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https://www.readbyqxmd.com/read/28918286/identifying-combinatorial-biomarkers-by-association-rule-mining-in-the-camd-alzheimer-s-database
#1
Balázs Szalkai, Vince K Grolmusz, Vince I Grolmusz
The concept of combinatorial biomarkers was conceived when it was noticed that simple biomarkers are often inadequate for recognizing and characterizing complex diseases. Here we present an algorithmic search method for complex biomarkers which may predict or indicate Alzheimer's disease (AD) and other kinds of dementia. We show that our method is universal since it can describe any Boolean function for biomarker discovery. We applied data mining techniques that are capable to uncover implication-like logical schemes with detailed quality scoring...
August 17, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28835442/cyp-mediated-sulfoximine-de-imination-of-azd6738
#2
Barry C Jones, Roshini Markandu, Chungang Gu, Graeme Scarfe
In hepatic S9 and human liver microsomes (HLM) the sulfoximine moiety of the ATR inhibitor AZD6738 is metabolised to its corresponding sulfoxide (AZ8982) and sulfone (AZ0002). The initial de-imination to AZ8982 is nominally a reductive reaction but in HLM required NADPH and was inhibited by 1-aminobenzotriazole (ABT) at 1mM. Studies in a panel of 11 recombinant cytochrome P450s (CYPs) - CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1 CYP2J2, CYP3A4 and CYP3A5 - confirmed that the de-imination was an oxidative process, mediated largely by CYP2C8 with some CYP2J2 involvement, whilst the subsequent oxidation to the sulfone was carried out largely by CYP2J2, CYP3A4 and CYP3A5...
August 23, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28833042/-what-and-where-was-when-memory-for-the-temporal-order-of-episodic-events-in-children
#3
Damian Scarf, Hannah Boden, Lisa G Labuschagne, Julien Gross, Harlene Hayne
In the past, researchers have shown that the individual components of episodic memory (i.e "what," "where," and "when") may emerge at different points in development. Specifically, while children as young as three can accurately report the "what" and "where" of an event, they struggle to accurately report when the event occurred. One explanation for children's difficulty in reporting when an event took place is a rudimentary understanding, and ability to use, temporal terms. In the current experiment, we employed a physical timeline to aid children's reporting of the order in which a series of episodic events occurred...
August 21, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28797127/the-resqu-index-a-new-instrument-to-appraise-the-quality-of-research-on-birth-place
#4
Saraswathi Vedam, Chris Rossiter, Caroline S E Homer, Kathrin Stoll, Vanessa L Scarf
OBJECTIVE: Place of birth is a known determinant of health care outcomes, interventions and costs. Many studies have examined the maternal and perinatal outcomes when women plan to give birth in hospitals compared with births in birth centres or at home. However, these studies vary substantially in rigour; assessing their quality is challenging. Existing research appraisal tools do not always capture important elements of study design that are critical when comparing outcomes by planned place of birth...
2017: PloS One
https://www.readbyqxmd.com/read/28766185/when-your-mind-skips-what-your-eyes-fixate-how-forced-fixations-lead-to-comprehension-illusions-in-reading
#5
Elizabeth R Schotter, Mallorie Leinenger, Titus von der Malsburg
The phenomenon of forced fixations suggests that readers sometimes fixate a word (due to oculomotor constraints) even though they intended to skip it (due to parafoveal cognitive-linguistic processing). We investigate whether this leads readers to look directly at a word but not pay attention to it. We used a gaze-contingent boundary paradigm to dissociate parafoveal and foveal information (e.g., the word phone changed to scarf once the reader's eyes moved to it) and asked questions about the sentence to determine which one the reader encoded...
August 1, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28764412/the-nonlinear-schr%C3%A3-dinger-equation-with-generalized-nonlinearities-and-pt-symmetric-potentials-stable-solitons-interactions-and-excitations
#6
Zhenya Yan, Yong Chen
We investigate the nonlinear Schrödinger (NLS) equation with generalized nonlinearities and complex non-Hermitian potentials and present the novel parity-time-( PT-) symmetric potentials for the NLS equation with power-law nonlinearities supporting some bright solitons. For distinct types of PT-symmetric potentials including Scarf-II, Hermite-Gaussian, and asymptotically periodic potentials, we, respectively, explore the phase transitions for the linear Hamiltonian operators. Moreover, we analytically find stable bright solitons in the generalized NLS equations with several types of PT-symmetric potentials, and their stability is corroborated by the linear stability spectrum and direct wave-propagation simulations...
