke, Juliane G Bogner-Strauss
Elevated circulating fatty acids (FAs) contribute to obesity-associated metabolic complications, but the mechanisms by which insulin suppresses lipolysis are poorly understood. We show that α/β-hydrolase domain-containing 15 (ABHD15) is required for the anti-lipolytic action of insulin in white adipose tissue (WAT). Neither insulin nor glucose treatments can suppress FA mobilization in global and conditional Abhd15-knockout (KO) mice. Accordingly, insulin signaling is impaired in Abhd15-KO adipocytes, as indicated by reduced AKT phosphorylation, glucose uptake, and de novo lipogenesis...
May 15, 2018: Cell Reports
https://www.readbyqxmd.com/read/29763980/arterial-stiffness-in-people-with-type-2-diabetes-and-obstructive-sleep-apnoea
#3
M Hvelplund Kristiansen, A M Banghøj, E Laugesen, L Tarnow
AIMS: To examine whether people with Type 2 diabetes with concurrent obstructive sleep apnoea have increased arterial stiffness as compared with people with Type 2 diabetes without obstructive sleep apnoea. METHODS: In a study with a case-control design, 40 people with Type 2 diabetes and treatment-naïve moderate to severe obstructive sleep apnoea (Apnoea-Hypopnoea Index ≥15) and a control group of 31 people with Type 2 diabetes without obstructive sleep apnoea (Apnoea-Hypopnoea Index <5) were examined...
May 15, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29759959/health-care-professionals-attitudes-toward-and-experiences-of-using-a-culture-sensitive-smartphone-app-for-women-with-gestational-diabetes-mellitus-qualitative-study
#4
Lisa Garnweidner-Holme, Therese Hoel Andersen, Mari Wastvedt Sando, Josef Noll, Mirjam Lukasse
BACKGROUND: The increasing prevalence of gestational diabetes mellitus (GDM) among women of different ethnic backgrounds provides new challenges for health care professionals, who often find it difficult to provide information about the management of this disease to such individuals. Mobile health (mHealth) may act as a useful tool for blood sugar control and care process enhancement. However, little is known about health care professionals' experiences and attitudes toward the use of mHealth for women with GDM...
May 14, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29759065/high-resolution-mapping-of-traffic-related-air-pollution-with-google-street-view-cars-and-incidence-of-cardiovascular-events-within-neighborhoods-in-oakland-ca
#5
Stacey E Alexeeff, Ananya Roy, Jun Shan, Xi Liu, Kyle Messier, Joshua S Apte, Christopher Portier, Stephen Sidney, Stephen K Van Den Eeden
BACKGROUND: Some studies have linked long-term exposure to traffic related air pollutants (TRAP) with adverse cardiovascular health outcomes; however, previous studies have not linked highly variable concentrations of TRAP measured at street-level within neighborhoods to cardiovascular health outcomes. METHODS: Long-term pollutant concentrations for nitrogen dioxide [NO2 ], nitric oxide [NO], and black carbon [BC] were obtained by street-level mobile monitoring on 30 m road segments and linked to residential addresses of 41,869 adults living in Oakland during 2010 to 2015...
May 15, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29757410/chronic-kidney-disease-and-peripheral-nerve-function-in-the-health-aging-and-body-composition-study
#6
Ranjani N Moorthi, Simit Doshi, Linda F Fried, Sharon M Moe, Mark J Sarnak, Suzanne Satterfield, Ann V Schwartz, Michael Shlipak, Brittney S Lange-Maia, Tamara B Harris, Anne B Newman, Elsa S Strotmeyer
Background: Chronic kidney disease (CKD) is associated with poor mobility. Peripheral nerve function alterations play a significant role in low mobility. We tested the hypothesis that early CKD is associated with altered sensory, motor and autonomic nerve function. Methods: Participants in the Health, Aging and Body Composition cohort who had kidney function measures in Year 3 (1999-2000) and nerve function measurements at Year 4 (2000-01) were analyzed (n = 2290)...
May 10, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29752867/topical-application-of-culture-expanded-cd34-umbilical-cord-blood-cells-from-frozen-units-accelerates-healing-of-diabetic-skin-wounds-in-mice
#7
Jennifer Whiteley, Theresa Chow, Hibret Adissu, Armand Keating, Ian M Rogers
Chronic and nonhealing wounds are constant health issues facing patients with type 2 diabetes. As the incidence of type 2 diabetes mellitus (T2DM) increases, the incidence of chronic wounds and amputations will rise. T2DM is associated with peripheral arterial occlusive disease, which leads to the development of nonhealing skin ulcers after minor trauma. Patients develop severe pain limiting their mobility and ability to work and take care of themselves thus putting a significant burden on the family and society...
May 12, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29748905/diabetes-care-in-the-digital-era-a-synoptic-overview
#8
REVIEW
Farhad Fatehi, Anish Menon, Dominique Bird
PURPOSE OF REVIEW: Diabetes care is undergoing a remarkable transformation by the advancements in information and communications technology (ICT). The aim of this review is to provide a general overview of various ICT-based interventions for diabetes care, challenges of their adoption, and consider future directions. RECENT FINDINGS: A number of systematic reviews have examined studies on various aspects of telemedicine and eHealth for diabetes care, but they are generally focused on one specific type of technology application for diabetes care...
