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Michael P Chu, J Randolph Hecht, Dennis Slamon, Zev A Wainberg, Yung-Jue Bang, Paulo M Hoff, Alberto Sobrero, Shukui Qin, Karen Afenjar, Vincent Houe, Karen King, Sheryl Koski, Karen Mulder, Julie Price Hiller, Andrew Scarfe, Jennifer Spratlin, Yingjie J Huang, Saba Khan-Wasti, Neil Chua, Michael B Sawyer
Importance: Capecitabine is an oral cytotoxic chemotherapeutic commonly used across cancer subtypes. As with other oral medications though, it may suffer from drug interactions that could impair its absorption. Objective: To determine if gastric acid suppressants such as proton pump inhibitors (PPIs) may impair capecitabine efficacy. Design, Setting, and Participants: This secondary analysis of TRIO-013, a phase III randomized trial, compares capecitabine and oxaliplatin (CapeOx) with or without lapatinib in 545 patients with ERBB2/HER2-positive metastatic gastroesophageal cancer (GEC); patients were randomized 1:1 between CapeOx with or without lapatinib...
October 13, 2016: JAMA Oncology
Stephen Flach, Marie Croft, Jie Ding, Ron Budhram, Todd Pankratz, Mike Pennick, Graeme Scarfe, Steven Troy, Jay Getsy
PURPOSE: Gastroesophageal reflux disease involves the reflux of gastric and/or duodenal content into the esophagus. Prokinetic therapies, such as the selective 5-hydroxytryptamine receptor 4 agonist revexepride, may aid gastric emptying. This Phase I study evaluated the pharmacokinetics and excretion pathways of [(14)C]revexepride in healthy individuals using a microtracer approach with accelerator mass spectrometry. PARTICIPANTS AND METHODS: Six healthy men received a single oral dose of 2 mg [(14)C]revexepride containing ~200 nCi of radioactivity; blood, urine, and fecal samples were collected over a 10-day period...
2016: Drug Design, Development and Therapy
Damian Scarf, Jillian G Hayhurst, Benjamin C Riordan, Mike Boyes, Ted Ruffman, John A Hunter
OBJECTIVE: Mental health problems are a leading cause of health-related disability during adolescence. The objectives of the current study were to investigate whether participating in an adventure education programme (AEP) increased adolescents' resilience and elucidate how social connectedness contributes to any increase. METHOD: Adolescents who participated in the AEP had their resilience measured on the first (Time 1) and last day (Time 2) of a 10-day voyage...
September 27, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Jin Su Kim, Hun Ki Cho, Ki Won Young, Sang Young Lee, Ji Soo Kim, Kyoungtae Lee
BACKGROUND: Scarf osteotomy has been used in hallux valgus surgery due to its large fixation surface for screws and low postoperative complications. However, screws may cause skin irritation from their head, which may require an additional surgical procedure to remove. METHODS: This study included 115 patients (106 females and 9 males, 115 feet) who underwent hallux valgus correction with a scarf osteotomy using bioabsorbable screws between September 2010 and September 2012...
September 25, 2016: Foot & Ankle International
Jun Young Choi, Ji Woong Yeom, Yu Min Suh, Jin Soo Suh
BACKGROUND: We aimed to compare the postoperative height of the second metatarsal head relative to the first metatarsal head using axial radiographs among 3 different commonly used osteotomy techniques: proximal chevron metatarsal osteotomy (PCMO), scarf osteotomy, and distal chevron metatarsal osteotomy (DCMO). METHODS: We retrospectively reviewed the radiographs and clinical findings of the patients with painful callosities under the second metatarsal head, complicated by hallux valgus, who underwent isolated PCMO, scarf osteotomy, or DCMO from February 2005 to January 2015...
September 22, 2016: Foot & Ankle International
Damian Scarf, Karoline Boy, Anelisie Uber Reinert, Jack Devine, Onur Güntürkün, Michael Colombo
Learning to read involves the acquisition of letter-sound relationships (i.e., decoding skills) and the ability to visually recognize words (i.e., orthographic knowledge). Although decoding skills are clearly human-unique, given they are seated in language, recent research and theory suggest that orthographic processing may derive from the exaptation or recycling of visual circuits that evolved to recognize everyday objects and shapes in our natural environment. An open question is whether orthographic processing is limited to visual circuits that are similar to our own or a product of plasticity common to many vertebrate visual systems...