July 2017: Chaos
https://www.readbyqxmd.com/read/28731582/episodic-foresight-beyond-the-very-next-event-in-3-and-4-year-old-children
#7
Hannah Boden, Lisa G Labuschagne, Ashley E Hinten, Damian Scarf
Testing episodic foresight in children generally involves presenting them with a problem in one location (e.g., Room A) and, after a spending a delay in a different location, telling them they will be returning to Room A. Before they go, children are presented with a number of items, one of which will allow them to solve the problem in Room A. At around 3 to 4 years of age children display episodic foresight, selecting the item that will allow them to solve the problem. To date, however, no study has assessed whether 3- and 4-year-old children can plan beyond the very next event, selecting the correct item when there is a delay before returning to Room A...
July 21, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28708906/effectiveness-of-periapical-radiography-versus-cone-beam-computed-tomography-with-different-kilovoltage-settings-in-the-detection-of-chemically-created-peri-implant-bone-defects-an-in-vitro-study
#8
Lucas Rodrigues Pinheiro, William C Scarfe, Marcelo Augusto de Oliveira Sales, Bruno Felipe Gaia, Arthur Rodriguez Gonzalez Cortes, Marcelo Gusmão Paraiso Cavalcanti
PURPOSE: To determine the effectiveness of cone beam computed tomography (CBCT) images obtained with different kilovoltage settings compared with intraoral periapical photostimulable storage phosphor (PSP) plate images in the detection of chemically created peri-implant defects utilizing a bovine rib bone model in vitro. MATERIALS AND METHODS: After placing 80 implants in bovine ribs, peri-implant circumferential bone defects of different sizes were created with 70% perchloric acid...
July 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28707141/do-literate-pigeons-columba-livia-show-mirror-word-generalization
#9
Damian Scarf, Michael C Corballis, Onur Güntürkün, Michael Colombo
Many children pass through a mirror stage in reading, where they write individual letters or digits in mirror and find it difficult to correctly utilize letters that are mirror images of one another (e.g., b and d). This phenomenon is thought to reflect the fact that the brain does not naturally discriminate left from right. Indeed, it has been argued that reading acquisition involves the inhibition of this default process. In the current study, we tested the ability of literate pigeons, which had learned to discriminate between 30 and 62 words from 7832 nonwords, to discriminate between words and their mirror counterparts...
July 13, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28676769/spacing-repetitions-over-long-timescales-a-review-and-a-reconsolidation-explanation
#10
Christopher D Smith, Damian Scarf
Recent accounts of the spacing effect have proposed molecular explanations that explain spacing over short, but not long timescales. In the first half of this paper, we review research on the spacing effect that has employed spaces of 24 h or more across skill-related tasks, language-related tasks and generalization for adults and children. Throughout this review, we distinguish between learning and retention by defining learning (or acquisition) as performance at the end of training and retention as performance after a delay period...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28657402/in-vitro-evaluation-of-the-inhibition-and-induction-potential-of-olaparib-a-potent-poly-adp-ribose-polymerase-inhibitor-on-cytochrome-p450
#11
Alex McCormick, Helen Swaisland, Venkatesh Pilla Reddy, Maria Learoyd, Graeme Scarfe
1. In vitro studies were conducted to evaluate potential inhibitory and inductive effects of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib, on cytochrome P450 (CYP) enzymes. Inhibitory effects were determined in human liver microsomes (HLM); inductive effects were evaluated in cultured human hepatocytes. 2. Olaparib did not inhibit CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2D6 or CYP2E1 and caused slight inhibition of CYP2C9, CYP2C19 and CYP3A4/5 in HLM up to a concentration of 100 µM. However, olaparib (17‒500 µM) inhibited CYP3A4/5 with an IC50 of 119 µM...
June 28, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28627978/scarf-pin-related-hijab-syndrome-a-new-name-for-an-unusual-type-of-foreign-body-aspiration
#12
Aram Baram, Fahmi H Kakamad, Delan Ahmed Bakir
Background Foreign body aspiration refers to the inhalation of an object into the respiratory system and is a serious and potentially fatal event. A distinct group of patients has recently been recognized among Muslim nations. These patients include women who wear headscarves and place the safety pin in their mouth prior to securing the veils, leading to accidental foreign body aspiration. The aim of this study was to analyze the main presentation, diagnosis, treatment, and outcome of patients with scarf pin aspiration...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28576099/solitons-and-their-stability-in-the-nonlocal-nonlinear-schr%C3%A3-dinger-equation-with-pt-symmetric-potentials
#13
Zichao Wen, Zhenya Yan
We report localized nonlinear modes of the self-focusing and defocusing nonlocal nonlinear Schrödinger equation with the generalized PT-symmetric Scarf-II, Rosen-Morse, and periodic potentials. Parameter regions are presented for broken and unbroken PT-symmetric phases of linear bounded states and the linear stability of the obtained solitons. Moreover, we numerically explore the dynamical behaviors of solitons and find stable solitons for some given parameters.