May 10, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29740786/rapid-evidence-review-of-mobile-applications-for-self-management-of-diabetes
#9
Stephanie Veazie, Kara Winchell, Jennifer Gilbert, Robin Paynter, Ilya Ivlev, Karen B Eden, Kerri Nussbaum, Nicole Weiskopf, Jeanne-Marie Guise, Mark Helfand
BACKGROUND: Patients with diabetes lack information on which commercially available applications (apps) improve diabetes-related outcomes. We conducted a rapid evidence review to examine features, clinical efficacy, and usability of apps for self-management of type 1 and type 2 diabetes in adults. METHODS: Ovid/Medline and the Cochrane Database of Systematic Reviews were searched for systematic reviews and technology assessments. Reference lists of relevant systematic reviews were examined for primary studies...
May 8, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29737584/metformin-increases-the-cytotoxicity-of-oxaliplatin-in-human-dld-1-colorectal-cancer-cells-through-down-regulating-hmgb1-expression
#10
Wen-Shih Huang, Chien-Tsong Lin, Cheng-Nan Chen, Shun-Fu Chang, Hsin-I Chang, Ko-Chao Lee
Colorectal cancer (CRC) is the fourth most common cause of cancer death worldwide. Chemotherapy has been the major strategy for treating patients with advanced CRC. Oxaliplatin (OXA) is used as both an adjuvant and neoadjuvant anticancer agent available to treat advanced CRC. High-mobility group box 1 protein (HMGB1) is a critical regulator of cell death and survival. HMGB1 overexpression has been shown to be resistant to cytotoxic agents. In addition, Metformin, a widely used drug for diabetes, has emerged as a potential anticancer agent...
May 8, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29735475/effectiveness-of-internet-based-interventions-on-glycemic-control-in-patients-with-type-2-diabetes-meta-analysis-of-randomized-controlled-trials
#11
Ying Shen, Fengbin Wang, Xing Zhang, Xiaorou Zhu, Qiudan Sun, Edwin Fisher, Xinying Sun
BACKGROUND: The popularity of internet as an area of research has grown manifold over the years. Given its rapid development and increasing coverage worldwide, internet-based interventions seem to offer a promising option to ameliorate huge burdens brought by type 2 diabetes mellitus. However, studies conducted by different researchers have provided contradictory results on the effect of internet-based interventions in glycemic control. OBJECTIVE: This meta-analysis aims to summarize currently available evidence and evaluate the overall impact of internet-based interventions on glycemic management of type 2 diabetic patients...
May 7, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29734114/the-early-signaling-pathway-of-live-yeast-cell-derivative-in-thp-1-monocytes
#12
Eric I Gruenstein, Donna J Schlemm, Mridula Bethi, Stephen J Keller
Live yeast cell derivative (LYCD) is a medicinal yeast extract that has been used in the treatment of burns, wounds and hemorrhoids for over 70 years. It has been shown to enhance the closure of skin wounds in diabetic mice by increasing inflammation, angiogenesis, formation of granulation tissue and epithelial migration. An active fraction of LYCD has been identified as a mixture of peptides ranging in size from 5 kDA to 17 kDA. Despite its widespread use over many years, understanding of the mechanism by which LYCD acts to effect tissue repair responses is very limited...
April 22, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29729133/impact-of-multiple-chronic-conditions-on-activity-limitations-among-older-mexican-american-care-recipients
#13
Diane M Collins, Brian Downer, Amit Kumar, Shilpa Krishnan, Chih-Ying Li, Kyriakos S Markides, Amol M Karmarkar
INTRODUCTION: Older Mexican Americans are living longer with multiple chronic conditions (MCCs). This has placed greater demands on caregivers to assist with basic activities of daily living (ADL) or instrumental activities of daily living (IADL). To understand the needs of older Mexican-American care recipients, we examined the impact of MCC on ADL and IADL limitations. METHODS: We analyzed data from 485 Mexican American care-receiving/caregiving dyads. Selected MCCs in the analysis were diabetes, hypertension, stroke, heart disease, arthritis, emphysema/chronic obstructive pulmonary disease, cognitive impairment, depression, and cancer...
May 3, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29724709/usefulness-of-a-novel-mobile-diabetes-prevention-program-delivery-platform-with-human-coaching-65-week-observational-follow-up
#14
Andreas Michaelides, Jennifer Major, Edmund Pienkosz, Meghan Wood, Youngin Kim, Tatiana Toro-Ramos
BACKGROUND: It is widely recognized that the prevalence of obesity and comorbidities including prediabetes and type 2 diabetes continue to increase worldwide. Results from a 24-week Diabetes Prevention Program (DPP) fully mobile pilot intervention were previously published showing promising evidence of the usefulness of DPP-based eHealth interventions on weight loss. OBJECTIVE: This pilot study extends previous findings to evaluate weight loss results of core (up to week 16) and maintenance (postcore weeks) DPP interventions at 65 weeks from baseline...