October 4, 2016: Proceedings of the National Academy of Sciences of the United States of America
Stephen Flach, Graeme Scarfe, Jeffrey Dragone, Jie Ding, Mark Seymour, Mike Pennick, Todd Pankratz, Steven Troy, Jay Getsy
PURPOSE: Chronic constipation is a prevalent gastrointestinal disorder globally. It is often treated with medications such as laxatives. Newer therapies to improve gastric motility include the selective 5-hydroxytryptamine receptor-4 agonist prucalopride, which is licensed for the treatment of chronic constipation in adults. The aim of this study was to investigate the pharmacokinetic properties and excretion of prucalopride in healthy individuals, using a microtracer approach with (14)C radioactivity detection using liquid scintillation counting and accelerator mass spectrometry...
September 2016: Clinical Therapeutics
Yusuf Parvez, Mohammed Ashraf Kandath
Foreign body (FB) aspiration is commonly seen in children but less commonly in adolescents. Headscarf pin aspiration is common in Muslim girls, who inappropriately place the pins between their lips while securing the scarf on the head. Bronchoscopy is the treatment modality of choice, and surgery is rarely required. An 11-year-old girl was admitted as a case of accidental aspiration of headscarf pin. X-ray chest showed a radiopaque object in the left bronchus piercing the lung parenchyma. Computed tomography (CT) chest confirmed the diagnosis...
July 2016: Lung India: Official Organ of Indian Chest Society
Solomon Barkley, Samantha J Scarfe, Eric R Weeks, Kari Dalnoki-Veress
Laplace pressure driven snap-off is a technique that is used to produce droplets for emulsions and microfluidics purposes. Previous predictions of droplet size have assumed a quasi-equilibrium low flow limit. We present a simple model to predict droplet sizes over a wide range of flow rates, demonstrating a rich landscape of droplet stability depending on droplet size and growth rate. The model accounts for the easily adjusted experimental parameters of geometry, interfacial tension, and the viscosities of both phases...
September 21, 2016: Soft Matter
Andrew J Kolarik, Amy C Scarfe, Brian C J Moore, Shahina Pardhan
Accurate motor control is required when walking around obstacles in order to avoid collisions. When vision is unavailable, sensory substitution can be used to improve locomotion through the environment. Tactile sensory substitution devices (SSDs) are electronic travel aids, some of which indicate the distance of an obstacle using the rate of vibration of a transducer on the skin. We investigated how accurately such an SSD guided navigation in an obstacle circumvention task. Using an SSD, 12 blindfolded participants navigated around a single flat 0...
2016: PloS One
Luis M Gordillo-Fernández, Mercedes Ortiz-Romero, Jose Luis S M Salcini Macías, José Valero-Salas, Julia Álvarez-Pérez, Álvaro Fernández-Garzón
Metatarsus adductus is a structural deformity that may be associated with hallux valgus and that may lead to metatarsal pain and functional abnormality of the foot. Correcting hallux valgus is complicated in these cases because of the deviation in adduction of the lesser metatarsals, especially the second metatarsal that occupies the first intermetatarsal space. We report the case of a 49-year-old man who underwent a scarf osteotomy in the first metatarsal, shortening and abductor oblique distal osteotomies of the lesser metatarsals, and arthrodesis of the central toes with Z-lengthening of the capsule and long extensor tendons of the toes...
July 2016: Journal of the American Podiatric Medical Association
Jana Zímová, Pavlína Zímová
Trichotillomania (TTM) is defined by the Diagnostics and Statistic Manual of Mental Disorders, 4th edition (DMS-IV) as hair loss from a patient`s repetitive self-pulling of hair. The disorder is included under anxiety disorders because it shares some obsessive-compulsive features. Patients have the tendency towards feelings of unattractiveness, body dissatisfaction, and low self-esteem (1,2). It is a major psychiatric problem, but many patients with this disorder first present to a dermatologist. An 11-year-old girl came to our department with a 2-month history of diffuse hair loss on the frontoparietal and parietotemporal area (Figure 1)...
June 2016: Acta Dermatovenerologica Croatica: ADC
Damian Scarf, Saleh Moradi, Kate McGaw, Joshua Hewitt, Jillian G Hayhurst, Mike Boyes, Ted Ruffman, John A Hunter
This study sought to examine the role of belonging in the increases in resilience observed following an adventure education programme (AEP). First, we demonstrate that group belonging makes a significant contribution to the improvement in resilience participants' experienced over the course of the AEP. Second, we demonstrate that this increase in resilience is maintained 9 months following the AEP and that group belonging maintained a significant contribution when controlling for participants' initial resilience level and other psychosocial variables (i...