May 2017: Chaos
https://www.readbyqxmd.com/read/28479160/technique-for-preventing-troughing-in-scarf-osteotomy
#14
Su Chan Lee, Seung Hyun Hwang, Chang Hyun Nam, Ji-Hoon Baek, Soon Yong Yoo, Hye Sun Ahn
Scarf osteotomy is a common operative procedure for mild-to-moderate hallux valgus. We describe a simple supportive technique that prevents troughing intraoperatively without additional bony procedures.
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28476096/hallux-valgus-correction-comparing-percutaneous-chevron-akin-peca-and-open-scarf-akin-osteotomies
#15
Moses Lee, James Walsh, Margaret M Smith, Jeff Ling, Andrew Wines, Peter Lam
BACKGROUND: Minimally invasive surgery is being used increasingly, including for hallux valgus surgery. Despite the growing interest in minimally invasive procedures, there have been few publications on percutaneous chevron/akin (PECA) procedures, and no studies have been published comparing PECA to open scarf/akin osteotomies (SA). METHODS: This was a prospective, randomized study of 50 patients undergoing operative correction of hallux valgus using one of 2 techniques (PECA vs open SA)...
May 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28455499/families-of-stable-solitons-and-excitations-in-the-pt-symmetric-nonlinear-schr%C3%A3-dinger-equations-with-position-dependent-effective-masses
#16
Yong Chen, Zhenya Yan, Dumitru Mihalache, Boris A Malomed
Since the parity-time-([Formula: see text]-) symmetric quantum mechanics was put forward, fundamental properties of some linear and nonlinear models with [Formula: see text]-symmetric potentials have been investigated. However, previous studies of [Formula: see text]-symmetric waves were limited to constant diffraction coefficients in the ambient medium. Here we address effects of variable diffraction coefficient on the beam dynamics in nonlinear media with generalized [Formula: see text]-symmetric Scarf-II potentials...
April 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429477/the-emerging-role-of-maxillofacial-radiology-in-the-diagnosis-and-management-of-patients-with-complex-periodontitis
#17
REVIEW
William C Scarfe, Bruno Azevedo, Lucas R Pinheiro, Menik Priaminiarti, Marcelo A O Sales
Contemporary periodontal therapy has evolved to become more interdisciplinary and increasingly involves more complex treatments, including bone and soft-tissue regenerative procedures. Therapeutic options require an imaging modality or combination of techniques that are capable of providing a diagnostic osseous baseline and facilitating quantification of smaller increments of bony change, both loss and additive, which are comparable over time. Intra-oral and panoramic radiography are the modalities most commonly used to identify the location, quantify the amount and the pattern of alveolar bone loss and determine response to therapy...
June 2017: Periodontology 2000
https://www.readbyqxmd.com/read/28407000/blindness-enhances-auditory-obstacle-circumvention-assessing-echolocation-sensory-substitution-and-visual-based-navigation
#18
Andrew J Kolarik, Amy C Scarfe, Brian C J Moore, Shahina Pardhan
Performance for an obstacle circumvention task was assessed under conditions of visual, auditory only (using echolocation) and tactile (using a sensory substitution device, SSD) guidance. A Vicon motion capture system was used to measure human movement kinematics objectively. Ten normally sighted participants, 8 blind non-echolocators, and 1 blind expert echolocator navigated around a 0.6 x 2 m obstacle that was varied in position across trials, at the midline of the participant or 25 cm to the right or left...
2017: PloS One
https://www.readbyqxmd.com/read/28405709/-scarf-osteotomy
#19
H-J Trnka, P Bock
Hallux valgus is one of the most common deformities of the lower extremity. Multiple etiologies have been discussed, and various techniques have been described. The SCARF osteotomy is indicated for moderate to severe hallux valgus deformities. The technique historically used by carpenters allows immediate postoperative weight bearing and also entails the possibility to correct the distal metatarsal articular angle by rotation of the osteotomy. The SCARF osteotomy has also been successfully used in revision surgeries...
May 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28367688/first-metatarsophalangeal-contact-properties-following-proximal-opening-wedge-and-scarf-osteotomies-for-hallux-valgus-correction-a-biomechanical-study
#20
Cameron Kia, Ryu Yoshida, Mark Cote, Jessica DiVenere, Lauren E Geaney
BACKGROUND: Proximal opening wedge osteotomy (POWO) is an established procedure for moderate to severe hallux valgus. A common concern of this procedure is that it results in lengthening of the first metatarsal, which could cause increased intra-articular pressure of the first metatarsophalangeal joint (MTP) and may ultimately lead to arthritis because of these altered mechanics. The purpose of this study was to use a cadaveric model to compare intra-articular pressures and articulating contact properties of the MTP joint following either scarf osteotomy or POWO...
April 2017: Foot & Ankle International
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