May 3, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29723439/lc-esi-ms-ms-study-of-repaglinide-and-its-forced-degradation-products
#15
C Purna Chander, B Raju, M Ramesh, G Shankar, R Srinivas
RATIONALE: Stress stability studies of drugs have been recognized as an essential part of the drug development process. These studies are used to investigate the intrinsic stability of the drugs and for the development of a selective stability indicating assay method (SIAM). Stress testing is also useful for the formulation and packaging development, shelf-life determination and designing of manufacturing processes. As per regulatory guidelines, stress degradation studies and structural characterization should be carried out to establish degradation pathways of the drug, which is essential from both efficacy and safety point of view...
May 3, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29710485/stimulation-of-klf14-plk1-pathway-by-thrombin-signaling-potentiates-endothelial-dysfunction-in-type-2-diabetes-mellitus
#16
Jun-Sheng Hao, Chao-Juan Zhu, Bin-Yuan Yan, Chang-You Yan, Rui Ling
Type 2 diabetes mellitus (T2DM) promotes a high oxidative stress and hypercoagulable state that drives microvascular injury and multiple-organ abnormality. Elevated thrombin activity underlies T2DM-linked endothelial dysfunction, but the mechanistic links between T2DM/oxidative stress axis and thrombin-associated endothelial pathologies are incompletely understood. In this work, immunohistochemical studies and quantitative analysis using isolated endothelial cells (ECs) identified accumulated Kru¨ppel-like family of transcription factor 14 (KLF14) deposits in ECs from multiple organs as distinct features of T2DM mice...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29708791/dietary-management-of-older-people-with-diabetes
#17
Jane McClinchy
Diabetes UK's revised nutrition guidelines for the prevention and management of diabetes, published recently, encourage education in self-management and include additional guidance for older people with diabetes. The incidence of diabetes in older people is increasing. Many older people with diabetes are healthy and mobile, and live in the community, but a number are frail and living in care homes. Those who are frail are at increased risk of malnutrition from a range of causes. Older people with diabetes should be assessed for malnutrition risk and referred to a dietitian if required...
May 2, 2018: British Journal of Community Nursing
https://www.readbyqxmd.com/read/29708777/healthcare-encounters-for-pok%C3%A3-mon-go-risks-and-benefits-of-playing
#18
Erika M Barbero, Diane M Carpenter, Joetta Maier, Daniel S Tseng
OBJECTIVE: Our aim was to quantify the health risks and benefits of Pokémon Go, an augmented reality game played on the mobile phone utilizing real-world locations. MATERIALS AND METHODS: Healthcare encounters containing references to Pokémon Go in Kaiser Permanente Northern California (KPNC) from July 5, 2016 to November 5, 2016 were reviewed. Subjects were classified according to the nature of the healthcare encounter subsequent to playing Pokémon Go: adverse event/injury, self-reported benefit, or incidental mention...
April 30, 2018: Games for Health
https://www.readbyqxmd.com/read/29707151/high-levels-of-circulating-endothelial-progenitor-cells-in-patients-with-diabetic-retinopathy-are-positively-associated-with-arhgap22-expression
#19
Yu-Chuen Huang, Wen-Ling Liao, Jane-Ming Lin, Ching-Chu Chen, Shih-Ping Liu, Shih-Yin Chen, Yu-Ning Lin, Yu-Jie Lei, Huan-Ting Liu, Yu-Jen Chen, Fuu-Jen Tsai
Diabetic retinopathy (DR) is a common microvascular complication of diabetes. Circulating endothelial progenitor cells (EPCs) are derived from bone marrow and are characterized by pathological retinal neovascularization. Rho GTPase Activating Protein 22 ( ARHGAP22 ) is a DR susceptibility gene that interacts with its downstream regulatory protein ras-related C3 botulinum toxin substrate 1 (Rac1), to assist in endothelial cell angiogenesis and increasing capillary permeability. The aim of this study was to elucidate the relationship between ARHGAP22 expression and EPC levels in type 2 diabetes (T2D) patients with DR...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29704494/metformin-a-first-line-drug-for-type-2-diabetes-mellitus-disrupts-the-malat1-mir-142-3p-sponge-to-decrease-invasion-and-migration-in-cervical-cancer-cells
#20
Chenglai Xia, Shaofeng Liang, Zhihong He, Xiaolan Zhu, Ruihong Chen, Jinman Chen
The molecular mechanisms underlying the anti-neoplastic properties of metformin, a first-line drug for type 2 diabetes, remain elusive. To explore the novel anti-neoplastic mechanisms of metformin, the transwell chamber and wound-healing assays were used to evaluate its effects on the migration and invasion of human cervical cancer cells. Real-time PCR and Western blotting were used to measure the gene and protein expression, respectively, of microRNA (miRNA) miR-142-3p, long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript-1 (MALAT1), and high-mobility group AT-hook 2 (HMGA2)...
April 25, 2018: European Journal of Pharmacology
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