September 2016: British Journal of Social Psychology
Jack Sharkey, Lauren Scarfe, Ilaria Santeramo, Marta Garcia-Finana, Brian K Park, Harish Poptani, Bettina Wilm, Arthur Taylor, Patricia Murray
The incidence of end stage kidney disease is rising annually and it is now a global public health problem. Current treatment options are dialysis or renal transplantation, which apart from their significant drawbacks in terms of increased morbidity and mortality, are placing an increasing economic burden on society. Cell-based Regenerative Medicine Therapies (RMTs) have shown great promise in rodent models of kidney disease, but clinical translation is hampered due to the lack of adequate safety and efficacy data...
June 30, 2016: European Journal of Pharmacology
Devendra Mahadevan, Stephen Lines, Stephen Hepple, Ian Winson, William Harries
BACKGROUND: The purpose of this RCT was to compare the extended plantar limb (modified) chevron osteotomy with the scarf osteotomy in correcting hallux valgus deformity and improving functional scores and patient satisfaction. METHODS: Patients were randomly assigned and kept blind to surgical allocation. Cases requiring additional procedures including the Akin osteotomy were excluded. Outcomes were measured at 1 year following surgery. RESULTS: 84 patients (109 feet) were analysed (60 modified chevron; 49 Scarf)...
June 2016: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
William D Harrison, Christopher R Walker
Current practice and controversies in UK bunion surgery are discussed. Patients tend to be offered a distally based metatarsal osteotomy, such as a chevron or scarf osteotomy, for mild to moderate symptomatic bunions. Greater deformities are managed with a more extreme scarf, supplemented with a proximal phalangeal osteotomy. A proximal fusion in the form of the Lapidus-type procedure is still reserved for the most severe, hypermobile, or arthritic cases. Minimally invasive techniques for bunions have failed to disseminate into common UK practice...
June 2016: Foot and Ankle Clinics
Anje J Scarfe, Susanne Schuhmann-Hingel, Joanna K Duncan, Ning Ma, Yasoba N Atukorale, Alun L Cameron
A continuous paravertebral block is used when pain relief is required beyond the duration of a single-injection paravertebral block. Surgical procedures requiring an incision into the pleural cavity are some of the most painful procedures postoperatively and, if not managed appropriately, can lead to chronic pain. The current gold standard for post-cardiothoracic surgery pain management is epidural analgesia, which has contraindications, a failure rate of up to 12% and risk of complications such as epidural abscess and spinal haematoma...
May 30, 2016: European Journal of Cardio-thoracic Surgery
Shivani Santosh, Debdulal Dutta Roy, Partha Sarathi Kundu
AIM: To explore relation between cognitive self-regulation, social functioning, and psychopathology in schizophrenia. MATERIALS AND METHODS: A total of 100 patients diagnosed with schizophrenia according to International Classification of Diseases (ICD)-10 were taken from Department of Psychiatry of two postgraduate hospitals of Kolkata, India. All subjects gave informed consent. After recording sociodemographic and clinical details, the Positive and Negative Syndrome Scale for Schizophrenia (PANSS), Schizophrenia Research Foundation India-Social Functioning Index (SCARF-SFI), and specially designed questionnaire on cognitive self-regulation was administered...
July 2015: Industrial Psychiatry Journal
R Ballas, P Edouard, R Philippot, F Farizon, F Delangle, N Peyrot
AIMS: The purpose of this study was to analyse the biomechanics of walking, through the ground reaction forces (GRF) measured, after first metatarsal osteotomy or metatarsophalangeal joint (MTP) arthrodesis. PATIENTS AND METHODS: A total of 19 patients underwent a Scarf osteotomy (50.3 years, standard deviation (sd) 12.3) and 18 underwent an arthrodesis (56.2 years, sd 6.5). Clinical and radiographical data as well as the American Orthopaedic Foot and Ankle Society (AOFAS) scores were determined...
May 2016: Bone & Joint Journal
G Jansen, F Mertzlufft
Aside from suicide attempts or autoerotic accidents, serious injuries from strangulation are rare. In 1929, the accidental death of the famous dancer Isadora Duncan gained high profile. However, even today there are reports of accidental strangulations. These are referred to as Isadora Duncan or long-scarf syndrome and are oftentimes lethal. In the pre-hospital setting, airway management has been challenging, as even a correctly placed airway device may initiate a rapid and marked deterioration of the patient's condition...
May 2016: Der Anaesthesist
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